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심주현 ( Joo Hyun Shim ),허훈 ( Hoon Hur ) 한국정맥경장영양학회 2015 한국정맥경장영양학회지 Vol.7 No.2
Accurate measurement of body composition between lean and adipose tissue mass and distribution of lipid burden may be important in the care of nutritional problems in patients observed in clinical practice and the measurement of outcomes in clinical research. In this review, we discuss the most accurate imaging methods for use as clinical tools in measurement of body composition and distribution. Dual-energy x-ray absorptiometry (DXA) is a non-invasive technique for assessment of body composition, and the radiation exposure is relatively minimal. However, measurements are influenced by thickness of tissue and lean tissue hydration. Computed tomography (CT) is a gold-standard imaging method for body composition analysis at the tissue-organ level, however the radiation generated by the CT scan is relatively high, thus it should not be considered for a measurement, which can be repeated frequently. Magnetic resonance imaging (MRI) has been a useful modality in the assessment of body composition changes in various clinical studies. However, limitations of MRI for assessment of body composition are related to its high cost and technical expertise necessary for analysis. Proper methods for measurement of body composition in specific medical situations like sarcopenia should be evaluated for determination of comparative validity and accuracy, within the context of cost-effectiveness in patient care. In conclusion, an ideal body imaging method would have a significant utility for earlier detection of nutritional risks, while overcoming the limitations of current imaging studies such as DXA, CT, and MRI.
Methionine Adenosyltransferase 1: 간경화 환자에서 단백체학 분석을 통한 조기 간세포암 진단표지자
이주호 ( Joo Ho Lee ),전미정 ( Mi Jung Jun ),심주현 ( Ju Hyun Shim ),송기원 ( Gi-won Song ),탁은영 ( Eunyoung Tak ),오보라 ( Bora Oh ),유은실 ( Eunsil Yu ),최상운 ( Sang-woon Choi ),안지현 ( Jihyun An ),이단비 ( Danbi Lee ),김강모 ( 대한간암학회 2018 대한간암학회지 Vol.18 No.1
Background/Aims: Because there is a lack of effective biomarkers, we aimed to discover proteomic candidate markers for hepatocellular carcinoma (HCC) in cirrhotic patients at the highest-risk of HCC, and to validate the markers. Methods: We collected tumor tissue from 5 cirrhotics with HCC, and from 5 cirrhotics without HCC, who underwent liver resection or transplantation. These tissue samples were analyzed by 2-dimensional difference gel electrophoresis coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and potential markers were validated at the transcriptional and translational levels. We also performed western blot assays using other blood samples from 10 cirrhotics with HCC and 10 without HCC. Results: Among the 66 distinguishable spots on 2-D gel images, we identified 15 proteins overexpressed more than 1.5 fold in terms of volume ratio in the tumors. Ten of the over-expressed proteins were identified by MALDI-TOF MS; of those, only methionine adenosyltransferase 1 (MAT1), a protein specific for liver, and acyl-CoA dehydrogenase were significantly up-regulated in tumors in further immunoblotting analyses (Ps<0.05). There was no between-pair difference in MAT1 mRNA measured by real-time polymerase chain reaction (P=0.96). However, in western blots of serum samples, distinct MAT1 bands were observed in all 10 HCC patients, but in only 2 of the non-HCC patients. Conclusions: MAT1 is a potential marker for surveillance in cirrhotic patients with and without prior HCC. (J Liver Cancer 2018;18:33-43)
박주경 ( Joo Kyung Park ),이상협 ( Sang Hyup Lee ),김상균 ( Sang Gyune Kim ),김휘영 ( Hwi Young Kim ),이정훈 ( Jeong Hoon Lee ),심주현 ( Joo Hyun Shim ),김주성 ( Joo Sung Kim ),정현채 ( Hyun Chae Jung ),송인성 ( In Sung Song ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.1
