맹출장애를 가진 하악 제1대구치의 치료 : 증례 보고

전현순,양연미,백병주,김재곤,Jeon, Hyunsoon,Yang, Yeonmi,Baik, Byeongju,Kim, Jaegon 대한소아치과학회 2013 大韓小兒齒科學會誌 Vol.40 No.4

하악 제1대구치 맹출장애의 빈도는 전체 인구의 0.01%로 드물게 나타나며, 발생 원인과 발견 연령 등에 따라 매복, 일차적 만기잔존(primary retention), 이차적 만기잔존(secondary retention) 등으로 분류된다. 치료로는 주기적 관찰, 외과적 노출술, 외과적 노출술 후 교정적 견인술, 탈구를 동반한 교정적 견인술, 외과적 재위치술, 발치 등의 방법을 적용할 수 있다. 이 증례보고는 각각 매복, 일차적 만기잔존, 그리고 이차적 만기잔존으로 진단된 5명의 환자들에서 다양한 치료방법을 이용하여 하악 제1대구치를 성공적으로 교합유도한 증례들을 보여준다. 맹출장애를 갖는 하악 제1대구치는 치아의 평균적인 맹출시기에 임상 및 방사선검사를 통해 매복, 일차적 만기잔존, 그리고 이차적 만기잔존으로 적절하게 진단내려질 수 있으며, 치아의 맹출 정도, 대합치와 인접치와의 관계, 환자의 연령, 협조도, 경제적 상황을 종합적으로 고려하여 치료되어야 한다. With a prevalence rate of 0.01%, the presence of eruption disturbances of mandibular first molar has rarely been in populations. Eruption disturbances of permanent molars have been usually manifested as impaction, primary retention, and secondary retention. The treatments of eruption disturbances are carried out by: periodic observation; surgical exposure; forced eruption after surgical exposure; forced eruption with luxation; surgical repositioning; and extraction. This case report show successfully erupted mandibular first molars by various treatment methods on five patients diagnosed with impaction, primary retention, and secondary retention, respectively. Eruption disturbances of the mandibular first molar can be properly diagnosed with impaction, primary retention, and secondary retention by clinical and radiographic examination at normal eruption time of the mandibular first molar. The treatment should be done synthetically, considering eruption state of affected tooth, the relationship between the affected tooth and the adjacent or opposite tooth, the patient's age, treatment compliance, and economic state.

전북대학교병원 소아치과에 내원한 어린이에서 선천적으로 결손된 치아의 유병률 및 분포

전현순,양연미,백병주,김재곤,Jeon, Hyunsoon,Yang, Yeonmi,Baik, Byeongju,Kim, Jaegon 대한소아치과학회 2013 大韓小兒齒科學會誌 Vol.40 No.4

이 연구는 2008년 1월부터 2012년 12월까지 소아치과에 내원한 7~15세 사이 아동 중, 파노라마방사선사진을 촬영한 3302명을 대상으로 하여 치아결손증의 유병률 및 선천적 결손치의 분포에 대해 분석하기 위함이었다. 치아결손증의 유병률은 남자(5.9%)가 여자(4.7%)보다 약간 높게 나왔으며, 남자에서 평균 선천적 결손치 수는 3.58개, 여자는 2.43개였다. 평균 선천적 결손치 수는 상악보다 하악에서 통계적으로 유의하게 높은 비율을 보였고(p < 0.05), 좌측과 우측치열간의 선천적 결손치 수의 차이는 통계적으로 유의하지 않았다(p > 0.05). 선천적 결손치가 가장 많이 분포하는 부위는 하악 제2소구치였으며 반대로 선천적 결손치가 가장 적게 분포하는 부위는 상 하악 제1대구치, 상악 중절치였다. 치아결손증 환자들에서 선천적 결손치의 악궁 내 대칭성 혹은 악궁 간 대칭성은 80.3%로 높게 나타났다. 이 연구의 결과는 임상의에게 선천적 결손치의 수와 위치에 대한 가치 있는 정보를 제공하여 정확한 진단을 내리고 바람직한 치료계획을 수립하는데 기여할 것이다. The goal of this study was to analyze prevalence and distribution of congenitally missing teeth in 3302 patients from 7 to 15 years old, who had visited and taken panoramic radiographs at the Department of Pediatric Dentistry, from January 2008 to December 2012. The prevalence of hypodontia in the males (5.9%) was slightly higher than in the females (4.7%). In the affected patients, the mean number of congenitally missing teeth in the mandible was statistically higher than in the maxilla (p < 0.05). However, there was no significant difference in the number of congenitally missing teeth between left and right dentitions (p > 0.05). Excluding the Mn. third molars, the most frequent congenitally missing teeth site was the Mn. second premolars. In contrast, the most infrequent congenitally missing teeth sites were the Mx. and Mn. first premolars, and Mx. central incisors. The bilateral combination or antagonistic quadrants combination of congenitally missing teeth in hypodontia patients was 80.3%. The result of this study will contribute to clinicians to make accurate diagnosis and establish favorable treatment plans, by offering invaluable data about the number and distribution of congenitally missing teeth.

