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- 저자 : 이수봉 ( Soo Bong Lee ) (검색결과 105 건)
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이수봉 ( Soo Bong Lee ) 택민국학연구원 2009 국학연구론총 Vol.0 No.4
<琴浦奇遇錄>은 사람마다 그의 運福이 觀相과 音聲에서 나타난다는 것이다. 즉 사람은 運福을 타고났다는 運命論을 통하여 一夫多妻制를 合理化시킨 작품이다. 靑松에 사는 趙百恒이라는 몰락한 兩班이 아내의 針線으로 살아가는 무능한 書生이었다. 아내마저 잃고 실의에 빠져 있을때 門中의 주선으로 別監자리를 얻어 생활하다가 그마저 잃고 말았다. 어느 날 非夢似夢間에 곧 別監자리를 잃을 것이니 “東萊로 내려가라.”라는 그 때의 생각이 떠올라 釜山浦東萊에 갔다. 비를 피해 들어간 집에서 35세의 寡婦를 만난다. 그녀의 財物을 싣고 고향으로 가는 중 그녀가 背信한다. 趙郞은 琴湖江에서 大聲痛哭했다. 뜻밖에도 京華의 大家집 과부 딸이 大丈夫의 음성을 듣고 配匹이 될 것을 간청 받았다. 京華女는 東萊女를 찾아갔더니 趙百恒의 觀相을 보아 내 財物로는 그 사람의 運福을 도저히 채울 수가 없기 때문에 破約했다고 하면서 京華女의 財物이 합쳐지면, “그 사람의 運福을 다할 수 있다.”라고하면서, 일단 내가 “約束을 어겼으니” 자신은 副室이 되고, 京華女는 本室이 되기로 의논되었다. 그날로 趙百恒은 차례로 그女와 同寢하고, 고향인 靑松德洞으로 돌아와 잘 살았다고 전해지는 이야기이다. 東萊女는 觀相을, 京華女는 音聲을 知感하여 受動的인 남성을 적극적으로 作配하는 이색적인 作品構圖라 하겠다. This story proposed that the man should be destined to be borne with his physiognomy and his natural phone, which rationalized the system of polygyny in the pretext of fatalism. Once there lived a very poor scholar, Jo Baeg Han in Cheongsong who could narrowly live on his wife``s small income of the needlework. Unfortunately, his wife died. When he was in the sorrowful state, a family introduced him a small income post called Beolgam, but this work was lost. He left his village and went to Donglae, Pusan by the order of his dream. In a rainy day, he went into a widow``s house to avoid rain. Mr. Cho was fallen in love with the widow who was 35 years old. But again both were separated, and the widow left Donglae and carried his property to her hometown. Mr. Cho was crying at the Geomho riverside. A daughter of the rich widow, Gyeonghwa asked to marry him because she sympathized his miserable state. But things did not go well. The girl, Geongwha visited her friend, Dongrae and said to her that all my property could not satisfy his wealthy physiognomy, so if you could add your wealth to mine, then we could marry Mr. Cho together. At last, Gyeongwa became the second wife and Dongrae became the first wife. Cho baeghwan came back to his hometown with two wives and large property and lived a happy life. This story consists of two scenes of choice, Dongrae``s choice of his physiognomy and Geongwha``s choice of his phone, and two wives made his character optimistic and positive to lived well.
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균혈증 및 패혈증의 임상 양상 및 예후 인자에 대한 고찰
이수봉(Soo Bong Lee),이우철(Woo Chul Lee),정현철(Hyun Chul Jung),송상헌(Sang Heun Song),이동원(Dong Won Lee),김용범(Yong Bum Kim),정주섭(Joo Seop Chung),곽임수(Ihm Soo Kwak),조군제(Goon Jae Cho),나하연(Ha Youn Rha),장철훈(Chul Hun Ch 대한내과학회 1999 대한내과학회지 Vol.56 No.3
N/A Objectives : In spite of the improvement in therapeutic strategy, the mortality rate from sepsis is still high. The purpose of this study was to examine the clinical characteristics and prognostic factors of sepsis to get help in treatment and estimation of prognosis of sepsis. Methods : We analyzed the clinical and bacteriologic data of 313 admitted patients with bacteremia at Pusan National University Hospital from Jan., 1996 to Dec., 1997 retrospectively and all patients were categorized into 4 groups (bacteremia, sepsis, severe sepsis, septic shock) by the definition from American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, 1992. Results : 1) Male to female ratio was 1.22 : 1 and mean age was 52 years. 2) The overall mortality rate was 32.3% and the mortality rates of bacteremia, sepsis, severe sepsis and septic shock were 14.9%, 22.8%, 52.0%, and 95.2%, respectively. 3) Underlying diseases predisposing to bacteremia were diabetes mellitus(14.4%), solid cancer (13.1%), hematologic malignancy(10.2%) and liver cirrhosis(9.9%), but the most common was no underlying disease. 4) Among the total 80 species of isolated microorganisms, gram-positive organisms were responsible in 169 cases, gram-negative organisms in 218 cases. E. coli was isolated most frequently, followed by S. aureus, S. epidermidis, K. pneumoniae, Enterococcus spp., Enterobacter spp., Str. viridans group, CNS, P. aeruginosa and S. typhi. 5) Although the source of bacteremia could not be identified in 28.8% of the patients, the others had the primary site of infections ; skin(17.9%), gastrointestinal tract(16.9%), respiratory tract(12.5%), urinary tract(9.9%) and biliary tract(7.3%). 6) The mortality rate in patients with gram-positive bacteremia was 39.4%, with gram-negative bacteremia was 20.9% and with polymicrobial bacteremia was 33.3%. MRSA sepsis showed the highest mortality rate(58.8%), followed by Enterococcus spp.(50.0%), K. pneumoniae (35.0%), P. aeruginosa(27.3%) and E. coli(18.8%). 7) There was significant relation between etiologic organisms of bacteremia and the primary site of infections. 8) Using logistic regression analysis, mortality was predicted by disseminated intravascular coagulation, severity of sepsis and severity of underlying diseases. Conclusion : Sepsis occurred in 16 patients among 1,000 adult admitted patients and overall mortality rate was 32.3%, still high. The mortality rate had positive correlation with the severity of sepsis. Among 16 evaluated risk factors of mortality, mortality was predicted by disseminated intravascular coagulation, severity of sepsis and severity of underlying disease.
