이상증상 기반 미병 분류도구의 신뢰도 및 타당도 연구

이영섭,백영화,박기현,진희정,이시우,Lee, Youngseop,Baek, Younghwa,Park, Kihyun,Jin, Hee-Jeong,Lee, Siwoo 대한예방한의학회 2016 대한예방한의학회지 Vol.20 No.3

Objectives : The number of people in Mibyeong state that complain of physical and mental discomfort but without a clear medical diagnosis has rapidly increased, but the conventional medical system is insufficient to care for these people. By establishing an evaluation instrument for Mibyeong state, it will be possible to provide a research base for Mibyeong management system and expand the clinical area of integrative medicine. Methods : Mibyeong Index was designed to measure inconvenience and resilience of subject's complains including four physical symptoms (fatigue, pain, low sleep quality, indigestion) and mental distress include anxiety, anger, depression. A 21-item quality of healthy measure was developed and tested. We used results of a nation-wide stratified sampled adult data in Korea. Results and Conclusions : Mibyeong index had adequate internal consistency, Cronbach's alpha was 0.88 in general population(N=1,110). The correlation between establised quality of life questionnaires (including SF-12 and EQ-D5 VAS) and the Mibyeong index were from 0.468 to 0.493. The national promotion of advanced health for an aging society and original Mibyeong care technology based on traditional Korean medicine can be developed by a self-care system that enhancing health before suffering illness. We expect that this instrument could be contribute to health management of people in Mibyeong state.

세척 및 1-MCP 처리가 복숭아 ‘천중도 백도’의 후숙 및 품질에 미치는 영향

이영섭(Youngseop Lee),황병호(Byoungho Hwang),임수연(Sooyeon Lim),김종기(Jongkee Kim) 한국원예학회 2013 한국원예학회 학술발표요지 Vol.2013 No.5

한국한의학연구원의 사상체질 연구동향 : 2007년부터 2010년까지의 논문을 중심으로

이영섭(Youngseop Lee),김상혁(Sang-Hyuk Kim),이시우(Kim Siwoo Lee) 한국한의학연구원 2012 한국한의학연구원논문집 Vol.18 No.1

Objective : The aim of this study is to investigate current status of Sasang constitutional medicine researches and to provide source in setting a development strategy and making a policy on the Sasang constitutional medicine. Method : This study analyzed trends in research as represented in the 142 articles of Korea Institute of Oriental Medicine in the field of Sasang constitution medicine from 2007 to 2010. Result : The main themes of studies were Sasang constitution clinical study (68, 47%) and developing instruments for measuring diagnosis (48, 33%), especially pulse diagnosis (25, 17%). Genetic researches and trends studies on Sasang constitutional medicine were respectively 17 (12%) and 8 (5%). As a result, Korea Institute of Oriental Medicine established Sasang clinical information bank, and discovered clinical character of Sasang constitution to develope various diagnosis tools include constitution survey form and pulse diagnosis instrument. Genetic researches also discover constitution related genes such as FTO and MC4R, and explore association between heredity and Sasang constitution. Conclusion : The abovementioned achievements of Korea Institute of Oriental Medicine were limited to diagnosis process. unquestionably studies for reproducibility and authenticity of constitution diagnosis were important mission of Sasang constitutional medicine. However, to develop the advance of Sasang constitutional medicine, not only constitution diagnosis but also constitutional treatment studies should be conducted.

