Structure-Function of the TNF Receptor-like Cysteine-rich Domain of Osteoprotegerin

신준,Young-Mee Kim,Song-Zhe Li,임승길,이원태 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.3

Osteoprotegerin (OPG) is a soluble decoy receptor that inhibits osteoclastogenesis and is closely associated with bone resorption processes. We have designed and determined the solution structures of potent OPG analogue peptides, derived from sequences of the cysteine- rich domain of OPG. The inhibitory effects of the peptides on osteoclastogenesis are dose-dependent (10−6M−10−4M), and the activity of the linear peptide at 10−4M is ten-fold higher than that of the cyclic OPG peptide. Both linear and cyclic peptides have a β-turnlike conformation and the cyclic peptide has a rigid conformation, suggesting that structural flexibility is an important factor for receptor binding. Based on structural and biochemical information about RANKL and the OPG peptides, we suggest that complex formation between the peptide and RANKL is mediated by both hydrophobic and hydrogen bonding interactions. These results provide structural insights that should aid in the design of peptidyl-mimetic inhibitors for treating metabolic bone diseases caused by abnormal osteoclast recruitment.

우루시올이 제거된 생옻 추출물 제조장치

신준,이태연 한국기계기술학회 2017 한국기계기술학회지 Vol.19 No.5

In this study, manufacturing equipments for urushiol free raw rhus verniciflua stem(RRVS) extracts are developed which do not need for drying process and high pressure device. The three layered pressure tank and heating medium oil boiler are designed which are more efficient than the conventional ones, and the safety of the tank is assured by the structural analysis software. Finally, the RRVS extracts are prepared by water extraction technique at 100℃ using the developed equipments. In the physicochemical experiments for the RRVS extracts, an allergen such as urushiol is not detected, whereas the antioxidant such as polyphenol and flavonoid are contained.

플라즈마 멸균기용 진공 챔버의 설계 및 평가

신준,이태연 한국기계기술학회 2018 한국기계기술학회지 Vol.20 No.4

It is essential for medical equipment sterilization operations to prevent infections in the hospital. The low temperature plasma sterilization method using oxygenated water has the advantage of high efficiency and short time in sterilizing processes. However, a chamber which can hold constant vacuum condition without deformation is essential in the sterilizing system to apply plasma sterilization technique. In this study, therefore, the vacuum chamber is developed for 70 liter plasma sterilization device. The vacuum chamber is designed by checking the thickness, edge fillet value and rib of chamber through each simulation. And the performance of the chamber is investigated by vibrational modes and heat stress simulation. The prototype vacuum chamber is tested by experiments to verify the safety and efficiency for 0.1 Torr vacuum, and the result shows the expected vacuum level and displacement.

