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자색고구마 신자미로부터 분리한 안토시아닌 분획물의 항산화 활성과 산화스트레스에 대한 간세포 보호 효과
장환희,남송이,김미주,김정봉,김행란,이영민,Jang, Hwan Hee,Nam, Song Yee,Kim, Mi Ju,Kim, Jung Bong,Kim, Haeng Ran,Lee, Young Min 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.6
Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide ($H_2O_2$)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF ($10{\mu}g/mL$) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The $H_2O_2$-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, $10{\mu}g/mL$). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in $H_2O_2$-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against $H_2O_2$-induced oxidative stress by inducing protective system.
캘리그라피가 노인의 우울과 고독감에 미치는 영향: 내러티브 연구
장환희 동방문화대학원대학교 자연치유연구소 2024 자연치유연구 Vol.8 No.2
This study is a narrative study on the effect of calligraphy on depression and loneliness in the elderly. Currently, research on calligraphy activities for the elderly is insignificant. Therefore, it is necessary to approach it as a method for psychological healing of the elderly. The purpose of the study is to serve as basic data to help heal the emotions of the elderly with depression and loneliness. Participants in the study were 67years old female seniors who complained of depression and loneliness. A total of 10 calligraphy activities were conducted to participants from May to August 2023. Data analysis was tailored to the narrative search procedure, and quantitatively, depression and loneliness were measured. The results of this study were, first, participants' pain was physical pain, depression, and loneliness. Second, the cause of the participant's pain was innate vulnerability, chronic pain caused by aging, and depression and loneliness caused by loss due to the death of husband and children, resulting in social isolation. Third, the effect of calligraphy activities brightened the participants' facial expressions, decreased solitude and depression due to loss, positive changes in life, and increased self-esteem. Fourth, the participants' depression and loneliness decreased. In conclusion, it was found that calligraphy activities are effective for depression and loneliness in the elderly.
장환희,최요한,유인규,한지수,김민정,가학현 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.5
Objective: Prostaglandins (PGs) function in various reproductive processes, including luteolysis, maternal pregnancy recognition, conceptus development, and parturition. Our earlier study has shown that PG transporters ATP-binding cassette, subfamily C, member 4 (ABCC4) and solute carrier organic anion transporter family, member 2A1 (SLCO2A1) are expressed in the uterine endometrium in pigs. Since several other PG transporters such as ABCC1, ABCC9, SLCO4C1, and SLCO5A1 are known to be present in the uterine endometrium, this study investigated the expression of these PG transporters in the porcine uterine endometrium and placenta. Methods: Uterine endometrial tissues were obtained from gilts on day (D) 12 and D15 of the estrous cycle and days 12, 15, 30, 60, 90, and 114 of pregnancy. Results: ABCC1, ABCC9, SLCO4C1, and SLCO5A1 mRNAs were expressed in the uterine endometrium, and levels of expression changed during the estrous cycle and pregnancy. Expression of ABCC1 and ABCC9 mRNAs was localized mainly to luminal and glandular epithelial cells in the uterine endometrium, and chorionic epithelial cells during pregnancy. Conceptuses during early pregnancy and chorioallantoic tissues from mid to late pregnancy also expressed these PG transporters. Estradiol-17β increased the expression of ABCC1 and SLCO5A1, but not ABCC9 and SLCO4C1 mRNAs and increasing doses of interleukin-1β induced the expression of ABCC9, SLCO4C1, and SLCO5A1 mRNAs in endometrial explant tissues. Conclusion: These data showed that several PG transporters such as ABCC1, ABCC9, SLCO4C1, and SLCO5A1 were expressed at the maternal-conceptus interface, suggesting that these PG transporters may play an important role in the establishment and maintenance of pregnancy by regulating PG transport in the uterine endometrium and placenta in pigs.