저산소증에 의한 활막 섬유모세포에서 I CAM-1 발현의 증가

전현순 ( Hyun Soon Jeon ),백홍선 ( Hong Sun Baek ),황병연 ( Byung Yun Hwang ),류완희 ( Wan Hee Yoo ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1

Objective: Hypoxic conditions are thought to be exist in inflamed arthritic synovium. Several in vitro and in vivo studies indicate that hypoxia can initiate events that lead to pro-adhesive changes. Therefore, this study was designed to examine the effects of hypoxia on the expression of ICAM-1 by cultured human synovial fibroblasts. Methods: Synovial fibroblasts were isolated from patients with RA and cultured at hypoxic condition. To quantify the expression of ICAM-1 mRNA in synovial fibroblasts, RT-PCR was performed. The levels of cytokines in culture supernatants were measured by ELISA. The activation of NF-κB was analyzed by electrophoretic mobility shift assay. The assay of adhesive reaction between synovial fibroblasts and lymphocytes was performed by photographic evaluation with colloidin blue staining and measurement of fluorescent intensity of BCECFAM in lymphocytes. Results: The expression ICAM-1 mRNA was increased at 12 to 48 hours of hypoxic stimuli and peaked at 24 hours (p<0.01). The concentration of IL-1 and TNF-α was increased as the duration of hypoxic stimuli was increased. Hypoxia also induced activatation of NF-κB, which was inhibited by antioxidant (pyrrolidine dithiocarbamate). Fibroblast-lymphocyte adhesive interaction was increased significantly by hypoxic stimuli (p<0.01). Conclusions: Synovial hypoxia may have an important role in inflammatory synovitis, in part, as a cause of adhesion molecule (ICAM-1) expression in synovial fibroblasts and recruitment of inflammatory cells.

기관지천식 환자에서 angiotesin converting enxyme과 endothelial nitric oxide synthase 유전자의 다형성에 관한 연구

전현순(Hyun Sun Jeon),천기태(Ki Tae Cheon),이홍범(Heung Bum Lee),이양근(Yang Keun Lee),김달식(Dal Sik Kim),이용철(Yong Chul Lee) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.4

N/A Background: Angiotensin converting enzyme (ACE) is heavily expressed in the lung and plays a role in the metabolism of angiotensin II, bradykinin and substance P. Nitric oxides. including those produced by endothelial nitric oxide synthase (ecNOS). may regulate vascular and airway tone in the lung and influence various aspects of airway homeostasis. They are potentially involved in the pathogenesis of asthma, but the role of ACE and ecNOS gene in bronchial asthma is not completely understood, Objective To examine the possible involvement of ACE and ecNOS genes in the genetic basis for bronchial asthma. we investigated the association between genetic polymorphism and bronchial asthma, and its severity. Method: We determined the ACE and ecNOS genotypes by the polyrnerase chain reaction in 160 patients with bronchial asthma and 121 healthy subjects. Severity of asthma was classified by the guideline of NHLBI/WHO workshop. Results: The frequency of the ID genotypes of ACE and bb genotype of ecNOS was highest in both groups, respectively. The distribution of ACE genotypes did not differ between the two groups (p=0.27). There was a higher frequency of the bb genotype of ecNOS in the asthma group than in the control population (p=0.004). In asthmatic patients, there were no differences in the distribution of ACE and ecNOS genotypes in different severity groups (p= 0.17, 0.06), Conclusion: These results suggest that the polymorphism of the ecNOS gene. not ACE gene. may be associated with develop>ment of asthma. But, the severity of asthma may not be influenced by polymorphisms of the ecNOS and ACE genes. (J Asthma Allergy Clin Immunol 20: 609-618, 2000)

전북지역 알레르기 환자에서 원인 알레르겐의 변화

전현순 ( Hyun Sun Jeon ),이용철 ( Yong Chul Lee ),이흥범 ( Heung Bum Lee ),이양근 ( Yang Keun Rhee ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.6

토끼 허혈성 하지 모델에서 VEGF 발현 Naked DNA 벡터인pCK-VEGF의 근육내 투여가 측부혈관형성에 미치는 영향

체제건(Jei Keon Chae),전현순(Hyun Sun Jeon),박은진(Eun Jin park),김종묵(Jong Mook Kim),김덕경(Duk Kyung Kim),김선영(Sun Young Kim) 대한약학회 2001 약학회지 Vol.45 No.1