미병에 대한 한국 일반인의 인식과 미병률 현황 : 전국조사

이은영,이영섭,박기현,유종향,이시우,Lee, Eunyoung,Lee, Youngseop,Park, Kihyun,Yoo, Jonghyang,Lee, Siwoo 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objectives : The purpose of this study was to reveal the prevalence of Mibyeong and its symptoms including fatigue, pain, sleep disturbance, dyspepsia, depression, anxiety and anger by using the national survey. Methods : Questionnaires were collected by Gallup Korea. Participants were chosen through stratified sampling method based on area, gender and age. Questionnaire was designated to confirm the recognition, managing of Mibyeong, investigation of life habit, medical history, basic information, QoL questionnaires (Short Form-12, EuroQol-5D) and understanding of Mibyeong medical service conditions. Generally all questionnaires were used for survey the Mibyeong status in public except QoL questionnaires. Questionnaires were fulfilled by professional surveyor as face to face interview. Descriptives was used for data analysis and the results were expressed as percentage ratios (%) Results : 1,101 of people were acquired in this study. Eighty point two (80.2%) percent of participants did not know the concept of Mibyeong accurately even though 80.6% complained of Mibyeong related symptoms. Among them, fatigue was accounted for the highest response (70.7%)in this study. Sixty point four percent of participants identified non-smoking, stop drinking, eating habits and sleeping habits as a way to manage their Mibyeong related symptoms. In addition, exercising (60.8%), visiting medical institution (58.4%) and taking health functional food (52.7%) were presented. Only 23.1% among people with symptoms Mibyeong visited medical facilities. Moreover, the quality of life was found to be significantly correlated with health status. Conclusions : This study could contribute to express the importance of announcing the concept of Mibyeong and status to Korean public. Moreover, more Mibyeong studies should be conducted in the future to evaluate the Mibyeong status objectively.

미병 정량 지표에 관한 중국의 임상연구 동향 분석 - China National Knowledge Infrastructure를 중심으로 -

여민경,이영섭,Yeo, Minkyung,Lee, Youngseop 대한예방한의학회 2018 대한예방한의학회지 Vol.22 No.1

Objectives : The purpose of this study was to analyze the trend of clinical research on quantitative indicators of Mibyeong in traditional chinese medicine(TCM). Method : The journal search was performed using china national knowledge infrastructure(CNKI) database. Our inclusion criteria were as following: TCM clinical researches for quantitative indicators of Mibyeong. Exclusion criteria were as following: non-TCM clinical researches, used intervention methods. Results : Eleven clinical researches were analyzed in this study. Four of these researches classify the Mibyeong as a type of pattern identification(PI) and studied the characteristics of the PI quantitative indicators. Mibyeong diagnosis was done through guidelines and questionnaires, each was used at a similar rate. Quantitative indicators mentioned in the selected researches were blood indices, nailfold capillary, complexion, color of tongue substance and coating, pulse wave diagrams and heart rate variability. Among them, seven researches related to blood indices were the most. Blood indicators include whole-blood viscosity, plasma viscosity, fibrinogen, packed cell volume(Hct), triglycerides, total cholesterol, HDL-C, LDL-C, glucose, BUN/CREA, luteinzing hormone, estradiol, follicle stimulating hormone, IgA, IgG, etc. Conclusions : Based on this results, in combination with western medicine, it seems necessary to try to interpret the Mibyeong in more various ways. Even if the same Mibyeong, it is necessary to identify the index which changes according to the PI or chief complaint, and to set the Mibyeong standard corresponding thereto.

허울(虛鬱) 기반 미병 평가도구 개발 및 예비타당성 검증

백영화,이영섭,박기현,이시우,유종향,Baek, Younghwa,Lee, Youngseop,Park, Kihyun,Lee, Siwoo,Yoo, Jonghyang 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : This study aimed to develop and preliminary validate the Mibyeong Questionnaire (MQ) based on Deficiency-Stagnation pattern, which was report of a person's health condition that comes directly from the person. Method : The first phage of developing a MQ was to generate and exhaustive list of all MQ issue that are relevant to the domain of interest, using literature research and expert group discussions. Through those steps, we established MQ with 33 items divided into two parts: 21-item deficiency pattern and 12-item stagnation pattern. The second phage, we examined the preliminary tests of reliability and validity including the 16-item Deficiency of MQ (16D-MQ), with data (n=1,890) already collected on the Korean medicine data center in KIOM. Results : Exploratory factor analysis revealed three factors of the 16D-MQ. These factors were fatigue(Qi, 氣); psychic and physical elements(Shen, 神); and skin and hair(Jing, 精). Cronbach's coefficient alpha was 0.876 and the intraclass correlation coefficients was 0.368-0.538. In support of criteria validity, the 16D-MQ was weakly correlated with EQ-5D and physicians's opinion, but it was acceptable. Conclusion : The MQ shows that it has an appropriate level of internal consistency and validity. We think further study to reveal its reliability and validity, including stagnation pattern as well as deficiency pattern, is needed.

