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윤다래,이지숙,노현인,이서라,류재환,Yoon, Da-Rae,Lee, Jee-Sook,Noh, Hyun-In,Yi, Seo-Ra,Ryu, Jae-Hwan 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.2
Objectives : This study was aimed to provide the basic characteristic of patients who visited an Oriental medical hospital emergency room. Methods : We performed a retrospective study on 1,119 patients who visited Kyunghee University Oriental Medical Hospital Emergency Room from June 1, 2011 to March 31, 2012. Results and Conclusions : 1. In distribution of sex, the rate of males was 44.1%, and that of females was 55.9%. The male to female ratio was thus 1:1.26. The patients' average age was 54.64 and the 6th decade of life was the peak age group. 2. Most of the patients visited the Oriental medical hospital emergency room between 11:00 and 23:00. 3. In distribution by days of the week, the most common was Sundays (24.5%), followed by Mondays (16.7%). 4. In the month distribution, the most was December (12.4%), followed by November (10.0%). 5. The patients were grouped as follows: neurological diseases 58.9%, musculoskeletal disease 27.5%, internal medical disease 10.4%, and others 3.2%. 6. Admission rate of patients being treated was 38.8%, and the admission to the intensive care unit (ICU) was 4.5%. of total visiting patients.
Long-term evaluations of teeth and dental implants during dental maintenance period
윤다래,김용건,조진현,이재목,이상규 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.3
PURPOSE. This study was designed to evaluate the teeth and dental implants during dental maintenance therapy over 3 years in different conditions after periodontal and dental prosthetic treatment. MATERIALS AND METHODS. 166 patients received maintenance therapy. 59 patients were treated with 2% minocycline-HCl ointment as local drug delivery (LDD) (L group) and 107 patients were treated without LDD (NL group). Clinical data was collected in maintenance period for evaluation. Patients were classified into groups depending on the application of LDD with maintenance therapy, the type of dental treatment before maintenance period (Pre-Tx), the frequency (F-MT), and regularity (R-MT) of maintenance therapy. RESULTS. The numbers of lost teeth (N-teeth, P=.003) and newly placed dental implants (N-implants, P=.022) are significantly different according to Pre-Tx. F-MT among patients who received surgical dental treatment before maintenance period showedstatistical differences in N-teeth (P=.041), but not in N-implants (P=.564). All of the patients in L group showed high F-MT (F-MT1). In NL group, there were no statistical differences in N-teeth or N-implants according to F-MT or R-MT. In F-MT1 group, application of LDD made N-teeth significantly different from both Pre-Tx groups while no significant difference could be found in N-implant. Independent t-test and one-way ANOVA were selected for statistical analysis. CONCLUSION. The regular maintenance therapy and LDD can be effective for teeth during maintenance period. It is not only pharmacological efficacy in decreasing bacterial species that makes LDD a useful adjunct. Application of LDD also motivates patients to take adequate check-ups in the aspects of both frequency and regularity.
LC-Oribitrap/MS와 다양한 분리조건을 이용한 의약물질 및 호르몬 분석법 연구
전다래 ( Darae Jeon ),김영은 ( Young-eun Kim ),이혜리 ( Hyeri Lee ),김형섭 ( Hyoung Seop Kim ),신선경 ( Sun-kyoung Shin ),윤정기 ( Jeong-ki Yoon ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-
호르몬제를 포함한 의약물질은 주로 인간의 질병 치료 목적 및 동물들의 질병 치료, 예방 등의 다양한 목적으로 광범위하게 사용되고 있다. 수질 중 의약물질과 호르몬은 고상추출법 및 액-액추출법 등을 이용하여 전처리하고 액체크로마토그래피(HPLC)를 이용하여 분석하는 방법으로 연구되었다. 하지만, 이 방법은 다양한 종류의 의약물질 및 호르몬류를 분석하는데 분석과정이 복잡하고 오랜 시간이 소요된다는 단점이 있다. 본 연구에서는 이런 단점을 보완하고자 자동으로 전처리되는 On-line SPE가 연계된 LC-Orbitrap 질량분석기를 활용하여 67종의 의약물질 (Tamoxifen, Ibuprofen 등) 4종의 호르몬 (Estrone, Progesterone 등) 동시 분석 가능한 분리 조건을 확인하고자 하였다. 분석기기는 Thermo사의 Q Exactive Plus와 Dionex Ultimate 3000-Q을 사용하였고, 데이터 처리는 다성분 분석에 적합한 Full scan/ddMS<sup>2</sup> 방법을 이용하였다. 시료 (1 mL)를 Hypersil GOLD aQ (20×2.1 mm, 12 μm, Thermo) 트랩컬럼을 통해 전처리한 후, 7종의 분석컬럼(CORTECS C18+, T3, XbridgeBEH 등)과 이동상 (methanol, acetonitrile)에 대해 분석감도 및 분리효율을 비교하였다. 그 결과 T3(100×2.1 mm, 1.6 μm, Waters) 컬럼과 0.1% Formic acid와 Methanol(0.1% Formic acid)의 이동상이 선택되었다. 확립된 분석법의 유효성 평가 결과 100∼5,000 ng/L에서 0.99 이상의 직선성을 보였으며, 정량한계는 140.63∼830.78 ng/L에서 산출되었다. 이때의 정확도는 87.1 %∼108.5 %이었고, 정밀도 1.46 %∼8.38 %를 보여 모두 양호한 결과를 보였다. 따라서 수계에 잔류하는 의약물질을 전처리와 분석까지 23분의 짧은 시간으로 분석 가능하였으며, 다양한 수환경에서 의약물질 및 호르몬류의 분석법 적용이 가능할 것으로 생각된다.
