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Immunomodulatory activity of sodium silicate containing selenium in LPS-stimulated immune cells
윤자선,윤영원,이범준,이준엽,백낙영,강봉수,윤지영,김당영,설자경,정재황,김종수,남상윤 한국예방수의학회 2013 예방수의학회지 Vol.37 No.1
Selenium salts are toxic in large amounts, however, trace amounts are necessary for cellular function in many organisms, including all animals. Selenium is a component of the antioxidant enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce certain oxidized molecules in animals and some plants). In addition, sodium silicate (Na2SiO3) possesses a number of biological activities, especially in improvement of cell growth. However, few studies on the effects of sodium silicate and selenium on an immune system have been reported so far. The objective of this experiment was to investigate the effect of soluble sodium silicate/Se on lipopolysaccharide (LPS)-induced inflammatory response in RAW264.7 cells. The production of nitric oxide (NO) and proinflammatory cytokines was examined in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The cells were cultured in Dulbecco's modified Eagle’s medium (DMEM). Concentration of 10 ppm or less of soluble sodium silicate/Se had no cytotoxic effect on RAW264.7 cells. The soluble sodium silicate/Se decreased LPS-induced production of NO but did not affect the levels of TNF-α, IL-2, and IFN-γ in RAW264.7 cells. In addition, the sodium silicate/Se induced up regulation of IL-1β level in a dose-dependent manner. These results suggest that the soluble sodium silicate/Se has a synergistic effect in down-regulation of inflammatory response in vitro.
Effect of sodium silicate on immune activity and safety in mice
노호현,윤영원,이범준,설자경,윤자선,윤지영,김당영,남상윤,정재황,김종수 한국예방수의학회 2013 예방수의학회지 Vol.37 No.2
Sodium silicate (SS, Na2SiO3) is known as water glass or liquid glass. It possesses a number of biological activities, especially in improvement of cell growth. However, there were few reports on effects of the SS on an immune system have been reported so far. In this study, we investigated the immunostimulant effects of SS in mice. A total of 20 male ICR mice (eight-week-old) were divided into four groups (five mice for each group), and this experiment was duplicated. Animals were fed with the tap water containing 0%, 1%, 2%, and 3% sodium silicate solution for two weeks. After the animals had been sacrificed, spleen, thymus, and serum were obtained. Complete blood cell (CBC) counts and white blood cell (WBC) differential counts in blood have been performed using an automatic hematology analyzer. Cytokines (IL-2, IL-4, INF-γ, TNF-α) levels in spleen, thymus, and serum were measured using commercial ELISA assay kits. SS (2%) as drinking water increased phagocytic activity by approximately 60% compared with the control. Levels of IL-2, IL-4, and TNF-α levels in spleen, thymus, and serum were not changed by SS treatments. However, IFN-γ in thymus showed a decrease in the 3% SS group compared with the control group. No significant differences in CBC counts and WBC differential counts were observed among experimental groups. These results suggest that SS treatments by drinking do not cause any toxicity and do not modulate immune response as determined by cytokine levels in mice.
Prevalence of endoparasite infection on stray dogs in Chungbuk province
민경덕,김당영,강봉수,윤재선,설자경,윤자선,정재황,남상윤,윤영원,김종수,이범준 한국예방수의학회 2013 예방수의학회지 Vol.37 No.1
As the companion animal industry has shown rapid development in Korea, the number of stray animals has increased. This phenomenon has become a social issue in terms of animal welfare, as well as public health-related problems. However, the authorities have difficulty in coping with the problems, because the number of research studies on stray animals is insufficient. In this study, 49 feces of stray dogs were examined in three animal shelters located in Chung-buk province,in order to establish baseline data for parasite distributions on stray dogs. The zinc-sulfate flotation and formalin-ether sedimentation methods were used for parasite isolation. The examined dogs consisted of 26 males and 23 females, and they were categorized as three groups, including puppies (<1y), juveniles (1-3y), and adults (>3y). On microscopic examination,28 feces were considered as infected (57.14%). The isolated parasite eggs were composed of 11 different species. The most frequent species was Ancylostoma caninum (28.57%), followed by Isospora canis (24.49%), Trichuris vulpis (10.20%),Toxocara leonina (6.12%), etc. The older dogs had a higher prevalence rate, however, no significant relevance were observed between sex and prevalence. All cases of Toxocara leonina infection (n=3) belonged to the male group, and all cases of Trichuris vulpis infection (n=5) belonged to the juvenile group. Infection of A. caninum and I. canis were identified as the most frequent case of co-infection. A. caninum and I. canis were the parasites showing the greatest infestation in Chungbuk. In addition, as zoonotic parasites were identified, a proper surveillance system should be required.