We have recently reported the development of a high efficiency expression vector, pCK, which can drive a high level of gene expression in mouse skeletal muscle. In this study, we tested the therapeutic potential of pCK expressing human VEGF165, pCK-VEGF, in the rabbit ischemic hind limb model. To determine the optimal dose of plasmid DNA, various concentrations of pCK-CAT, were injected into the muscle of a rabbit hind limb and the levels of CAT activity were determined. It was found that the expression level of the exgenously added gene became stable between 250 and 1,000ug. Based on this result, we tested whether intramuscular transfer of 500ug of pCK-VEGF could actually modulate collateral vessel development in a rabbit ischemic hind limb model. It was found that reative to the control group injected with the pCK lacking the VEGF sequence, single intramuscular doses (500ug) of pCK-VEGF produced statistically significant augmentation of collateral vessels as determinde by the angiographic vessel count, maximal blood flow by Doppler flowmeter, and the number of capillaries by histology. These results suggest that a single 500ug-delivery of pCK-VEGF is potent enough to induce sufficient angiogenic activity and achieve therapeutic benefit on this rabbit model.

슬관절 골관절염 환자에서 AVOCADO/SOYBEAN UNSAPONIFIABLES (ASU)의 효과: ASU 단독치료와 ASU-Nasproxen 병용치료의 효과 및 위장관 부작용의 비교

김종화 ( C H Kim ),이동민 ( D H Lee ),김용성 ( Y S Kim ),최보금 ( B G Choi ),박주형 ( J H Park ),김신재 ( S J Kim ),이치국 ( C K Lee ),전현순 ( H S Jeon ),류완희 ( W H Yoo ),곽재용 ( J Y Kwak ),백홍선 ( H S Baek ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.1

ASU 치료는 증상을 갖고 있는 슬관절의 골관절염 환자의 통증 개선과 관절 기능을 호전시키고, 약물투여 중지 후에 지속효과를 갖는 증상개선 약제로서 안전하게 사용할 수 있을 것으로 보인다. 소염진통제인 naproxen과의 병용치료와의 비교에서는 병용치료 군에서 효과의 발현시기와 전반적인 평가에서는 우월하였으나, 부작용이 보다 많이 발생하였다. 따라서 ASU를 골관절염의 약물치료의 한 방법으로 사용될 수 있을 것으로 보이며, 단순진통제 및 소염진통제 등의 약물 등과 같이 단일요법으로서의 사용과 다른 약물과의 병용치료의 효과 및 안정성에 대해서는 보다 많은 연구가 필요할 것으로 보인다. Objective: To compare the efficacy and safety between avocado/soybean unsaponifiables (ASU) alone and ASU-naproxen combination in the treatment of symptomatic osteoarthritis (OA) of the knee and to determine persistent efficacy after stopping medication and gastrointestinal tolerability. Methods: One hundred twenty-five patients with symptomatic OA of the knee were included in 20-week trial with 12-week treatment period and 8-weeks post-treatment follow-up. Efficacy was evaluated by Lequesne`s index (LI), pain score (VAS; visual analong scale. 10cm) at 4-week interval during the study and physician`s and patient`s global assessment at 20th week. Gastrointestinal side effects were evaluated by questionnaire for gastrointestinal symptoms and number of the ingested antacids during the study. Results: Sixty-three patients were received ASU alone, while sixty-two patients were received ASU and naproxen. Mean±SD scores of pain VAS score were reased from baseline at 8th and 12th weeks after medication in the former groups and 4th, 8th and 12th weeks in the latter groups. Mean±SD scores of LI were decreased from baseline at 12th week after medication in the former groups and 4th, 8th, 12th week in the latter groups. Both scores of LI and pain VAS were maintained at 8th week after stopping medication. The scores of LI and pain VAS scale were significantly decreased in combination group than ASU alone group at 4th and 8th weeks, but tended to lower in combination group at 12th week and post-treatment period. The improvement of physician`s global assessment was seen in 65.4% of combination and 53.2% of ASU alone group. The patient`s global assessment was similar to it. Twenty-six patients (20.8%) could not complete the 20-week study and the causes are different in two groups: side effects are more common cause in combination group and low efficacy and non-compliance were more common in ASU alone group. Gastrointestinal side effects are the most common adverse effects of the both groups, and the frequencies are more common in patients received naproxen as a combination therapy. Conclusion: ASU showed immediate and persistent efficacy in the treatment of patients with symptomatic OA of the knee. The combination of ASU and naproxen was more effective than ASU alone during the treatment period, but similar at post-treatment period. Gastrointestinal side effects were more frequent in combination group than ASU alone.

다발성 골침범을 보인 원발성 골(骨)림프종 1례

전현순,곽재용,임창열 大韓血液學會 1999 大韓血液學會誌 Vol.34 No.3

당뇨병 환자에서 관동맥 스탠팅의 임상적 고찰

전현순,채제건,문성기,김원호,고재기 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.3