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      • KCI등재

        Bl6 Melanoma세포에서 Citrus Essential Oil이 Melanin 생성에 미치는 영향

        임혜원(Hye Won Lim),조남영(Nam Young Cho),윤미연(Mi Yun Yoon),차상복(Sang Bok Cha),김경원(Kyoung Won Kim),박영미(Young Mi Park),이지윤(Ji Yun Lee),이진희(Jin Hee Lee),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2003 약학회지 Vol.47 No.1

        This study is performed to investigate the effects of citrus essential oils on melanin production in Bl6 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity cell growth and cytotoxicity in Bl6 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1μM MSH-stimulated Bl6 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be development to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.

      • KCI등재

        프로바이오틱 유산균 발효에 의한 배초향 잎 추출물의 피부 항산화 및 항염증 활성 증대

        임혜원 ( Hye-won Lim ),이윤진 ( Yoonjin Lee ),황옥화 ( Yu-hua Huang ),윤지영 ( Ji-young Yoon ),이수희 ( Su Hee Lee ),김경훈 ( Kyunghoon Kim ),임창진 ( Chang-jin Lim ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 한국미생물·생명공학회지 Vol.45 No.1

        본 연구에서, 비발효(ARE) 및 발효(ARE-F) 배초향 잎 열수 추출물의 피부 항산화 및 항염증 효능을 비교함으로써 프로바이오틱 발효의 효과를 검토하였다. ARE-F는 Lactobacillus rhamnosus HK-9 발효에 의하여 ARE로부터 제조되었다. In vitro 항염증 효능은 지질다당류(LPS)에 의하여 자극된 HaCaT 각질세포에서 일산화질소(NO), 활성산소종(ROS) 및 유도형 일산화질소 합성효소(iNOS) 분석에 의하여 평가되었다. In vitro antiradical 활성은 2,2-diphenyl-2-picrylhydrazyl radical (DPPH) 소거 측정법에 의하여 평가되었다. LPS 자극에 의하여 증가된 NO, ROS 및 iNOS 수준에 미치는 ARE-F의 감소효과가 ARE에 의한 효과보다 현저히 강하였다. 그러나, ARE와 ARE-F의 DPPH 소거 효능에는 차이가 발견되지 않았다. ARE-F가 증강된 피부 항산화 및 항염증 효능을 갖고 있는데, 이 결과는 프로바이틱 세균 발효가 배초향 잎의 일부 약리학적 효능을 증가시키는 효과적인 방법일 수 있음을 암시해 주고 있다. 요약하면, 배초향 잎 추출물의 피부 항산화 및 항염증 활성이 프로바이오틱 세균인 L. rhamnosus HK-9에 의한 발효에 의하여 증강한다. This study aimed to investigate the effects of probiotic fermentation by comparing the skin antioxidant and anti-inflammatory properties of non-fermented (ARE) and fermented (ARE-F) hot water extracts of Agastache rugosa leaves. ARE-F was obtained via ARE fermentation using Lactobacillus rhamnosus HK-9. In vitro, anti-inflammatory properties were evaluated by analyzing the levels of nitric oxide (NO), reactive oxygen species (ROS), and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated HaCaT keratinocytes. In vitro antiradical activity was measured using 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Attenuation of LPS-stimulated NO (p < 0.01), ROS (p < 0.001) and iNOS (p < 0.05) levels by ARE-F was significantly stronger than that by ARE in HaCaT keratinocytes. However, no differences were observed between the DPPH radical scavenging activities of ARE and ARE-F. ARE-F possesses enhanced skin antioxidant and anti-inflammatory properties, suggesting that probiotic bacterial fermentation can be considered an effective tool for augmenting some pharmacological properties of A. rugosa leaves. In brief, the skin antioxidant and anti-inflammatory potentials of A. rugosa leaf extract are augmented by the fermentation with L. rhamnosus HK-9, a probiotic bacterium.

