세침흡인 세포검사로 진단된 복벽의 자궁내막증 -2예 보고-

정명자,정연준,황호명,장규윤,문우성,강명재,이동근,Chung, Myoung-Ja,Jeong, Yeon-Jun,Hwang, Ho-Myong,Jang, Kyu-Yoon,Moon, Woo-Sung,Kang, Myoung-Jae,Lee, Dong-Geun 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.1

The incidence of endometriosis in post-operative abdominal scars is rare. We describe two cases of abdominal endometriosis diagnosed by fine needle aspiration (FNA). Both patients presented with subcutaneous masses at previous cesarean section scars with cyclic symptoms of pain. The cytologic smears were cellular and comprised two distinct cell populations consisting of epithelial and stromal components. An epithelial component consisted of flat sheets of polygonal cells and the second stromal component showed crowded clusters of spindle cells or isolated single cells. Hemosiderin-laden macrophages were found in the background. FNA offers a safe and effective tool for diagnosis of abdominal wall endometriosis.

골격외 간엽성 연골육종의 세침흡인 세포학적 소견 - 1예 보고 -

정명자,오소영,강명재,이동근,최호열,김상호,Chung, Myoung-Ja,Oh, So-Yeong,Kang, Myoung-Jae,Lee, Dong-Geun,Choi, Ho-Yeul,Kim, Sang-Ho 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

Extraskeletal mesenchymal chondrosarcoma is a relatively rare tumor and its cytologic findings have rarely been reported. We experienced a case of mesenchymal chondrosarcoma of soft tissue of the right lateral neck diagnosed by fine needle aspiration biopsy in a 59 year-old man. Cytologic findings showed two cell components. One was an undifferentiated, small cell component with moderate amount of cytoplasm and spindle nuclei. The second population was a chondroid component. These cytologic findings were diagnostic to mesenchymal chondrosarcoma.

유아의 부정적 정서에 대한 부모의 반응에 관한 연구

정명자(Chung, Myoung Ja),임유경(Lim, You Kyoung),김동례(Kim, Dong Rye) 한국생활과학회 2011 한국생활과학회지 Vol.20 No.6

The purpose of this study was to examine the difference of the father’s and mother’s reactions to their children’s negative emotions, relations among the children’s variables, parent’s variables, and parent’s reactions. The subjects selected were 183 mothers and 183 fathers with children aged three to five-years-old, from a childcare center and kindergarten in Kwang-ju. Parental emotion-related practices regarding children’s negative emotions were assessed with an adaptation of the CCNES(Fabes et al, 1990) that was modified by Kim Hee-Jung(1994). Descriptives, Pearson’s correlation coefficient, were used for data analysis by using the SPSS 15.0 program. The results of this study can be summarized as follows: First, fathers and mothers used more positive reactions than negative reactions when their children showed negative emotions. The mothers were significantly higher than fathers on encouragement of expression, punitive, and distress reactions. Second, the children’s age and gender, parent’s age, level of education and income were negatively and positively correlated to the father’s and mother’s reactions to their children’s negative emotions.

지방모세포종의 세침흡인 세포학적 소견 - 2예 보고 -

오소영,정명자,문우성,강명재,이동근,Oh, So-Yeong,Chung, Myoung-Ja,Moon, Woo-Sung,Kang, Myoung-Jae,Lee, Dong-Geun 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Lipoblastoma is a rare benign neoplasm occurring exclusively in children below the age of three years. It affects chiefly the upper and lower extremities, and less commonly head and neck area, trunk, mediastinum, mesentery, and retroperitoneum. We present two cases of lipoblastoma occurring in the mediastinum of a 21-month-old boy and in the back of a 15-month-old boy. The characteristic features of Fine needle aspiration cytology smears were the presence of immature fat cells in the form of spindle-shaped cells, stellate cells and vacuolated lipoblasts along with lipocytes against a myxomatous background. Two tumors were histologically confirmed to be lipoblastomas. Lipoblastoma can be cytologically diagnosed by considering the cytologic findings and the age of the patient.

