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1 , 2 - dimethylhydrazine 으로 유발되는 대장암발생의 기전에 관한 조직 및 조직화학적 연구
이유복(Yoo Bock Lee),박찬일(Chan Il Park),이기범(Kyi Beom Lee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2
N/A To investigate the histogenesis of colonic carcinoma, 1,2-dimethylhydrazine(DMH) was injected to Sprague-Dawley rats for 6 to 24 weeks, 20 mg/kg/week, and gross and microscopic studies of the colonic mucosa were made with special emphasis on changes of transitional mucosa(TM), such as the pattern and nature of mucin contents and epithelial dysplasia. The tunor developed in 1/10 in 6~16 weeks treated groups, 1/6 in 20 weeks and 5/6 in 24 weeks treated group. Majority of the tumors were adenocarcinomas, while a few cases of signet ring cell carcinoma wero observed in 24 weeks treated group. Histologic and histochemical changes of the remaining colonic mucosa, especially at the TM consisted of enlargement of the crypts due to goblet cell(G-C) hyperplasia with increased mucin production during 8 to 16 weeks treatment, followed by epithelial dysplasia, such as loss of polarity, nuclear hyperchromacity and reduction of the secretory function. The content of mucin increased during 8 to 16 weeks treatment and was comprised of predominantly sulfomucin, while the content, especially sulfomucin, markedly decreased as dysplastic changes progressed and was accompanied by a relative increase of sialomucin. These findings suggest that the histogenesis of colonic carcinoma takes steps of initia1 G-C hyperplasia with increased sulfomucin production and later dysplastic changes of G-C, accompanied by reduction of sulfomucin secretion and a relative increase of sialomucin.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 간내결석증의 담관변화에 관한 조직화학적 연구
이유복(Yoo Bock Lee),박찬일(Chan Il Park),이광길(Kwang Gil Lee),노병선(Byoung Seon Rhoe),김호근(Ho Guen Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
N/A A pathological study of hepatolithiasis is performed to elucidate the role of hepatobiliary lesions in the formation of hepatic stones. A total of 21 cases of left lateral segmentectomized livers were included in this study and tissue samples were taken from the intrahepatic large bile ducts and their tributaries. Groesly, the stones were usually impacted in the intrahepatic large ducts and their more peripheral tributaries although in 2 cases (9.5%) the stones were restricted to the peripheral tributaries. Histolagically, the affected ducts showed simple epithelial hyperplasia (100%), atypical epithelial hyperplaiia (42.6%), and mucinous metaplasia (100%). Histochemically and immunohistochemically, a marked proliferation of endocririe cells were found in the affected ducts. None of the case of mucinous metaplasia were poaitive for carcinoembryonic antigen (CEA), and in case of sirnple epithelial hyperplasia, only one out of 21 cases were positive for CEA. In atypical epiihelial hyyerplasia 5 cases out of 9 cases were positive for CEA. We conclude that large amount af mucus production and proliferation of epithelial and endocrine cells are important pathologic findinga of hepatolithiasie and the atypical epithelial hyperplasia in hepatolithiasis is a precancerous lesion of cholangiocarcinoma, both histologically and immunohistoehemically.
증례 : 전신성 Aspergillosis 를 합병한 한국형 출혈열의 1 예
이상용 ( Sang Yong Lee ),박정호 ( Jung Ho Park ),홍천수 ( Chein Soo Hong ),조정실 ( Jung Sil Cho ),김대현 ( Dae Hyun Kim ),이유복 ( Yoo Bock Lee ) 대한내과학회 1973 대한내과학회지 Vol.16 No.10
Described here a patient of K.H.F. with very unusual complication, systemic aspergillosis. The patient was 29 year-old male who entered the Severance hospital with rather typical clinical course of K.H.F. although azotemia was successfully corrected by hem
인체 피부에 기생한 Leishmania tropica의 전자현미경적 관찰
서영훈,허규정,등영건,김정숙,이유복,Seo, Young-Hoon,Hur, Kyu-Chung,Deung, Young-Kun,Kim, Chung-Sook,Lee, Yoo-Bock 한국현미경학회 1980 Applied microscopy Vol.10 No.1
중동지방에 다녀온 48세의 한국인 남자 피부에 발생한 leishmania증 1예에 대하여 광학 및 전자현미경적 관찰을 하여 문헌 고찰과 아울러 보고하였다. 광학현미경적으로는 조직구 침윤을 주로 하는 만성 육아종성염증반응을 보였고 Giemsa염색상 다수의 leishmania충체를 조직구내에서 관찰할 수 있었다. 전자현미경적으로는 난원형의 단세포 또는 분열중인 충체가 조직구내에 존재하였고 충체는 이중막으로 싸였으며 그 바로밑에 microtubule이 배열되고 세포질내에는 신장된 mitochondrion내에 kinetoplast가 존재하고 그 전방에 flagella가 위치하였으며 기타 다수의 ribosome과 드물게 Golgi complex등을 관찰할 수 있었다. 이와같은 특징은 Leishmania tropica의 promastigote stage와 일치하였다. Leishmania증은 원칙적으로 열대병이나 열대지방과의 접촉이 빈번함에 따라 앞으로 우리나라에서도 보다 많은 증예가 발생할 것으로 사료된다. A case of cutaneous leishmaniasis developed in a 48 year old Korean male who returned from middle east was studied by light and electron microscopic observations. Light microscopically, the lesion consisted of heavy chronic ill-defined granulomatous inflammation involving entire thickness of the dermis, composed of mainly histiocytic and small mononuclear cell infiltrations without evidence of necrosis or giant cell formation. Giemsa staining revealed numerous intracellular micro-organisms within histiocytes, showing dark stained central dot surrounded by light stained cytoplasm. Electron microscopically, the organisms were observed mostly ovoid in shape and frequently binary mitotic features within the host cells. follicle consisted of double unit membranes and microtubules, which are immediately below these membrnae. A long kinetoplast was noted within a very elongated mitochondrion at the center of the organisms and a flagella rose in front of the kineoplast but ended within the cytoplasm. Large numbers of free ribosomes, occasional Golgi complex and SER were also noted, but RER was seldom found. These ultrastructural features corresponded to promastigote stage of Leishmania tropica. In principle, leishmaniasis is a tropical disease and can not be found in temperate zone. However, travel to mideast by many Koreans may contract this disease while they are in endemic regions.