      • KCI등재
      • KCI등재

        ‘위기’의 은유적 개념화 양상

        임혜원(Lim Hye-won) 한글학회 2020 한글 Vol.- No.330

        이 연구는 ‘위기’ 개념에 대한 한국어 은유 표현을 분석함으로써 한국어 사용자의 개념화 방식을 살피는 데 목적이 있다. 이를 위해 이 연구에서는 위기의 개념화 방식을 존재론적 은유에 의한 개념화와 사건 구조은유에 의한 개념화로 나누어 살펴보고 있다. 존재론적 은유에 의해 ‘위기’는 우리의 인지 공간에서 물건으로 간주되거나 사람이나 동물 같은 생명체로 간주되어 만지고 다룰 수 있고 생겨나 변화할 수 있는 속성을 지닌 것으로 표현된다. 또한 위기는 사건을 공간 관점에서 개념화하는 사건 구조 은유 속에서 특정한 장소나 장애물로 간주된다. 한국어 사용자는 위기 개념을 불, 폭탄, 거센 물결, 생명체, 구석, 절벽, 수렁, 나쁜 날씨, 질병 등을 통해 이해하는데, 이것들은 우리 삶에 큰 영향을 초래하고 통제하기 어려우며 그래서 위험하기도 하고 두렵기도 한 대상들이다. 이와 같은 분석을 통해 한국어 사용자가 위기 상황을 어떻게 받아들이는지, 위기 개념을 어떻게 이해하고 표현하는지를 알 수 있다. The purpose of this study was to analyze the metaphorical expression about crises to examine how Korean speakers perceive the concept of crisis. The first way to conceptualize crises is to substantiate them in cognitive space as something that can be touched and moved. This conceptualization uses an ontological metaphor, which is a method of objectifying crises as objects or organisms, such as people or animals. Crises can also be conceptualized as places or obstacles in an event structure metaphor of [changes as movements]. This study found that Korean speakers understand the concept of crisis in terms of various things, such as fire, strong waves, organisms, corners, cliffs, bogs, bad weather, disease, and explosion, all of which have a great impact on people’s lives, are dangerous, and therefore are things that people fear. This study’s results show how Korean speakers understand crises and how they understand and express crisis concepts.

      • KCI등재

        국어 사물 개념의 은유적 확장 연구 -대화 말뭉치를 바탕으로-

        임혜원 ( Hye Won Lim ) 한국어의미학회 2006 한국어 의미학 Vol.19 No.-

        In a cognitive linguistic approach, metaphor is to understand one thing in terms of another. For example, we metaphorically understand some abstract concepts as some objects existing in physical world. Such metaphorical understanding is reflected in language. This paper explores metaphorical extensions of THING concepts in Korean using corpus data to reveal how Korean language users understand and use the concepts of THING. More specifically, we examine how abstract concepts are metaphorically understood in terms of THING concepts. Since things are essential in our daily life, various thing concepts constitute source domain concepts for a large number of abstract target domain concepts. THING concepts are built upon our physical experiences and the knowledge about the things enables us to understand other abstract concepts metaphorically. In order to find metaphors that are based on THING concepts and that are frequently used, we examined relevant metaphorical expressions attested in spoken Korean corpus. We can find the metaphorical conceptualization of THING in terms of QUANTITY, WEIGHT, TEMPERATURE, BRIGHTNESS, DENSITY OF THE THING based on the attributes of THING such as touching and handling the objects. Also we can find the metaphorical extension of SOLID, a state of things, in terms of SIZE, SHAPE, FEELS OF THE THING based on the attributes of THING such as grasping and manipulating the objects. Finally we can find the metaphorical extension of LIQUID, because of the nature of the liquid such as fluidity. This research validates cognitive processes by which language users understand abstract concepts in terms of concrete concepts. Also, those thing metaphors are of experiential basis, for they are motivated by physical experiences of Korean language users.

