아트로핀 및 팜 함유 다중챔버 단일주사기 및 KMARK-1: 비글개를 이용한 단회 근육투여 비교 생체이용률 연구

이근우,안서연,권태근,정인홍,김동연,Lee, Keunwoo,An, Seoyeon,Kwon, Taekeun,Jung, Inhong,Kim, Dongyeon 한국군사과학기술학회 2017 한국군사과학기술학회지 Vol.20 No.4

In this study, multi-chambered single autoinjector(2in1) and KMARK-1 containing atropine and 2-PAM(pyridine-2-aldoxime methylchloride) were administered to the beagle's muscle, and blood samples were taken for a certain period of time to compare and evaluate the pharmacokinetic profiles of the two drugs. Male beagles were used and classified into two test groups(G1, G2), and crossover pharmacokinetic studies were performed in two test groups. Blood samples were collected from the jugular vein for analysis after administration. The 90 % confidence interval(CI) for log transformed data indicated that the Cmax for both atropine(log 0.9683 ~ log 1.113) and 2-PAM(log 0.9453 ~ log 1.214) was within the limits of bioequivalence criteria, but the AUC for atropine(log 1.1786 ~ log 1.3238) failed to meet this criteria. This is expected as the amount of atropine dose is 25 % higher for the test as compared to the reference formulation. In summary, in view of the ATNAA(antidote for nerve agent of US) authorization, the Cmax equivalence was more important than AUC equivalence, so in this study, we also focused on verifying the equality of Cmax between the two autoinjectors.

CRT용 Shadow Mask 소재

이근우,김충호,김은기,김동수,최광혜,Lee, Geun-U,Kim, Chung-Ho,Kim, Eun-Gi,Kim, Dong-Su,Choe, Gwang-Hye 한국정보디스플레이학회 2001 한국정보디스플레이학회지 Vol.2 No.5

영상 및 NFC 기반 실시간 시약 계량 등록 시스템

이근우,정상호,정회경,Lee, Keunwoo,cheong, Sangho,Jung, Hoekyung 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.6

사물인터넷을 이화학, 약학, 생물학 및 의학 등 다양한 연구실험분야에 적용한 경우 다양한 센서와 기기를 부착하여 지능적으로 연구장비 및 환경을 모니터링하고 제어함으로써 연구실험자의 안전성과 편의성을 증대시킬 수 있다. 시약의 정확하고 편리한 기록관리 및 실험과정의 연구이력과 근거, 역추적성 등을 위해서는 실시간 시약 계량 및 등록의 연구지원 자동화 서비스를 제공해야 한다. 현재 기존 시약관리방법은 전산 관리방법을 이용하지만 시약등록과 관리가 일체화된 자동화가 많이 이루어져 있지 않다. 또한 수기에 의한 기록 관리가 대부분으로 실험에 대한 기록오류 및 많은 시약에 대한 계량 및 등록에 대한 소요시간이 큰 점 등 번거로움과 문제점들이 많다. 이에 본 논문에서는 영상인식 및 NFC(Near Field Communication) 방식에 의한 시약 등록과 동시에 전자저울로 계량 측정된 시약정보를 자동으로 관리할 수 있는 IoT 기반 실시간 시약 계량 및 등록 방법을 연구하였다. When IoT is applied to various research experiment fields such as physics, pharmacy, biology and medicine, it can increase the safety and convenience of researchers by intelligently monitoring and controlling research equipment and environment with various sensors and devices. For accurate and convenient record management and the research history and the basis but also for the reverse tracking, real-time reagent measurement and registration should be provided as a research support automation services. Currently, existing methods of reagent management are operated by computerized method, but reagent registration and management are not automated. And also record is managed manually, there are many hassles and problems such as a record error and too much time required for quantification and registration for many reagents. In this paper, we study a real time reagent measuring and registration method based on IoT to resolve the problems aforementioned, by the information of the reagent acquired by image recognition and NFC method.

