韓國人 隔離集團의 遺傳學的 硏究

이정주,Lee, Chung Choo 한국통합생물학회 1978 동물학회지 Vol.21 No.1

서울, 강남구 서수동 일대가 격리된 集團이기 때문에 ankyloglossia가 높은 빈도로 나타났는지를 간접적으로 究明하고저 실시한 연구에서 다음과 같은 결과를 얻었다. 이 集團의 PTC 味覺 値에 관한 分布相은 他集團과 대개 일치하였다. 그러나 味盲者의 빈도는 남자가 여자보다 有意하게 높았으며 ankyloglossia가 남자에서 많이 발생한 현상과 비슷하였다. 그러나 味盲과 anakyloglossia가 어떤 상호관계가 있는지는 알 수 없었다. 舌運動의 rolling과 folding과 되는 경우는 서울의 他集團과 비교할 때 그頻度가 낮은 편이었다. twisting이 되는 경우는 남녀에 따라 차이가 심하였다. 色感異常의 頻度는 6.21%로 다른 集團보다 약간 높았다. 이와같은 결과로 보아 이 集團은 遺傳的으로 격리된 集團으로 추측되며, 舌動的, PTC 味覺 및 ankyloglossia 사이의 관계와 ankyloglosia의 遺傳樣式등은 앞으로 더 追究해야 할 문제로 생각된다. This study has been carried out with the object of researching into the situation of the genetic isolation of a Korean population located near Seoul. The results obtained are summarized as follows: In general, the distribution of P.T.C. threshold values in the population is close to that of the Seoul population. But the nonataster frequency of male in the population is higher than that of female, and this is in agreement with the status of ankyloglossia frequency in male. However the relationship between the two traits has not been clarified. The gene frequencies of rolling and folding of tongue are slightly lower than that of the Seoul population. The gene frequency conditioning the ability to twist the tongue is lower in the male than in the female. The color-blindness is 6.21 percent, and it is slightly higher than that of other Korean population. All considered, the studied population might be regarded to have been kept in genetic isolation.

On the Frequency and Distribution of the Acatalasemia and Hypocatalasemia in Korean Population

이정주,Lee, Chung Choo The Korean Society for Integrative Biology 1975 동물학회지 Vol.18 No.3

The purposes of this study were to investigate the frequencies of acatalasemia and hypocatalasemia in Korean population to compare with those of Japanese, Chinese and chiefly Taiwan population. The results obtained were as followings; 1. In south area of Korea, Jeonju, Gwangju, Busan and Daegu, a total of 3,629 individuals were tested. No acatalasemia was found but 0.26% of hypocatalasemia in Jeonju, 0% in Gwangju, 0.21% in Busan and 0.06% in Daegu were found. 2. The frequency of hypocatalasemia in south area of Korea was found to be lower than in middle area. 3. The frequency of hypocatalasemia in this study was similar to that of Chinese(in Taiwan) and higher than that of Japanese. 4. The reason of the geographical differences in the freqency of the hypocatalasemia was considered to be due to the natural selection. And the reason of the higher frequency of Korean population living in Japan was considered that originally the frequency of Korean population is higher, and the maintenace of this higher degree is obliged to the assortative mating beteen them.

노동시장에서 본 노사분규의 원인 - 한 일 비교 -

이정주(Chung Choo Lee) 한국노동경제학회 1989 勞動經濟論集 Vol.12 No.1

N/A

계배근원세포의 분화에서 막표면단백질의 변화와 섬유아제포성장인자의 작용

강만식,이정주,송우근 ( Man Sik Kang,Chung Choo Lee,Woo Keun Song ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.2

In order to study the cell fusion mechanism in chick embryo muscle cells in culture, the changes of cell surface proteins and the effect of FGF during myogenesis were analyzed by using lactoperoxidase-catalyzed iodination and purified FGF addition to the culture medium, respectively. Both quantitative and qualitative changes were observed in ^(131)I-labelled surface proteins during myogenesis. The proteins with molecular weight of 245K and 66K decreased as the fusion proceeded, and 130K and 93K proteins appeared in the course of fusion. The 245K protein seems to be the LETS protein, and the appearance of 130K and 93K proteins may be due to proteolytic cleavage of the 245K protein. At the same time, four labelled proteins were detected in the cultured medium, which seem to be released from the membrane surface proteins by proteolysis in the course of myoblast fusion. In order to examine the effect of mitogen on myoblast fusion, FGF was partially purified from bovine brain. When FGF was added to culture medium, myoblast exhibited an increase in DNA synthesis and the delay in fusion. These results suggest the possibility that the onset of myoblast fusion is due to the depletion of replication-promoting components in culture medium. The changes of cell surface protein, the engagement of these proteins in myoblast fusion, and the effect of environmental factors on myoblast fusion were discussed.

