동시적 항암화학방사선요법 시행 후 수술에 성공한 진행성 흉선암종

임현우 ( Hyun Woo Lim ),이명준 ( Myung Jun Lee ),박정호 ( Jeong Ho Park ),박주호 ( Joo Ho Park ),이선영 ( Sun Young Lee ),전현정 ( Hyun Jung Jun ),조도연 ( Do Yeun Cho ) 대한내과학회 2010 대한내과학회지 Vol.78 No.5

Thymic carcinoma is a rare, but aggressive, tumor that often metastasizes to regional lymph nodes and distant sites and often has a poor prognosis. Although the efficacy of induction therapy in thymic carcinoma is unclear, we report the clinical course of a patient who underwent complete surgical resection after effective induction chemoradiotherapy. A 66-year-old man was diagnosed with a poorly differentiated thymic carcinoma (Masaoka stage Ⅲ). The tumor was considered unresectable due to sternal invasion and surrounding fat infiltration. Two cycles of chemotherapy, consisting of paclitaxel (180 mg/m2 on D1) and cisplatin (80mg/m2 on D1) combined with mediastinal radiotherapy (total 50 Gy) were performed concurrently; the mass decreased to a resectable size. Subsequently, he received adjuvant chemotherapy and adjuvant radiation therapy. He is currently alive and ambulatory and has remained disease-free for 19 months. This case demonstrates that induction chemoradiotherapy with paclitaxel and cisplatin may be tolerated and useful for patients with locally advanced thymic carcinoma. (Korean J Med 78:645-649, 2010)

Octacosanol과 박과식물 추출물을 주성분으로 하는 혼합물의 지구력 증진 효과

임현우(Hyun Woo Lim),김성규(Sung Kyu Kim),이민원(Min Won Lee) 대한약학회 2005 약학회지 Vol.49 No.6

Octacosanol is known to enhance endurance activities, control cholesterol in body and improve the function of cardiopulmonary. Citrulline, which is main compound of watermelon, is known to improve angiectasia through stimulating production of nitric oxide. To improve endurance activity, swimming test on rats was carried out using four samples such as 1% octacosanol, citrulline, the extracts of barks of watermelon and products, mixture of 1% octacosanol and the extracts of barks of watermelon (6:4). Biochemical assays on the liver and serum of tested rats were also performed using commercial analysis kits. In result, it was shown that swimming time of Ⅲ group increased by 26% and that of Ⅴgroup was increased by 22% at the swimming test. As a result of biological assays on the liver and serum of tested rats, it was possible to confirm stability of toxicity. When compared with creatine kinase of control group(549.11±39.15 U/ℓ), citrulline (644.11±50.67 U/ℓ) and products group (646.00±46.99 U/ℓ) were largely increased. When compared with inorganic phosphate of control group (12.01±0.75 ㎎/㎗), citrulline (13.03±0.94 ㎎/㎗) and products group (12.90±0.55 ㎎/㎗) showed similar results. Also, when compared with lactic acid and glucose of control group (152.91±13.45, 103.00±8.69 ㎎/㎗), citrulline (125.53±15.54, 83.75±7.29 ㎎/㎗) and products group (135.26±11.50, 78.57±9.79 ㎎/㎗) were largely decreased. As these test results, it was determined that 1% octacosanol and extracts of barks of watermelon had some effect of improving endurance activity. Futhermore, it was thought that it could be used as source of functional food.

신재생에너지 도입에 의해 관성에너지 감소에 따른 주파수 안정도 분석

임현우(Hyun Woo Lim),박성수(Seong Su Park),응웬 녹 득(Ngoc Duc Nguyen),심재웅(Jae Woong Shim) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.7

유방암치료 후 흉골에 발생한 방사선속발성 골육종 1예

임현우 ( Hyun Woo Lim ),전현정 ( Hyun Jung Jun ),염윤식 ( Yoon Shick Yom ),윤대성 ( Dae Sung Youn ),정원규 ( Weon Kuu Chung ),손장신 ( Jang Shin Sohn ),조도연 ( Do Yeun Cho ) 대한내과학회 2010 대한내과학회지 Vol.78 No.4

Radiation-induced osteosarcoma is a very rare complication of radiation therapy, with a poor prognosis. We experienced a case of radiation-induced osteosarcoma of the sternum, in a patient who had had breast cancer treated with surgery, adjuvant chemotherapy, and adjuvant radiation therapy 6 years earlier. A 53-year-old woman complained of a painful anterior chest wall mass. The mass was diagnosed as osteosarcoma on biopsy. The radiation-induced osteosarcoma had an aggressive nature. (Korean J Med 78:512-517, 2010)