미셀을 이용한 한외여과막공정에 의한 시안함유 중금속폐수의 처리

이근우,조순행 ( Kune Woo Lee,Soon Haing Cho ) 대한환경공학회 1993 환경종합 학술대회 Vol.- No.-

OCTOPUS : 다중링크상태분석기

이근우,Lee, Geun-U 한국전자통신연구원 1992 전자통신 Vol.14 No.3

SMX-1 시스팀과 같이 다수의 신호링크들이 운용되면서 신호망의 시험 및 운용이 이루어질 때 부분적인 분석 검증이 아닌 시스팀의 전반적인 검증에서부터 망차원에서의 동작여부를 판단하여 시스팀을 수정, 보완해가야 할 필요성이 있다. 그러나, 범용의 링크상태분석기를 사용하는 것은 한정된(1 또는 2 링크)신호링크만을 제공하기 때문에 다수의 신호링크에 대한 실시간 상태분석을 할 수 없는 점, 이미 정해진 메시지만을 추출/검색할 수 있기때문에 사용자가 원하는 형태의 니모닉 검색/추출이 되지 않는 기능상의 미비점, 다수의 신호링크를 제공하기 위해서 고가의 링크상태 분석기를 여러대 구입하는 것은 중복구매로 인한 예산문제 등 많은 문제점들이 있다. OCTOPUS는 이러한 문제점들을 해결하기위해 제안된 다중링크상태분석기로서, 상태분석시 다수의 신호링크를 제공할 수 있고, 사용자가 원하는 형태의 니모닉 검색/추출이 가능하며, SMX-1 연구결과인 부산물을 이용한다는 측면과, No. 7 레벨2 프로토콜을 이용한 레벨2 비가용원인이유 파악기능제공, 유사한 형태의 HDLC(데이터링크 프로토콜) 처리기능등을 제공할 수 있다는 것이 장점이다. OCTOPUS의 하드웨어는 자체 개발된 SMX-1시스팀의 하드웨어를 사용하며 그위에 링크상태 분석기용 소프트웨어를 탑재하게 된다.

신경작용제 해독제 의약품 품목허가 사례 연구

이근우,안서연,허병일,Lee, Keunwoo,An, Seoyeon,Hur, Byungil 한국군사과학기술학회 2016 한국군사과학기술학회지 Vol.19 No.1

The US Army used MARK-1 composed of atropine autoinjector and 2-PAM autoinjector as a medical countermeasure against nerve agent poisoning. Recently, it has been being replaced by the ATNAA(Antidote Treatment Nerve Agent AutoInjector) for improvement the convenience in use and rapid detoxification effect. ATNAA(FDA approval, NDA 21-175, 2002. 1. 17) is a multi-chambered autoinjector that sequentially delivers atropine and 2-PAM through a single needle to allow Warfighters to survive against lethal exposure to nerve agents. In this paper, our group investigated the case of FDA approval of ATNAA in a point of the various data required by FDA guideline, thereby making it easy to meet the KFDA guideline for the approval of the prototype our group has been developed. The purpose of this study is to provide a reference for efficient research activities to minimize time and cost. Additionally, the purpose of this study is to provide a reference for the planning for the development of similar drug.

SMX/CMP 시스팀 소형화 설계 및 분석

이근우,오현주,주진천,Lee, K.W.,Oh, H.J.,Joo, J.C. 한국전자통신연구원 1993 전자통신동향분석 Vol.8 No.3

SMX/CMP는 통신망기술연구실에서 개발한 대용량 stand-alone 신호중계교환기 SMX-1을 이용하여 지능망 또는 이동통신망의 노드에 CCS No.7 접속이 가능하도록 설계된 CCS No.7 프로토콜 처리장치이다. 기존의 SMX/CMP는 2대의 대형 랙으로 구성되었으며, CCS No.7 프로토콜 처리 장치로서는 너무 크기 때문에 소형으로 되어야 한다는 요구가 있었다. 상호연결시스팀인 HSCU-8채널의 설계와 물리적인 재구성으로 SMX/CMP을 소형화 하였다.

