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안상훈(Sang Hoon Ahn),한광협(Kwang Hyub Han),윤영훈(Young Hoon Youn),홍성필(Sung Pil Hong),백용한(Yong Han Paik),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),송기준(Ki Jun Song),김동기(Dong Kee Kim),서일(Il Suh) 대한내과학회 2001 대한내과학회지 Vol.60 No.2
Background : Hepatocellular carcinoma (HCC) is one of the most common neoplasms in the world. Although screening test for HCC has been performed, the high risk factors were not well evaluated in Korea. This study was undertaken to evaluate the risk factors of HCC development in Korea. Methods : We studied a total of 2,020 patients who visited Yonsei University Medical Center for regular check-up including ultrasonography (US) and alpha-fetoprotein (AFP) from January 1990 to December 1998. All the detailed data of clinical parameters were obtained by our self-exploited data base system prospectively and analyzed by SAS program. Results : Among 2,020 subjects, 1295 were male and 725 were female (mean age, M: 47 years, F: 50 years). 117 (5.8%) out of 2,020 subjects developed HCC during follow-up period (33months). Annual detection rate of HCC was 1.64%. The independent risk factors by univariate analysis were liver cirrhosis, chronic hepatitis, hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, old age (over 40 years old), heavy alcoholics, severe liver parencymal echogenic pattern in US, initial level of serum AFP (>20 ng/mL) or alanine aminotransferase (ALT) (>40 IU/L). Multivariate analysis with a proportional hazards model showed liver cirrhosis (p=0.000), chronic hepatitis (p=0.014), HCV infection (p=0.007), HBV infection (p=0.049), and old age over 40 years old (p=0.000) to be significant risk factors for HCC. We also found that the more risk factors, the higher HCC development. The development of HCC might not be related to history of smoking, family history of HCC, previous therapy such as interferon (IFN), diet, drugs, and transfusion. Conclusion : Screening test for early detection of HCC should be reconsidered according to the relative risk rate of these risk factors.(Korean J Med 60:123-130, 2001)
원발성 간암환자에서 절제술후 간내재발에 미치는 요인분석
박형석(Hyung Seok Park),송시영(Si Young Song),한광협(Kwang Hyup Han),전재윤(Chae Youn Chon),문영명(Young Myong Moon),강진경(Jin Kyung Kang),박인서(In Seo Park),민진식(Jin Sik Min) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1
N/A Background/Aims: The prognosis of hepatocellular carcinoma is very grave. The most effective method of improving survival in patients with hepatocellular carcinoma is early diagno. ' and curative hepatic resection. Recently, diagnosis of HCC at early stage has been greatly enhanced by the advent of screening techniques. However long-term survival after curative resection remains low because of high recurrence rate. To identify factors affecting intrahepatic recurrence and to analyze patterns of intrahepatic recurrence, we evaluated 72 patients who underwent curative hepatic resection. Methods: Total 72 patients were evaluated and 33 recurred cases were divided into the three patterns according to the recurrence pattern. Pattern I;recurrence near the resected margin, and pattern II;nodular recurrence, and pattern III;widespread multinodular recurrence. Results: We found 33 cases of intrahepatic recurrence. The serum AFP level of recurred group was significantly higher than that of non-recurred group, and tumor size was larger in recurred group. No difference was noted in age, sex, serum albumin, bilirubin and HBsAg between two groups. The recurrence time of pattern I was earlier than other patterns, and cirrhosis combining rate was higher in pattern 11. The portal vein and bile duct invasion rate was higher in pattern I and III than pattern Il. The survival rate of recurred group was lower than that of non-recurred group, and survival of pattern I was lower than other groups. Conclusions: It is suggested that careful follow-up is needed when tumor size is larger than 10 cm, portal vein and bile duct is infiltrated by tumor cel), and AFP is higher than 400 ng/ml. (Korean J Gastroenterol 1995;27:72-82)
조현근(Hyeon Geun Cho),정준표(Jun Pyo Chung),박효진(Hyo Jin Pack),윤영원(Young Won Yoon),신은택(Eun Tack Shin),전재윤(Chae Youn Chon),박인서(In Suh Park),김기황(Ki Whang Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.6
The term Biloma was introduced by Gould and Patel to describe encapsulated extrahepatic collections of bile in 1979, and has subsequently been expanded to include intra- hepatic bile collections. Various imaging modalities have been utilized to identify bilomas, in- cluding computerized tomography, ultrasonography, magnetic resonance imaging and radionucleotide studies. Needle aspiration is essential to confirm the diagnosis. Most of biloma resulted from biliary ductal disruption due to abdominal surgery or trauma. Less frequently bilomas have also been reported in association with hepatoma, gall bladder cancer and bile duct pathology. Recently we experienced a case of biloma developed spontanceously in a pa- tient with pancreatic cancer presenting as acute pancreatitis and report with a review of liter- atures.(Korean J Gastroenterol 1994; 26: 1053 1057)
한국의 Helicobactor pylori 감염 진단에서 새로운 상용 혈청학적 검사방법인 GenediaTM과 기존의 상용 검사 방법과의 비교 검토
박인서,전재윤,문영명,문병수,이용찬,윤영훈,신성관 대한소화기학회 2000 대한소화기학회지 Vol.36 No.1
Background/Aims : A new commercial enzyme linked immunosorbent assay (ELISA) test using Korean Helicobacter pylori (H. pylori) as an antigen, GenediaTM test, was compared to other serologic tests for H. pylori infection. Methods: Among two hundred seventy three subjects, H. pylori-positive group was consisted of 132 patients (50 peptic ulcer diseases, 52 chronic gastritis, and 30 gastric cancers) and H. pylori-negative group was consisted of 141 patients (121 adults and 20 pediatric patients). Endoscopic antral biopsy specimens were obtained for microscopy and rapid urease test (CLOTM test). We also performed GenediaTM IgG, IgA ELISA, G.A.P IgG, IgA ELISA, and Cobas-core IgG EIA. H. pylori infection was defermined when H. pylori was detected histologically or the results of CLOTM tests were positive. Results : The sensitivities and specificities of the serologic tests were 96.2% and 46.1% in GenediaTM IgG, 91.7% and 52.5% in GenediaTM IgA, 81.8% and 46.8% in G.A.P IgG, 25.0% and 85.1% in G.A.P IgA, 96.9% and 38.6% in Cobas-core test, respectively. In H. pylori-negative pediatric patients, the specificity of the tests was 80% in GenediaTM IgG, 95% in GenediaTM IgA, 60% in G.A.P. IgG, 100% in G.A.P IgA, and 75% in Cobas-core test. Conclusions: In Korea, GenediaTM test was comparable or superior to general serologic tests used for diagnosing H. pylori infection. However, it is necessary to improve the specificity of the GenediaTM test.