      • KCI등재

        한국어 대화자료에 나타난 이동은유

        임혜원 ( Hye Won Lim ) 한말연구학회 2002 한말연구 Vol.- No.10

        This paper explores the uses of the movement metaphors in Korean based on a colloquial corpus. Linguistic forms in general reflect cognitive processes of language users in terms of their conceptualization of the events or states. Thus Korean movement metaphors show Korean language users` cognitive processes to understand events or actions. Korean movement metaphors are based on more general substance metaphor, whereby people understand abstract objects like events or actions in terms of concrete objects. Also Korean movement metaphors are based on such space conceptualization as to understand non-spatial concepts through spatial concepts. From an analysis on a quantitative approach, the uses of movement metaphors by Korean speakers reveal the following characteristics. Firstly, Korean language users could cognize events or actions as involving subject-moving or object-moving according to such factors as appearances, temporal process, and interactions with co-participants, etc. Secondly, movement metaphors can appear in parallel movement and vertical movement according to positive/negative and qualitative evaluations of the language users with regard to the events or actions concerned. Thirdly, movement metaphor can also appear as movement either out of or into a container. These characteristics are based on physical and psychological experiences of Korean language user. We can identify general cognitive processes by which language users understand abstract concepts as concrete concepts as shown above. To study movement metaphors by means of colloquial corpus is important in both studying metaphors used in natural settings and capturing language user`s cognitive processes in a non-biased way.

      • KCI등재후보

        한국어 대화에 나타난 수직공간개념화 은유

        임혜원(Lim Hye-won) 담화·인지언어학회 2003 담화와 인지 Vol.10 No.1

        This paper explores the uses of the vertical spatialization metaphors in Korean based on a colloquial corpus. There are various kinds of metaphors in Korean vertical spatialization metaphors, for examples, MORE IS UP; LESS IS DOWN, HAVING FORCE IS UP; BEING SUBJECT TO FORCE IS DOWN, ACT1VI1Y IS UP; INACTIVITY IS DOWN, CENTER IS UP; PERIPHERY IS DOWN, and HOT IS UP; COLD IS DOWN. Each metaphor has its own internal systemacity and coherence. Also, Korean vertical spatialization metaphors have systemacity and coherence among its subclasses extending from MORE IS UP; LESS IS DOWN metaphor. In this research, we can identify general cognitive processes by which language users understand abstract concepts in terms of concrete concepts. Also, we can find that Korean vertical spatialization metaphors are based on physical experiences of Korean language users.

      • KCI등재

        성인(成人) 남성(男性)의 드레스 셔츠 소비자(消費者) 실태조사(實態調査) 1 -착용실태(着用實態)와 구매실태(購買實態)를 중심(中心)으로-

        임혜원 ( Hye Won Lim ),손희순 ( Hee Soon Sohn ) 한국패션비즈니스학회 2000 패션 비즈니스 Vol.4 No.4

        The porpose of this research is helping product developments and establishment men`s marketing strategies. This contents are divided into two parts; the dress shirt`s wearing condition and the dress shirt`s buying condition. The subjects of the research were male that aged 25-50 and their company is resided in Seoul. The conclusion of this research is summarized as below ; 1. Many consumers have wrong term recognition of dress shirt. Most of men know their dress shirt`s sizing designation as casual method(ex, …95, 100…). Therefore it is happened fitness complains. Dress shirt`s wearing frequency for a week is 1-2 days or 5days mostly. A number of dress shirt`s wearing period for one is 6-12 months. Dress shirt`s wearing frequency fand wearing period varies according to their age, unmarried or married situation, scholarship, occupation. So the manufacturer of men`s dress shirt grasps the factor`s for their character. 2. The conclusion of dress shirt`s buying motivation is need better than impulse buying. If company planning season event, the selling will be improved. Most of men buy their dress shirt by themselves. It means a lot of men are interested in their clothes comparing to old days. And men`s favorite purchase place is a department store and agent. when they purchasing, the color and size is very important factor. But dress shirt`s sizing designation is not yet established. Therefore the dress shirt`s sizing designation is needed as possible.

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