대상포진의 임상적 고찰과 Acyclovir 치료

이하린 ( Ha Rin Lee ),이민재 ( Min Jae Lee ),함정희 ( Jeong Hee Hahm ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

Background : Herpes zoster is an acute localized infection caused by varicella-zoster virus and characterized by unilateral pain and vesicular eruptions along the sensory dermatomes. Objective : The purpoe of this study was to elucidate the clinical features of herpes zoster and estimate the current theeap utic effect of Aeyclovir on herpes zoster. Method : We studied 517 cases of herpes zoster by retrospective method comparing annual incidence, age and monthly vacations, predilection site, associated conditions, complication and disease progress according toicylovir treatmentat at the department of dermatology, Ewha Womans University Hospital over 4 years(1990-1993). Results : 1. The average annual incidence during the 4 years was 0.2%, being on the increase recently. There was no significant, mannual, seasonal and monthly variation and the majority of cases occurred mast frequently were the fifth decade. 2. The dermatomal involvement of herpes zoster were most frequently on the thoracic dermatome (54.7%), followed by cervical, ophthalmic branch of trigeminal nerve, lumbar, sacral, maxillary branch of trigeminal nerve and mandibular branch of trigeminal nerve. The frequencies of associ ated conditions in herpcsioster, in descending order, were diabetes mellitus, hypertension, infectious disease, gastritis urgastric ulcer, malignant neoplasm, cardiovascular disease and postoperative condition. 3. The duration of treatment in herpes zoster was 3.8 weeks and significantly shortened in acyclovir-using group(p<0.05). The duration of treatment was significantly prolonged in associated disease (p <0.01). 4. Postherpetic neuralgil was the most common complication(11.2%), followed by ophthalmic complications, varicelliform erptions, secondary bacterial infections, meningoencephalitis, recurrent herpes zoster, keloid fomation, urinary retention, ptosis and hypopigmentation. Postherpetic neu ralgia increased with age and was observed most frequently in the ophthalmic branch of trigerninal nerve. Conclusion . The annwal incidence of herpes zoster shows a tendency to increase recently but there was no significant monthly or seasonal variation. The most common anatomical distribution was on the thoracic dematome. Herpes zoster was commonly associated with systemic disorders and the treatment durat,ion was prolonged in associated diseases. Acyclovir has a significant effect in shortening the treatment duration. Postherpetic neuralgia was the most common complication of herpes zoster and was observed most frequently in the ophthalmic branch of trigeminal nerve. (Kor J Dermatol 1995;33(4): 661-668)

다중지능 교수.학습 전략 기반 중학교 「기술.가정」 교과서 의생활 영역의 활동과제 분석

이하린(Lee, Ha Rin),심현섭(Shim, Huen Sup),채정현(Chae, Jung Hyun) 한국가정과교육학회 2021 한국가정과교육학회지 Vol.33 No.4