연통내 배기가스 중 이산화탄소 저감장치 개발

신준 한국기계기술학회 2014 한국기계기술학회지 Vol.16 No.4

중국 장사요의 편년과 한국 출토 장사요 자기 연구

신준 한국문화유산협회 2011 야외고고학 Vol.0 No.12

이 논문은 장사요에서 생산된 기물의 유형분류 및 편년을 주 고찰 대상으로 삼았다. 현재까지 알려진 중국의 기년묘(紀年墓) 출토 유물 등의 편년 자료를 기준으로, 장사요 요지의 고고학 발굴 층위에 의한 상대편년 자료와의 비교 분석을 통하여 시기에 따른 장사요 자기의 발전과정을 밝혀 보았다. 아울러 이들 편년 자료를 바탕으로 한국 출토 장사요 자기의 연대 및 유입시기를 추정하였다. 중국 출토 장사요 자기에 대한 유형 분석을 통하여 얻어진 장사요 제자(制瓷)수공업의 발전단계는 크게 세 시기로 나누어 볼 수 있다. 제 1기는 8세기 중기부터 8세기 말로, 청유자기가 주류를 이루며 완·접시·호와 같은 기종에 악주요의 영향이 나타난다. 제 2기는 9세기 초부터 당 선종(宣宗) 대중연간(大中年間, 847~860년)으로, 청유(靑釉)·녹유 ( 釉)·장유(醬釉)·백유(白釉) 등 다양한 품종이 나타나며, 유하채회(釉下彩繪)·첩화 (貼花)·시문(詩文) 등의 장식이 유행하고 산화동(酸化銅)을 착색제로 하는 동홍유(銅紅釉)자기가 출현한다. 제 3기는 당 의종(懿宗) 함통원년(咸通元年, 860년)부터 오대(五代) 시기로, 둥근 관(管) 형태의 긴 주구와 굽은 귀 모양의 손잡이를 가진 집호가 출현하고, 유하채회·첩화·시문 등의 장식이 여전히 유행하지만, 당말 오대에 이르러 쇠락하기 시작한다. 현재 한국에서 출토되고 있는 장사요 자기는 거의 대부분이 경주에 집중되고 있다. 장사요의 발전 계보(系譜)와 기년자료 등과의 비교를 통하여 국내 출토 장사요 자기는 그 생산연대가 대략 9세기 전반경으로 판단되며, 상품으로서의 무역자기를 대량 생산하는 장사요의 특성상, 생산연대와 거의 동일시기에 국내로 유입되었을 것으로 생각된다. This paper deals with the typology and chronology of Changsha wares. A process of development was set up and determined by comparing the relative chronology of artifacts excavated from the Changsha kiln itself with the Changsha wares buried as grave goods in tombs with absolute dates. Through this procedure, the Changsha wares excavated from sites in Korea may be dated. Through the analysis of their typology, it was possible to identify three stages in the development of hand manufactured Changsha wares. The first stage spans from the middle of the 8th century to the end of the 8th century. In this period, blue glazed bowls, dishes and jars contained influences of the Yuezhou kiln. The second stage spans from in the early part of the 9th century to the Taijung period(大中年間, 847~860) of the reign of Tang Xuanzong(宣宗). In this stage many kinds of glazed ware, such as blue glazed, green glazed, brown glazed and white glazed ware, appeared. Under glazes of copper oxide and iron oxide applied on the milky white glaze, applique motifs and poetry and prose designs became popular. The third stage spans from the First Year of Hamtong(咸通元年, 860) of the reign of Tang Yizong(懿宗) to the period of the Five Dynasties. In this period, ewers appeared which had pipe shaped long spouts and curved ear shaped handles. Under glaze painting, applique motifs and poetry and prose designs were still popular, but the techniques declined towards the end of the Tang Dynasty and the period of the Five Dynasties. At present, Changsha wares excavated in Korea mostly come from the ancient capital city of Gyeongju. These can be dated as belonging to the first half of the 9th century through comparisons with Changsha ware vessels that have absolute dates and the process of development of Changsha wares. One of the most important characteristics of the Changsha kiln was the mass-production of trade wares. Therefore, Changsha wares were introduced into the Korean peninsula within a very short period of time after they were produced.

역전파 알고리즘에 의한 덕트내 소음의 능동제어

신준,김흥섭,오재응,Shin, Joon,Kim, Heung-Seob,Oh, Jae-Eung 대한기계학회 1994 대한기계학회논문집 Vol.18 No.9

With the improvement of standard of living, requirement for comfortable and quiet environment has been increased and, therefore, there has been a many researches for active noise reduction to overcome the limit of passive control method. In this study, active noise control is performed in a duct system using intelligent control technique which needs not decide the coefficients of high order filter and the mathematical modeling of a system. Back propagation algorithm is applied as an intelligent control technique and control system is organized to exclude the error microphone and high speed operational device which are indispensable for conventional active noise control techniques. Furthermore, learning is performed by organizing acoustic feedback model, and the effect of the proposed control technique is verified via computer simulation and experiment of active noise control in a duct system.

