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      • KCI등재

        Development and Validation of Osteoporosis Risk-Assessment Model for Korean Men

        김현창,오순민,송보미,남병호,이유미,문성환,김덕용,강대룡 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.1

        Purpose: The aim of the present study was to develop an osteoporosis risk-assessment model to identify high-risk individuals among Korean men. Materials and Methods: The study used data from 1340 and 1110 men ≥50 years who participated in the 2009 and 2010 Korean National Health and Nutrition Examination Survey, respectively, for development and validation of an osteoporosis risk-assessmentmodel. Osteoporosis was defined as T score ≤-2.5 at either the femoral neck or lumbar spine. Performance of the candidate models and the Osteoporosis Self-assessment Tool for Asian (OSTA) was compared with sensitivity, specificity, and area under the receiver operating characteristics curve (AUC). A net reclassification improvement was further calculated to compare the developedKorean Osteoporosis Risk-Assessment Model for Men (KORAM-M) with OSTA. Results: In the development dataset, the prevalence of osteoporosis was 8.1%. KORAM-M, consisting of age and body weight, had a sensitivity of 90.8%, a specificity of 42.4%, and an AUC of 0.666 with a cut-off score of -9. In the validation dataset, similar results were shown: sensitivity 87.9%, specificity 39.7%, and AUC 0.638. Additionally, risk categorization with KORAM-M showed improvedreclassification over that of OSTA up to 22.8%. Conclusion: KORAM-M can be simply used as a pre-screening tool to identify candidates for dual energy X-ray absorptiometry tests.

      • KCI등재

        Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population

        조혜민,김현창,강대룡,오순민,김병극,서일 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.4

        Purpose: Although inconsistent, reports have shown fibrinogen levels to be associatedwith atherosclerosis. Accordingly, since cigarette smoking is associated with increased levels of fibrinogen and atherosclerosis, it may also affect the association between fibrinogen and atherosclerosis. We investigated the associations between fibrinogen and carotid intima-media thickness (IMT) according to smoking status in a Korean male population. Materials and Methods: Plasma fibrinogen levels were measured in 277 men aged 40‒87 years without a history of myocardial infarctionor stroke. High-resolution B-mode ultrasonography was used to examine the common carotid arteries. IMT level was analyzed both as a continuous (IMT-max, maximum value; IMT-tpm, 3-point mean value) and categorical variable (higher IMT; presence of plaque). Serial linear and logistic regression models were employed to examine the association between fibrinogen and IMT according to smoking status. Results: Fibrinogen levels were positively associated with IMT-max (standardized β=0.25, p=0.021) and IMT-tpm (standardized β=0.21, p=0.038), even after adjusting for age, body mass index, systolic blood pressure, fasting glucose,and total cholesterol to high-density lipoprotein cholesterol ratio in current smokers (n=75). No significant association between fibrinogen and IMT, however, was noted in former smokers (n=80) or nonsmokers (n=122). Adjusted odds ratios (95% confidence interval) for having plaque per one standard deviation higher fibrinogenlevel were 2.06 (1.09‒3.89) for current smokers, 0.68 (0.43‒1.10) for formersmokers, and 1.06 (0.60‒1.87) for nonsmokers. Conclusion: Our findings suggestthat cigarette smoking may modify the association between fibrinogen and carotid atherosclerosis. Further studies are required to confirm this finding in differentpopulations.

      • KCI등재

        First Report on Isolation of Salmonella Enteritidis from Eggs at Grocery Stores in Korea

        김영조,송보라,임종수,허은정,박현정,위성환,오순민,문진산 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.2

        Salmonella Enteritidis is responsible for causing foodborne diseases upon consumption of egg products. While cases of S. Enteritidis isolation from eggs have been reported in other countries, no such cases have previously been reported in Korea. In this study, we report the first isolation and identification of S. Enteritidis from domestically distributed eggs in Korea. Eggs were collected from eight countrywide grocery stores during different seasons between 2011 and 2012. Egg contents and washing solution of egg shells were incubated in buffered peptone water, and the enriched broth was further enriched in tetrathionate broth and Rappaport-Vassiliadis. The secondary enriched broth was streaked on xylose lysine desoxycholate agar. The suspected colonies were confirmed to S. Enteritidis by a biochemical test, serotyping, and PCR test. Genetic relat-edness among the isolates was analyzed using Diversilab Salmonella kit. Three strains of S. Enteritidis were isolated from egg contents and egg shells collected from grocery stores of the Eumseong-city in the fall of 2011. All three stains showed resistance to chloramphenicol, streptomycin, nalidixic acid, and ampicillin by the disk diffusion method. In addition, the isolates showed more than 99% DNA homology, indicating that they were presumably identical strains. Therefore, there is a requirement to monitor and control against S. Enteritidis from eggs in Korea.