원발성 간암과 감별이 어려웠던 비전형적인 간혈관종 1예
최병현,김진석,조영준,전재윤,한광협,문영명,백용한,정재연,고준상 대한소화기학회 2000 대한소화기학회지 Vol.35 No.2
Hepatocellular carcinoma is one of the major cancers in Korea. Early detection and diagnosis are the most important for the treatment of hepatocellular carcinoma. Ultrasonography combined with the measurement of serum α-fetoprotein is an effective screening method to detect small hepatocellular carcinoma. A 53-year-old man who had chronic hepatitis B was referred to our hospital under the suspicion of having hepatocellular carcinoma. Ultrasonogrphy had revealed a 3 cm diameter hyperechoic mass, suggesting hemangioma. Magnetic resonance (MR) imaging was performed for suspicion of having hepatocellular carcinoma due to elevated serum α-fetoprotein level. Since MR imaging was consistent with possible hepatocellular carcinoma, but not specific for hemangioma, red blood cell scan, needle aspiration biopsy, and angiography were performed. However, those results were not conclusive. Thus, the patient was followed at regular intervals. Since serum α-fetoprotein level became normal, but tumor size was not changed dng long term follow-up, we diagnosed the lesion as atypical hemangioma.
Helicobacter pylori 감염 치료법에서 Lansoprazole과 Omeprazole의 효과 비교
김원호,김도영,강진경,박인서,전재윤,문영명,이용찬,윤영훈,신성관,나호균,문병수 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Background/Aims: The effectiveness of curative therapy for Helicobacter pylori (H. pylori) infection may vary according to the eradication rate, side effects, and compliance of regimen. Lansoprazole, one of proton-pump inhibitor, has been claimed to have greater anti-H. pylori activity than that of omeprazole in vitro. However, there is no literature concerning the comparison of therapeutic efficacy of these two drugs in Korea. Thus, we investigated the efficacy of combination therapy with amoxicillin, metronidazole, and either lansoprazole or omeprazole. Methods: Eighty Patients with H. pylori infection were treated with one of four regimens: lansoprazole 30 mg UID, amoxicillin 1.0 g BID (LA); lansoprazole 30 mg UID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (LAM); omeprazole 20 mg BID, amoxicillin 1.0 g BID (OA); omeprazole 20 mg BID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (OAM), for 14 days. Results: The eradication rates were 33.3% in LA, 50.0% in OA, 76.5% in LAM and 83.3% in OAM. The most frequently observed side effect was diarrhea or loose stool. Conclusions: Low dose lansoprazole-based regimen showed comparable eradication rate, side effects and compliance, as compared with omeprazole-based regimen. Further study using lansoprazole at various doses may be needed to evaluate the efficacy of anti-H. pylori eradication regimens in Korea.
만성 B형 활동성 간염에서 poly(A). poly(U)의 치료 효과
김원호,강진경,박인서,문영명,전재윤,한광협,함기백,윤정구,최흥재,임대순 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3
The two major approaches to the treatment of chronic hepatitis B are 1) directed toward the eradication of the virus and 2) designed to modulate cellular and humoral immunity. Progress has been made in the development of antiviral chemotherapeutic agents for hepatitis B, but as yet no safe and reliably effective treatment or combmations of treatments are available. It has been demonstrated that interferon is useful in suppressing hepatitis B viral replication, but the relatively low response rate of Asian patients to interferon treatment has been documented due to the fact that mostly they acguired infections perinatally or during childhood. Poly(A). poly(U) is a double stranded helical ribopolyuncleotide complex, which stimulates both humoral and cell mediated immune response, and enhances the splenic NK activity as well as induces the production of the interferon. In this study, we have measured sequentially the leveils of alanine aminotransferase (ALT) and 2, 5-oligoadenylate synthetase (2-5 AS) activities and hepatitis B viral markers in patients with histologically proven chronic active heaptitis after weekly intravenous injection of poly(A). poly(U) to find out that poly(A). poly(U) may be used as the therapeutic agent in the treatment of chronic active hepatitis B. The results were as follows: ALT levels after the weekly administrations of poly(A).poly(U) have declined significantly to the normal level except one case as times passed, especially after 5 weeks. Serum 2-5 AS activities were elevated significantly after the administration of poly(A).poly(U). The complete responses were noted in four cases out of eleven cases (36.4%) until 5 months after discontinuance of poly(A).poly(U). The partial responses were noted in five cases (45.5%). No specific side effects were noted except the light-headness just one time in only one case. In conclusion, the administration of poly(A).poly(U) in the patients with chronic active hepatitis B seems to be effective, simple and safe method, although more extensive and detailed immunologic researches are required.