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      • 간세포암종의 세침흡인 세포학적 소견 - 247예에 대한 연구 -

        이광길,이종태,최수임,박찬일,Lee, Kwang-Gil,Lee, Jong-Tae,Choi, Soo-Im,Park, Chan-Il 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1

        Hepatocellular carcinoma (HCC) is malignant tumor frequently occurring in Koreans. There have been few reports regarding the cytologic findings of fine needle aspiration (FNA) of HCC. Most have suggested a diagnostic problem in the cytology distinguishing HCC from some benign hepatic lesions-for example, a regeneration nodule in cirrhosis and liver cell adenoma. In spite of its high frequency in Korea, no cytologic study has been reported, concerning the FNA of HCC. In an attempt to achieve cytologic criteria for the diagnosis of HCC, the authors studied retrospectively cytopathologic findings of 247 cases of HCC. These cases were confirmed either by histoiogic examination including lobectomy, biopsy, or ceil block material, or, when tissue diagnosis was unavailable, by a high serum alpha-fetoprotein level (over 400 I. U.). All aspiration smears were stained by the Papanicolaou method. In each case, the smears were analyzed for cell patterns and various cytomorphology of the tumor cells. The smear background was assessed for the presence of tumor cell necrosis and inflammatory components and compared to that of metastatic carcinomas. The cell patterns were classified as trabecular, acinar, dispersed, and irregular. The cytologic parameters analyzed included the degree of nuclear atypia and the presence of mitoses, intranuclear cytoplasmic inclusions, nucleolar prominency, endothelial lining, multinucleated giant cells, eosinophiic globules, bile, and Mallory body. Most of the FNA of HCC showed markedly cellular smears. The tumor cells were most frequently arranged in a trabecular pattern (80.3%). The irregular (12.6%), the acinar (5.5%), and the dispersed patterns (1.7%) followed in decreasing frequency. Individual hepatoma cells were larger than normal liver cells. However, they had morphologic features characteristic of the hepatic cells the cells were round or polygonal, their cytoplasm was abundant and granular with eosinophilic or amphophilic stainability, and their nuclei were round to oval, located centrally, and tended to have prominent nucleoli. Anaplasia and pleomorphism of tumor cells were generally mild to moderate. These findings existed even in very well differentiated cases. Mitotic figures were present in about 85% of the cases. Prominent nucleoli were observed only in about half the cases. The frequency of other cytologic features was as follows intranuclear cytoplasmic inclusion in 86.8% : endothelial lining in 56.1% : bile in 19.8% : and giant cells in 60.1%. Clear cells were often present in 11.7%, Most aspiration smears of HCC displayed clean background without necrosis or inflammatory material in contrast to the dirty, necrotic background of metastatic cancers and cholangiocarcinomas. Based on the above mentioned features, it is suqqested that the cytologic critieria most important for the diagnosis of HCC include a markedly cellular smear, trabecular pattern, hepatocytoid appearance of tumor cells, endothelial lining, the presence of bile, giant cells, intranuclear cytoplasmic inclusions, and prominent nucleoli, Among these, trabecular pattern, endothelial lining, giant cells and clean smear background are points to be considered in differentiating HCC from metastatic and cholangiocellular carcinoma.

      • KCI등재

        봉독이 TGF-β1으로 유도된 간세포 Apoptosis에 미치는 영향

        이광길(Kwang-Gil Lee),여주홍(Joo-Hong Yeo),한상미(Sang-Mi Han),우순옥(Soon-Ok Woo),박지현(Ji-Hyun Park),김수정(Soo-Jung Kim),이우람(Woo-Ram Lee),김경현(Kyung-Hyun Kim),박관규(Kwan-Kyu Park) 한국양봉학회 2008 韓國養蜂學會誌 Vol.23 No.3