남송이,이진영,고정숙,김정봉,장환희,김행란,이영민 한국국제농업개발학회 2014 韓國國際農業開發學會誌 Vol.26 No.4
본 연구에서는 오미자 추출물이 보유하고 있는 것으로 알려진 항산화, 항균, 항염증 활성의 용매별 추출에 따른 변화를 구명하고 관련 기초자료를 제공하고자 하였다. 오미자를 물과 70% 에탄올, 99.9% 메탄올로 추출한 후, 폴리페놀 함량, 라디칼 소거능, SOD 유사활성, 항균활성, NO 생성 저해능을 평가하였다. 그 결과, 오미자 물 추출물의 폴리페놀 함량은 9.2 mg/g이었고 에탄올과 메탄올 추출에 의해서 각각 70.7%, 77.2% 증가하였다. DPPH 라디칼 소거능은 에탄올 추출물에서 IC50이 399.7 μg/mL으로 항산화능이 가장 높았고, 메탄올 추출물(400.8 μg/mL), 물 추출물(992.4 μg/mL)의 순으로 나타났다. 이를 통해, 물 추출물보다 유기용매 추출물의 폴리페놀 함량이 높음에 따라 소거활성이 증가하여, 폴리페놀 함량과 라디칼 소거활성은 연관성이 있음을 확인하였다. 병원균 3종 E.coli, S. typhimurium, St. aureus에 대한 항균 활성은 물 추출물의 경우 38.9~64.5%인 반면 유기용매 추출물에서는 70.0 ~ 85.6%로 증가하였다. 반면에 NO 생성에 대해서는 물 추출물이 대조군에 비해 35.7% 저해시켰으나 에탄올과 메탄올 추출에 의해서 각각 22.1%, 25.7% 감소하였다. 결론적으로 오미자의 유기용매(에탄올, 메탄올) 추출물은 물 추출물에 비하여 라디칼 소거능과 SOD 유사 활성, 항균 활성이 우수하였다. 반면에 항염증능은 유기용매 추출물에 비해 물 추출물이 우수한 활성을 보였다. 본 실험결과는 오미자 추출물을 건강 기능식품 개발 소재나 가공식품으로 활용할 때 주요 대상으로하는 건강기능성을 증진시키는데 기초자료로 활용할 수 있을 것으로 생각된다. The present study was performed to investigate antioxidant and antimicrobial activities of Schizandra chinensis Baillon under different extraction conditions. Extraction yield of water extract, 70% ethanol extract, and methanol extract from S. chinensis was 17.7, 32.9, and 36.6% respectively. Total polyphenol content was 9.2-16.3 mg/g in S. chinensis extracts and was increased significantly by ethanol and methanol extraction (p < 0.05). Radical scavenging activity against DPPH and ABTS·+ was significantly higher in ethanol and methanol extracts than in water extract (p < 0.05). Ethanol and methanol extracts from S. chinensis also showed effective superoxide dismutase-like activity compared with water extract (p < 0.05). S. chinensis water extract exhibited strong antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium, which was increased significantly by ethanol and methanol extraction (p < 0.05). On the other hand, inhibitory effect of S. chinensis water extract on nitric oxide production was more effective than ethanol and methanol extract.
권인영・김채연・김하정・신유정・이도경・장환희・정예은,김채연,김하정,신유정,이도경,장환희,정예은,양숙자,손지희 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52
Purpose: The purpose of this study is to obtain comprehensive understanding of Korean middle-age men's experience in their andropause. The findings of this study will provide supportive data for development of nursing interventions. Methods: This study is explored by hermeneutic phenomenological analytic method suggested by van Manen. Data was collected through in-depth interviews with 7 middle aged men between July and September, 2017. Before the interviews, preliminary questionnaire was preformed for all participants. Results: The analysis produced five themes: 'My body is getting weaker than before', 'A sense of despondency with current life', 'Regarding andropause not as much important as menopause', 'The obscurity of one's life about andropause', 'Cut off andropause from life'. Conclusion: This study explored Korean middle-age men's experience in their andropause. Although most participants experienced physical and psychological symptoms, they denied that they are andropause. Moreover, they lacked knowledge and showed attitude of indifference. In addition, Andropause is not as commonly recognized in the society of Korea. Even if they perceive it, they cannot reveal the fact and respond poorly. It brings up the necessity to provide proper information and education. A variety of nursing interventions are also required for the men for their physical or mental recovery and health care. Therefore, this study offers the deep understanding of the significance and nature of the experience in andropause. Furthermore, this study may put foundation for development in nursing care of studies of this subject.
스프링프레임워크를 이용한 신뢰성 평가 커뮤니티 웹 사이트의 설계 및 구현
김환희(Hwanhee Kim),장재준(Jaejun jang),이성복(Songbokg Lee),신경섭(Kyungsub Sin),박은주(Eunju Park),임한규(Hankyu Lim) 한국정보기술학회 2016 Proceedings of KIIT Conference Vol.2016 No.6
현대인들은 스마트폰의 보급과 빠른 인터넷으로 인해 수많은 정보들을 손쉽게 구하고 얻을 수 있다. 하지만 제공되는 정보들이 모두 신뢰성을 가진 것은 아니다. 페이스북이나 인스타그램 등은 ‘좋아요’를 통해 게시글에 대한 관심도의 표현은 가능하지만, 글의 신뢰도를 표현하지는 못한다. 본 논문에서는 게시글의 신뢰도를 표현하기 위해 웹 사이트의 게시글을 평가하는 방법을 제안하였다. 게시글의 평가를 통해 작성자의 신뢰성 평가가 가능하고, 이를 통해 보다 신뢰성 높은 정보의 공유가 가능한 커뮤니티 웹 사이트를 설계하고 구현하였다. In the modern world, people can easily obtain a lot of information due to supply of smartphone and fast internet. But not all information is reliable. By clicking ‘Like’ button in Facebook or Instagram, it is possible to express the interest about the post but it cannot express reliability. This paper suggests the method to evaluate post in web-site which can show its reliability. By evaluating the post, it is possible to evaluate reliability of the writer, and through this, we have designed and developed a community web-site which can share information with high reliability.