The Distributions of Blood Groups in Korean Population

강영선,이정주,Kang, Yung Sun,Lee, Chung Choo The Korean Society for Integrative Biology 1978 동물학회지 Vol.21 No.1

서울, 광주, 부산, 제주지방에서 총 863명을 대상으로 ABO, MNSs, Rh, Diego, Duffy, Kell, Kidd 및 P혈액형의 빈도와 분포를 조사하여 비교 고찰하였다. ABO혈액형의$I^B$인자의 빈도는 제주지방을 제외하면 북쪽에서 남쪽으로 가면서 낮아지고, $I^A$인자는 반대로 증가하는 경향성이 있었다. 그리고 과거 약 50년간에 있어서 한국인의 A형은 점차로 증가하고 B형을 감소되는 경향이 고찰되었다. NM혈액형의 $Ig^M$인자의 빈도도 제주지방을 제외하면 중부지방에서 남부지방으로 가면서 감소되었다. 한국인의 $Ig^M$인자 빈도는 0.518이었는데 이것은 중국의 북방과 일본의 사이에 든다. Rh혈액형의 $Rh^-$형은 0.26%이었고, CCDee형이 42.41%로 가장 높은 빈도 였으며, CcDEe형은 약 34%, ccdee형은 0.087%로 가장 낮았다. 한국인의 Di(a+)형은 6.633%였고, Fy(a+)형은 99.267% Fy(b+)형은 13.832%이었다. 제주지방의 Fy(b+) 빈도는 17%였는데, 이것은 한국인과 일본인집단(19.23%)의 중간에 해당한다. K+형은 서울에서 1예가 발견되었을 뿐이었다. Kidd혈액형의 JK(a+)형과 P혈액형의 P+형은 조사지역에 따라 가장 심한 빈도의 차이를 나타냈다. The blood samples collected from 863 school boys living in Seoul, Kwangju, Pusan and Cheju were tested for studies on the distributions and frequencies of ABO, MNSs, Rh, Diego, Duffy, Kell, Kidd and P blood groups. The $I^B$ gene frequencies appeared to be a cline, and this is decreased gradually from north to south except the Cheju population, but on the other hand those of $I^A$ gene increased oppositely. In Koreans A type of ABO group increased during past fifty years while B type decreased. $Ig^M$ gene frequencies also decreased from north to south district in Korea except Cheju. And the frequency of $Ig^M$ in Koreans was 0.518 which is between those of the north Chinese and the Japanese. In general Rh negative was 0.26 percent, and CCDee phenotype was of the highest frequency among all phenotypes, showing 42.41 percent, CcDEe, about 34% and ccdee, 0.087%. The frequencies of most Rh phenotypes in Koreans were close to those of the Japanese rather than to those of the Chinese and the Thais. Di(a+) type was 6.633 percent, and Fy(a+) and Fy(b+) type were 99.267 percent and 13.832 percent respectively. K+ type was observed only one case in Seoul. The frequencies of Jk(a+) and P+ type were the most varied depending on the populations studied.

Alterations in Surface Proteins and the Action of Fibroblast Growth Factor in Differentiating Chick Myoblasts

강만식,이정주,송우근,Kang, Man-Sik,Lee, Chung-Choo,Song, Woo-Keun 생화학분자생물학회 1984 한국생화학회지 Vol.17 No.2

In order to study the cell fusion mechanism in chick embryo muscle cells in culture, the changes of cell surface proteins and the effect of FGF during myogenesis were analyzed by using lactoperoxidase-catalyzed iodination and purified FGF addition to the culture medium, respectively. Both quantitative and qualitative changes were observed in $^{131}I$-labelled surface proteins during myogenesis. The proteins with molecular weight of 245K and 66K decreased as the fusion proceeded, and 130K and 93K proteins appeared in the course of fusion. The 245K protein seems to be the LETS protein, and the appearance of 130K and 93K proteins may be due to proteolytic cleavage of the 245K protein. At the same time, four labelled proteins were detected in the cultured medium, which seem to be released from the membrane surface proteins by proteolysis in the course of myoblast fusion. In order to examine the effect of mitogen on myoblast fusion, FGF was partially purified from bovine brain. When FGF was added to culture medium, myoblast exhibited an increase in DNA synthesis and the delay in fusion. These results suggest the possibility that the onset of myoblast fusion is due to the depletion of replication·promoting components in culture medium. The changes of cell surface protein, the engagement of these proteins in myoblast fusion, and the effect of environmental factors on myoblast fusion were discussed. 세포의 융합기작의 일단을 규명하기 위하여 계배 근원세포의 막표면 단백질을 lactoperoxidase를 써서 iodination하여 융합 전후의 막단백질의 변화를 분석하였고, fibroblast growth factor(FGF)를 소의 뇌로부터 추출하여 근원세포의 DNA 함성과 융합에 미치는 영향을 검토하였다. 융합과정 중에 막표면 단백질의 정성적 및 정량적 변화를 볼 수 있었는데, 융합이 진행됨에 따라 245K 와 66K 단백질은 점차 감소하였고 130K와 93K 단백질은 새로 출현하였다. 245K 단백질은 large, external, transformation-sensitive 단백질로 추정되며, 이 단백질의 가수분해 결과 130K와 93K 단백질이 출현하는 것으로 추정되었다. 또한 배양액 내에서 발견된 4개의 표지단백질도 막단백질의 가수분해 산물로 생각되었다. FGF를 배양액에 첨가하였을 경우 근원세포의 DNA 합성률은 증가를 보인 반면 융합은 지연되는 현상을 관찰할 수 있었다. 이러한 사실은 근원세포의 융합이 배양액 내에 존재하는 DNA 합성을 촉진하는 물질이 고갈됨에 따라 개시되는 것이 아닌가 하는 점을 암시해 주는 것으로 사료되었다. 근원세포의 융합과정에서 나타나는 막표면 단백질의 변화와 외적 요인이 세포융합에 미치는 영향에 대해 논의하였다.

