정맥내 자가통증조절시 Lidocaine 첨가가 Morphine 제통효과에 영향을 미치는가 ?

이윤우,최재찬,윤덕미,안은경 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.5

Background : Intravenous lidocaine has been reported previously to inhibit neuropathic pain. But it`s analgesic effect in postoperative pain has provided controversial results. The object of this study was to define the analgesic effect of intravenous lidocaine in addition to morphine on postoperative pain control. Method : Female patients scheduled for total abdominal hysterectomy were randomly assigned to one of two groups to be studied in a double-blind manner. Group M (n=20) and Group M+L (n=18) received intravenous morphine (0.1 mg/kg) or intravenous morphine (0.1 mg/kg) + lidocaine (30 mg), respectively, after closure of the peritoneum. Continuous infusion of morphine (1.5 mg/hr) or morphine (1.5 mg/hr) + lidocaine (60 mg/hr) was started immediately after i.v. bolus injection, respectively, until the end of the operation. Postoperative pain was managed with a PCA pump (Walkmed, Medex, USA), setting the basal rate of morphine (0.5 mg/hr) + bolus dose (1.5 mg) and lock out time of 10 min in group M, adding the lidocaine (basal rate: 20 mg/hr and bolus dose: 60 mg) to the same dose of morphine as group M in group M+L. Postoperative visual analogue pain scores (VAS), analgesic requirements and side effects were examined for 2 days postoperatively and compared between groups. Results : VAS at movement were significantly less (p$lt; 0.05) in group M+L than in group M of 2, 12, 24, 36 and 48 hrs after surgery. Patient-controlled morphine cumulative consumption in group M+L was significantly less (p$lt; 0.05) than in group M for 24 hours (26.3 mg vs 35.3 mg) after the operation (p$lt;0.01). Conclusions : Intravenous lidocaine reduces postoperative pain at movement and analgesic requirements. These results suggest that low-dose adminstration of i.v. lidocaine attenuates the postoperative hyperalgesic state. (Korean J Anesthesiol 1997; 32: 822∼829)

행사보고 : 2005 청소년 이공계 진로안내 엑스포 행사를 마치고

이윤우 한국화학공학회 2005 NICE Vol.23 No.5

자동시준형 분광굴절률 측정장치

이윤우,조현모,이인원 한국광학회 1994 한국광학회지 Vol.5 No.3

가시광선과 근적외선에서 광학유리 및 액체의 굴절률을 정밀측정하기 위하여 Littrow 프리즘을 이용한 자동시준형 분광굴절률 측정장치를 설계, 제작하였다. 먼저 여러가지 측정변수를 변화시켜 측정정확도를 분석하였으며 rotary encoder와 position sensitive detector를 이용한 고분해능 각도측정장치와 항온장치등을 제작하였다. 마이크로 컴퓨터를 사용하여 측정자동화 하였으며 자세한 설계변수와 성능평가 결과를 제시하였다. An automatic spectrorefractometer with a Littrow spectrometer arrangement has been designed and fabricated to measure the refractive indices of solids and liquids from the visible to the near IR. The achievable accuracy is numericaly analyzed by varying the measuring parameters and the electromechanical system for measuring the prism angle with a rotary encoder and a position sensitive detector is fabricated. The performance of the instrument is discussed in detail and the results of measurements are given. given.

진단지도를 통한 고지 재활용 공정의 청정화(Ⅵ)-신문고지를 탈묵하는데 있어서 약품과 펄핑시간에 따른 효과-

이윤우,류정용,Benjamin FABRY,성용주,송봉근,김용환,송재광 한국펄프·종이공학회 2003 한국펄프·종이공학회 학술발표논문집 Vol.- No.-