The clinical manifestations of intestinal tuberculosis are non-specific. But, abdominal pain, low grade fever, weight loss, anorexia, and diarrhea are major symptoms of intestinal tuberculosis. Massive bleeding has been reported as a rare manifestation of
장대성(Dae Sung Chang),심주현(Joo Hyun Shim),서성준(Seong Jun Seo),송계용(Kye Yong Song),홍창권(Chang Kwun Hong) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.5
Lentigo maligna(LM) is a pigmented lesion that occurs on the sun-exposed skin of an older patients and may become lentigo maligna melanoma(LMM). Currently the percentage of LM type melanoma appears to be increasing, and this rise has been attributed to increasing UV radiation exposure. In addition to UV radiation, estrogen and progesterone, and nonpermanent hair dyes have been proposed as risk factors. A case is a 66-year-old female with a 3 years history of pigmented patch. She had a gradually enlarging irregular bordered brown to black mottled patch on the right temple area. Histologic examination revealed atypical melanocytes along the basal layer of atrophic epidermis, arranged in solitary units and small nests. Perilesional skin showed many scattered melanophages and regressing nevus cell nests which suggested preexisting nevus underwent regressive change. On the basis of clinicopathologic examination we diagnosed this case as lenigo maligna arising from nevocytic nevus and then we removed the lesion by wide surgical excision and could not find any recurrence until now.
얼굴 모공 분포와 모공에 영향을 미치는 요인에 관한 연구
정혜정 ( Hye Jung Jung ),서현이 ( Hyun Yi Suh ),심주현 ( Joo Hyun Shim ),이갑석 ( Kap Sok Li ),안지영 ( Ji Young Ahn ),박미연 ( Mi Youn Park ),홍창권 ( Chang Kwun Hong ),윤재일 ( Jai Il Youn ),김범준 ( Beom Joon Kim ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.12
Background: Pores are the openings of the pilosebaceous unit or the apocrine gland. Increase in pore size or in the number of dilated pores may be a cosmetic problem. To date, epidemiological studies on the numbers of dilated pores have been rarely reported. Objective: To analyze the distribution of pores and the factors affecting pores. Methods: We compared the number of dilated facial pores on the face according to site, age group, and sex. The relations of pore counts to wrinkle severity and to the amount of hydration were also analyzed. DermavisionTM, a device that can take cross-polarization, parallel polarization, and ultraviolet light images, was used. Parameters were measured at three points: the forehead, cheek, and nose. Results: The results revealed that dilated pores were more common on the nose and forehead. The pore counts were increased with age, and the increment was significant between participants in their 30s and 40s. Moreover, dilated pore counts were affected by wrinkle severity. The amount of hydration did not affect the counts of dilated pores. Conclusion: In this study, the number of dilated pores differed depending on the location. Moreover, it was confirmed that pore counts were higher in older persons. The pore counts showed a correlation with wrinkle severity. (Korean J Dermatol 2014;52(12):851∼857)
간세포암이 병발한 윌슨병(Wilson`s disease)
김휘영 ( Hwi Young Kim ),박주경 ( Joo Kyung Park ),심주현 ( Joo Hyun Shim ),이정훈 ( Jeong Hoon Lee ),김윤준 ( Yoon Jun Kim ),윤정환 ( Jung Hwan Yoon ),이효석 ( Hyo Suk Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
In Wilson`s disease, liver cirrhosis is a common complication. However, hepatocellular carcinoma rarely develops in Wilson`s disease, in contrast to other liver diseases, such as postnecrotic cirrhosis or hemochromatosis. It has been speculated that the accumulated copper in the liver may prevent the development of hepatocellular carcinoma and the use of chelating agents may decrease the copper in the liver resulting in the development of carcinoma. However, there are various evidences contradicting this hypothesis. We report a 45-year-old male patient of Wilson`s disease with hepatocellular carcinoma, and the literature was reviewed. (Korean J Med 69:S782-S786, 2005)