연돌효과 저감을 위한 E/V샤프트 냉각장치의 적용에 대한 연구

임현우(Hyun-woo Lim),이준호(June-ho Lee),서정민(Jung-min Seo),송두삼(Doo-sam Song),이중훈(Jung-hun Lee) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-

The stack-effect in high-rise buildings in winter causes many problems such as difficulties in opening or closing doors, infiltration, energy loss, noise and fire protection. Stack effect is influenced by temperature difference between the interior and exterior of building and the height of building. As an attenuation method for stack effect, the architectural methods are generally used. However, as though architectural methods were fully adopted, the problems are reported as ever in tall building. In this study, a new method to reduce stack effect will be suggested. As an active control method against the stack effect, E/V shaft natural cooling method is suggested. In this paper, the concept of E/V shaft natural cooling system and its reduction performance of stack effect by simulation and field measurement will be reported.

유기재배 단감과원과 자연재배 단감과원의 토양화학성 및 과실특성 비교

임현우(Hyun Woo Lim),조정안(Jung An Jo),김월수(Wol Soo Kim) 한국원예학회 2017 한국원예학회 학술발표요지 Vol.2017 No.5

CFD 시뮬레이션을 통한 엘리베이터 샤프트 냉각 시스템의 성능 검토

임현우(Lim Hyun-Woo),이준호(Lee June-Ho),이중훈(Lee Joong-Hoon),송두삼(Song Doo-Sam) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(계획계)

The stack-effect in high-rise buildings in winter causes many problems such as difficulties in opening or closing doors, infiltration, energy loss, noise and fire protection. Stack effect is influenced by temperature difference between the interior and exterior of building and the height of building. As an attenuation method for stack effect, the architectural methods are generally used. However, as though architectural methods were fully adopted, the problems are reported as ever in tall building. In this study, a new method to reduce stack effect will be suggested. As an active control method against the stack effect, E/L shaft natural cooling method is suggested. In this paper, the concept of E/L shaft natural cooling system and its reduction performance of stack effect by CFD simulation will be reported.

입력 성형화를 이용한 이산시간 슬라이딩 모드 제어

임현우(Lim Hyun Woo),정정주(Chung Chung Choo) 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10

코드섬유-고무 복합재료의 물성치에 대한 계면의 영향

임현우(Hyun-Woo Lim),김종국(Jong-Kuk Kim),염영진(Young-Jin Yum) 대한기계학회 2010 大韓機械學會論文集A Vol.34 No.5

고무의 비선형성과 대변형으로 인해 코드-고무 복합재료의 정확한 거동을 파악하기는 어렵다. 코드와 고무 사이에 제 3 의 상을 가정해서 세 가지 상에 대한 모델링을 하기도 하지만 코드-고무 복합재료 계면의 두께와 물성을 결정하기 힘들다. 본 연구에서는 2 차원 일반화된 평면변형률요소와 평면변형률요소를 사용한 유한요소법을 적용하여 여러 가지 계면 두께를 갖는 코드-고무 복합재료의 유효탄성계수와 무차원 탄성계수를 구하였다. 고무물성은 네오-후크 모델을 적용하였고 여러 가지 하중상태와 몇 가지 계면 물성치에 대한 고찰을 하였다. 그 결과 계면 물성치와 계면 두께는 코드-고무 복합재료의 비선형성과 유효탄성계수에 영향을 미침을 알 수 있었다. The nonlinearity and high deformability of rubber make accurate analysis of the behavior of cord-rubber composites a challenging task. Some researchers have adopted the third phase between cord and rubber and have carried out three-phase modeling. However, it is difficult to determine the thickness and properties of the interface in cord-rubber composites. In this study, a two-dimensional finite-element method (2D FEM) is used to investigate the effective and normalized moduli of cordrubber composites having interfaces of various thicknesses; this model takes into account the 2D generalized plane strain and a plane strain element. The neo-Hookean model is used for the properties of rubber, several interface properties are assumed and three loading directions are selected. It is found that the properties and thickness of the interface can affect the nonlinearity and the effective modulus of cord-rubber composites.