악성 구강상피에서 삼차원적 배양을 이용한 비타민의 발암억제 연구

이윤우,이흥수,김수남 원광대학교 치의학연구소 2002 圓光齒醫學 Vol.11 No.1

Since immortalization by Human Papilloma Virus -16 is one possible early step towards carcinogensis in oral epithelia, and Oncogene transfected immortalized cells are more advanced for cancer cells. We studied the differential effect of vitamins A(14μM/ml), C(lMM/ml), D(100μM/ml), and E(lμm/ml) on normal human oral keratinocyte(NHOK), HPV-16 E6E7 immortalized human oral keratinocyte(IHOK), Oncogene transfected HPV-16 immortalized cells(OTOK), and two oral squamous cell line(HNSCC30, HNSCC31) according to carcinogenesis stage. The vitamin effect was evaluated by morphology, cell viability, and orgnaotypic culture. 1. Vitamin A has a greater negative effect on growth for all NHOK, IHOK, HNSCC, especially N-Ras transfected IHOK. 2. Vitamin D & E revealed no significant cell activity on NHOK, IHOK, ad OTOK. 3. Vitamin C was found increased cell viability to IHOK and OTOK. 4. In primary oral squmaous cell carcinoma(HN30), vitamin D and C showing increased cell growth, but vitamin E showing no effect. 5. In metastatic oral squamous cell carcinoma(HN31), vitamin C has proliferative effect, but vitamin D & E has anti-proliferative effect. 6. Vitamin A treated normal and malignant cells by organotypic culture, showed reduction of epithelial layer and invasion to connective tissue., especially in IHOK & oncogene-transfected IHOK. In conclusion, three-dimensional culture system may be useful as a model to acess the efficiency of agents such as all trans retinoic acid can preventing progression of these premaligant lesion to maligant oral carcinoma(chemopreventive agent).

반도체 시장 현황과 우리의 전략

이윤우 한국공학기술학회 2002 공학교육과 기술 Vol.9 No.4

소뇌교각종양에 대한 신경이과학적 분석

이윤우,이강대,유태현,김한규 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.4

실시간 렌즈 성능평가장치 설계 및 제작

이윤우,조현모,이인원,홍경희,이환규 한국광학회 1995 한국광학회지 Vol.6 No.1

복사기. 팩스 렌즈 등 대향생산되는 광학계를 실시간에 성능평가하기 위하여 5개의 십자형 슬릿 물체와 3개의 2차원 CCD를 상분석장치로 사용한 자동평가장치를 개발하였다. 시험렌즈의 사양에 따라 물체와 렌즈, 그리고 상분석장치를 이동시키는 자동정렬장치를 제작하였으며 슬릿의 수직 및 수평방향 선분포 함수를 CCD에 의햐여 동시에 측정하였다. 그리고 렌즈의 축상 및 비축상 MTF와 배율, 편심, 그리고 회전위치에 따른 최적방향 등을 자동으로 실시간에 측정할 수 있었다.

구강병으로 인한 모친과 아동의 활동제한일수에 관한 연구

이윤우,이홍수 대한구강보건학회 1999 大韓口腔保健學會誌 Vol.23 No.3

The purpose of the present study was to prepare basic data on the social oral health status of mother and child by examining patterns of activity restriction due to oral illness for mothers and children and the correlation factor. Research was carried out on 1,907 pairs of mother and child. Research was conducted by means of questionnaires. The total 40 variables were used for the study, 38 independent variables, including the age, the number of family members, education, oral health belief. etc. and 2 dependent variables, the number of activity restriction days. The percentage of mothers and children who experienced activity restriction due to oral illness was calculated. The multiple regression analysis was adopted to examine related factors to the number of activity restriction days far mothers and children. The findings of analysis can be summarized as follows: 1. As to activity restriction due to oral illness, 44.2% of mothers and 66.2% of children experienced. 2. The annual average days of activity restriction for mothers were 4.24, while the average days for children was 3.82. 3. Variables correlated with the number of mothers' activity mestriction days were the number of children, the birth order, employment, susoeptibility out of the oral health belief, valuation on the dentist and the number of visits to dentists for preventing purpose. 4. Variables correlated with the number of child's activity restriction days were mother's employment, mother's concem about a medical fee, mother's frequency of tooth brushing, the number of mothers activity restriction days, susceptibility and seriousness out of the child's oral health belief and the frequency of child's visit to the dental clinic for oral health protection. 5. Susceptibility out of the oral health belief was most highly correlated to the number of activity restriction days for mothers and children.

대구경 비구면 광학기술과 응용

이윤우,문일권,김학용,양호순,Lee, Yun-U,Mun, Il-Gwon,Kim, Hak-Yong,Yang, Ho-Sun 한국광학기기산업협회 2014 光學世界 Vol.151 No.-

대구경 비구면 거울은 대형 천체 망원경이나 고해상도 위성 카메라 등에 사용하는 핵심부품이다. 일반적인 디지털 카메라와 비교하면 매우 크므로 설계 및 제작이 같은 크기의 구면보다 훨씬 어렵다. 특히 경량화가 많이 될수록 중력이나 온도변화와 같은 외부의 힘에 의한 변형이 쉽게 발생하기 때문에 이러한 효과를 줄여주는 광기계 설계 및 해석이 더욱 중요해진다. 지상용과 우주용은 사용 환경에 차이가 있어서 설계 요구조건이 달라지고 이에 따라 지지구조물이나 반사경의 경량화 모양 등에 많은 차이가 있다. 본 논문에서는 대구경 비구면 광학기술가운데 가장 어려운 광기계 설계에 관하여 지상용과 우주용으로 나누어 자세히 설명하고자 한다.