본 논문의 목적은 2015개정 교육과정의 중학교 ｢기술⋅가정｣ 교과서에서 의생활 영역의 활동 과제를 분석하여 개선점을제시하는 데 있다. 본 연구의 분석 대상은 12개 출판사의 ｢기술⋅가정 ①｣ 교과서 의생활 영역 본문의 활동 과제이다. 다중지능교수⋅학습 전략 분석 기준은 선행 연구를 참조하여 가정교과 전공 교수 1인과 의생활 전공 교수 1인에게 검토를 받고 연구자와협의 과정을 거쳐 재구성하였다. 이렇게 재구성한 분석 기준을 중심으로 12종 ｢기술⋅가정｣ 교과서의 의생활 영역 활동 과제를분석하였고 그 결과에 대해서는 전문가 11인에게 내용 타당도 검증을 받았다. 내용타당도 지수인 CVI는 0.94로 높게 나타났다. 다중지능 교수⋅학습 전략을 기반으로 ｢기술⋅가정｣ 교과서 의생활 영역의 활동 과제를 분석한 결과, 논리수학지능이 31.02%로가장 높은 비중을 차지하였다. 그 다음이 언어지능으로 23.81%, 시⋅공간지능이 17.08%, 자기이해지능이 14.71%, 대인관계지능이5.79%, 신체운동지능이 5.22%, 자연탐구지능이 2.37%, 그리고 음악지능이 0.00%의 순으로 나타냈다. 이 연구 결과에서 알 수있듯이, 의생활 영역에서 높은 비중을 차지 것은 논리수학지능, 언어지능, 시⋅공간지능, 자기이해지능과 관련된 교수⋅학습전략이었다. 한편 가정교과의 교수⋅학습 방법으로 권장되는 대인관계지능과 신체운동지능, 자연탐구지능과 관련된 교수⋅학습전략은 상대적으로 적은 비중을 차지하였으며 음악지능 교수⋅학습 전략은 전무하였다. 따라서 앞으로 ｢기술⋅가정｣ 교과서의생활 영역의 활동과제에는 논리수학이나 언어지능, 시⋅공간지능, 자기이해지능 교수⋅학습 전략 못지않게 대인관계, 신체운동, 자연탐구, 음악지능과 관련된 교수⋅학습 전략도 제시하는 것이 요구된다. The purpose of this study was to make suggestions for improvement by analyzing the activity tasks in the clothing life area in middle school ｢Technology & Home Economics｣ textbooks of the 2015 revised curriculum. For this purpose, the multiple intelligence teaching-learning strategy analysis criteria were reconstructed and used for analysis. The activity tasks of the clothing life area of ｢Technology & Home Economics I｣ textbooks from 12 different publishers were analyzed based on the reconstructed analysis criteria, and the content validity was verified by 11 experts. The content validity, assessed by CVI was 0.94. According to the results, the logical⋅mathematical intelligence accounted for the highest proportion with 31.02%, followed by linguistic intelligence(23.81%), visual/spatial intelligence(17.08%), intrapersonal intelligence(14.71%), interpersonal intelligence(5.79%), bodily/kinesthetic intelligence(5.22%), naturalistic intelligence(2.37%), and musical intelligence(0.00%). The results showed that the teaching-learning strategies most frequently implemented in clothing life area were logical/mathematical intelligence, linguistic intelligence, visual/spatial intelligence, and intrapersonal intelligence. On the other hand, teaching-learning strategies related to interpersonal intelligence, bodily/kinesthetic intelligence, and naturalistic intelligence were used at a relatively low proportion. Therefore, it is recommended to expand the teaching-learning strategies of interpersonal, bodily/kinesthetic, naturalistic and musical intelligence, for a more balanced intelligence development of students.

자기결정성과 리더의 참여적 의사결정이 사내벤처 창업의도와 혁신행동에 미치는 영향 : 역할확장 자기효능감의 매개효과를 중심으로

이하린(Harin Lee),박윤희(Yoonhee Park) 한국기업교육학회 2021 기업교육과인재연구 Vol.23 No.3

이 연구는 혁신의 역설 극복에 중점을 두고 이를 해결할 방안으로 사내벤처에 주목하였다. 이에 따라 사내벤처의 성공적 운영을 위하여 사내벤처제도 운영기업을 대상으로 조직원의 사내벤처 창업의도와 혁신행동의 선행요인을 분석하였다. 즉 이 연구의 목적은 개인의 자기결정성과 리더의 참여적 의사결정이 사내벤처 창업의도와 혁신행동에 미치는 영향을 역할확장 자기효능감의 매개효과를 중심으로 분석하는 데에 있다. 이에 따라 사내벤처제도를 운영하고 있는 기업의 재직자를 대상으로 눈덩이 표집 방법을 활용하여 설문조사를 실시하였고, 최종적으로 216명의 자료를 분석에 활용하였다. SPSS 21.0과 AMOS 21.0을 활용한 구조방정식모형 분석을 통해 자료를 분석하였으며 분석결과는 다음과 같다. 첫째, 자기결정성은 사내벤처 창업의도에는 부(-)적 영향을 미치지만 혁신행동에는 정(+)적 영향을 미치는 것으로 나타났다. 둘째, 자기결정성과 사내벤처 창업의도간 관계, 자기결정성과 혁신행동간 관계에서 역할확장 자기효능감의 매개효과가 확인되었다. 셋째, 리더의 참여적 의사결정은 혁신행동과 역할확장 자기효능감에 유의미한 영향을 미치지 못한 것으로 나타났다. 이러한 연구결과는 조직원의 역할확장 자기효능감이 제고될 기업환경을 조성할 필요성과 함께, 조직원의 자기결정성과 사내벤처 창업의도간 관계와 관련하여 추가적인 후속 연구가 필요함을 시사한다. 나아가 이 연구는 해당 연구결과에 따른 이론적·실무적 시사점 및 향후 연구 방향도 함께 제언하였다. Corporate venture may solve innovation paradox, ultimately leading to national economic growth. For the successful operation of corporate venture, however, it is essential to discover the antecedents of corporate-venture entrepreneurial intention and innovative behavior of employees. Therefore, this study investigated the relationships between an individual’s self-determination and leader’s participative decision making, and corporate-venture entrepreneurial intention and innovative behavior with the mediation effect of role-breadth self-efficacy. For analysis, this study surveyed 216 employees working for corporate venture operating companies in Korea. Data were analyzed by the structural equation modelling using SPSS 21.0 and AMOS 21.0. According to the results of the study, self-determination had a significant direct and indirect impact on employees’ innovative behavior and corporate-venture entrepreneurial intention via role-breadth self-efficacy. However, the relationship between self-determination and corporate-venture entrepreneurial intention and the relationship between leader’s participative decision making and innovative behavior were contrary to expectations. Theoretical and practical implications and suggestions for the future research directions were also proposed based on the results of the study.

