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센서 재료 , 제조공정 및 기타 : 실리콘 웨이퍼 공정용 알루미나 정전척의 제작과 특성에 관한 연구
정광진(Kwang Jin Jeong),박용균(Yong Gyun Park),이영섭(Young Seop Lee),조동율(Tong Yul Cho),천희곤(Hui Gon Chun) 한국센서학회 1999 센서학회지 Vol.8 No.6
Alumina electrostatic chucks for silicon wafer process with wide range of electrical resistivity were fabricated by controlling the amount of TiO₂ addition(0, 1.3, 2.0, 2.8 wt%). The dependence of electrostatic force on applied voltage, temperature and humidity was investigated. In addition, response characteristics on applied voltage and relationship between electrical resistivity and electrostatic force characteristics such as Coulomb force and Johnsen-Rahbeck force were discussed.
정아현(Jung A hyun),이동현(Lee Dong-Hyun),김진영(Kim Jin-Young),김창기(Kim Chang Ki),김현구(Kim Hyun-Goo),이영섭(Lee Yung-Seop) 한국태양에너지학회 2020 한국태양에너지학회 논문집 Vol.40 No.6
We evaluated the forecast performance of solar radiation on the Korean Peninsula from the solar radiation data provided by the UASIBS-KIER model of KIER with the solar radiation forecast data generated by the GFS model of the NCEP. In this study, the spatial and temporal downscaling of the GFS model, a cumulative solar radiation forecast model per 3 hours units, was conducted to measure forecast performance. First, in the case of spatial downscaling, K-means clustering of solar radiation values corresponding to all latitude and longitude values of the Korean Peninsula was performed, and seven clusters were formed. Second, in the case of temporal downscaling, the cumulative solar radiation forecast value over 3 h was converted to the cumulative solar radiation value over 1 h. To measure the downscaling performance, the downscaling results of the cumulative forecast over 1 h of the GFS model were compared with the observed solar radiation values of the UASIBS-KIER model. We performed downscaling by using the same average ratio as the cumulative value over 3 h. In addition, we performed downscaling by using the correlation between the cumulative value over 1 h by the UASIBS-KIER model. Based on the rRMSE and rMAE, the use of the correlation was found to be more efficient that the use of the same average ratio.
Protein Kinase C alpha Protects Against Multidrug Resistance in Human Colon Cancer Cells
이세경,이영섭,Adeeb Shehzad,정재창,손종경,Jae-Tae Lee,Jeen-Woo Park 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.1
Multidrug resistance is the phenomenon by which, after exposure to a single chemotherapeutic agent, cancer cells evade the agent’s cytotoxic effects as well as become resistant to several classes of diverse drugs. ATP-binding cassette (ABC) transporters are a family of transporter proteins that contribute to drug resistance via an ATP-dependent drug efflux pump. P-glycoprotein (P-gp) is a prominent ABC superfamily protein encoded by the mdr gene which has the ability to mediate the cellular extrusion of xenobiotics and anticancer drugs from tumor cells. Exclusively expressed P-gp cells from the human colon cancer HCT15/DOX line showed resistance to doxorubicin while parental HCT15 cells treated with doxorubicin displayed typical signs of apoptosis. In order to verify the hypothesis that expression of MDR is controlled in part, by protein kinase C (PKC), expression patterns of different PKC isoforms were examined in both cell lines. Of the PKC isoforms evaluated, the membrane translocation and expression levels of PKC were strikingly increased in HCT15/ DOX cells. PKC reversed doxorubicin-induced apoptosis through the scavenging of ROS as well as inhibition of PARP cleavage. In addition, inhibition of PKC with Go6976, a specific inhibitor of classical PKC, led to reduced MDR expression and increased doxorubicin-induced apoptosis. Knockdown of PKC by siRNA diminished the protective effects of PKC for doxorubicin-induced apoptosis. These results suggested that over-expression and activity of PKC is closely as-sociated with the regulation of the MDR phenotype in human colon cancer HCT15 cells and provided insight into a new strategy for inhibiting doxorubicin resistance in human cancers.