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Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
신춘식,장연지,이훈구,허원기 한국유전체학회 2009 Genomics & informatics Vol.7 No.4
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved in several cellular processes, including ribosome biogenesis, nutrient response, autophagy and aging. However, due to the functional diversity of TOR pathway, we do not know yet some key effectors of the pathway. To find unknown effectors of TOR signaling pathway, we took advantage of a green fluorescent protein (GFP)-tagged collection of budding yeast Saccharomyces cerevisiae . We analyzed protein abundance changes by measuring the GFP fluorescence intensity of 4156 GFP-tagged yeast strains under inhibition of TOR pathway. Our proteomic analysis argues that 83 proteins are decreased whereas 32 proteins are increased by treatment of rapamycin, a specific inhibitor of TOR complex 1 (TORC1). We found that, among the 115 proteins that show significant changes in protein abundance under rapamycin treatment, 37 proteins also show expression changes in the mRNA levels by more than 2-fold under the same condition. We suggest that the 115 proteins indentified in this study may be directly or indirectly involved in TOR signaling and can serve as candidates for further investigation of the effectors of TOR pathway.
신춘식,김남호,노창주 한국마린엔지니어링학회 1996 한국마린엔지니어링학회지 Vol.20 No.1
In recent years, as the electonic industry has become more advanced, the LPM(Linear Pulse Motor) has appeared in a wide range of applications because of easier control, operation by open-loop control, high positioning accuracy, and retrieval of position or velocity data by the input pulses. In this study, we deal with the development of a position detection device attached to a hybrid LPM in our laboratory. Precise position detection signals could be sensed by the synchronous rectifier method from the LPM stator scale. In addition, we can keep the amplitude constant by using an AGC(Automatic Gain Control) circuit. Experimental results show that the position data is good enough to perform the LPM position control.
Numerical Visualization of Supersonic Microjet Flows
신춘식,이종성,김희동 한국가시화정보학회 2009 한국가시화정보학회지 Vol.7 No.2
Supersonic microjets acquire considerable research interest from a fundamental fluid dynamics perspective, in part because the combination of highly compressible flow at low-to-moderate Reynolds number is not very common, and in part due to the complex nature of the flow itself. In addition, microjets have a great variety engineering applications such as micro-propulsion, MEMS(Micro-Electro Mechanical Systems) components, microjet actuators and fine particle deposition and removal. Numerical simulations have been carried out at moderate nozzle pressure ratios and for different nozzle exit diameters to investigate and to understand in-depth of aerodynamic characteristics of supersonic microjets. Supersonic microjets acquire considerable research interest from a fundamental fluid dynamics perspective, in part because the combination of highly compressible flow at low-to-moderate Reynolds number is not very common, and in part due to the complex nature of the flow itself. In addition, microjets have a great variety engineering applications such as micro-propulsion, MEMS(Micro-Electro Mechanical Systems) components, microjet actuators and fine particle deposition and removal. Numerical simulations have been carried out at moderate nozzle pressure ratios and for different nozzle exit diameters to investigate and to understand in-depth of aerodynamic characteristics of supersonic microjets.