백서 피부에서 약물대사 효소의 활성도와 유전자 발현에 미치는 All - trans - retinoic Acid의 영향

이하린 ( Ha Rin Lee ),함정희 ( Jeong Hee Hahm ),홍영숙 ( Young Sook Hong ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.1

Background : The activity of drug metabolizing enzymes and the modulation of their expression by inducers in the skin are the key factors for understanding of pharmacological and toxic effects of topically applied drugs. The role of these enzymes is of major importance, as they may contribute to determine the steady-state levels of biologically active substances. 3-Methylcholanthrene and all-trans- retinoic acid have been known to be inducers of the drug metabolizing enzymes. And all-trans- retinoic acid has many biological actions including anti-cancer effects. Objective: The purpose of this study was to evaluate the effect of all-trans-retinoic acid on inducing the expression and modulation of genetic polymorphism of drug metabolizing enzymes as well as to estimate the role of all-trans-retinoic acid in carcinogenesis and drug interactions. Methods : We analyzed the activities of CYP1A1(Cytochrome P450 1Al), NADPH cytochrome P450-reductase, UGT1 and GST after administration of 3-methylcholanthrene and all-trans-retinoic acid to the Sprague-Dawley male rats. We observed the inducible gene expression of CYP1A1, UGT1, GSTJt by RT-PCR and the genetic polymorphism of CYP1A1, UGT1, GSTK by PCR. Results . 1. The expression of CYP1A1, NADPH cytochrome P450-reductase, UGT1 and GST was induced by 3-methylcholanthrene and all-trans-retinoic acid. That of NADPH cytochrome P450-reductase and UGT1 is pronouncedly enhanced by all-trans- retinoic acid. 2. The effects of 3-methylcholanthrene and all-trans-retinoic acid on inducing the expression of CYP1A1 and UGT1 correlated with an increase of mRNA expression levels of CYP1A1 and UGT1. The modulation of mRNA expression levels of GST ㅠ was downregulated by all-trans-retinoic acid. 3. The genetic polymorphism of CYP1A1 was induced by 3-methylcholanthrene and all-trans- retinoic acid, and that of GSTM1 was not affected by the inducers. The induction of genetic polymorphism of GST ㅠ was down regulated by all-trans-retinoic acid. Conclusion: 3-Methylcholanthrene and all-trans-retinoic acid modulate the inducible expression and genetic polymorphism of drug metabolizing enzymes differentially. All-trans-retinoic acid can modulate the metabolism of procarcinogen such as 3-methylcholanthrene by inducing drug metabolizing enzymes. Furthermore, the elucidation of the molecular mechanisms underlying the regulation of drug metabolizing enzymes by 3-methylcholanthrene, all-trans-retinoic acid and other drugs could help to understand their respective roles in drug interactions and carcinogenesis. (Korean J Dermatol 1998;36(2) 193-203)

