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황납추출물이 도파민세포 보호효과 및 파킨슨병 행동장애에 미치는 영향
임혜선,문병철,박건혁,Lim, Hye-Sun,Moon, Byeong Cheol,Park, Gunhyuk 한국환경과학회 2022 한국환경과학회지 Vol.31 No.5
Parkinson's Disease (PD) is a chronic neurodegenerative disorder caused by the progressive loss of dopaminergic neurons, leading to decreased dopamine levels in the midbrain. Although the specific etiology of PD is not yet known, oxidative stress, inflammation, and subsequent apoptosis have been proposed to be closely related to PD pathophysiology. Cera Flava (CF) is a natural extract obtained from beehives and is isolated through the heating, compression, filtration, and purification of beehives. CF has been used in traditional medicines for its various clinical and pharmacological effects. However, its effects on neurodegenerative diseases are unknown. Therefore, we investigated the effects of CF against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD in mice and explored the underlying mechanism of action. In MPTP-induced PC12 cells, CF protected NADH dehydrogenase activity and inhibited lactate dehydrogenase. In the mouse model, CF promoted recovery from movement impairments, prevented dopamine depletion, and protected against MPTP-induced dopaminergic neuronal degradation. Moreover, CF downregulated glial and microglial activation. Taken together, our results suggest that CF improves behavioral impairments and protects against dopamine depletion in MPTP-induced toxicity by inhibiting glial and microglial activation.
임혜선(Hye-Sun Lim),장태우(Tai-Woo Chang) 대한산업공학회 2012 산업공학 Vol.25 No.4
In this study, we investigate the cooperative relationships between researchers who have co-authorship in the logistics-related journals in Korea by using social network analysis (SNA). We analyzed the co-authorship data of 781 articles published from 2005 to 2011 in four journals of ‘Logistics Study’, ‘Journal of Korean Society of SCM’, ‘Korea Logistics Review’ and ‘Journal of Shipping and Logistics.’ We examined the trend of cooperative research in the field of logistics with basic data of the co-authorship network. Then, we analyzed structural properties of the network and the sub-networks of research groups having co-authorship. We could verify the authors who play important roles within the network by using SNA indicators. In addition, we constructed the keyword networks based on the keyword data of all articles by research groups in order to understand the research topics of each group, and thereby we could draw several implications on the cooperative researches in the field of logistics.
반려동물을 상실한 성인의 성인애착, 반려동물애착의 군집유형에 따른 애착강도, 애도의 차이
임혜선(Hye Sun Lim),홍혜영(Hye Young Hong) 한국상담학회 2022 상담학연구 Vol.23 No.5
본 연구의 목적은 반려동물을 상실한 성인의 성인애착, 반려동물애착에 따른 군집을 분류하고 각 군집에 따라 애착강도, 애도의 차이를 확인하고자 하였다. 이를 위해 반려동물을 상실한 성인 410명을 대상으로 군집분석, 다변량분석을 실시하였다. 군집분석 결과, 반려인의 성인애착과 반려동물애착에 따라 ‘불안정성인애착-반려동물불안애착군집’(N=175), ‘안정성인애착-안정반려동물애착군집’(N=72), ‘성인회피애착-안정반려동물애착군집’(N=81), ‘성인불안애착-불안정반려동물애착군집’(N=82)이 도출되었다. 다변량분산분석 결과, 군집에 따라 애착강도, 애도에서 유의한 차이가 나타났다. ‘불안정성인애착-반려동물불안애착군집’은 다른 군집에 비해 애착강도와 애도가 가장 높았고, 애도의 하위요인에서는 슬픔/비애, 죄책감이 높은 것으로 나타났다. ‘안정성인애착-안정반려동물애착군집’은 애착강도가 다른 군집에 비해 높았으며, 애도의 하위요인에서는 슬픔/비애가 높은 것으로 확인되었다. ‘성인회피애착-안정반려동물애착군집’은 평균수준의 애착강도를 보였으며, 애도는 다른 군집에 비해 낮은 것으로 나타났다. ‘성인불안애착-불안정반려동물애착군집’은 애착강도와 애도가 가장 낮았으며, 애도의 하위요인에서는 분노/트라우마가 가장 높은 것으로 확인되었다. 이 연구 결과는 반려동물을 상실한 성인의 인간관계와 반려동물관계의 애착양상을 통합적으로 제시하고, 애도상담개입을 위한 기초자료를 마련하는데 의의가 있다. 마지막으로 본 연구의 한계점과 후속 연구를 위한 제언을 논의하였다. The goal of the current study is to classify the cluster groups in adult with the loss of their companion animal according to their adult attachment and companion animals attachment, and to identify the differences in attachment strength and mourning according to each cluster group. For the goal, survey responses from a total of 410 adults were used to conduct cluster analysis and multivariate analysis. Results of the cluster analysis, based on adult attachment and attachment to companion animal, the following 4 groups such as; ‘Insecure adult attachment-Anxious attachment to companion animal group’(N=175), ‘Secure adult attachment-Secure attachment to companion animal group’(N=72), ‘Avoidance adult attachment-Secure attachment to companion animal group’(N=81), and ‘Anxious adult attachment-Insecure attachment to companion animal group’(N=82) were derived. The results of multivariate ANOVA showed statistically significant differences in attachment strength and mourning depend on clusters. ‘Insecure adult attachment-Anxious attachment to companion animal group’ had the highest attachment strength and mourning, and grief and guilt were high in the sub-factors of mourning. ‘Secure adult attachment-Secure attachment to companion animal group’ had a higher attachment strength compared to the other groups, and grief was high in the sub-factors of mourning. ‘Avoidance adult attachment-Secure attachment to companion animal group’ had an average attachment strength, mourning was lower compared to the other groups. ‘Anxious adult attachment-Insecure attachment to companion animal group’ had the lowest attachment strength and mourning, and anger/trauma was found to be the highest in the sub-factors of mourning. These finding results are meaningful in presenting the human relationships among adult who have lost their companion animals and the attachment aspect of the companion animal relationship in an integrated way, and preparing the essential data for the intervention of grief counseling. Finally, limitations of the current study, and suggestions for future studies were discussed.
QC Tools를 활용한 패밀리 레스토랑 고객 서비스 품질향상에 관한 연구
임혜선 ( Hye Sun Lim ),정다희 ( Da Hee Jung ),김용수 ( Yong Soo Kim ) 한국경영공학회 2011 한국경영공학회지 Vol.16 No.1
This article presents a six sigma project for improving customer service quality in family restaurant using QC tools. The project was carried out based on DMAIC process. First, a defect rate was defined as low service level. Customer service satisfaction data were analyzed, the results showed that the sigma level was 2.5. In this study, in order to raise the sigma level, we performed analysis using FDPM(functional deployment process map), fishbone chart, linear regression analysis, effort-performance matrix, and so on. In this manner, five detailed activities were determined to improve the customer satisfaction levels. As a result, the sigma level of defects has improved from 2.5 to 3.2.