온열환경과 부자이중탕(附子理中湯)이 Rat의 면역반응 및 지질대사에 미치는 효과
노현인,윤다래,이서라,이인희,홍성인,류재환,Noh, Hyun-In,Yoon, Da-Rae,Yi, Seo-Ra,Lee, In-Hee,Hong, Sung-In,Ryu, Jae-Hwan 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.1
Objectives : This study was designed to test the effect of a warm environment and Bujaijung-tang on immune and lipid metabolism in rats. Methods : The extract from Bujaijung-tang was made by the pharmacy department of Kyung-Hee oriental medical hospital. The animals were divided into four groups, by room or warm environment and Bujaijung-tang administration. Each group had 8 Sprague-Dawley Rats. We measured body temperature twice a week, body weight three times a week. After 3 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured. Results : 1. warm environment induced weight loss in rats. 2. warm environment induced a decrease of total cholesterol and low-density lipoprotein (LDL) cholesterol gain. 3. warm environment and Bujaijung-tang induced an increase of tumor necrosis factor (TNF)-${\alpha}$ concentration. Conclusions : The warm environment had a hyperlipidemia modulating effect. The warm environment and Bujaijung-tang had an immune modulating effect.
상엽(桑葉)의 고지방식이 유도 비만 쥐에 대한 조직학적 및 혈청학적 항비만 효과 연구
이지숙,노현인,윤다래,이서라,류재환,Lee, Jee-Sook,Noh, Hyun-In,Yoon, Da-Rae,Yi, Seo-Ra,Lew, Jae-Hwan 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.3
Objectives : Mori Folium is used for hyperlipidemia or diabetes. The study was designed to test the anti-obesity effect of Mori Folium on body weight, hepatic fat accumulation and serum lipid level. Methods : The extract from Mori Folium was made by the pharmacy department of Kyung-hee oriental medical hospital. Normal diet, high-fat diet, 30% reduced diet and Mori Folium groups were set. The normal group was administered normal rat food, but the other three groups were administered high fat food. We measured body weight once a week. After 3 weeks experiment, hepatic lipid accumulations were measured. Also we compared serum lipid levels among the 4 groups after 3 weeks. Results : Mori Folium had no effect on body weight, but the 30% reduced diet had an inhibitory effect on body weight gain. Mori Folium had more inhibitory effect on hepatic fat accumulation than a 30% reduced diet. Mori Folium also has more inhibitory effect on serum triglyceride than 30% reduced diet. Conclusions : Mori Folium has anti-obesity effect on hepatic lipid accumulaion and serum triglyceride level in high fat diet induced rats.
한방병원 중증치료실 입원 환자의 임상적 분석 - 주 질환 및 합병증 위주로 -
노현인,이지숙,윤다래,이서라,류재환,Noh, Hyun-In,Lee, Jee-Sook,Yoon, Da-Rae,Yi, Seo-Ra,Ryu, Jae-Hwan 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.2
Objectives : This study was designed to quantify the characteristics, main diagnosis and complications in the intensive care unit (ICU) at an Oriental Medical Hospital. Methods : The medical records of 44 patients admitted to the ICU at Kyunghee Oriental Medical Hospital between January 1, 2011 and December 31, 2011 were reviewed. Basic characteristics of patients, admission channel, main diagnosis, east-western medical therapy, mortality, and complications were investigated retrospectively based on medical notes. Results : 1. The total number of patients was 44. Males were 63.6%, females 36.3%. Average admission days was 15.9. 2. The most frequent age group is eighties, 38.6%. 3. The most frequent disease is cerebrovascular disease, 61.3%. 4. The medical therapy done after admission to ICU was intubation. Central vein insertion was performed next, followed by Foley's catheter insertion, ventilator, tracheostomy, nasogastric intubation, and thoracentesis in order. The proportion of Oriental medical treatment provided to the patients of ICU was as follows: herbal medication only 6.8%; herbal medication plus acupuncture 31.8%; herbal medication, acupuncture electro-acupuncture, plus subcutaneous acupuncture 2.3%; and none 27.3%. 5. The number of cases of complications occurred since ICU admission was 18. The most frequently observed complication was infection, including 6 cases of pneumonia and 4 cases of urinary tract infection. Conclusions : We suggest that ICUs of Oriental medical hospitals need to be managed effectively to treat diseases including cerebrovascular disease and prevent complications.