백서 잔여 신장에서 TGF- β 수용체 발현에 관한 연구

강명재(Myoung Jae Kang),윤현상(Hyun Sang Yoon),정명자(Myoung JA Chung),문우성(Woo Sung Moon),이동근(Dong Geun Lee) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1

N/A TGF-β1 plays a major role in the regulation of extracellular matrix synthesis and degradation. TGF-β1 exerts its biological effects by interacting with specific cell surface receptors including type I and II receptors(TGFβ RI and RII). The purpose of this study is to investigate the expression of TGF β RI and RII proteins in the kidney during the development of glomerulosclerosis and renal fibrosis in rats with subtotal nephrectomy. Forty male Sprague-Dawley rats weighing 200 to 220 grams were divided into two groups: 25 rats were subjected to 5/6 renal ablation and 15 to sham operation. The animals were sacrificed 1, 2, 4, 8, and 16 weeks following operation and the kidneys were removed for histological and immunohistochemical studies for TGF-β1, TGFβRI, and TGFβRII. The results showed increased glomerulosclerosis, interstitial fibrosis, and mononuclear cellular infiltration with time and progressively higher immunohistochemical TGF-β1, TGF βRI, and TGFβRII staining in rats with subtotal nephrectomy. We conclude that increase in TGFβRI and RII expression in remnant kidney rats may be causally related with the development of renal fibrosis.

성상세포종에서의 p27^kip1 단백의 발현

김대용,손현진,정명자,강명재,Kim, Dae Yong,Son, Hyun Jin,Chung, Myoung Ja,Kang, Myoung Jae 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.4

Objective : The cyclin-dependent kinase inhibitor $p27^{kip1}$ protein is a negative regulator of the cell cycle, and its degradation is required for entry into the S phase. Loss of $p27^{kip1}$ expression has been reported to be associated with aggressive behavior in a variety of tumors of epithelial and lymphoid origin. However, its association with various astrocytic tumors has not been clearly demonstrated. We studied to investigate the relationship of $p27^{kip1}$ expression with the biological behavior of astrocytic tumors in addition to study on the role of $p27^{kip1}$ in the tumorigenesis of these tumors. Patients and Methods : From 1990 to 1998, a total of 29 astrocytic tumor of all grades obtained by operative resection were included for evaluation. We studied the expression of $p27^{kip1}$ protein immunohistochemical assay in astrocytic tumors and compared the findings with the clinicopathologic parameters. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded sections by the avidin-biotin-peroxidase complex method. According to WHO classification, all cases were divided into astrocytomas(4 cases), anaplastic astrocytomas(9 cases), and glioblastomas(16 cases) by 3 pathologists. Clinical information was obtained from medical records, and others such as location and size of tumors from imaging studies. Results : Mean $p27^{kip1}$ protein labeling indexes(LI, mean${\pm}$standard deviation) of astrocytomas, anaplastic astrocytomas, and glioblastomas were $80.6{\pm}9.1$, $63.6{\pm}21.0$, and $28.9{\pm}18.7$, respectively, and were inversely correlated with grade of glial tumors(p<0.0001). Mean $p27^{kip1}$ protein LI in the recurrent group was lower than that in the nonrecurrent group, but there was no significant difference statistically(p=0.464). Additionally, $p27^{kip1}$ protein expression did not show any significant relationship to other prognostic factors such as age(p=0.1643), tumor size(p=0.8), or location(p=0.8). Conclusion : These results suggested that reduced expression of $p27^{kip1}$ protein may play a important role in the malignant transformation process of astrocytic tumor cells.

양안 위눈꺼풀에 발생한 표피하 석회 결절

박영명(Young Myoung Park),정명자(Myoung Ja Chung),유인천(In Cheon You),조남천(Nam Chun Cho),안민(Min Ahn) 대한안과학회 2021 대한안과학회지 Vol.62 No.4

