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Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report
우현선,이경화,윤필훈,김수지,박인근,김영생,안희경,홍준식,신동복,심선진 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4
Oxaliplatin is a third-generation platinum derivative used for metastatic or advancedcolorectal cancer treatment. Although myelosuppression is the most common causeof oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immunemediatedthrombocytopenia are reported. We report a case of a 57-year-old womanwith colon cancer who developed gum bleeding and petechiae after oxaliplatininfusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within4 days with no recurrence following discontinuation of oxaliplatin. Physicians need tobe aware of the risk of severe acute thrombocytopenia following oxaliplatinadministration.
洪思奭,金榮植,禹麟根 최신의학사 1959 最新醫學 Vol.2 No.1
Polygalital obtained from Polygala japonica Hout tuyn has been studied Pharmacologically; the Polygalitol has practically similar action as glucose upon frog heart, vessels, or rabbit ear vessel, however, the former does not affect rabbit blood sugar and perfusing solution of frog heart as the latter, whicih' shows profounding increase or consume respectively, The problems, particularly possible energy source of polygalitol in the body, are remained in further investigation.
Inula Sesquiterpene Lactone 이 식물호흡에 미치는 영향
권영명,우원식,우인근,이민제 ( Young Myung Kwon,Won Sick Woo,Lin Keun Woo ) 생화학분자생물학회 1973 BMB Reports Vol.6 No.2
In order to investigate the mode of biological action of alantolactone, its effects on the respiration and the growth of plants were examined. The rate of respiration of Chloredlu pyrenoidosa was greatly enhanced in the presence of Inula sesquiterpene lactones(alantolactone+isoalantolactone), but the growth of cells was profoundly inhibited. Although Inula sesquiterpene lactones increased the oxygen consumption of the aged potato tuber slices, no effect was observed in the case of the fresh slices. And Inula sesquiterpene lactones also inhibited the activation of the respiration of the slices during the aging process.
김영생,조은경,우현선,홍준식,안희경,박인근,심선진,경선영,강신명,박정웅,정성환,박진희,이재훈,신동복 대한암학회 2016 Cancer Research and Treatment Vol.48 No.1
Purpose This study aimed to evaluate the efficacy and safety of pemetrexed versus gefitinib in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy. Materials and Methods Patients with advanced (stage IIIB or IV) or recurrent NSCLC were randomly assigned to receive either 500 mg/m! of pemetrexed intravenously every 3 weeks or gefitinib 250 mg/day orally. The primary end point was progression-free survival (PFS) at 6 months. Results A total of 95 patients were enrolled (47 for pemetrexed and 48 for gefitinib). Most patients were male (72%) and current/ex-smokers (69%), and 80% had non-squamous cell carci- noma. The epidermal growth factor receptor (EGFR) mutation status was determined in 38 patients (40%); one patient per each arm was positive for EGFR mutation. The 6-month PFS rates were 22% and 15% for pemetrexed and gefitinib, respectively (p=0.35). Both arms showed an identical median PFS of 2.0 months and a median overall survival (OS) of 8.5 months. In EGFR wild-type patients, higher response rate (RR) and longer PFS as well as OS were achieved via pemetrexed compared with gefitinib, although there were no signifi- cant differences (RR: 39% vs. 9%, p=0.07; median PFS: 6.6 months vs. 3.1 months, p=0.45; median OS: 29.6 months vs. 12.9 months, p=0.62). Toxicities were mild in both treatment arms. Frequently reported toxicities were anemia and fatigue for pemetrexed, and skin rash and anorexia for gefitinib. Conclusion Both pemetrexed and gefitinib had similar efficacy with good tolerability as second-line treat- ment in unselected patients with advanced NSCLC. However, pemetrexed is considered more effective than gefitinib for EGFR wild-type patients.
Oxaliplatin에 의한 면역 매개성 혈소판 감소증의 예
장필규,신동복,심선진,김영생,박인근,우현선,류혜승 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
배경: platinum계열 약제인 Oxliplatin은 대장암을 비롯한 여러 암에 쓰인다. Oxaliplatin 사용한 환자의 3-4%에서 grade 3-4의 혈소판 감소증이 관찰된다. marrow suppression sinusoidal injury, immune mediated의 3가지 기전으로 분류되며, 이중 immune mediated thrombocytopenia는 비교적 최근에 알려졌고, 증례 보고를 통해서만 보고되었으며 정확한 발생률도 알려지지 않았다. 진단은 주로 임상적으로 내려지며, 저절로 회복되는 경우가 많다. 우리는 oxaliplatin에 의한 immune mediated thrombocytopenia가 강력히 의심되는 증례가 있어서 보고하고자 한다. 증례: 57세 여자로 2008년 5월 대장암(선암) 진단받고 우측 결장절제술 후 adjuvant FOLFOX4 12차까지 완료 후 2009년 재발되어 FORFIRI 3차 시행하고 우측신장 절제술과 XELOX 7차까지 시행하였다. 추적관찰 중 2011년 다시 재발되어 FORFOX4 12차 후 2013년 1월부터 mFORFOX6 7차까지 시행 중이다. 6차 항암 중 oxaliplatin 주입 후 머리에서 허리까지 통증을 느꼈으며 9시간 뒤 잇몸 출혈 발생하였다. 내원 당시 Hb 11.3 g/dL, WBC 3,440/mm, Platelet 129,000/mm (ANC 1850)에서 Hb 10.1 WBC 3,100 platelet 4,000 (ANC 1278) 으로 감소되었다가 혈소판 수혈 후 점상 출혈은 호전되었으며 혈소판 수치도 다음날 34,000으로 증가 후 더 이상 감소되지 않았다. 20% 감량 후 시행한 7차 항암 중에도 주입 후 이전과 동일 부위로 통증을 느꼈으며 5시간 뒤 잇몸 출혈 발생하며 Hb 11.9, WBC 670, PLT 2,000 (ANC 299.49)으로 감소하여 G-CSF사용하며 혈소판 수혈 후 회복되었다. 본 증례는 immune mediated thrombocytopenia의 특징인 자주 노출된 후 발생한 점과 주입후 즉각적인 반응을 보이며 약물중단 후 저절로 호전되는 특징을 보이고 있다. 요약: Oxaliplatin은 흔하게 쓰는 약이지만, immune mediated thrombocytopenia는 널리 알려져 있지는 않다. 타 논문에서 급성 혈소판 감소증으로 사망한 증례가 보고된 경우도 있으며, 적절한 조치가 이루어지지 않으면 심각한 합병증을 유발할 수 있어 Oxaliplatin에 의한 immune mediated thrombocytopenia가 의심되는 본 저자들은 증 1예로 보고하는 바이다.