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Cisplatin 경동맥화학색전술 후 발생한 용혈성 요독 증후군 1예
석창현 ( Chang Hyeon Seock ),이단비 ( Danbi Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ) 대한간암학회 2012 대한간암학회지 Vol.12 No.2
Hemolytic uremic syndrome (HUS) is a rare condition compromising the clinical triad of acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. HUS may be associated with a variety of etiologies, and chemotherapeutic agents have also been reported to be associated with HUS, including mitomycin, cisplatin, bleomycin, and most recently gemcitabine. HUS also has been observed in association with a number of disseminated malignancies in adults, most typically adenocarcinoma of the stomach and breast. But there was no case report of HUS after cisplatin based transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We experienced a case of HUS after cisplatin based TACE and reported this case with several literature reviews.
담관 침범 및 간문맥혈전증을 동반한 간세포암 환자의 효과적인 치료
안지현 ( Jihyun An ),이단비 ( Danbi Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ) 대한간암학회 2013 대한간암학회지 Vol.13 No.2
Bile duct invasion of hepatocellular caricinoma (HCC) is rare, ranging from 1.2% to 9%. Moreover, the standard treatment of HCC with bile duct invasion is not yet established. We report a case of HCC with bile duct invasion and portal vein thrombosis which was successfully treated by trasarterial chemoembolization and radiotherapy. A 38-year-old female patient visited our hospital due to right upper quadrant pain. The level of total and direct bilirubin was 6.8 and 4.0 mg/dL, respectively. Her blood test showed HBs Ag positive and the level of alphafetoprotein was 43,000 ng/mL. Her CT scan revealed lobulating hypervascular mass involving right hepatic lobe, portal vein and both intrahepatic ducts. We performed endoscopic biliary drainage using biliary stent. She had been diagnosed as HCC on endobiliary biopsy. She was treated with radiotherapy (RT) to portal vein thrombosis, and seven transarterial chemoembolizations. After of all, we carried out radiotherapy to hepatic vein thrombosis and residual HCC near hepatic vein. After the RT, she has been taken care at outpatient clinic without evidence of recurrence during 8 months.
간동맥화학색전술 후 외과적 절제가 가능하였던 담관 침범 간세포암종 종양 병기 축소 후 근치적 치료
허내윤 ( Nae Yun Heo ),이한주 ( Han Chu Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ),서동진 ( Dong Jin Suh ) 대한간암학회 2011 대한간암학회지 Vol.11 No.1
A surgical resection is a major curative treatment of hepatocellular carcinoma (HCC) in Korea. However, the respectability of HCC at the time of diagnosis is low (10-30%) because the cancer is often identified as advanced stage. Nevertheless, some of the patients were known to have a curative resection after successful downstaging therapy. We report a HCC with bile duct invasion which was successfully downstaged by the transarterial chemoembolization and treated by surgical resection.
석창현 ( Chang Hyeon Seock ),이단비 ( Dan Bi Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ) 대한간암학회 2012 대한간암학회지 Vol.12 No.1
According to AASLD practice guideline, for patients who present with advanced hepatocelluar carcinoma, new data indicates the efficacy of sorafenib in prolonging life. But there are no data comparing combination transarterial chemoemboliation with sorafenib to sorafenib treatment alone. We experienced a case that treated a patient with combination therapy including transarterial chemoembolization for intrahepatic hepatocelluarcarcinoma, radiation therapy for portal vein thrombosis and sorafenib treatment. He was in stable disease state after 6 months later. Therefore, it seems to be need to study for comparing combination therapy to sorafenib, or to transarterial chemoembolization.
증례 : 소화기 ; 시스플라틴을 이용한 경동맥 화학색전술 후 발생한 용혈성 요독증후군 1예
양지은 ( Jee Eun Yang ),김강모 ( Kang Mo Kim ),심주현 ( Ju Hyun Shim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Leef ) 대한내과학회 2013 대한내과학회지 Vol.85 No.1
Hemolytic uremic syndrome (HUS) is a rare disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. These characteristics are related to the formation of platelet-rich microthrombi in the microvasculature. HUS is associated with a variety of etiologies, including cisplatin. Previously reported HUS cases after cisplatin administration were almost always related to systemic combination chemotherapy that included cisplatin. Transarterial chemoembolization (TACE) is commonly used in treatment of hepatocellular carcinoma, and most centers in Korea use cisplatin. A 70-year-old female with hepatocellular carcinoma was treated with TACE including cisplatin and subsequently developed clinical and laboratory findings compatible with HUS. (Korean J Med 2013;85:67-72)