http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
NMR Structural Studies on Novel Disintegrin, Saxatilin from Gloydius saxatilis Venom
신준,이동희,홍성유,정광해,김두식,이원태 한국자기공명학회 2007 Journal of the Korean Magnetic Resonance Society Vol.11 No.1
A new disintegrin protein named saxatilin was purified from Korean snake venom (Gloydius saxatilis). Saxatilin is a 73 residue small ploypeptide, which has a primary recognition motif in extracellular matrix, Arg-Gly-Asp (RGD) sequence. Data from inhibition activity assay for the αvβ3 integrin showed that saxatilin showed about 5000-fold higher activity than those of RGD peptides, suggesting that RGD sequence may not be sufficient to induce full cellular function of this site. The solution structures calculated from NMR data were well converged for backbone atoms except RGD loop. The structure revealed that most of tight turns are stabilized by medium range NOE contacts and the RGD motif is located far from the rigid core of the C-terminal domain. The three-dimensional fold and biological function of saxatilin are discussed with those of salmosin, which is a disintegrin protein derived from Agkistrodon halys brevicaudus.
Structure-Function of the TNF Receptor-like Cysteine-rich Domain of Osteoprotegerin
신준,Young-Mee Kim,Song-Zhe Li,임승길,이원태 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.3
Osteoprotegerin (OPG) is a soluble decoy receptor that inhibits osteoclastogenesis and is closely associated with bone resorption processes. We have designed and determined the solution structures of potent OPG analogue peptides, derived from sequences of the cysteine- rich domain of OPG. The inhibitory effects of the peptides on osteoclastogenesis are dose-dependent (10−6M−10−4M), and the activity of the linear peptide at 10−4M is ten-fold higher than that of the cyclic OPG peptide. Both linear and cyclic peptides have a β-turnlike conformation and the cyclic peptide has a rigid conformation, suggesting that structural flexibility is an important factor for receptor binding. Based on structural and biochemical information about RANKL and the OPG peptides, we suggest that complex formation between the peptide and RANKL is mediated by both hydrophobic and hydrogen bonding interactions. These results provide structural insights that should aid in the design of peptidyl-mimetic inhibitors for treating metabolic bone diseases caused by abnormal osteoclast recruitment.
신준,오재응,Shin, Joon,Oh, Jae-Eung 대한기계학회 1992 대한기계학회논문집 Vol.16 No.10
본 연구에서는 자동차의 발달에 따른 정비 전문가의 상대적인 능력 감퇴를 보 완하고 진단의 정확성을 높일 수 있도록 소음계측에 의한 인공 지능적 뉴로-퍼지 진단 기법을 연구하였다. 이를 위하여 진단결과에 영향을 미치는 많은 작용변수와 다양한 차량상태 등을 고려함으로서 보다 신뢰성 있는 결과를 산출해내기 위한 퍼지(fuzzy) 추론 방식의 판단법을 도입하였으며, 진단이 실패했을 경우나 입력된 데이터가 충분하 지 못할 경우에 시스템 자체의 지식을 확장시켜 나갈 수 있도록 해밍네트(hamming net )에 의한 패턴인식 기법을 적용하였다. 그리고 컴퓨터 시뮬레이션과 자동차를 대상 으로 고장진단 실험을 실시하여 기존의 진단기법과의 비교를 통한 뉴로-퍼지 진단기법 의 효율성과 알고리즘의 타당성을 검증하였다. In the diagnostic process for automobile, Neuro-Fuzzy technique was compared with the conventional diagnostic method for the verification of performance, and proto-type system was developed. For the utilities of the system, 1/3 octave filter(band-pass filter) and A/D converter were used for data acquisition and then data were analyzed using octave band processing and pattern recognition using hamming network algorithm. In order to raise the reliability of the diagnostic results by considering many operating variables and condition of automobile to be diagnosed, fuzzy inference technique was applied in combining several information. The validation of this diagnostic system was examined through computer simulation and experiment, and it showed an acceptable performance for diagnostic process.
신준,김흥섭,오재응,Shin, Joon,Kim, Heung-Seob,Oh, Jae-Eung 대한기계학회 1994 대한기계학회논문집 Vol.18 No.9
With the improvement of standard of living, requirement for comfortable and quiet environment has been increased and, therefore, there has been a many researches for active noise reduction to overcome the limit of passive control method. In this study, active noise control is performed in a duct system using intelligent control technique which needs not decide the coefficients of high order filter and the mathematical modeling of a system. Back propagation algorithm is applied as an intelligent control technique and control system is organized to exclude the error microphone and high speed operational device which are indispensable for conventional active noise control techniques. Furthermore, learning is performed by organizing acoustic feedback model, and the effect of the proposed control technique is verified via computer simulation and experiment of active noise control in a duct system.
신준 한국기계기술학회 2020 한국기계기술학회지 Vol.22 No.1
This paper is one of basic studies for development of fuel rail to secure strength of GDI system. The fuel rail supports high pressure of 200~250bar and stores fuel while reducing pulsation during injection. Therefore, the structural characteristics of the conventional fuel rail was investigated with respect to stress and displacement. Then, the study focused on reducing stress concentration on fuel rail design to enhance the strength of each components. It was found that the maximum stress was not affected to the dimensions of taper lengths and angles of holes for fuel pipe. Also, it was found that the shape of holes for fuel pipe was key factor to reduce maximum stress, and the bridge between injector and mounting holder was effective structure to reduce the stress of injectors and displacement of the fuel rail system.
신준,이태연 한국기계기술학회 2016 한국기계기술학회지 Vol.18 No.2
Pico hydropower, which refers to generation under 5kW, has been adopted in many places in the world as a cost effective and reliable power supply. The turbine units are important components for picohydropower and must be portable, simple to maintain. In this study, therefore, Turgo turbine units were developed which reported to be reliable, robust and able to operate efficiently over a range of flow rates. A 2D steady-state mathematical model was developed to calculate the performance and design the optimal geometry of Turgo runner. Also, a laboratory-scale simulator was constructed to test the operating performance and experiments were carried out to determine the effect on turbine efficiency of variation in speed and jet diameter. Under the best conditions, developed Turgo turbine efficiency was observed to be over 90% at a speed of 900rpm.