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IgA 신병증에서 혈중 Vascular Endothelial Growth Factor 농도의 임상적 의의
이수봉(Soo Bong Lee),이동원(Dong Won Lee),김용범(Yong Bum Kim),정현철(Hyun Chul Jung),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4
목 적: Vascular Endothelial Growth Factor(VEGF)는 혈관 내피 세포의 증식과 혈관 신생, 혈관 투과도의 증가 등을 유발하는 특이한 성장인자로서 신장에서도 생성된다고 하나 아직 완전한 기능은 밝혀지지 않은 상태이다. 이에 저자들은 원발성 사구체 질환 중에서 가장 흔한 IgA 신병증 환자를 대상으로 질병의 중증도와 관련된 여러 인자들과 혈청 VEGF 농도 사이의 상관관계를 알아보기 위해 본 연구를 시행하였다. 방 법 : 부산대학교병원 신장내과에 입원하여 신생검 시행결과 IgA 신병증으로 진단된 21명의 환자를 대상으로 혈청 VEGF를 Sandwich ELISA 방법으로 정량 하였으며 조직학적 소견을 포함한 질환의 중증도를 반영하는 인자들과 혈청 VEGF 농도와의 상관관계를 조사하였다. 결 과: 조직학적 중증도, 조직 표본중의 반월(crescent)의 비율, 혈청 중의 크레아티닌, 알부민, IgA들의 각각의 농도와 24시간 요단백 배설량, 크레아티닌 청소율을 구하여 이들과 혈청 VEGF 농도와의 상관관계를 분석한 결과 조직학적 등급(r=0.471, p<0.05), 세포성 반월의 비율 (r=0.485, p<0.05), 간질 섬유화의 정도(r=0.562, p<0.01), 24시간 요단백 배설량(r=0.439, p<0.05), 그리고 혈청 알부민 농도(r=-0.594, p<0.01)가 각각 의미 있는 상관관계를 보였다. 반월이 관찰되지 않았던 17명을 대상으로 한 조사에서는 혈청 알부민 농도만이 혈청 VEGF 농도와 의미 있는 상관관계를 보였다. 7명의 조직학적 등급 IV, V인 환자를 대상으로 혈청 VEGF의 농도를 조사한 결과 반월의 존재 여부에 따라 유의한 차이를 보였다. 결 론: IgA 신병증에서 혈중 VEGF 농도는 조직학적 소견에서 사구체 경화와 같은 만성적인 변화보다는 급성 신손상을 반영하는 세포성 반월(cellular crescent)의 형성과 의미 있는 양(positive)의 상관 관계를 보인다. 따라서 혈청 VEGF 농도는 IgA 신병증 환자에서 급성 신 손상의 정도, 그 중에서도 특히 세포성 반월 형성을 반영하는 좋은 표지자로 판단된다. Background : Vascular endothelial growth factor (VEGF) is a potent enhancer of microvascular permeability and a selective endothelial cell growth factor. In human kidney, VEGF is expressed mainly in glomerular visceral epithelial cells. We investigated the relationship between serum levels of VEGF and factors reflecting the severity of disease including histological patterns in order to elucidate the relevance of VEGF in the pathogenesis of IgA nephropathy. Methods : Serum VEGF was studied using a sandwich ELISA from 21 patients with IgA nephropathy. Histological patterns are classified to 5 grades by WHO classification and frequencies of crescent and glomerular sclerosis, degree of interstitial fibrosis were recorded. Serum concentrations of creatinine, albumin, IgA, amounts of 24 hour urine protein excretion, and creatinine clearances are also evaluated. Results : Serum VEGF levels were significantly correlated with histological grade(r=0.471, p<0.05), frequency of cellular crescent(r=0.485, p<0.05), degree of interstitial fibrosis(r=0.562, p<0.01), and 24 hour urine protein excretion(r=0.439, p<0.05), and inversely with serum albumin concentration(r=-0.594, p<0.01). Studies in 17 patients without crescent formation revealed that only serum albumin concentration showed significant correlation with serum VEGF level. Conclusion : Serum VEGF concentration is mainly correlated with cellular crescent formation reflecting activity of the disease rather than chronic structural changes such as glomerular sclerosis or interstitial fibrosis. Elevated serum VEGF concentration seems to be due to the release of relatively large amounts of stored VEGF from damaged visceral epithelial cells. Serum VEGF concentration may be a useful marker to evaluate the degree of acute renal injury, especially cellular crescent formation.
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