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Polystyrene Latex Bead에 의한 뇌혈관연축 모델에서 K<sup>+</sup> 통로활성제의 전신투여
장성조,강성돈,윤기중,Jang, Sung Jo,Kang, Sung Don,Yun, Ki Jung 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.6
Objectives : It has been reported that the presence of a pharmacologically inactive foreign substance, polystyrene latex bead, in subarachnoid space activates a non-specific immunological response and elicits arterial narrowing. Recently the activation of potassium($K^+$) channels may be of benefit in relieving cerebral vasospasm. The present study examined the effects of systemic administration of a ATP-sensitive $K^+$ channel activator, cromakalim, on the polystyrene latex bead-induced cerebral vasospasm. Methods : The spasm models similar to that caused by subarachnoid blood injection were created by injection of bead into rabbit cisterna magna. Intravenous injections of cromakalim were administered twice daily(bid) 30 minutes after induction of vasospasm. Animals were killed by perfusion-fixation 2 days after vasospasm. Basilar arteries were removed and sectioned, and the luminal cross-sectional areas were measured. Results : Injection of bead elicited an arterial constriction, reducing arterial diameter to 33.3% of resting tone. Cromakalim inhibited bead-induced constriction at a dose of 0.3mg/kg(Mann-Whitney test, p<0.01). Conclusion : These results support the concept that the cellular events triggered by inactivation of ATP-sensitive $K^+$ channels are responsible for the pathogenesis of vasospasm. The findings also indicate that cromakalim represents a potential therapeutic agents for the treatment of cerebral vasospasm.
장성조,김태영,김종문,Jhang, Sung Jo,Kim, Tae Young,Kim, Jong Moon 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.1
Cephalhematoma is a common entity in infancy, usually caused by difficult labor. On the other hand, calcified cephalhematomas are seen infrequently, even by pediatric neurosurgeons, Indications for surgery and techniques have not been clearly defined. In this report, we present a child with a large, calcified cephalhematoma and discuss its surgical technique.
베체트 증후군 환자에서 Dapsone에 의해 발생한 중증의 DRESS 증후군
이창훈 ( Chang Hoon Lee ),장성조 ( Sung Jo Jang ),오성렬 ( Seong Rheol Oh ),김현정 ( Hyun Jung Kim ),이명수 ( Myeung Su Lee ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3
Dapsone has been used for several dermatological conditions such as immunobullous disease and ulticarial vasculitis. Dapsone is very useful drug for treating the mucocutaneous manifestations of Behcet`s disease. The widely recognized side effects of dapsone are headache, methemoglobinemia and hemolysis. The severer, but rarer side effect of dapsone is known as dapsone hypersensitivity syndrome, which consists of exfoliative dermatitis, hepatitis, lymphadenopathy and hemolytic anemia. When this is associated with eosinophilia, we can diagnose and treat this drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a syndrome of fever, rash, and internal organ involvement that`s secondary to administering the offending medication. We describe here a 47-year-old woman who was hospitalized with fever, skin rash, hemolytic anemia, lymphadenopathy, eosinophilia, pleural effusion and life threatening hepatitis, which could lead to hepatic failure, within three weeks of starting of dapsone therapy for controlling her oral and genital ulcers. We diagnosed the woman as suffering with DRESS syndrome and we started treatment with corticosteroid. Three weeks after starting therapy, her symptoms almost completely resolved and she was discharged.