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      • KCI등재후보

        규폐증에 병발한 현미경적 다발성 혈관염 ( Microscopic polyangiitis )

        정예경(Ye Keong Jung),강양욱(Yang Wook Kang),조대경(Dae Keong Cho),고재민(Jae Min Ko),전용덕(Yong Duk Jeon),박성수(Sung Soo Park),박문향(Moon Hyang Park) 대한내과학회 2000 대한내과학회지 Vol.59 No.5

        Microscopic polyangiitis (MPA) is a distinct type of systemic small vessel vasculitis affecting small sized vessels with few or no immune deposit and no granulomatous inflammation. Cause or pathogenetic mechanism of MPA has been unknown but association with silicon or silica exposure or pulmonary silicosis has been reported rarely and supports hypothesis that environmental factors are important modulating or triggering factors of the vasculitis in the indivisual who may be genetically predisposed. We report a case of microscopic polyangiitis with underlying pulmonary silicosis in 43 year-old male. He was admitted due to hemoptysis, dyspnea, fever and bilateral pulmonary infiltration with underlying small nodular densities in whole lung field and egg-shell calcification of both hilar areas. Laboratory findings showed hematuria, proteinuria and rapid deterioration of renal function. Renal biopsy revealed focal segmental necrotizing glomerulonephritis with early cellular crescents accompanied with membranous glomerulonephropathy and perinuclear-antineutrophil cytoplasmic antibody was positive. Under the diagnosis of MPA, he has been managed with high dose steroid, cyclophosphamide and hemodialysis. Chest infiltration decreased and hemoptysis and hypoxia was improved but renal function was not recoverd and he needed regular hemodialysis continuously. (Korean J Med 59:569-576, 2000)

      • KCI등재후보

        범자율신경 기능장애가 동반된 전신성 홍반성 루푸스

        송정수(Jung Soo Song),박원(Won Park),김화숙(Hwa Sook Kim),민효영(Hyo Young Min),전용덕(Yong Duk Jeon),박성수(Sung Soo Park),박문향(Moon Hyang Park) 대한내과학회 2000 대한내과학회지 Vol.59 No.5

        Autonomic neuropathy can occur as a neurologic manifestation in patients with systemic lupus erythematosus (SLE). Its precise prevalence and pathogenesis were not fully evaluated. Recent studies reported that about half of patients with SLE had autonomic neuropathy. Autonomic neuropathies include cardiovascular, gastrointestinal, genitourinary, sudomotor, lacrimal, and pupillary dysfunction. Autonomic nerve dysfunction significantly affects clinical course of the disease, and especially cardiovascular autonomic dysfunction may cause arrhythmias increasing the risk of sudden death. Pan-dysautonomia has been rarely reported as a neurologic complication of SLE. We experienced a patient with SLE presenting pan-dysautonomic manifestations. A 23-year-old man was admitted due to dizziness and syncopal attack. He complained various autonomic symptoms, such as orthostatic syncope, dysphagia, severe constipation, indigestion, and anhidrosis. Autonomic nerve function tests and the clinical manifestations revealed that he had pan-autonomic dysfunction. During hospitalization, respiratory and cardiac arrest developed soon after syncopal attack. He recovered after prompt cardiopulmonary resuscitation. But his autonomic dysfunctions improved slightly after 7 months of therapy. Early detection and aggressive treatment are needed to prevent potentially fatal dysautonomic attack in patient with SLE.(Korean J Med 59:577-582, 2000)

      • 흉부 대동맥류에 의한 주기관지 폐쇄로 발생한 무기폐 1예

        문가슬 ( Ga Seul Moon ),나수지 ( Su Sie Rah ),이승훈 ( Seug Hun Lee ),차혁환 ( Hyuk Whan Cha ),이다현 ( Da Hyun Lee ),조준성 ( Jun Sung Jo ),전용덕 ( Yong Duk Jeon ) 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.2