미병 특허 동향 조사

진희정,이영섭,유하나,이시우,Jin, Hee-Jeong,Lee, Youngseop,Yu, Hana,Lee, Siwoo 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : The purpose of this study was to analyze for the patent application tendency in mibyeong. Mibyeong is a concept in Korean Medicine meaning sub-health state, and treatment of mibyeong can be understood as preventive medicine. This concept laid a foundation for the development of Korean, Japanese and Chinese traditional medicine. In this paper, we describe a meaningful data for efficient R&D through patent analysis of mibyeong focusing on the Korea, Japan and China. Method : We collected patents about mibyeong using Focust, IPDL search tools. We analyzed patents according to the year, topic, country and etc. Results & Conclusion : We collected 1,577 patents and selected 807 patents as useful patents. After detailed analysis on mibyeong patent, we got to know that research about mibyeong was a growing field. In the collected patents, the patents on treatment device(except treatment compositions) were the majority and system of providing information were the second largest. We think that the mibyeong field is growing at a fast pace with high activity, and this research should be updated annually.

증상 정도, 기간, 불편정도 및 회복력 기반 미병 설문지의 신뢰도 및 구성 타당도 평가

장은수,윤지현,이영섭,Jang, Eunsu,Yoon, Ji-Hyeon,Lee, Youngseop 대한한의진단학회 2017 大韓韓醫診斷學會誌 Vol.21 No.1

Objectives The purpose of this study was to evaluate the reliability and the validity of Mibyeong Questionnaire (MQ). The subjects enrolled in this study was 165 from July 2015 to Jan. 2016. The surveys were conducted twice with 3 month terms. Methods The Cronbach's ${\alpha}$ analysis for internal reliability, Pearson Correlation Coefficient analysis for test-retest reliability, Factor analysis with varimax rotation for construct validity, Kappa analysis for diagnostic reliability were used. The significant p-value was less than 0.05. Results and Conclusions The result showed that the Cronbach's ${\alpha}$ of MQ was .857-.937 and total was .913. The reliabilities between test and retest for the MQ were .666-.832 (0.416-0.673, in case of including recovery question) in intraclass correlation coefficient (ICC). The Kappa of recovery question in each item was ranged 0.23(80.6% in agreement rate) to .46(87.9% in agreement rate). In test-retest the Kappa value of Mibyeong diagnosis referred by median value was .418(71% in agreement rate). This study revealed that MQ is a reliable and valid questionnaire.

경량전철 국산화의 경제적 파급효과

이연호(Neonho Lee),이영섭(Youngseop Rhee),조택희(Taek-Hee Cho) 한국철도학회 2008 한국철도학회논문집 Vol.11 No.4

건강군과 미병군의 한열지표 차이에 관한 연구

김수정,이시우,이영섭,Kim, Sujung,Lee, Siwoo,Lee, Youngseop 대한예방한의학회 2017 대한예방한의학회지 Vol.21 No.1

Objectives : In this study, we diagnosed Mibyeong group of adult by taking into Mibyeong Index consideration, and identified the correlation of a Mibyeong group with cold-heat pattern and life quality of them. Methods : The questionnaires were collected by Gallup Korea professional surveyor through face to face interviews. To analyze the differences between health and mibyeong group, we used the descriptive statistics, Pearson's correlation, ANOVA. And multinomial logistic regression was used to generate the odds ratios (ORs) and 95 % confidence interval (CI) for the differences between health and mibyeong group. Results and Conclusions : The gender composition of respondents in this study that there 545 male (49.5%) and 555 female (50.5%). The score of both cold pattern(health: $21.33{\pm}4.25$, MI 1: $22.43{\pm}4.29$, MI 2: $24.09{\pm}5.03$; post hoc test, p <0.001) and heat pattern(health: $18.4{\pm}4.01$, MI 1: $19.48{\pm}4.10$ MI 2: $19.88{\pm}4.81$; post hoc test, p <0.001) in mibyeong group is higher than the score health group. And, these result have no relevance to age. The score of both Physical component summary (PCS) and Mental component summary (MCS) in health group is higher than the score mibyeong group. Cold-heat pattern and quality of life vary significantly according to health status. This results suggest the analysis of cold-heat pattern and quality of life by health status could provide the setting of direction to promote public health depending on health status.