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ICR마우스에서 phenytoin의 최기형성 및 dimethyl sulfoxide의 항최기형 효과
이재권,이창업,이문한,류판동,조명행,성하정,박진봉,Lee, Jae-kwon,Lee, Chang-eop,Lee, Mun-han,Ryu, Pan-dong,Cho, Myung-haing,Sung, Ha-jung,Park, Jin-bong 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.4
Phenytoin(PHT), a commonly prescribed anticonvulsant, has been known as a teratogen in experimental animals and human. However, PHT has strain-specific teratogenic effects for mice and human. Dimethyl sulfoxids(DMSO) has been known to antagonize the teratogenic effects of secalonic acid D, a toxic mold metabolite that has similar teratogenic effects to PHT. Therefore, this study was performed to examine the embryopathic effects of PHT in terms of treatment period and the antiteratogenic effect of DMSO in ICR mice. PHT(75mg/kg, BW) was administered intrapetitoneally on day 10, 10-11 and 10-12 of gestation with or without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Major malformation of fetuses treated with PHT on day 10, 10-11 and 10-12 of gestation was cleft palate, and the percentages of fetus with cleft palate were 14.5%, 31.7% and 51.7%, respectively. Also, there was a significant decrease of cleft palate from 51.7% in PHT alone group to 30.8% in PHT plus DMSO group. Our findings suggest that cleft palate is one of major malformation by PHT treatment in ICR mouse and DMSO has strong antiteratogenic effect.
Phenytoin의 태아 구개열 유발과 모체 혈청 Corticosterone 증가에 대한 Dimethyl Sulfoxide 억제 작용
이재권,이창업,이문한,류판동,이영재,성하정,Lee, Jae-Kwon,Lee, Chang-Eop,Lee, Mun-Han,Ryu, Pan-Dong,Lee, Young-Jae,Sung, Ha-Jung 한국독성학회 1992 Toxicological Research Vol.8 No.2
It is well known that phenytoin (PHT), a commonly prescribed anticonvulsant, has teratogenicity in experimental animals and human. The major malformation induced by PHT in mouse is cleft palate. The mechanisms of the embryotoxic effects of PHT are unknown. However, PHT and synthetic glucocorticoids share several features with respect to their teratogenicity, and it was known that PHT increased maternal corticosterone level. Therefore PHT-induced cleft palate may be mediated indirectly by elevated maternal corticosterone. Recently it was reported that secalonic acid Dinduced cleft palate and elevated endogenous corticosterone level, and that such effects were antagonized by DMSO. The purpose of this work was to investigate whether the elevated maternal corticosterone is associated with the teratogenicity of PHT in the ICR mouse fetuses by treatment with PHT or PHT plus DMSO. PHT (74mg/kg, BW) was daily administered intraperitoneally on day 10~12 of gestation with and without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Maternal serum corticosterone and fetal PHT levels were determined by HPLC. The results are summarized as follows. 1)The percentage of cleft palate incidense in fetuses following treatment with PHT on day 10~12 of gestation was 51.7%. 2)There was a significant decrement in the cleft palate incidence in fetuses to 30.8% in the group treated with PHT plus DMSO compared with 51.7% in that with PHT alone. 3) Maternal serum corticosterone levels following treatment with PHT on day 10~12 of gestation increased by 116~343% compared with that of vehicle control. Such effect was antagonized by DMSO. 4)PHT concentration in the fetuses was not affected by DMSO. These results suggest that PHT-induced cleft-palate in fetuses seems to be closely associated with the elevation of maternal corticosterone level.