        흉부 대동맥류에 의한 기관지 압박에 의한 증상은 대부분 무증상이나 호흡곤란, 기침, 흉통, 쉰소리 등으로 나타날 수도 있다. 저자들은 고열과 전신 쇠약감을 주소로 내원한 만성신부전 환자에서 폐렴 진단 하에 항생제 치료 후 증상 호전되던 중 갑자기 발생한 흉부대동맥류의 팽창으로 인한 주기관지 폐쇄에 의한 폐쇄성 무기폐 소견이 관찰되었고 흉부 대동맥류 혈관 내 스텐트 그라프트 삽입술을 시행하였지만 흉부대동맥스텐트 삽입 후 발생한 복부대동맥 파열로인한 사망으로 추정되는 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Obstructive atelectasis is the most common type in pulmonary atelectasis and results from reabsorption of gas from the alveoli when communication between the alveoli and the trachea is obstructed. Causes of obstructive atelectasis include foreign body, bronchogenic tumor, and mucous plugging and extrinsic compression of an airway by neoplasm, lymphadenopathy, aortic aneurysm, or cardiac enlargement. We report a 64-year-old female patient who had saccular aneurysmal dilatation of the thoracic descending aorta and bronchial obstruction due to compression of a rapidly expanding thoracic aortic aneurysm, as a result, had been presented atelectasis of left whole lung.

      • SCOPUSKCI등재

        혈액 투석기의 재사용시 투석막에 따른 혈액 요소 질소와 β₂-Microglobulin 제거율의 변화

        이태훈,고재민,손진희,송성욱,전용덕,정성오,조대경,정예경 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.6

        Background: We performed the study on the changes of β₂-microglobulin(β₂M) clearance and urea reduction ratio after reuse of dialyzers with three different membranes. Methods: 9 patients who had received regular hemodialysis rnore than five years were enrolled. Three kinds of dialyzer membrane were used; i.e.: Two of them were high-flux and the other was low-flux. Dialyzer reprocessing was performed by an automated machine using glutaraldehyde and bleach. Each dialyzer was reused 10 times. Solute clearance was determined for each dialyzer after the 1st, 5th, 8th and 10th reuse. Results: Urea clearance was well maintained after reuse with both high-flux and low-flux membrane but β₂M clearance was significantly greater with high-flux dialyzers than low-flux dialyzer. Effects of each dialyzer reuse on β₂M clearance showed no significant decrease until the 10th reuse and no significant difference in β₂M clearance between the two high-flux dialyzers(polyamide vs PEPA membrane, p=0.197). Conclusion: Reuse rs was cost-effective. After reuse of dialyzer, clearance of solute ws maintained in both small & large solutes until the 1O th reuse. Further study is needed regarding the maintenance of solute clearance with increased number of reuses.

      • KCI등재후보

        유기용제 취급근로자들의 요중대사물질과 말초임파구 자매염색분체교환 발현빈도에 관한 조사연구

        김돈균,황인경,류철인,이수일,정갑열,이용환,이충렬,현원일,김석봉,전용덕 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

        저자들은 유기용제 취급여성근로자 90명을 대상으로 1988년 7월부터 1989년 8월까지 말초혈액임파구에서의 자매염색분체교환의 발현빈도를 조사하고 이들의 업종, 근속연수, 요중마뇨산 농도등이 자매염색분체교환의 발현빈도에 미치는 영향을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 유기용제 취급근로자들의 말초혈액임파구에서의 자매염색분체교환의 발현빈도는 대조군에 비하여 유의하게 증가되었다. 2. 말초혈액임파구에서의 자매염색분체교환의 발현빈도가 가장 높은 업종은 프라스틱제품 제조업이었다. 3. 근속연수가 말초혈액임파구에서의 자매염색분체교환의 발현빈도에 미치는 영향은 현저하지 않았다. 4. 요중마뇨산농도와 말초혈액임파구에서의 자매염색분체교환의 발현빈도간에는 유의한 상관관계가 있었다. In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaluate the effect of organic solvents on the health in industrial workers, the authors studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocytes from 90 female workers expoxed to organic solvents and 20 non-exposed female workers. The results obtained were as follows : 1. The frequency of sister chromatid exchanges in peripheral lymphocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 control subject. 2. The frequency of sister chromatid exchanges was significantly increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chromatid exchanges by carriers of the exposed workers.

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