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항-U<sub>1</sub>RNP 항체 양성인 신생아 홍반성 루푸스 1례
안병훈,이구창,윤태영,김미정,An, Byung-Hoon,Lee, Gu Chang,Yoon, Tae Young,Kim, Mi-Jung 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.3
저자들은 전신성 홍반성 루푸스 산모에서 출생한 생후 1개월된 신생아에서 매우 드물게 나타나는 항-$U_1RNP$ 항체 양성으로 인한 신생아 홍반성 루푸스 1례를 경험하였기에 그 임상적 특징을 문헌고찰과 함께 보고하는 바이다. Neonatal lupus erythematosus(NLE) is a distinct subset of lupus characterized by cutaneous findings, cardiac conduction defects, hepatic or hematologic abnormalities. These manifestations are associated with the presence of maternal auto-antibodies such as anti-SSA/Ro, anti-SSB/La, and rarely anti-RNP($U_1RNP$) antibodies. Cases of $U_1RNP$ antibody-positive NLE have somewhat atypical cutaneous manifestation without cardiac or systemic abnormalities. We report a case of cutaneous NLE associated with $U_1RNP$ antibodies.
노윤우 ( No Yun U ),이구창 ( Lee Gu Chang ),어성훈 ( Eo Seong Hun ),하태선 ( Ha Tae Seon ),김미경 ( Kim Mi Gyeong ),김지연 ( Kim Ji Yeon ),윤태영 ( Yun Tae Yeong ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9
Neonatal lupus erythematosus(NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, particularly autoantibodies of Ro family. The patient with NLE exhibits one or more of the following findings:
Cutis Marmorata Telangiectatica congenita 1 예
윤태영,김미경,김연수,노윤우,이구창 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.1
The cutis marmorata telangiectatica congenita(CMTC) is characterized by the presence of purplish, reticulated vascular network with a localized or generalized distribution. The condition is present at birth and tends to improve with age, although some patients have lesion that remains relatively fixed throughout life. Multiple birth defects have been found in 50% of patients with CMTC. We experienced a case of CMTC in a 5-days-old infant. The patient had purplish reticulated patches with telangiectasia on the both arms, chest, abdomen, back, and both legs. The area of involved skin showed an atrophic change. There were no other associated anomalies. Also, we reviewed cases previously reported in Korea.
Eosinophilic Ulcer of the Tongue
노윤우,이구창,김미경,김연수,윤태영 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.1
Eosinophilic ulcer of the tongue, which is characterized by an ulcer with indurated and elevated border that is usually covered by a pseudomembrane, is a benign reactive lesion. It rapidly develops, and spontaneously resolves in a few weeks. It occurs mostly on the tongue, and has a peak onset in the fifth to sixth decades of life. We experienced an eosinophilic ulcer of the tongue in a 65 years old man, The patient showed a single ulcer on right side of his tongue, but had neither subjective symptom nor previous oral or genital ulcers, arthralgia, and erythema nodosum-like skin lesions. The ulcer was 1.2 ㎝ sized with indurated border. Histopathologically, the lesion exhibited ulceration, and a mixed, dense cellular infiltrate composed of eosinophils, lymphocytes, and neutrophils extended from the dermis into muscular layer. The lesion had completely disappeared in two weeks, and did not recur yet for follow-up period of nine months. Only one cane of eosinophilic ulcer of oral mucosa have been reported in the Korean dermatological literature, so it is the second case of eosinophilic ulcer of the tongue in Korea. (Korean J Dermatol 2003;41(1) : 141∼143)
노윤우,이구창,김미경,김연수,윤태영 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.4
Lichen striatus is an uncommon, self-limited, unilateral, linear dermatosis of unknown etiology, ordinarily seen in children from 5 to 15 years of age. Clinically lichen strains consists of a continuous or interrupted band of discrete or confluent, flat-topped, smooth or scaly papules. Multiple lesions are so rare that only 3 cases have been reported in the Korean literature.
노윤우,이구창,김미경,김연수,윤태영 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.7
Florid cutaneous papillomatosis(FCP) is a disease consisting of multiple acuminate keratotic papules in association with an underlying malignancy. Most common underlying malignancy is gastric adenocarcinoma. Other associated malignancies are breast cancer, bladder cancer, hepatobiliary cancer, ovarian cancer and uterine cancer. An association of FCP with other signs of internal cancer is common, with malignant acanthosis nigricans usually appearing many times with sign of Leser-Trelat. We experienced a florid cutaneous papillomatosis associated gastric adenocarcinoma in an 84 years old woman. The patient had a severe itching and showed numerous tiny papules on the trunk(FCP) and brown verrucose papules on the axillae(acanthosis nigricans) and hyperkeratotic yellowish tiny papules on the palms(tripe palm). Histopathologically, the lesion of the trunk exhibited papillomatosis, hyperkeratosis, and acanthosis in the epidermis. Gastroscopic biopsy revealed gastric adenocarcinoma.