      • KCI등재

        유가공품 중 칼슘 및 프락토올리고당 영양강화 함량 분석

        박지성,박재우,조병훈,송성옥,위성환,오순민,김진만,Park, Ji-Sung,Park, Jae-Woo,Cho, Byung-Hoon,Song, Sung-Ok,Wee, Sung-Hwan,Oh, Soon-Min,Kim, Jin-Man 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.6

        본 연구는 시중에서 유통중인 유가공품 중 칼슘과 프락토올리고당 영양소 강조 또는 함유 표시 제품에 대해 실제 함량을 분석하였다. 칼슘 강화 유제품에 대하여는 우유류, 발효유류, 치즈류 등 40개 제품을 수집하여 칼슘 함량을 조사하였다. 그 결과 우유류 12제품의 1회 제공량당 칼슘 함량 표시는 105~500 mg (1.1~2.5 mg/mL)이었으며, 분석값은 1.0~2.4 mg/mL로 표시값에 대한 분석값은 87~127%이었다. 발효유류 12제품의 1회 제공량당 칼슘 함량 표시는 30~110 mg (0.4~1.4 mg/g)이었으며, 분석값은 0.3~1.6 mg/g로 표시값에 대한 분석값은 89~131%이었다. 치즈류 16제품의 1회 제공량당 칼슘 함량 표시는 84~2000 mg (3.5~20 mg/g)이었으며, 분석값은 4.2~23.0 mg/g으로 표시값에 대한 분석값은 83~127%이었다. 분석대상 시료의 칼슘함량 표시 대비 실제 분석값은 모두 80% 이상으로 축산물의 표시기준을 충족하였다. 프락토올리고당 강화 유제품에 대하여는 시중 유통 24개 제품에 대하여 그 함량을 조사한 결과 발효유 4.2~30.8 mg/g, 농후발효유 8.7~10.6 mg/g, 유음료 18.5 mg/mL, 연성가공치즈 1.3 mg/g으로 나타났다. 축산물의 표시기준에서 프락토올리고당에 대해서는 표시내용과 실제 함량 사이의 인정범위를 규정하고 있지는 않으나, 이들 24개 제품 중 실제 4개 제품에서는 명확한 함량이 표시되었으며, 분석값은 9.1~18.9 mg/g으로 표시량 대비 83~154%의 결과를 나타내었다. Nutrients fortified dairy products declare their contents on the label for nutrition claim and marketing. However, there are few monitoring studies about relations between actual quantities of fortified nutrients and the described ones on the label. This study was carried out for comparing actual fortified nutrient contents with labeled ones. Forty calcium fortified dairy products and twenty four fructooligosaccharides (FOS) fortified dairy products were sampled at supermarkets located in Anyang, Korea from March to November in 2010. Calcium contents were analyzed by using inductively coupled plasma optical emission spectrometry followed by microwave sample digestion, and FOS contents were analyzed by HPLC-ELSD followed by solvent extraction. In fresh milk, calcium contents ranged from 1.0 to 2.4 mg/mL, and those values were 87~127% of their labeled contents. In fermented milk products and cheeses, calcium contents ranged from 0.3 to 1.6 mg/g (89~131% of their labeled contents), 4.2 to 23.0 mg/g (83~127% of their labeled contents), respectively. FOS contents ranged from 9.09 to 18.89 mg/g in FOS contents labeled products and showed 83~154% compared to their labeled quantity, and ranged from 1.3~30.8 mg/g in products without quantity labeling. In conclusion, the amounts of calcium and FOS in dairy products were above 80% compared to their labeled ones and conformed to the Korean official livestock products labeling standard.

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