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GC/MS에 의한 담석과 담즙내의 Cholesterol, Bile Acids 및 Sterols의 동시 Profiling
양윤정,이선화,김현주,정봉철,Yang, Yoon Jung,Lee, Seon Hwa,Kim, Hyun Joo,Chung, Bong Chul 대한화학회 1998 대한화학회지 Vol.42 No.3
담즙산 분비 저하 및 콜레스테롤의 과도한 분비는 담석 형성의 주된 원인으로 담즙내의 담즙산과 콜레스테롤 및 그 전구 물질인 스테롤의 상대적인 농도는 담즙 성분의 이상을 알아보기 위한 중요한 지표로 알려져 있다. 이에 본 연구에서는 염기를 이용한 가수 분해와 pH 14와 1에서 두 번의 액체-액체 추출을 거친 후, $MSTFA/NH_4I$ 혼합액으로 유도체화 시키는 전처리 방법과 GC/MS를 이용한 새로운 분석 방법을 설정, 담즙산과 스테롤 그리고 콜레스테롤의 동시 분석을 시도하였다. 그 결고 회수율은 73.56-96.95% 이었고 within-a-day 및 day-to-day 분석의 RSD 값은 각각 1.72-13.79%, 0.68-14.10% 이었으며, 이 방법을 간내 담석증 환자에 적용하여 담즙과 담석내에 존재하는 7종의 스테롤과 5종의 담즙산, 그리고 콜레스테롤의 농도 및 그들간의 상대적인 농도 분포를 측정한 결과 담즙고 담석에서 현저히 다른 차이를 보였다. Cholesterol supersaturation in bile, which causes gallstone formation, is the result of low bile acid secretion or high cholesterol secretion. The quantitative analysis of cholesterol, bile acids and sterols which are precursors of cholesterol have been used to examine the changes in bile component. We described a simple, sensitive and reproducible method for simultaneous determination of cholesterol, five bile acids and seven sterols in human bile juices and gallstones by capillary column gas chromatography-mass spectrometry (GC/MS). Clinical samples were hydrolyzed by alcoholic KOH, extracted twice (pH 14 and 1) and derivatized to trimethylsilyl (TMS) ether with $MSTFA/NH_4I$ (N-methyl-N-trimethylsilyltrifluoroacetamide/ammonium iodide) mixture in order to be detected on the GC/MS. The good quality control data were obtained through within-a-day and day-to-day test (RSD values were 1.72-13.79, 0.68-14.10, respectively) and the recovery range of them was 73.56-96. 95 Using this method, biliary and gallstone compositions in the patients with intrahepatic stones were analyzed. The amounts and its relative distribution of cholesterol, bile acids and sterols showed different pattern in bile juices and gallstones.
한국 노인의 식품안정성에 따른 인구사회학적 특성, 영양섭취상태 및 정신건강상태
양윤정(Yoon Jung Yang) 대한지역사회영양학회 2015 대한지역사회영양학회지 Vol.20 No.1
This study was performed to investigate the associations of food security with socio-demographic characteristics, nutrient intakes and mental health status among older Korean adults. Methods: This study was conducted using data from the 2008-2010 Korea National Health and Nutrition Examination Survey (KNHANES). Subjects were 4,451 adults aged 65~98 years. Food security was measured using a self-reported question on food sufficiency of subjects’ household. Based on the answers, study subjects were classified into secure, mildly insecure, moderately insecure, and severely insecure groups. Dietary intake was estimated by 24-hour dietary recall. Nutrient intake was assessed by dietary reference intakes (DRI). As for mental health status, the data on mental stress, depression, and suicide ideation were used. Results: Rate of food insecurity in older adults was 14.3%. Old age, being female, low education, low income level, living alone, and discomfort in daily living were more related to food insecurity. Means of nutrient intakes were significantly different according to food security status. Intakes of calcium, potassium, and vitamin B2 were lower than recommended intakes in all groups. Consumption amounts of soy and soybean products, vegetables, mushrooms, fruits, vegetable oils, meats, eggs, seafood, and dairy products were lower in food insecure groups. Mental stress, depression, and suicide ideation were higher in food insecure groups independent of the gender and income level. Conclusions: These present findings suggested that food security is related to mental health as well as nutrition status in older Korean adults. A national system that include food and psychosocial support programs for the elderly should be considered in order to improve the overall health of older Korean adults. Korean J Community Nutr 20(1): 30~40, 2015
CFA에 의해 유도된 백서(白鼠)모델 관절염(關節炎)에서 대강활탕(大羌活湯)의 진통효과(鎭痛效果)
서윤정 ( Yoon Jung Seo ),구성태 ( Sung Tae Koo ),양윤정 ( Yoon Jung Yang ),김산 ( San Kim ),유인식 ( In Sik Yoo ),임규상 ( Kyu Sang Lim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.4
Objectives: Daeganghwal-Tang(DGHT) is one of the prescriptions used for the treatment of rheumatoid arthritis(RA) in oriental medicine. The present study aimed to examine the analgesic effect of DGHT on a rat model of CFA-induced arthritis, and the relations between DGHT-induced analgesia and endogenous nitric oxide(NO) and inducible NO synthase(iNOS)/neuronal NOS. Methods: CFA-induced arthritis model used to test the effect of DGHT was chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 18 days. The reduced stepping force of the limb was presumably due to a painful knee. DGHT dissolved in water was orally administrated. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 4 hours. Results: DGHT produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 2 hours. DGHT produced the improvement of stepping force of the affected hindlimb in a dose-dependent mariner. Both NO production and nNOS/iNOS protein expression which is increased by arthritis were suppressed by DGHT administration. Conclusions: The data suggest 1) that DGHT produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and 2) that DCHT-induced analgesia modulate endogenous NO through the suppression of nNCS/iNOS protein expression.
