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소세포폐암에서 Multidrug Resistance-1 유전자의 다형성과 Etoposide-cisplatin 항암화학요법 반응의 관계
손지웅 ( Ji Woong Sohn ),이신엽 ( Shin Yup Lee ),이수정 ( Su Jung Lee ),전효성 ( Hyo Sung Jeon ),이재희 ( Jae Hee Lee ),박재형 ( Jae Hyung Park ),김은진 ( Eun Jin Kim ),차승익 ( Seung Ick Cha ),김창호 ( Chang Ho Kim ),강영모 ( You 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
배경 및 목적 : Multidrug Resistance-1 (MDR1) 유전자는 다약제내성에 관여하는 P-glycoprotein을 암호화한다. MDR1 유전자의 다형성은 P-glycoprotein의 발현과 기능의 차이를 일으켜 항암화학요법 반응에 영향을 미칠 수 있을 것이다. 저자들은 소세포폐암 환자에서 MDR1 유전자의 다형성과 일배체형에 따른 항암화학요법에 대한 반응을 조사하였다. 대상 및 방법 : 경북대학병원에서 병리적으로 소세포폐암으로 진단받고
유준부 ( Joon Boo Yu ),이신엽 ( Shin Yup Lee ),전진영 ( Jin Young Jeon ),변형기 ( Hyung Gi Byun ),임정옥 ( Jeong-ok Lim ) 한국센서학회 2013 센서학회지 Vol.22 No.3
The exhaled breath contains gases generated from human body. When disease occurs in the body, exhaled breath may include gas components released from disease metabolism. If we can find specific elements through analysis of the exhaled gases, this approach is an effective way to diagnose the disease. The lung function has a close relationship with exhalation. Exhaled gases from COPD (Chronic Obstructive Pulmonary Disease) patients can be analyzed by gas chromatography-mass spectroscopy (GC-MS) and a gas sensor system. The exhaled breath for healthy person and COPD patients had different components. Significantly more benzendicarboxylic acid was detected from COPD patients than in healthy persons. In addition, patients had a variety of decane. Phosphorous compounds with different isomers were detected from patients. The results obtained by gas sensor system were processed by PCA (Principal Component Analysis). The PCA results revealed distinct difference between the patients and healthy people.
김민 ( Min Kim ),차승익 ( Seung Ick Cha ),신경민 ( Kyung Min Shin ),윤길숙 ( Ghil Suk Yoon ),배정현 ( Jung Hyun Bae ),윤원경 ( Won Kyung Yoon ),이신엽 ( Shin Yup Lee ),김창호 ( Chang Ho Kim ),박재용 ( Jae Yong Park ),정태훈 ( Tae 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.4
Hot tub lung is a lung disorder associated with exposure to hot tub water contaminated with Mycobacterium avium complex (MAC). Although its pathogenesis remains unclear, it may be considered hypersensitivity pneumonitis (HP) rather than an infectious disease. We report a case which fulfilled the current diagnostic criteria of hot tub lung. A patient had worked as a cleaner in the public bath for approximately one year and presented with dyspnea for over one month. The computed tomographic finding of bilateral ground glass attenuation and pathologic finding of granulomatous inflammation were consistent with HP. MAC was isolated from bronchoalveolar lavage fluid and hot tub water. After corticosteroid treatment without antimycobacterial medication, the patient improved and there has been no recurrence. The patient has since discontinued working in the public bath.
호흡기 ; 의료시설폐렴의 임상적 및 세균학적 특성 의료시설폐렴의 임상적 및 세균학적 특성
윤원경 ( Won Kyung Yoon ),김민 ( Min Kim ),김이영 ( Yi Young Kim ),이윤지 ( Yun Ji Lee ),황보엽 ( Yup Hwang Bo ),최금주 ( Keum Ju Choi ),황준현 ( Jun Hyun Hwang ),정승욱 ( Seung Wook Jung ),유승수 ( Seung Soo Yoo ),이신엽 ( Shin 대한내과학회 2010 대한내과학회지 Vol.78 No.6
Background/Aims: Healthcare-associated pneumonia (HCAP) occurs outside hospitals, but its characteristics are similar to those of hospital-acquired pneumonia (HAP). We evaluated the clinical and microbial characteristics of HCAP in Korea. Methods: Of 130 subjects with suspected pneumonia, 49 were classified as HCAP and 81 as HAP. We retrospectively examined the clinical presentations, outcomes, pathogens, and drug resistance rates of Pseudomonas aeruginosae in both groups. Results: The clinical presentations, including the symptoms and laboratory findings, at the time of hospitalization were comparable