Molecular Genetic Studies of Korean Population - 4. Genetic Structure of Adenylate Kinase ( AK ) -

김영진,백상기,이정주,김종순,안광숙 ( Yung Jin Kim,Sang Gi Paik,Chung Choo Lee,Jong Soon Kim,Gwang Sook Ahn ) 한국유전학회 1987 Genes & Genomics Vol.9 No.3

Red cell adenylate kinase(AK) phenotype and gene frequency was determined by horizontal starch gel electrophoresis for 509 unrelated adult individuals living in the 6 provinces of Korea> Only one type of AK 1 phenotype was found for all individuals surveyed, thus the genes for AK systems were fixed for single allele, AK1. The frequencies of AK1 and AK2 were 1.000 and 0.000, respectively in Korea. In the literature data on the phenotypes and gene frequencies of the AK are widely scattered have been complied, and here certain trends in the AK2 gene distribution were considered.

일반사육시설 마우스의 잠재질병 조사연구

이흥식(Heungshik S. Lee),이영순(Yong Soon Lee),이정주(Chung Choo Lee),정기성(Gey Seong Jeong) 한국실험동물학회 1994 Laboratory Animal Research Vol.10 No.1

Genetic Polymorphism of Es - 7 , Es - 8 and Es - 10 of Wild House Rat(Rattus norvegicus)Population in Korea

이정주,김남근,정기화,이숙환 한국유전학회 1996 Genes & Genomics Vol.18 No.2

The phenotypic polymorphism and allele frequencies of wild house rat (Rattus norvegicus) population in Korea (Seoul) were studied. The following esterases were analysed : esterase-7 (Es-7), esterase-8 (Es-8) and esterase-10 (Es-10). Two alleles of Es-7, Es-7^a and Es-7^b were found in Korean wild house rat population. The allele frequencies of Es-7^a and Es-7^b were 0.029 and 0.971, respectively. There were three alleles, in Es-8, Es-8^a, Es-8^b and Es-8^c. The allele frequencies of Es-8^a, Es-8^b and Es-8^c were 0.071, 0.907 and 0.022, respectively. Three alleles of Es-10, Es-10^a, Es-10^b and Es- 10^c were found. The allele frequencies were calculated as 0.907, 0.071 and 0.022, respectively. Es-7^a, Es-8^b and Es-10^c alleles were first found in Korean wild rat population.

한국인 집단의 적혈구 효소의 다형현상 및 유전적 변이

이정주,남궁용 한국유전학회 1986 Genes & Genomics Vol.8 No.2

Polymorphisms of six red cell enzymes were studied on unrelated individuals from three areas (Seoul, Kangreung and Cheju) of Korea by horizontal starch gel electrophoresis. There were two G-6-PD alleles, GdB^+ and GdB^-, in Korean populations. The allele frequencies of GdB^+ in males were 0.9723 in Seoul, 0.9689 in Kangreung and 0.9726 in Cheju. Three soluble GOT alleles, GOT¹_s, GOT²_s and GOT³_s, were found in Korean populations. The allele frequencies of GOT¹_s were 0.9832 in Seoul, 0.9852 in Kangreung and 0.9851 in Cheju. It was interesting to note that GOT³_s allele was detected in Korean populations. The frequencies of GOT³_s were 0.0049 in Seoul and Kangreoung, and 0.0030 in Cheju. In esterase D study, two common alleles, EsD¹and EsD²were found. Allele frequencies of EsD¹were 0.6702 in Seoul, 0.6640 in Kangreung and 0.6716 in Cheju. There were two common acid phosphatase alleles, AcP^a and AcP^b, in Korean populations. AcP^c allele which was common in Caucasoids and rare alleles were not found. The allele frequencies of AcP^a were 0.3930 in Seoul, 0.4071 in Kangreung and 0.3826 in Cheju. In LDH and MDH studies, only the normal phenotype and no variant type were found. No variant type was found in both enzyme systems. So, LDH and cytoplasmic MDH seem to be monomorphic traits in Korean populations. The gene frequencies and polymorphic phenotypes of the above red cell enzymes were discussed in comparison with the other populations.