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Isolation of Genes Related to Light and Low Temperature Stress in Barley (Hordeum vulgare L.)
옥승한,신성훈,신정섭,김경남,천종은 한국육종학회 2004 한국육종학회지 Vol.36 No.1
To investigate low temperature- and light stress-induced genes of Hordeum vulgare L. cv. Dongbori #1, suppression subtractive hybridization (SSH) was performed with mRNAs from leaf samples that treated with low temperature (4oC) and extremely high light density (1500mmolm-2s-1). Ninety six clones were randomly selected from SSH library. Using dot blot analysis, 20 of 96 clones randomly selected were identified to be differentially expressed. Of these 20 clones, two showed homology to senescence-associated genes and one was similar to cytochrome P450 like-TBP, while the remaining 17 clones did not match to the known genes. Furthermore, a cDNA library was constructed using mRNA isolated from Hordeum vulgare L. cv. Dongbori #1 leaves treated with low temperature (4oC). cDNAs of 176 clones randomly selected from this library were isolated and sequenced. Database comparisons of cDNAs in GenBanks non-redundant databases using BLAST revealed that 129 of the 176 cDNAs (73.3%) showed a high degree of sequence homology to genes from other organisms. The energy category showed a considerably higher gene expression level (21.7%) than other categories, and genes of disease/defense category were also found at high frequencies (11.6%).
옥승한,신정섭,Ji Ung Jeung,Hyo Mi Kang,Kwang Wook Jung,Jong Suk Lee 한국원예학회 2004 Horticulture, Environment, and Biotechnology Vol.45 No.4
Fifteen oriental Cymbidium species and lines were examined for assessing genotype identification and estimating genetic relationships by using newly designed 18 primer-sets for gene-specific sequence tagged site-polymerase chain reaction (STS-PCR) and cleaved amplified polymorphic sequence (CAPS) markers. Out of 18 STS-PCR primers, seven pairs (39%) were verified to show reliable polymorphisms. These PCR amplified products by the 18 STS-PCR primer-sets were digested with four restriction enzymes, AluI, HinfI, HaeIII and RsaI. Through the CAPS analysis, 11 (61%) of the 18 STS-PCR primers produced several polymorphic bands by all or any those enzymes in these 15 Cymbidium species. Genetic relationship among species based on the STS-PCR and CAPS analysis was examined using the program of unweighted pair group method with arithmetic mean. The classification using the molecular markers was well matched with those by horticultural, morphological, and physiological descriptions.
기계학습 기반 시군구 건강수명 산정 모형 및 경상북도 데이터를 이용한 실증
옥승은,변준영,김남형,송재욱 한국경영과학회 2024 經營 科學 Vol.41 No.1
This study presents a model for estimating healthy life expectancy in Gyeongsangbuk-do at the city, county, and district level using machine learning. Quality-adjusted life expectancy (QALE) was calculated at each level using Graville correction and life tables. Next, 43 factors related to healthy life expectancy, including demographic and health care policy variables, were obtained from national health data. Machine learning was used to estimate healthy life expectancy. It was confirmed that LightGBM and artificial neural network had superior estimation performance compared to the multiple linear regression model commonly used in healthcare and medical science. Using the artificial neural network model with the best performance, we conducted additional factor analysis using Shapley additive explanations. Our findings confirmed that the depression experience rate and perceived stress rate were the most significant factors affecting healthy life expectancy in all cities, counties, and districts in Gyeongsangbuk-do. However, the sensitivity analysis revealed that the ranking of factors causing an increase or decrease in healthy life expectancy varied across cities, counties, and districts. Thus, it was confirmed that tailored policies, accounting for regional circumstances, are necessary to promote health and enhance equity.
박선정,옥승아,박윤정,한성림,신선혜 한국영양학회 2024 Journal of Nutrition and Health Vol.57 No.4
Purpose: Adipocyte dysfunction has been reported in diabetes, and stimulating thermogenesis and suppressing senescence in adipocytes potentially alleviates metabolic dysregulation. This study aimed to investigate thermogenesis and cellular senescence in diabetic adipocytes under basal conditions and in response to stimuli. Methods: White and brown primary adipocytes derived from control (CON) and db/db (DB) mice were treated with β-agonists, such as norepinephrine (NE) and CL316,243, and 18-carbon fatty acids, including stearic acid, oleic acid (OLA), linoleic acid (LNA), and α-linolenic acid, and the expression of the genes related to thermogenesis and cellular senescence was measured. Results: Although no difference in the thermogenic and cellular senescence gene expression in white adipose tissue (WAT) was noted between the CON and DB mice, brown adipose tissue (BAT) from the DB mice exhibited lower uncoupling protein 1 (Ucp1) expression and higher cyclin-dependent kinase inhibitor (Cdkn)1a and Cdkn2a expression levels compared to that from the CON mice. Stromal vascular cells isolated from the BAT of the DB mice displayed higher peroxisome proliferator-activated receptor gamma (Pparg), CCAAT/ enhancer-binding protein alpha (Cebpa), Cdkn1a, and Cdkn2a expression levels. White adipocytes from the DB mice exhibited lower Ucp1, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (Pgc1a), and PR domain containing 16 (Prdm16) expression levels regardless of β-agonist treatment. NE upregulated Pgc1a in both white and brown adipocytes from the CON mice, but not in those from the DB mice. Although none of the fatty acids were observed to downregulate the cellular senescence genes in fully differentiated adipocytes, the OLA-treated brown adipocytes derived from DB mice exhibited lower Cdkn1a and Cdkn2b expression levels than the LNA-treated cells. Conclusion: These results indicate that the lower thermogenic capacity of diabetic adipocytes may be related to their cellular senescence, and different fatty acids potentially exert divergent effects on the expression of cellular senescence genes.