목적: 소아에서 발생한 양안 위눈꺼풀의 표피하 석회 결절 1예를 보고하고자 한다. 증례요약: 과거 외상의 기왕력이나 전신질환의 과거력이 없는 5세 여자 환자가 8개월 전부터 발생한 양안 상안검의 종괴를 주소로 내원하였다. 종괴는 통증 없이 서서히 크기가 커졌으며, 단단하고 황백색으로 돌출되어 있었다. 우안의 병소는 내안각 주변의 위눈꺼풀에 위치하였으며, 크기는 0.2 × 0.2 cm였다. 좌측의 병소는 우안에 비해 조금 더 내측에 위치하고 있었으며, 크기는 0.2 × 0.1cm였다. 소아황색육아종, 물사마귀로 의심하여 절제생검을 실시하였다. 병리검사상 병변은 다양한 크기의 칼슘 침착물을 포함하고 있었으며, 과증식되거나 과다각화증을 보이는 상피조직의 아래 혹은 과다각화증을 보이는 상피조직내에 위치하고 있었다. 표피하 석회 결절로 진단되었으며, 절제 후 재발 없이 잘 회복되었다. 결론: 눈꺼풀에서 발생한 통증이 없는 황백색의 융기성 병변에 대해서는 표피하 석회 결절을 감별진단으로 고려해야 한다. Purpose: To report a case of bilateral subepidermal calcified nodules of the upper eyelid in a child. Case summary: A 5-year-old girl with no history of trauma or systemic disease was referred for assessment of bilateral eyelid masses that had appeared 8 months prior. The masses grew slowly without pain, and were hard, elevated, and yellowish-white in color. The right eyelid mass was close to the medial canthus and measured 0.2 × 0.2 cm. The mass of the left upper eyelid was smaller (0.2 × 0.1 cm) and closer to the medial side. The clinical impression was juvenile xanthogranuloma and molluscum contagiosum. Excisional biopsy of the bilateral eyelid masses was performed. Histologic findings revealed that the lesions were composed of variable-sized multiple calcium deposits, lined by hyperplastic and hyperkeratotic epidermis or within the hyperkeratotic epidermis. The diagnosis was subepidermal calcified nodules (SCNs) for both of the bilateral eyelid masses. The patient made a complete recovery after the excision, without recurrence. Conclusions: SCNs should be considered during differential diagnosis of a painless, elevated, yellowish-white eyelid lesion.

림프유상피형 말초 T세포 림프종의 세침흡인 세포학적 소견 - 결핵성 림프절염과 감별이 어려웠던 1예 -

박호성,홍종명,정명자,문우성,Park, Ho-Sung,Hong, Jong-Myung,Chung, Myoung-Ja,Moon, Woo-Sung 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.2

The diagnosis of peripheral T cell lymphoma is difficult due to the varying size and shape of the neoplastic lymphoid cells and the frequent admixture of nonneoplastic mature lymphyocytes, histiocytes, eosinophils, and plasma cells. We report a case of peripheral T cell lymphoma, lymphoepithelioid ceil type, which was difficult to differentiate from tuberculous lymphadenitis due to the aggregates of epithelioid histlocytes mimicking granuloma and the past history of pulmonary tuberculosis. Fine needle aspiration cytology of the inguinal lymph node in a 63-year-old male was characterized by hypercellular aspirates composed of a mixture of small and intermediate-size lymphoid cells and large lymphoid cells with background of confluent epithelioid histiocytes. The neoplastic lymphocytes demonstrated significant nuclear irregularity with protrusion and indentations of the nuclear membrane, prominent nucleoli, and frequent mitotic figures. The diagnosis of peripheral T cell lymphoma was confirmed by histological and immunohistochemical studios.

경부에 전이한 Sex Cord Tumor with Annular Tubules의 세침흡인 세포소견 - 1예 보고 -

오소영,강명재,정명자,문우성,이동근,Oh, So-Yeong,Kang, Myoung-Jae,Chung, Myoung-Ja,Moon, Woo-Sung,Lee, Dong-Geun 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

A sex cord tumor with annnular tubules is a relatively rare ovarian neoplasm. The cytologic findings from a fine needle aspiration biopsy of neck metastasis of a sex cord tumor with annnular tubules are described. The origin of the neck metastasis was the right ovary, and the tumor was diagnosed six years ago. The cytologic findings were characterized by tumor cells arranged in solid or follicular patterns. The tumor cells formed rosette-like or complex tubular structures with central rounded or coalesced hyaline materials. It was difficult to distinguish this tumor cytologically from granulosa cell tumor, thyroid follicular neoplasm, Sertoli-Leydig cell tumor, and Brenner tumor, but complex tubular structures were helpful in discriminating between these tumors.

수막의 고립성 섬유성 종양 - 1예 보고 -

공태식,손현진,최하영,문우성,정명자,Kong, Tae Shik,Son, Hyun Jin,Choi, Ha Young,Moon, Woo Sung,Chung, Myoung Ja 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.12

Solitary fibrous tumor(SFT) is a spindle cell neoplasm that usually arises in the pleura. Its involvement of the meninges is rare but increasingly being reported. Our case was a 33-year-old man who presented with clonic seizure around the right mouth angle and sensory disturbance at the right hand. Radiological studies showed a large extra-axial, dural-based mass in the left fronto-parietal region, typically isointense with gray matter and heterogeneous strong enhancement on T1-weighted images. Histologically, the tumor was composed of spindle-shaped cells growing in fascicles within the collagenous matrix. Immunohistochemical staining demonstrated diffuse CD34 positivity. Awareness of this neoplasm is necessary to accurate diagnosis.