방문판매 영업의 지역거점 구조 개선에 관한 연구

임현우(Hyun Woo Lim),이한석(Han Suk Lee),임종원(Jong Won Lim) 한국마케팅학회 2009 마케팅연구 Vol.24 No.4

고객을 직접 만나 상담하는 방문판매 영업에서는 잠재적인 매출이 일어날 수 있는 장소에 대한 정보가 필수적이다. 지역별 경제/인구구조가 안정적이고 대체수요와 추가수요가 높은 성숙기의 방문판매영업의 경우, 과거 판매발생의 위치정보가 미래의 지역별 영업활동 방향을 설정하는데 기여할 것이라고 본다. 본 연구는 한 사례기업을 대상으로 과거 판매 발생 공간 정보를 바탕으로 한 잠재적 매출의 공간 분포를 찾아내고자 하였다. 공간통계 기법의 하나인 G 통계량을 이용해 시장을 매출이 높은 지역들이 집적해 있는 핫스팟과 매출이 낮은 지역들이 집적해 있는 콜드 스팟으로 구분하였다. 서울의 경우 구도심(종로, 을지로, 동대문)은 콜드 스팟, 그리고 강남, 송파지역은 핫 스팟으로 나타났다. 실증조사 결과 콜드 스팟 지역의 영업거점은 매출 성장률도 상대적으로 낮고 자기판매지역 판매비율이 3% 이하인 경우도 있었다. 핫 스팟에는 서로 다른 지역 거점 소속의 방문판매 사원들이 서로 경쟁하고 있을 뿐 아니라 자기 판매 지역의 매출비중도 상대적으로 높게 나타났다. 사례기업의 경우 이러한 매출의 분포와 방문판매 영업 거점의 입지가 일치하지 않는 것으로 나타났다. 이에 따라 본 연구는 잠재 수요의 공간분포에 따라 지역 영업조직의 크기, 수 그리고 영업사원의 배치가 어떻게 변화하여야 할 것인가를 제시하였다. 수요밀도가 높을수록 대형점포의 집중배치의 지역영업구조가 바람직하며 수요가 지역적으로 분산되는 정도가 클수록, 소형 점포들의 분산배치가 이루어져야 할 것이다. 수요분포, 영업거점, 그리고 방문판매사원의 거주지의 공간적 불일치에 대한 유형별 실증분석을 통하여 불일치 지수를 파악하고 그 지수의 변화와 영업성과와의 차이를 분석하는 연구는 미래연구과제로 제시하였다. Often making face-to-face contacts with clients, door-to-door sales personnels are expected to have a good understanding of where their potential sales activities can be made. However, such information has often been neglected in locating and managing branches supporting door-to-door sales activities in practice. Location analysis for door-to-door sales business has also received little attention in the existing retail and marketing literatures. This paper aims at providing a framework for improving the location of door-to-door sales service branches by identifying local clusters of potential sales based on a spatial statistical approach. According to our case study on the door-to-door sales company in South Korea, most of the service branch managers believed that their sales growth mainly depend on the number of sales personnels. Therefore, practitioners have often located their service branches where they can easily recruit door-to-door sales personnels. With little geographic information about their potential clients, sales personnels would have difficulties planning efficient sales routes to increase their chance of making more sales contacts. Such low productivity often caused more sales persons staying idle at home eventually resulting in low job retention rate. When products reach their mature stage and regional socioeconomic structure is relative stable, it is more likely that new orders are often generated from the existing customers. Moreover, additional demand can be expected nearby the areas of present sales due to neighborhood effect. Door-to-door sales business in South Korea is such case, and the spatial distribution of the existing sales records will serve as a good indication of potential demand. This study is performed in the following three steps. First, the number of sales contracts occurred in January to August, 2008 are collected and aggregated for each administrative district, Dong in Seoul, Korea. Due to privacy and proprietary issues, actual numbers of sales contracts cannot be disclosed in this paper. Second, spatial clusters of potential sales are detected using G statistics of existing door-to-door sales data. Finally, hot-spots and cold spots of potential sales are identified, and their sales structures are compared in terms of market segmentation using Analysis of Variance (ANOVA). Spatial autocorrelation implies the degree of similarity between attribute values in one location and the values in the neighboring locations. As a global measures of spatial autocorrelation, General G statistic turned out to be statistically significant at 1% significance level in this study. This indicates that hot-spots (high-high clusters) of potential sales are dominant across the entire study region. Then Local G statistic of existing sales is calculated for each Dong to detect local clusters of potential sales. Assuming 5% statistical significance level, areas are identified as hot-spots if the z-score of local G statistic is greater than 1.96; and as cold-spots if the z-scores of local G statistic is less than -1.96. Hot spots refer to areas where high values of sales are clustered, whereas cold-spots refer to areas where low values of sales are clustered. The inner city areas such as Jongro, Uljiro, and Dongdaemun turned out to be cold-spots, while Gangnam and Songpa turned out to be hot-spots of door-to-door sales. The identified hot-spots and cold-spots of potential demand showed clear distinction in terms of sales branch activities. Sales branches in cold-spot areas were suffering from relatively low sales growth rate, and only less than 3% of the sales were made within its assigned sales districts on average. In the hot-spot areas, sales persons from different branches were competing against one another, and about 10% of the sales were being made within its own sales districts. The major problem identified from this case study is that the current service branches are not located according to the customer de