        간세포사멸은 다양한 원인으로 발생하는 만성간질환의 주요 특징 중에 하나이다. 봉독(Apis mellifera)은 예로부터 만성 염증성 관절염, 만성 간질환과 같은 다양한 만성질환의 치료법으로 사용되어져 왔다. 그러나 만성 간질환에서 봉독의 과학적인 치료효능에 대해서 알려진 바가 적어 본 연구에서는 TGF-β1으로 유도된 간세포 apoptosis 모델을 만성 간질환 모델로 이용하여 봉독의 효과를 살펴보고자 하였다. TGF-β1으로 유도된 간세포 apoptosis는 봉독 처리로 apoptotic한 세포 형태의 변화가 저해되었고 세포 생존율도 증가하였다. 봉독은 TGF-β1으로 유도된 간세포 apoptosis에서 Bcl-2와 Bcl-xL의 활성을 증가시켰고, Bax, Caspase-3, Caspase-9의 활성을 감소시켰다. 결론적으로, TGF-β1으로 유도된 간세포 apoptosis에서 봉독의 처리는 Bcl-family의 발현 조절을 통하여 Capase의 활성을 억제하였다. 본 연구의 결과로 봉독은 간세포 사멸을 억제하여 만성간질환에 유용하게 적용될 수 있을 것이라 사료된다. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the TGF-β1-induced hepatocyte apoptosis. Bee venom treatment inhibited the apopotic cell morphology and increased cell viability in TGF-β1-induced hepatocyte apoptosis. With TGF-β1 treatment, bee venom treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase-3 and Caspase-9. In conclusion, bee venom treatment in TGF-β1-mediated hepatocyte apoptosis occurred through the regulation of Bcl-family with subsequent inactivation of the Caspase. These results suggest that bee venom treatment may be of use in preventing the hepatocyte cell death in chronic liver disease.

      • KCI등재
      • KCI등재

        기계안전분야 : 전동식 해머의 소음 특성 파악을 위한 흡차음 실험 연구

        이광길 ( Kwang Gil Lee ),최승주 ( Seung Ju Choi ) 한국안전학회(구 한국산업안전학회) 2011 한국안전학회지 Vol.26 No.5

        The aim of this paper is to evaluate noise characteristics of an electric power driven hammer. These investigation and analysis were made according to the ISO 1680/1 and MIL-STD 7410-1 and lead-wrapping experiment method that was used to identify the principal noise sources and analyze its noise. Hammer generates loud noise and it irritates and affects many people. Repeated exposures to loud noise can lead people to permanent hearing loss. Based on the contribution analysis, we confirm that the striker part is a major noise source and it has directional noise radiation pattern, which is left and right.

      • 유방 소엽성 암종의 복수의 세포학적 소견 - 1예 보고 -

        이미경,이광길,Lee, Mi-Kyung,Lee, Kwang-Gil 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

        We experienced a case of infiltrating lobular carcinoma of the breast in the ascitic fluid. The patient was a 49 year-old woman who presented with a palable mass of 3 months duration in the left upper quadrant of the abdomen and abdominal distension. Five years ago, she had undergone left radical mastectomy with chemotherapy and radiotherapy for infiltrating lobular carcinoma of the breast. The ascitic fluid smears revealed singly scattered small round to elliptical cells, many of which were arranged in characteristic indian-file patterns consisting of 3 to 5 cells. The tumor cells had scanty cytoplasm, rare cytoplasmic vacuoles and marked chromatin clumping with small, but prominent nucleoli.

      • 간에 전이된 흉선종의 세포학적 소견 - 1증례 보고 -

        김지영,이광길,Kim, Ji-Young,Lee, Kwang-Gil 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

        Extrathoracic metastases of thymomas are extremely rare, occurring in less than 2% of cases. We present a case of metastatic thymoma in the liver diagnosed by aspiration biopsy. A fine-needle aspirate from a hepatic mass of a 65-year old man who had a history of malignant thymoma locally invading pericardium was examined. Nests of epithelial cells with few scattered lymphocytes were present. The nuclei of the epithelial cells were round to oval and appeared relatively uniform and regular, with fine chromatin pattern. They had one or two, small but lather conspicuous nucleoli. Unlike previous reports on the findings of the aspiration cytology of thymomas, the characteristic biphasic pattern was not present in this case.