국내 도예 작업장의 안전수칙 실태연구와 매뉴얼 제안

이하린(Harin Lee) 한국조형디자인학회 2017 조형디자인연구 Vol.20 No.4

본 연구의 목적은 도자 재료학과 안전 보건학을 접목하여 대학의 도자 실기실, 1인 도예공방, 10인 이하의 소규모 작업장 등이 갖추어야 할 알기 쉬운 도예 실기실 안전수칙모듈을 개발하여 도예재료 및 작업환경에 관한 안전의식을 고취시키고 장단기적인 사고와 질병을 예방하고자 하는데 있다. 도예 실기실의 환경과 재료 및 안전보건의식조사를 위해 국내외 사례연구 및 도예인 설문조사를 하였다. 국내 대학의 도예과에는 한국산업안전보건공단에서 마련한 물질안전보건자료(MSDS:Material Safety Data Sheet) 1) 와 각 학교별 실험실 안전지침서를 비치하는 정도였고 1인 공방이나 소규모 작업장에서는 대부분 안전수칙을 구비하고 있지 않았다. 도자재료 및 안전의식에 관한 도예인 설문지 조사 결과 국내 대학의 도예학과나 단체가 개인 공방이나 10인 이하 소규모 작업장 보다는 재료학의 교육이나 시설적인 면에서는 다소 높은 수준과 인식도를 보였으나, 재료의 유해 성이나 안전보건 정보 및 교육적인 면의 인식도는 대체로 낮게 나타났다. 도예가들이 주로 사용하는 상, 하회 안료 및 금속산화물에 대한 유해성 인식 조사에서는 발색이 중요하므로 원료의 유해 성은 생각해본 적이 별로 없다고 응답한 경우가 25~37%로 꽤 높게 나타났다. 도자기 작업장의 분진에 대한 인식조사결과󰡐잘 모른다󰡑라고 응답한 경우가 20%,󰡐청소만 잘 하면 위험하지 않다 󰡑고 한 응답자들이 20%정도로 나타났다. 도자재료에 대한 전반적인 교육 및 경험수준은 높아졌 으나 소속 실기실에서 그 유해성을 인식하고 환경을 조정하거나 사용 시 주의하는 안전 의식도는 상대적으로 낮은 것으로 조사되었다. 위의 설문지 조사결과를 기반으로 한국에서 주로 사용되는 도자기 원료(소지, 유약, 안료) 및 소성, 실기실 관리 및 안전교육에 관한 도예 실기실 안전수칙을 개발하였다. This study aims to encourage the consciousness about ceramic materials and the work environment in the potters who operate a small scale business and to prevent long and short term incidents and diseases, developing an easy to know ceramic studio safety precaution module that ceramic rooms at college, one main ceramic studio, small scaled kiln equipped pottery studios with fewer than 10 persons should have by combining Ceramic Material Science and Safety Health. For a survey of their consciousness about ceramic studio environment, materials, safety and health, a study of the domestic and foreign cases was conducted, and a survey was conducted with potters. It was found that the Department of Ceramics of the domestic universities had Material Safety Data Sheets (MSDS) prepared by the Korea Occupational Safety & Health Agency and laboratory safety guidelines in each school, while most one-man studios or small-scale kiln-equipped pottery workshops were not equipped with safety precautions. As a result of a questionnaire survey on the potters’ consciousness about ceramic materials and safety, the Department of Ceramics of the domestic universities or organizations had a somewhat higher level and perception in terms of material science education or facilities than individual studios or small scaled kiln equipped pottery workshops with fewer than 10 persons; however, they had overall low perceptions about the harmfulness of materials or safety and health information and education. In the survey on the potters’ awareness about the harmfulness of over/under glazes and metal oxides they mainly used, 25 to 37% of the respondents responded that they hardly thought about the harmfulness of the materials, since coloring is important. As a result of an analysis of their awareness about dust in ceramic workshops, 20% responded that they did not know well, and about 20% responded that the materials are not hazardous if cleaned well. The overall levels of education and experience of ceramic materials increased, but the level of safety consciousness that the studios to which they belonged recognized the harmfulness, adjusted the environment, or they took notice when they used the substances were relatively low. Based on the result of the above questionnaire survey, this study developed ceramic studio safety manuals concerning the ceramic materials mainly used in South Korea (clay bodies, glazes and synthesized pigments), firing, studio management and safety education.

인공지능 이미지 인식 기술을 활용한 위험 알림 CCTV 서비스

이하린 ( Ha-rin Lee ),김유진 ( Yoo-jin Kim ),이민아 ( Min-ah Lee ),문재현 ( Jae-hyun Moon ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2

The number of single-person households is increasing every year, and there are also high concerns about the crime and safety of single-person households. In particular, crimes targeting women are increasing. Although home surveillance camera applications, which are mostly used by single-person households, only provide intrusion detection functions, this service utilizes AI image recognition technologies such as face recognition and object detection to provide theft, violence, stranger and intrusion detection. Users can receive security-related notifications, relieve their anxiety, and prevent crimes through this service.