관계형 데이터베이스 구성 요소의 의미 관계를 고려한 RDB to RDF 매핑 시스템
백두권 ( Doo Kwon Baik ),이석훈 ( Suk Hoon Lee ),성하정 ( Ha Jung Sung ),김장원 ( Jang Won Gim ) 한국정보처리학회 2014 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.3 No.1
시맨틱 웹의 확산을 위해 관계형 데이터베이스에 저장된 데이터를 온톨로지로 변환하는 연구가 활발히 진행 중이다. 관계형 데이터베이스에 저장된 데이터를 온톨로지로 변환하기 위한 연구들은 관계형 데이터베이스의 구성 요소와 RDF 구성 요소를 매핑하는 방식인 RDB to RDF 매 핑 모델을 주로 사용한다. 하지만 지금까지 제안된 매핑 모델들은 그 표현방식이 서로 다르며, 이는 사용자의 접근성과 재사용성을 떨어트린다. 이로 인해 표준화된 매핑 언어의 필요성이 대두되었으며, W3C에서는 RDB to RDF 모델의 표준 매핑 언어로서 R2RML을 제안하였다. R2RML 은 관계형 데이터베이스 스키마 정보만을 RDF로 변환하는 특징을 가진다. 이와 같은 이유로 관계형 데이터베이스의 테이블 명, 컬럼 명사이의 관계정보에 대한 온톨로지를 추가할 수 없다. 이 논문에서는 이러한 문제를 해결하기 위해 관계형 데이터베이스 구성 요소의 의미 관계를 고려한 RDB to RDF 매핑 시스템을 제안한다. 제안 시스템은 R2RML에서 정의한 관계형 데이터베이스의 스키마 정보에 RDFS 속성 정보를 확장하여 매핑 정보를 생성한다. 이러한 매핑 정보는 관계형 데이터베이스에 저장된 데이터를 RDFS 속성 정보가 포함된 RDF로 변환시킨다. 이 논문에서는 제안 시스템을 자바 기반의 프로토타입으로 구현하며, 비교 평가를 위해 관계형 데이터베이스에 저장된 데이터를 RDF로 변환하는 실험을 수행하고 결과를 D2RQ, RDBToOnto, Morph와 비교한다. 제안 시스템은 다른 연구들에 비해 변환한 온톨로지가 풍부한 의미관계를 표현하며, 데이터 변환 시간에서 가장 우수한 성능을 보인다. For the expansion of the Semantic Web, studies in converting the data stored in the relational database into the ontology are actively in process. Such studies mainly use an RDB to RDF mapping model, the model to map relational database components to RDF components. However, pre-proposed mapping models have got different expression modes and these damage the accessibility and reusability of the users. As a consequence, the necessity of the standardized mapping language was raised and the W3C suggested the R2RML as the standard mapping language for the RDB to RDF model. The R2RML has a characteristic that converts only the relational database schema data to RDF. For the same reasons above, the ontology about the relation data between table name and column name of the relational database cannot be added. In this paper, we propose an RDB to RDF mapping system considering semantic relations of RDB components in order to solve the above issue. The proposed system generates the mapping data by adding the RDFS attribute data into the schema data defined by the R2RML in the relational database. This mapping data converts the data stored in the relational database into RDF which includes the RDFS attribute data. In this paper, we implement the proposed system as a Java-based prototype, perform the experiment which converts the data stored in the relational database into RDF for the comparison evaluation purpose and compare the results against D2RQ, RDBToOnto and Morph. The proposed system expresses semantic relations which has richer converted ontology than any other studies and shows the best performance in data conversion time.
연구보문 : 유기화합물질 ; Octachlorostyrene의 환경중 노출평가에 관한 연구
김용석 ( Yong Seok Kim ),전용배 ( Yong Bae Jeon ),김태형 ( Tae Hyoung Kim ),성하정 ( Ha Jung Sung ),이규승 ( Kyu Seung Lee ) 한국환경농학회 2009 한국환경농학회지 Vol.28 No.2
옥타클로르스티렌은 환경중에서 잔류성이 높아 쉽게 분해되지 않으며 먹이연쇄상의 생물상에 고농도로 축적될 뿐만 아니라 환경 및 인간에 대한 독성이 매우 높은 물질군으로 알려져 있다. 따라서 본 연구에서는 옥타클로르스티렌에 대한 노출위험 가능성이 있는 오염 우려지역을 설정하여 그 지역의 수질, 토양 및 어류에 대한 옥타클로르스티렌의 잔류량을 조사하기 위해서 잔류분석법을 확립하고 잔류실태를 조사하였다. 그 결과 옥타클로르스티렌의 물에 대한 회수율은 93.1~토양에 대한 회수율은 90.4~94.8%, 어체에 대한 회수율은 81.5~90.2% 이었고 분석법의 검출한계는 물 0.0004 mg L-1이었고, 토양 및 어체는 각각 0.002 mg L-1이었다. 오염 우려지역으로 선정된 울산, 여수, 대전 및 시화공단에서 옥타클로르스티렌의 잔류량은 물, 토양 및 어체의 모든 시료에서 검출한계 미만이었고, 전국 각지의 소각장을 대상으로 실시한 토양시료에서도 옥타클로르스티렌은 검출되지 않았다. 따라서 우리나라는 아직 옥타클로르스티렌이 노출로부터 위험성이 없는 것으로 판단된다. Octachlorostyrene(OCS) has been persisted in environment because it has not been decomposed easily. And, it has been known as highly toxic compounds to the environment and human as well as accumulated as high concentrations in a biota through a food chain. Therefore, OCS was monitored for water, soil and fish sampled from the areas where were able to be contaminated with OCS. The recoveries of octachlorostyrene were 93.1~98.6% in water, 90.4~94.8% in soil and 81.5~90.2% in fish and detection limits were 0.0004 mg L-1 for water, and 0.002 mg kg-1 for soil and fish, respectively. OCS was not detected in water, sediment, soil and fish samples from Ulsan, Yeosu, Daejeon and Sihwa industrial complex and in soil sampled nearby incineration plants in all parts of the country. Accordingly, we estimated that there is no risk from exposure of OCS.