사료내 카드뮴 첨가가 체조직과 피모의 카드뮴, 아연, 철 및 구리함량에 미치는 영향

이근우,이현범,Lee, Keun-woo,Lee, Hyun-beom 대한수의학회 1987 大韓獸醫學會誌 Vol.27 No.2

This thesis was designed to find out whether the cadmium content of hair in living animals reflects the status of cadmium accumulation in internal organs or muscles so that this status can be used as a diagnostic method. Forty-five rats were divided into 4 experimental groups and one control group. The control group received a basal diet which contained zinc $100{\mu}g/g$, iron $80{\mu}g/g$ and copper $135{\mu}g/g$. The experimental group received experimental diets sllpplemented with 1, 10, 100 or $1,000{\mu}g/g$ cadmium as cadmium sulfate. Rats were dissected on the 28th or 56th day of experimental periods and tissues, blood and hair samples were taken, dried and burned to ash and analysed. The cadmium, iron zinc and copper concentrations were measured with an atomic absorption spectrophotometer. In addition feed efficiency and hematological changes were observed. The results obtained can be summerized as follows: A marked decrease in feed intake, weight gain and feed efficiency were observed from 1 or 2 weeks of experimental periods, which was in accordance with the dosage and periods. The cadmium contents of kidney, liver, spleen and muscle were significantly increased in all experimental rats; the accumulation was marked in kidney and liver tissues. It was shown that the cadmium contents of hair reflects the cadmium accumulation in internal organs and muscle; the higher the cadmium levels of diet and of rat tissues, the higher the cadmium content of hair. In the $100{\mu}g/g$ group of rats erythrocyte counts and. hemoglobin concentrations were decreased. A significant(p<0.01, p<0.05) increase in iron contents of kidney, liver and muscle was observed in 10, 100, $1,000{\mu}g/g$ groups of rats on the 28th day of experiment. A significant (p<0.01, p<0.05) increase in zinc contents of kidney, liver and muscle was observed in all experimental rats. On the other hand, serum zinc concentration was decreased. A significant(p<0.01) increase in copper contents in the liver was observed on the 28th day in $100{\mu}g/g$ and $1,000{\mu}g/g$ groups of rats. From these results it may be concluded that the analysis of hair for cadmium is a useful diagnostic approach for the cadmium status of internal organs and muscle in living animals.

섬유주세포에서 Dipyridamole이 활성산소종과 산화스트레스에 미치는 영향

이근우,김재우,Keun Woo Lee,Jae Woo Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.3

Purpose: To investigate the effects of dipyridamole (DPD) on the production of reactive oxygen species (ROS) and oxidative stress in cultured human trabecular meshwork cells (HTMC). Methods: Antioxidant activity of DPD was determined by DPPH assay. Primarily cultured HTMC were exposed to 0, 20, and 50 μm DPD using serum-deprived media. The effect of DPD on the production of ROS was assessed with the DCHFDA assay. The effect of DPD on the t-butyl hydroperoxide (tBHP)-induced oxidative stress was assessed with resazurin assay. Results: DPD showed significant antioxidant activity. DPD significantly decreased the production of ROS (p < 0.05) and improved cellular activity significantly after treatment with t-BHP (p < 0.05). DPD did not affect the generation of nitric oxides. Conclusions: DPD suppressed the formation of ROS and possessed cytoprotective activity against the oxidative stress in HTMC.

Cu/Ti-cappng/NiSi 전극구조 p^+/n 접합의 전기적 특성

이근우,김주연,배규식,Lee Keun-Yoo,Kim Ju-Youn,Bae Kyoo-Sik 한국재료학회 2005 한국재료학회지 Vol.15 No.5

Ti-capped NiSi contacts were formed on $p^+/n$ junctions to improve the leakage problem and then Cu was deposited without removing the Ti-capping layer in an attempt to utilize as a diffusion barrier. The electrical characteristics of these $p^+/n$ diodes with Cu/Ti/NiSi electrodes were measured as a function of drive-in RTA(rapid-thermal annealing) and silicidation temperature and time. When drive-in annealed at $900^{\circ}C$, 10 sec. and silicided at $500^{\circ}C$, 100 sec., the diodes showed the most excellent I-V characteristics. Especially, the leakage current was $10^{-10}A$, much lower than reported data for diodes with NiSi contacts. However, when the $p^+/n$ diodes with Cu/Ti/NiSi contacts were furnace-annealed at $400^{\circ}C$ for 40 min., the leakage current increased by 4 orders. The FESEM and AES analysis revealed that the Ti-capping layer effectively prohibited the Cu diffusion, but was ineffective against the NiSi dissociation and consequent Ni diffusion.