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Poly(DL-lactide-co-glycolide) 나노입자의 표면 수식
오유미,정택규,지상철,신병철,Oh, Yu-Mi,Jung, Taek-Kyu,Chi, Sang-Cheol,Shin, Byung-Cheol 대한화학회 2003 대한화학회지 Vol.47 No.6
생분해성 고분자인 poly(DL-lactide-co-glycolide)(PLGA)를 자발적 유화용매 확산(spontaneous emulsification solvent diffusion, SESD)법을 이용하여 표면이 양이온으로 수식된 나노입자로 제조하고 그 특성을 조사하였다. 고분자 용액은 에탄올과 아세톤의 이종 혼합 용매를 사용하였고, 유화제는 양이온성 유화제인 cetyltrimethylammonium chloride(CTAC), tetradecyltrimethylammonium bromide(TTAB)와 비이온성 유화제인 polyethylene glycol-block-polypropylene glycol 공중합체(Lutrol F68)를 사용하였다. 제조한 입자에 결합한 백신은 인플루엔자($H_3N_2,\;H_1N_1$, B strain)이었고 입자에 대한 백신의 코팅 양은 NHS-fluorescein을 사용하여 확인하였다. 양이온성과 비이온성 유화제가 표면에 수식된 입자의 크기는 160-180 nm와 80-90 nm이었고 제타포텐셜은 $50{\sim}60$ mV, -10 mV이었다. 백신 코팅 후 입자의 크기는 양이온성이 380-400 nm, 비이온성은 별다른 크기 변화가 없었다. 양이온이 수식된 입자에 코팅된 백신의 양은 22.73 ${\mu}g$/mg이었다. We studied on preparation of nanoparticles modified surface using biodegradable polymer, poly(DL-lactide-co-glycolide) (PLGA). Two kinds of PLGA nanoparticles were prepared by a spontaneous emulsification solvent diffusion (SESD) method using cetyltrimethylammonium chloride (CTAC) and tetradecyltrimethylammonium bromide (TTAB) as a cationic surfactant and polyethylene glycol-block-polypropylene glycol copolymer (Lutrol F68) as a nonionic surfactant. Model protein was coated on the surface of nanoparticles by the ionic complexation. The model protein was that influenza vaccine ($H_3N_2,\;H_1N_1$, B strain) labeled with NHS-fluorescein. The sizes of cationic nanoparticles were 140-160 nm and the surface charges were 50-60 mV. The sizes of nonionic nanoprticles were 80-90 nm and the surface charge was -10 mV. After coating vaccine on the surface of nanoparticles, the sizes of cationic nanoparticles were increased to 380-400 nm and the size of nonionic nanoparticles was not increased. The amount of coated vaccine on the cationic nanoparticles was 22.73 ${\mu}g$/mg.
상향류 활성탄 생물막 공정을 이용한 정체 수역 수질 개선 및 공정 내 미생물 군집 해석
오유미,이재호,박정진,최기충,박태주,이태호,Oh, Yu-Mi,Lee, Jae-Ho,Park, Jeung-Jin,Choi, Gi-Choong,Park, Tae-Joo,Lee, Tae-Ho 대한환경공학회 2010 대한환경공학회지 Vol.32 No.1
정체수역에서는 자연적 흐름의 차단으로 인해 자정능력이 떨어지며, 영양염류의 축적으로 인해 부영양화와 같은 문제점이 발생한다. 또한 비점오염물질의 유입은 정체수역 내 난분해성 물질을 증가시킨다. 본 연구에서는 정체수역의 수질개선을 위해 무산소조, 호기1조, 호기2조로 구성된 장치형 상향류 활성탄 생물막 반응기를 도입하여 정체수의 연속적 순환에 따른 오염물질 농도의 변화를 모니터링 하였다. 정체수역을 모사하기 위하여 $2m^3$의 저장탱크에 유원지의 호소수를 저장하였으며, 수질개선을 위한 최적 유입 유량을 산출하기 위하여 HRT가 6 hr, 4 hr, 2 hr 가 되도록 호소수의 유입 유량을 변화시켰다. 이 가운데 HRT 4 hr에서 SS, $BOD_5$, $COD_{Mn}$, $COD_{Cr}$, TN, TP의 제거 효율이 각각 69.8, 83.0, 91.3, 74.1, 74.7, 88.9%로 가장 좋은 수질 개선 효과를 얻을 수 있었다. 이에 HRT를 4 hr로 고정하고 골프장 연못수를 운전했을 때 SS, $BOD_5$, $COD_{Mn}$, $COD_{Cr}$ TN, TP의 제거 효율이 각각 78.5, 78.0, 80.2, 74.9, 55.6, 97.5% 달성되었다. 각 조건에서의 미생물 군집 변화를 PCR-DGGE를 사용하여 분석 결과, 유입수를 골프장 연못수로 교체함에 따라 미생물 군집에 변화가 나타났다. 또한 FISH에 의해 유입 유량 변화에 따른 질산화 미생물량의 변화를 관찰한 결과, HRT 4 hr의 조건에서 질산화 미생물이 가장 우점화됨을 알 수 있었다. 미생물량 및 INT-DHA를 이용한 미생물 활성도 실험 결과, HRT를 낮게 유지하였을 때에도 감소되지 않았다. 따라서 상향류 활성탄 생물막 공정을 정체 수역의 효과적인 수질 개선에 충분히 적용할 수 있을 것으로 기대한다. The capacity of natural purification was limited by the interruption of natural flow and the problems such as eutrophication were occurred by nutritive salts accumulation in stagnant stream. Moreover, the inflow of non-point sources causes non-degradable materials to increase in stagnant stream. In this study, an upflow biological activated carbon (BAC) biofilm process comprised of anoxic, aerobic 1, and aerobic 2 reactors were introduced for treatment of stagnant stream and SS, $BOD_5$, $COD_{Mn}$, $COD_{Cr}$, TN, and TP were monitored in the upflow BAC biofilm reactors with continuous cycling. In order to simulate stagnant stream, the lake water of amusement park and golf course were stored as influent in a tank of $2m^3$ and hydraulic retention time (HRT) was changed into 6, 4, and 2 hours. At HRT 4hr and the lake water of amusement park as influent, the removal efficiencies of SS, $BOD_5$, $COD_{Mn}$, $COD_{Cr}$, TN, and TP showed the best water quality improvement and were 69.8, 83.0, 91.3, 74.1, 74.7, and 