저농도 계면활성제로 유발되 자극성 접촉피부염에서 비침습적 측정방법을 이용한 피부 자극도 연구

이하린(Ha Rin Lee),최성호(Sung Woo Choi),김대호(Dai Ho Kim),김형옥(Hyung Ok Kim) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

N/A Background : The bioengineering methods for investigating irritant skin reaction have been developed for several decades to evaluate the irritation potential more objectively and quantitatively and obtain the information which is not obvious by the visual examination. Objective : The purpose of this study was to compare the irritant skin reaction of three kinds of surfactants with various low concentrations which produce little reaction visually and investigative the threshold concentration that is reliable for a patch test. Also we investigated the sensitivity and the correlation between visual examination and bioengineering methods in four different concentrations of surfactants. Methods : Twenty healthy volunteers were patch tested with 0.01%, 0.05%, 0.1%, 1.0% of sodium laury1 sulfate(SLS), cety1 trimethy1 ammonium chloride(CETAC), POE(20) sorbitan monolaurate (Tween-20) on the flexor side of the Lt. forearm. The result of patch test was evaluated by visual scoring, evaporimeter, colorimeter, and corneometer until 72 hours. Results : 1. SLS, anionic surfactant, showed the highest irritation potential in visual scoring, TEWL, and skin color measurement. And CETAC, cationic surfactant, showed the greastest irritation in corneometer measurements than other surfactants. 2. TEWL was the most sensitive method for evaluation of skin irritation and correlated most closely with visual examination. 3. Concentration of surfactant higher than 0.1% showed to produce reliable and constant result of skin irritation as the experimental primary irritant. Conclusion : SLS is proved to be the most appropriate primary irritant for studying irritant contact dermatitis, and the degree and mode of skin irritation is different according to the concentration and kinds of surfactants. TEWL measurement is the most sensitive bioengineering method, which could detect early stages of irritation and correlate well with visual examination. (Korean J Dermatol 1999;37(9) : 1276∼1285)

증례 : 신장 ; 리팜핀 유발성 ANCA 음성 반월상 사구체신염

이경남 ( Kyung Nam Lee ),송상헌 ( Sang Heon Song ),이하린 ( Ha Rin Rhee ),성은영 ( Eun Young Seong ),김일영 ( Il Young Kim ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm Soo Kwak ) 대한내과학회 2012 대한내과학회지 Vol.82 No.2

특이 병력이 없는 56세 남자가 폐결핵 치료 6주 후 전신부종과 신손상으로 왔고 신장 조직 검사를 통해 면역음성반월상 사구체신염으로 진단하였다. 폐결핵을 동반한 상태이므로 세포독성 약물은 사용하지 않았으며 약물 중단과 고용량 메칠프레드니솔론 치료를 통해 신기능 회복을 유도하였고, 리팜핀을 제외한 항결핵 약물로서 안정적으로 폐결핵을 치료할 수 있었다. A 56-year-old male with pulmonary tuberculosis was admitted to our hospital for evaluation of generalized edema. He began antituberculosis treatment with rifampin, isoniazid, ethambutol, and pyrazinamide. He experienced abnormal increments in weight and serum creatinine after 6 weeks. All serological findings, including anti-neutrophil cytoplasmic antibodies (ANCA), were negative. Rifampin was stopped because it might have caused the increase in creatinine. Renal biopsy was consistent with pauci-immune crescentic glomerulonephritis (CrGN). His renal function was improved by high-dose steroid treatment. Rifampin-induced, ANCA-negative pauci-immune CrGN is very rare; most cases of rifampin-induced acute renal failure are due to acute tubulointerstitial nephritis. We present here a case of rifampin-induced CrGN and pulmonary tuberculosis successfully treated with high-dose steroids and antituberculosis medications, excluding rifampin. (Korean J Med 2012;82:236-240)

식물 재배 환경 맞춤형 가정용 스마트 IoT 온실 개발

이세훈(Se-hoon Lee),이하린(Ha-Rin Lee),김한비(Han-Bi Kim) 한국컴퓨터정보학회 2022 한국컴퓨터정보학회 학술발표논문집 Vol.30 No.2

만성 실질환 환자에서 허혈성 심질환에 대한 좌심실 이완기능 장애의 영향

최보경 ( Bo Kyung Choi ),이경남 ( Kyung Nam Lee ),황인혜 ( In Hye Hwang ),김일영 ( Ii Young Kim ),이하린 ( Ha Rin Rhee ),성은영 ( Eun Young Seoung ),송상헌 ( Sang Heon Song ),이동원 ( Dong Won Lee ),이수봉 ( Soo Bong Lee ),곽임수 대한내과학회 2012 대한내과학회지 Vol.83 No.3

