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정만기,김보영 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.7
Immune system is believed to play an important role in cancer initiation as well as its progression, as evidenced by many studies revealing suppressed, defective anti-tumor immunity in cancer patients. Modulating various components in immune surveillance, such as cytokine, antigen-presenting cells, or B/T lymphocytes, to control and eradicate cancer has been an attractive theme, however, preclinical/clinical trials have not been successful enough to introduce immunotherapy into practice. Recently, enthusiasm on cancer immunotherapy has been revived mostly due to 1) growing body of data on the mechanism of immune checkpoint in cancer, and 2) promising studies performed in advanced, solid cancer patients treated with blocking antibodies targeting cytotoxic T lymphocyte-associated antigen-4 or programmed cell death protein-1 pathways. The immune checkpoints blockade is likely to be a novel armament in cancer management as the outcomes of ongoing clinical trials are released in future.
인후두 역류증에 대한 초치료로서 양성자 펌프 억제제4주 단기 치료의 효과
정만기,민진영,오재원,정한신,백정환,손영익 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.6
Background and Objectives:Proton pump inhibitors (PPIs) can improve the symptoms of laryngopharyngeal reflux (LPR)if used for more than 8 weeks, but little information is available on the effects of short-term PPI therapy as an initial treatmentfor LPR. We aimed to evaluate the efficacy of 4-week short-term PPI medication as an initial treatment for LPR and to identifyspecific symptoms which can predict the outcome of treatment. Subjects and Method:Among the patients complaining ofmore than 3 typical LPR symptoms for over 3 months, 62 patients with LPR symptom scores over 8 points were enrolled for thestudy. The patients were randomly subjected either to the 4 weeks of prokinetics (n=31) or PPI (n=31) medication. Changesin subjective symptoms and objective findings were assessed at first visit and 4 weeks after the medication. Results:Treatmentwith prokinetics or PPI resulted in more than 50% reduction of LPR symptom scores in 9.6% or 29% of the patientsrespectively and 25-50% reduction in 54.8% or 70.9% of them. Objective reflux findings didn’t get improved in either group.Analyses of the obtained reflux symptom scores failed to predict the treatment outcome of PPI medication. Conclusion:ShorttermPPI therapy is highly effective for the reduction of LPR symptoms in selected patients, which may validate the use of PPIas an initial treatment regimen for the patients with LPR. However, further studies are required to assess the long-term effects of4-week PPI therapy as an initial treatment regimen.
정만기,서해립,서호영 한국해양과학기술원 2011 Ocean science journal Vol.46 No.2
Euchaetid copepods (Calanoida, Clausocalanoidea) were collected from the southeastern region of Korea and the East/Japan Sea from June 2007 to August 2008. Seven species were found and redescribed in this study: five species from the genus Euchaeta (E. concinna, E. indica, E. longicornis, E. plana and E. rimana) and two species from the genus Paraeuchaeta (P. elongata and P. russelli). Using scanning electron microscopy, we observed detailed taxonomic features with special references to their genital structure. The euchaetid copepods show speciesspecific characteristics on their genital structures, in particular on the shapes of genital operculum and genital flange. Their zoogeographies were also discussed. They can be regarded as an indicator species of the Tsushima Warm Current and East Sea Intermediate Water.
집단인식체제의 인식역량과 투자 그리고 정책제언: 자동차업계의 미래차 투자를 중심으로
정만기,정송희 한국모빌리티학회 2022 모빌리티연구 Vol.2 No.1
Recently, the automobile industry has been encountering disruptive changes on various levels. On the one hand, there has been rising demand worldwide to increase electrified vehicle production in response to climate change. On the other hand, there are also more calls for the production of autonomous vehicles, which have already increased in numbers owing to ICT development. As a result, global automobile OEMs as well as their subcontractors are expanding R&D spending and facility investments despite the uncertainty of profitability. However, regarding the factors of investment, there are differences of opinion between two schools of thought: the standard view of economics and non-standard institutional view. According to the standard economic view such as that of Keynes’, investment is motivated by “animal spirits” or in other words, realized by the pursuit of profit. Both interest rates and anticipated return rates are critical factors in investment decision-making. When companies have to render decisions among several investment projects, marginal investment efficiency, which is decided by each project’s anticipated return rate and interest rate, becomes the main factor. On the contrary, the conventionalist from one of the institutional schools of economics thinks differently. According to this school of thought, investment is affected by the collective cognition capacity of the production system, which includes the manufacturing firm as well as the related subcontractors. In this study, we attempt to analyze the actual investment process according to the conventional school of economics view. From this perspective, economic behavior is carried out with a restrained rationality that is influenced by insufficiency and asymmetry of information. Investment behavior follows the similar process of economic behavior, which is realized under the limited information and restrained cognitive capacity. Success of investment relies on both collective cognitive capacity and differing views within and out of the firms on overall investment projects including funds, future return anticipation. Recently, KAMA conducted research on the status of investment in future vehicles actualized by Korean firms. In this study, we confirm our hypotheses by using these research results and interviews with high position CEOs of major automobile companies operating in Korea.