ISOLATION OF MALONAMIDASE FROM Rhizobium meliloti 1021

신준,김유삼 생화학분자생물학회 1992 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-

카카오프렌즈 캐릭터를 활용한 브랜드 전략에 대한 연구

신준,김승인 사단법인 한국브랜드디자인학회 2020 브랜드디자인학연구 Vol.18 No.1

This study is based on the case analysis based on David Arker's brand identity strategy theory, which is a single target called Kakao Friends. It distinguishes the main structure of the basic identity system and draws the elements that Kakao Friends has. Analyze intrinsic value, such as functions held by emoticons, and the characteristics of images formed in mobile platform to derive key identity structures. It also analyzes the relationship between its parent company, Kakao Talk, to draw a brand essence and to analyze the characteristics of its collaboration and professional character stores. This presents the core of the brand identity, the essence that binds it, and the structure of the extended identity that re-implement it. Since then, he has introduced his relationship with brand recognition and his value proposition and suggested the limitations of the character. According to the analysis, Kakao Friends characters, which have been linked to Kakao Talk's brand essence, had the core value of identity: accessibility, empathy and deficiency. In addition, extended identities were formed around visual and emotional images embodied by the use of emoticons. Extended identity was serving to offer value to consumers by transforming emoticons while maintaining existing core identities. Furthermore, it has led to stores that sell goods exclusively for their own brand characters, focusing on products that are easy to access. In conclusion, we could see that Kakao Friends is similarly controlling the propensity and design of businesses that serve around the core identity of empathy. This could suggest the formation of a strategic brand identity to have in the high value-added industry and the potential and importance of the character to do so. 본 연구는 카카오프렌즈 캐릭터를 데이비드 아커의 브랜드 아이덴티티 전략 이론에 따라 분석한다. 기본적인 아이덴티티 시스템의 구조를 구분해 브랜드 요소를 도출한다. 브랜드 아이덴티티의 핵심, 이를 묶어주는 에센스, 그리고 이를 다시 구현시켜주는 확장 아이덴티티의 구조를 구분한다. 이를 통하여 브랜드 인지도와의 관계와 가치제안을 분석한다. 분석 결과, 카카오톡의 브랜드 에센스인 연결에서 이어져 온 카카오프렌즈 캐릭터가 접근성과 공감 그리고 결핍이라는 아이덴티티의 핵심 가치를 지니고 있었다. 또한 이모티콘 사용으로 인해 구현된 시각적/정서적 이미지를 중심으로 확장 아이덴티티가 형성되어 있었다. 확장 아이덴티티는 기존의 핵심 아이덴티티를 유지한 상태에서 이모티콘을 변형 및 대입함으로써 소비자에게 가치를 제안하는 역할을 하고 있었다. 더 나아가 자사 브랜드 캐릭터 전용 굿즈 매장으로도 이어졌으며 접근성이 용이한 상품을 판매하고 있었다. 결론으로 카카오프렌즈는 공감의 핵심 아이덴티티를 중심으로 서비스와 디자인을 정체성 있게 조절하고 있음을 볼 수 있었다. 그래서 브랜드가 가진 고유한 통일된 이미지가 형성되고 차후 확장되는 사업에도 영향을 끼쳤다. 고부가가치 산업이 가져야 할 브랜드의 정체성 형성과 이를 위한 캐릭터에 대한 가능성과 중요성을 이 논문을 통하여 제시할 수 있었다.

연료레일의 응력 저감을 위한 최적 설계

신준 한국기계기술학회 2020 한국기계기술학회지 Vol.22 No.1

This paper is one of basic studies for development of fuel rail to secure strength of GDI system. The fuel rail supports high pressure of 200~250bar and stores fuel while reducing pulsation during injection. Therefore, the structural characteristics of the conventional fuel rail was investigated with respect to stress and displacement. Then, the study focused on reducing stress concentration on fuel rail design to enhance the strength of each components. It was found that the maximum stress was not affected to the dimensions of taper lengths and angles of holes for fuel pipe. Also, it was found that the shape of holes for fuel pipe was key factor to reduce maximum stress, and the bridge between injector and mounting holder was effective structure to reduce the stress of injectors and displacement of the fuel rail system.

원대 용천요의 요업상황과 동시기 침몰선 출수 용천요자기에 대한 고찰

신준 국립해양문화재연구소 2016 해양문화재 Vol.9 No.-