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증례 / 만성 C형 간염환자에서 동시에 진단된 간세포암과 Waldenstrom`s Macroglobulinemia 1례
윤휘중(Hwi Joong Yoon),김희진(Hee Jin Kim),이정일(Joung Il Lee),임근우(Keun Woo Lim),강선우(Sun Woo Kang),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byung Ho Kim),장영운(Young Woon Chang),장린(Rin Chang) 대한내과학회 1999 대한내과학회지 Vol.56 No.4
Hepatocellular cell carcinoma (HCC) is one of the most common and malignant neoplasm in the world. Waldenstrom's macroglobulinemia (WM) is a rare B-lymphocyte neoplasia characterized by monoclonal production of IgM Igs and by a marrow containing a diffuse infiltrate of plasmocytoid lymphocytes. A 67-year-old man was admitted because of multiple site pain, especially right flank and posterior neck pain. Physical examination showed hepatomegaly. Laboratory findings were as follows; total protein 8.6 g/dL, albumin 3.1 g/dL with monoclomal protein(IgM-λ). Hepatitis C virus(HCV) infection was detected by polymerase chain reaction(PCR). Computed tomography and celiac angiography disclosed HCC. Aspiration biopsy of the liver revealed HCC. Magnetic resonance imaging showed compression fracture and epidural mass in cervical spines. Bone marrow examination revealed normocellularity with an increase of lymphoplasmacytic series. He was diagnosed as having WM and HCC. HCC is frequently associated with other malignancies. As the site of the extrahepatic primary cancer, the stomach ranked first. WM is also known for its association with an increased incidence of a second neoplasm, most of which are less differentiated lymphomas. but an association with a non-lymphoreticular malignancy is quite rare. We report first case of synchronous HCC with bone metastasis and WM (IgM,λtype) in korean with chronic hepatitis C.
홍승재,양형인,윤휘중,이명수,강효종,김완욱,이상헌,조철수,김호연,Hong, Seung-Jae,Yang, Hyung-In,Yoon, Hwi-Joong,Lee, Myoung-Soo,Kang, Hyo-Jong,Kim, Wan-Uk,Lee, Sang-Heon,Cho, Chul-Soo,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.1
Background: Celecoxib, a COX-2 specific inhibitor, has recently been used for the treatment of rheumatoid arthritis. However, the molecular and cellular mechanisms of celecoxib against RA inflammation remain to be defined. To elucidate the action mechanism of celecoxib on inflammatory cells, we investigated the effect of celecoxib on the production of two important mediators of inflammation, nitric oxide and PGE2 Methods: RAW 264.7 cells stimulated with LPS were preincubated with various concentrations of celecoxib (from $10^{-8}$ to $10^{-5}$ M) and $10{\mu}M$ hydrocortisone, respectively. The production of NO and PGE2, the end products of iNOS and COX-2 genes, were estimated in culture supernatants by Greiss method and EIA, respectively. The expression of iNOS gene, COX-2 gene, $NF-{\kappa}B$, and $I-{\kappa}B$ were determined by RT-PCR and western blot analysis. Results: Celecoxib and hydrocortisone inhibited the production of NO and PGE2 in dose dependent manner, when RAW 264.7 cells were stimulated with LPS. The expression of iNOS was also down-regulated by celecoxib and hydrocortisone. Interestingly, COX-2 gene differentially expressed according to the dose of celecoxib, a decrease with lower dose ($10^{-8}$ M) but an increase with higher dose ($10^{-5}$ M). $NF-{\kappa}B$ binding activity was decreased by lower dose of celecoxib, whereas was not affected by higher dose of it. The expression of $I-{\kappa}B$ was suppressed by higher dose of celecoxib. Conclusion: The celecoxib strongly suppressed the production of NO and PGE2 in LPS-stimulated RAW264.7 cells. The decrease of NO seems to be linked to the inhibition of iNOS by celecoxib. The lower and higher dose of celecoxib differentially regulated the COX-2 expression and $NF-{\kappa}B$ activity.
만성골수성백혈병 및 급성임파구성혈병에서 Breakpoint Cluster Region ( bcr ) 유전자 재배열 관찰
김시영(Si Young Kim),윤휘중(Hwi Joong Yoon),조경삼(Kyung Sam Cho),최영길(Young Kil Choi) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A molecular genetic features in 14 CML patients and four acute lymphoblastic leukemia (ALL) patients. Genomic DNA was isolated from the cells of peripheral blood or bone marrow aspirates and digested with Bgl II and BamH I restriction endonuclease. A 5', 1.95-kb bcr (BglII/HindIII) probe and a 3, 1.2 kb bcr (Hind III/Bgl II) plasmid probe were used for hybridization. The results were as follows.: 1) In 14 CML patients, the bcr rearrangenment was detected in 13 patients, 2) The bcr rearrangement was detected in all seven Ph positive CML patients. 3) In five Ph1 negative CML patients, the bcr rearrangement was detected in four patients. 4) The bcr rearrangement was not detected in all four ALL patients, 5) One Ph1 positive ALL patient did not have ber rearrangement. In conclusion, the bcr DNA probe assay can determine the responses to therapy and the prognosis. It also can be used as a tumor marker in CML and ALL patients. In the future, this assay can be helpful for understanding the machanism of tumoriaenesis.
김태형(Tae Hyung Kim),윤휘중(Hwi Joong Yoon),김명임(Myung In Kim),김정훈(Jeong Hun Kim),김시영(Si Young Kim),조경삼(Kyung Sam Cho),장영운(Young Woon Jang),박용구(Yong Koo Park),이주희(Ju Hie Lee),이동호(Dong Ho Lee),이상목(Sang Mok L 대한내과학회 2001 대한내과학회지 Vol.60 No.3
Primary non-Hodgkin's lymphoma of the liver, an organ normally devoid of a native lymphoid tissue, is very rare. We report a case of primary hepatic T-cell lymphoma in a 18-year-old girl, with review of literature. The pateint admitted with fever for 5 months. The ultrasonography revealed a 10 × 7 cm sized mass in the left lobe of the liver. On abdominal CT, the mass was poorly enhancing and low attenuated. On MRI, the signal intensity of the mass was low in T1 weighted image, heterogeneously high in T2 weighted image, and peripherally enhanced in contrast enhancing T1 weighted image. The biopsy specimen obtained by laparatomy showed anaplastic tumor. The malignant cells were positive for T-cell lineage (CD3, CD44, CD45RO). There was no evidence of the lymphoma in other regions. The patient was treated with CHOP (cyclophosphamide, adriamycin, vincristine and prednisolone) chemotherapy without objective response. The patient died of sudden cardiogenic shock.(Korean J Med 60:260-265, 2001)