in both groups. The hospital mortalities of HCAP (28.6%) and HAP (34.6%) did not differ significantly; the length of the hospital stay was similar for all of the survivors (14 vs. 17 days, respectively). Of the identified pathogens, methicillin-resistant Staphylococcus aureus was significantly less common in HCAP than in HAP (two vs. 18 cases, respectively, p<0.01), whereas Klebsiella pneumoniae was more common in HCAP (five vs. zero cases, respectively, p<0.01). The frequency of other Gram-negative rods was similar in both groups. The rate of resistance to antibiotics in P. aeruginosae in both groups was substantial, with the highest resistant rate to ciprofloxacin (50% and 61.5% in HCAP and HAP, respectively). Conclusions: Although the clinical features and outcomes of HCAP were comparable to those of HAP in the study population, the frequency of methicillin-resistant S. aureus was significantly lower in HCAP compared to HAP. (Korean J Med 78:709-716, 2010)
한국인에서 DNMT3b의 39179G>T 다형성과 원발성 폐암의 위험도
이신엽,이재희,박재형,김은진,이수정,전효성,손지웅,차승익,김창호,정태훈,박재용 대한내과학회 2004 대한내과학회지 Vol.66 No.6
목적 : DNA 메틸화는 후생유전적인 변형의주요 기전이며 암 발생에서 중요한 역할을 한다. 유전자 촉진자의 메틸화는 유전자 발현의 중요한 조절기전으로 종양억제유전자 촉진자의 과메틸화는 종양억제유전자의 불활성화를 초래한다. 저자들은 한국인에서 de novo 메틸화에 관여하는 유전자인 DNMT3b의 39179G>T 다형성에 따른 폐암의 위험도를 조사하였다. 방법 : 경북대학교병원 호흡기내과에서 병리학적으로 폐암으로 진단된 392에(편평상피암 194예, 선암 128예, 대세포암 16예, 소세포암 54예)를 대상으로 하였으며 대조군은 경북대학교병원 건강검진센타를 방문한 건강인 가운데 환자군과 연령 및 성을 match하여 무작위로 선택한 391명을 대상으로 하였다. 시료는 전혈 5cc에서 DNA를 추출하고 PCR-RELP법을 통해 DNMT3b 유전자 다형성을 조사하였다. 결과 : DNMT3b 39179G>T의 유전자형은 환자군은 GG형, GT형, TT형이 각각 0.8%, 19.9%, 79.3%였고, 대조군은 각각 1.5%, 25.1%, 73.4%로 유의한 차이는 없었다. TT형에 대한 GT+GG형의 폐암 대응비(OR)는 0.71(95% CI\0.51∼1.00, p=0.05)이었다. 폐암을 조직형에 따라 구분한 경우 TT형에 대한 GT+GG형의 선암 대응비는 0.46 (95% CI=0.26∼0.80, p=0.006)으로 통계적으로 유의하게 낮았다. 선암 환자군과 대조군을 연령, 성, 흡연력 및 흡연양(흡연 갑-년)으로 구분하여 TT형에 대한 GT+GG형의 선암 대응비를 구하였을 때 61세 이상 (OR=0.23, 95% CI=0.09∼0.58, p=0.02), 35갑-년 이상(OR=0.34, 95% CI=0.13∼0.88, p=0.028)의 경우에서 유의하게 낮았다. 결론 : DNMT3b 유전자의 39179G>T 다형성은 한국인에서 선암의 위험도를 결정하는 유전적 인자 가운데 하나로 생각된다. Background : DNA methylation is the main mechanism of epigenetic modification of genes and plays an important role in carcinogenesis. The methylation of promoter can inactivate the tumor suppressor gene by repression of transcription. We investigated the relationship between the 39179G>T (-579bp from exon 1B) polymorphism in DNMT3b gene, which is involved in de novo methylation, and the risk of primary lung cancer in Koreans. Methods : The DNMT3b 39179G>T genotypes were determined using PCR-RFLP method in 392 primary lung cancer patients and 391 healthy controls who were frequency (1:1) matched based on age and sex. Results : although the frequencies of GG, GT, TT genotypes among cases (0.8%, 19.9%, 79.3%, respectively) were not significantly different from those among controls (1.5%, 25.1%, 73.4%, respectively) the frequency of wild-type G allele among cases was significantly different from that of controls (14.1% vs 10.7%, p=0.05). The combined GT and GG genotype was associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR)=0.71, 95% confidence interval (CI)=0.51∼1.00, p=0.05] when TT genotype was used as reference. When the lung cancers were categorized by tumor higtology, the combined GT and GG genotype was associated with a significantly decreased risk of adenocarcinoma (adjusted OR=0.46, 95% CI=0.26∼0.80, p=0.006). In adenocarcinoma, the decreased risk of the combined GT and GG genotype was statistically significant in older patients (≥61 years, adjusted OR=0.23, 95% CI=0.09∼0.58, p=0.002) and in heavier smokers(≥35 pack years, adjusted OR=0.34, 95% CI=0.13∼0.88, p=0.028) in stratification analyses. Conclusion : DNMT3b 39179G>T polymorphism may be a genetic determinant of lung cancer, especially adenocarcinoma in Koreans.