88.9%, respectively. At HRT 4hr and the lake water of golf course as influent, the removal efficiencies of SS, $BOD_5$, $COD_{Mn}$, $COD_{Cr}$, TN and TP were 78.5, 78.0, 80.2, 74.9, 55.6 and 97.5%, respectively. As the results of polymerase chain reaction - denaturing gel gradient electrophoresis (PCR-DGGE), microbial community was different depending on influent type. Fluorescence in situ hybridization (FISH) showed that nitrifying bacteria was dominant at HRT 4 hr. The biomass amount and microbial activities by INT-DHA test were not decrease even at lower HRT condition. In this study, the upflow BAC biofilm process would be considered to the water quality improvement of stagnant stream.
유입수문이 펌프장 흡수정 내 볼텍스 발생에 미치는 영향
오유미(Yu-Mi Oh),김영도(Young-Do KIM),김한일(Han-IL KIM),이동근(Dong-Keun LEE),박종호(Jong-Ho Park) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
In pumping stations, vortex generation such as free surface vortex and submerged vortex occurring near the pump intake, or at bell-mouth inlet has been an important flow characteristic which should be considered always to keep away the suction of air-entertained or cavitated flow. These problems are caused by unfavorable approach flow patterns at suction inlet that are subjected to sump configurations and operation conditions. In this research, the sump model test with gated inlet was mainly undertaken to observe the trend of vortex generation in the representative models, which were selected in the field survey of Kwater's Pump Sump. With experimental Result, the guidelines for pump sump with gated inlet are presented in this paper.
혈소판 감소증으로 발견된 사람면역결핍 바이러스 감염증 1예
오유미 ( Yu Mi Oh ),조재현 ( Jae Hyun Cho ),안수민 ( Soo Min Ahn ),윤창용 ( Chang Yong Yun ),심형훈 ( Hyoung Hun Sim ),김소연 ( Soyon Kim ),김윤권 ( Youn Kwon Kim ),유창민 ( Chang Min Yu ),이세한 ( Se Han Lee ) 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.1
Although hematologic abnormalities are common in patients with HIV infection, there are few reports of HIV infected patients who first presented with severe thrombocytopenia (<25,000 / μL). We experienced a case of HIV-infected patient presenting only severe thrombocytopenia. There was no other cause that can cause thrombocytopenia. He was treated with antiretroviral therapy. And thrombocytopenia improved after 7 months..
한국의 건강도시 현황 및 평가: 제 4기 유럽 건강도시 평과결과를 중심으로
오유미 ( Yu Mi Oh ),김혜정 ( Hye Jung Kim ),양유선 ( Yu Seon Yang ) 대한보건협회 2011 대한보건연구 Vol.37 No.2
Objectives: The Healthy Cities Project was proliferated in the European region as the WHO-EURO adopted the concept in 1984, while it was accelerated in Korea with the pilot project in 2004. In line with needs for evaluating Korean Healthy Cities in terms of environmental improvement, this study compares progress level between Korea and European cities and explores development strategy which fits into Korean Healthy Cities. Methods: To examine progress of the Healthy Cities in Korea, a survey was conducted with 56 respondents, who are project managers at local level, for a month(3-4) in 2010. The questionnaire includes 6 key factors; partnership, city health profiles, city health development plans, active participation by community, healthy equity and health impact assessment, which are derived from the evaluation of phase Ⅳ of the European Healthy Cities Network. Results: City health profiles and city health development plans are considered as an essential factor in the European Healthy City Network, while some of the Korean Healthy Cities do not meet those requirements. In terms of healthy equity and health impact assessment, European Healthy Cities move on the practice stage, while Korean Healthy Cities are still in the awareness stage. Conclusion: There are still many challenges for the Healthy Cities in Korea compared to the Europe, especially central government should support local governments` commitment in many ways to achieve qualitative progress. In conclusion, developing growth strategy and activating participation by community are priorities for Korean Healthy Cities to step forward.