      • 늑골에 발생한 거대세포종양의 세침흡인 세포학적 소견 - 1례 보고 -

        송건창,이광길,Song, Kun-Chang,Lee, Kwang-Gil 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.1

        Giant cell tumor(GCT) occurs very unusually in the rib(less than 1% of GCT). We present the cytologic features of GCT of the rib. It showed multiple cellular clusters composed of characteristic, benign looking osteoclast-like multinucleated giant cells and fibroblast-like mononuclear cells. The multinucleated giant cells contained numerous nuclei (average, 30 to 40 per cell, which were closely packed. The nuclei in giant cells were remarkably uniform and round to oval. The mononuclear, neoplastic stromal cells were elongated and spindle-shaped. There was no cytologically malignant portion in the tumor.

      • 폐로 전이한 유방의 악성 엽상종양 - 세침흡인 세포학적 소견의 1례 보고 -

        임현이,이광길,Yim, Hyun-Ee,Lee, Kwang-Gil 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

        Phyllodes tumor of the breast, especially malignant, is a rare tumor which has characteristic cytologic features. We recently experienced a case of fine needle aspiration cytology of malignant phyllodes tumor of the breast metastatic to the lung. The aspirate showed cellular smear with biphasic population of epithelial and stromal cells. Many individual large cells with round hyperchromatic nuclei were found in the necrotic background and stromal cell atypia was also present. Chondrosarcomatous fragments were also seen in cytologic specimens.

      • 유방의 비정형 증식성 병변의 세침흡인 세포학적 소견 - 1예 보고 -

        송건창,이광길,Song, Kun-Chang,Lee, Kwang-Gil 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1

        We experienced a case of fine-needle aspiration (FNA) cytology of breast which showed atypical proliferative lesion. It was very difficult to differentiate this case from malignancy, because of hypercellular smear and many clusters composed of large, atypical ductal cells. However, it showed other features favoring benignancy, such as tendency of cellular cohesiveness, only slightly increased nucleus/cytoplasm ratio and most importantly presence of myoepithelial cells. It's histologic diagnosis was intraductal hyperplasia with atypia. This case indicates that all atypical breast FNA specimen should lead to the suggestion of surgical biopsy for avoiding over- or under-diagnosis.

      • 초음파 유도하 세침 흡인 생검을 이용한 경부 결핵성 림프절염의 진단

        서광욱(Kwang Wook Suh),박정수(Cheong Soo Park),이종태(Jong Tae Lee),이광길(Kwang Gil Lee) 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.2

        The efficacy of the fine needle aspiration biopsy and cytological examination(FNABC) under ultrasonographic(US) guides for the diagnosis of cervical tuberculous lymphadenitis was assessed. There were one hundred and one patients whose neck masses were proven to be tuberculous lymphadenites with cytologic and/or histologic diagnosis. The physical characteristics shown by US revealed that all the cases were multiple lesions. Multiregional lesions were found in 80 cases(79.1%) and 19 cases(18.8%) were the bilateral lesion. The region V was the most prevalent site(n=69, 68.3%). US findings revealed 92 cases(90.9%) showed hypoechoic lesions and 9(9.1%) showed mixed echo patterns. There was no hyperechoic lesion (p<0.05). The sensitivity of FNABC was 77.2% and specificity was 99.0%. Diagnostic accuracy was 85.0%. There was no complication during the procedures. FNABC for the diagnosis of cervical tuberculous lymphadenitis is a safe, convinient procedure and has a high specificity. The pitfall of FNABC the low sensitivity, seemed to be compensated by US evaluations.

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