흰쥐의 신경병증성(神經病症性) 통증(痛症) 모델에서 양로(養老) 자침(刺鍼)의 진통효과(鎭痛效果)
구성태,양윤정,김산,유인식,임규상,Koo, Sung-Tae,Yang, Yoon-Jung,Kim, San,Yoo, In-Sik,Lim, Kyu-Sang 경락경혈학회 2004 대한침구의학회지 Vol.21 No.3
Objectives : The usage of acupuncture has gained popularity for certain chronic pain conditions. However, the efficacy of acupuncture in various diseases has not been fully established and the underlying mechanism is not clearly understood. In the present study, the effect of electroacupuncture (EA) applied to yangno$(SI_6)$ on the neuropathic pain was examined. Methods : A common source of persistent pain in human is a neuropathic pain. Neuropathic pain was induced by tight ligation of L5 spinal nerve. When rats developed pain behaviors, EA was applied for 30 min. under enflurane anesthesia with repeated train stimuli at the intensity of 10X of muscle twitch threshold. The foot withdraw latency of the hind limb was measured for an indicator of pain level after each manipulation. Results : EA increased the mechanical threshold of the foot in the rat model of neuropathic pain significantly for the duration of 1 hr. suggesting a partial alleviation of pain. EA applied to SI6 point produced a significant improvement of mechanical sensitivity of the foot lasting for at least 1 h. However, $ST_{36}$ point did not produce any significant increase of mechanical sensitivity. The improvement of mechanical threshold was interpreted as an analgesic effect. The analgesic effort was specific to the acupuncture point since the analgesic effect on the neuropathic pain model could not be mimicked by EA applied to a point, $ST_{36}$. In addition, this analgesic effect of EA is mediated by a adrenergic mechanism of descending control of spinal cord from the brain. Conclusions : The data suggest that EA produces a potent analgesic effect on the neuropathic pain model in the rat; and 2) that EA-induced analgesia is mediated by a adrenergic mechanism of descending control in a point specific manner.
GC/MS에 의한 뇨 중 내인성 에스트로겐의 Profiling
이선화,양윤정,김태욱,팽기정,정봉철,Lee, Seon Hwa,Yang, Yoon Jung,Kim, Tae Wook,Paeng, Ki Jung,Chung, Bong Chul 대한화학회 1997 대한화학회지 Vol.41 No.4
성 호르몬으로서의 역할과 암 성장의 잠재적 저해 효과를 지니고 있는 에스트로겐의 대사체들을 동시에 분석하기 위하여 Serdolit AD-2 수지와 효소 가수분해, 액체-액체 추출방법을 이용한 전처리 과정을 확립하였으며, MSTFA/TMSCl 혼합액에 의해 trimethylsilylether 형태로 유도체화된 에스트로겐들을 GC/MS의 SIM(selected ion monitorning) 방법으로 동시에 분석, 정량할 수 있는 조건을 설정하였다. 그 결과 회수율은 80.97~97.81%이었고, within-a-day 및 day-to-day 분석에서의 RSD값은 각각 0.24~25.35%, 1.05~23.94%이었으며, 이 방법으로는 소변 내에 존재하는 19종의 에스트로겐 대사체들을 정량하여 한국인 정상인 참고치(여자:22~35세, 남자: 39~57세)를 설정하였다. Estrogens, which play an important role in sex hormone and potential inhibitor of cancer cell proliferation were profiled for normal female and male. The nineteen endogeneous estrogens were simultaneously analyzed by selected ion monitoring method of GC/MS. Urinary estrogens were extracted by using Serdolit AD-2 resin, hydrolyzed with $\beta-glucuronidase/arylsulfatase$ from Helix pomatia, liquid-liquid extraction and quantitatively derivatized by MSTFA/TMSCl mixture in order to be detected on the GC/MS. The good quality-control data were obtained through the precision and accuracy test and the recovery range of them was 80.97∼97.81%. The Korean reference values of urinary estrogens were established and differences were found in normal female compared with normal male.