목적: 만성 실질환 환자에서 허혈성 심질환은 주된 사망 원인으로, 이와 연관된 위험인자를 파악하고 관리하는 것은 중요하다. 허혈성 심질환과 관련된 심장의 구조적인 변화 중특히 좌심실 이완기능 장애는 최근 발생률이 증가하고 있으며, 예후 또한 불량한 것으로 보고되고 있다. 따라서 본 연구는 만성 실질환 환자를 대상으로 심초음파를 이용하여 좌심실 이완기능 장애를 진단하고, 좌심실 이완기능 장애가 사망률 및 허혈성 심질환의 발생률에 미치는 영향에 대하여 알아보고자 하였다. 방법: 2005년 1월부터 2010년 5월까지 본원에서 심초음파를 시행한 만성 실질환 환자 중, 좌심실 구혈률이 55% 미만, 중등도 이상의 판막질환이 있는 환자와 관찰기간이 6개월 미만인 환자를 제외한 71명의 환자를 대상으로 하였다. 임상적 지표들은 의무기록 조사를 통해 수집하였고, 심초음파 검사, 혈액검사를 후향적으로 분석하였다. 결과: ROC curve를 이용한 허혈성 심질환과 연관된 좌심실 이완기능 장애의 진단 기준값은 E/E` = 15.55 (sensitivity: 100%, specificity: 64.7%, p = 0.005), E/A = 0.79 (sensitivity: 84.6%, specificity: 55.9%, p = 0.006)였다. 이 값을 기준으로 E/E` > 15.55, E/A > 0.79인 19명을 좌심실 이완기능 장애가 있는 환자군, Group I으로 지정하였고, 그 외 나머지 환자 52명을 Group II로 나누었다. 심초음파에서 Group I의 E/A, DT, E/E`값은 각각 1.27, 184.21, 19.08이었고 Group II에서는 0.73, 225.19, 13.58이었다(E/A, p < 0.001; DT, p = 0.017; E/E`, p <0.001). 좌심실 이완기능 장애에 영향을 미치는 인자를 분석하였고 연령, 허혈성 심질환의 병력, 낮은 혈색소 수치, 높은 저밀도 지단백 수치가 관련이 되었다. 또한 허혈성 심질환을 야기시키는 위험인자를 분석하였을 때는 좌심실 이완기능 장애, 흡연, 높은 저밀도 지단백 수치, 높은 부갑상선 호르몬수치가 상관관계가 있었다. 좌심실 이완기능 장애와 사망률 사이의 연관성을 살펴보면, 전체 사망률은 Group I, II에서 유의한 차이를 보이지 않았지만(p = 0.177), 허혈성 심질환을 나타내는 disease free survival로 비교하면 Group I이 Group II보다 의미있게 생존율이 감소하였다(p = 0.001). 결론: 만성 신질환 환자에서 좌심실 수축기능이 정상이라도 E/E` > 15.55, E/A > 0.79인 중등도 좌심실 이완기능 장애를 가진 환자는 허혈성 심질환의 발생률이 높았다. Background/Aims: Cardiovascular complications are commonly seen in patients with chronic kidney disease (CKD). Recently, the prevalence of left ventricular diastolic dysfunction (LVDD) has increased, and the importance of LVDD has emerged in patients with CKD. The objectives of this study were to identify diagnostic criteria for LVDD related to ischemic heart disease (IHD) and evaluate the prognostic impact of diastolic dysfunction in patients with CKD. Methods: A total of 71 patients with CKD who were evaluated between January 2005 and May 2010 were included in this study. These patients were evaluated by conventional echocardiography and tissue Doppler imaging (TDI) for diastolic dysfunction. Results: Diagnostic cutoff values for LVDD related to IHD were E/E` = 15.55 (sensitivity: 100%, specificity: 64.7%, p = 0.005) and E/A = 0.79 (sensitivity: 84.6%, specificity: 55.9%, p = 0.006), Group I consisted of 19 patients with an E/E` > 15.55 and E/A > 0.79. Group II consisted of the remaining patients. Factors contributing to LVDD were age, history of ischemic heart disease, anemia, and high low-density lipoprotein (LDL) level. Factors contributing to IHD were LVDD, smoking, high LDL level, and high parathyroid hormone (PTH) level. The disease-free survival for IHD was significantly lower in group I compared to group II (p= 0.001). However, there was no significant difference in overall survival between groups I and II (p = 0.177). Conclusions: Our study showed that moderate LVDD (E/E` > 15.55 and E/A > 0.79) in patients with CKD is positively associated with IHD.