SM-2015의 혈중 알코올 분해 및 숙취 개선 효과

신선미,박선영,김태연,Shin, Seon-mi,Park, Sun-young,Kim, Tae-yeon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

학생 건강에 대한 OECD와 한국의 통계지표

신선미,Shin, Sun-Mi 한국학교보건학회 2012 韓國學校保健學會誌 Vol.25 No.1

Purpose: The purpose of this study was to identify the statistical indicators of OECD and Korea for student health among Korea's approval statistics. Methods: Searching for health indicators by using Health at a Glance 2009, Society at a Glance 2009, and Education at a Glance 2009 through the formal OECD web site in 2010, and investigating the approval statistics through the Korean formal organizational web sites and published data in 2012. Results: Among OECD indicators, indicators for adolescent health were smoking and alcohol consumption, nutrition, physical activity, overweight and obesity, bullying, risk behaviors, and poverty children. However, most of Korea student health indicators were missing except poverty children and life satisfaction, because OECD has taken chiefly data from Health Behavior in School-aged Children survey (HBSC), international study, which has not been carried out in Korea. The Ministry Of Education, Science And Technology (MEST) and the Ministry of Health and Welfare, and National Youth Policy Institute in Korea have produced the major statistics for student health which was only 11 (1.3%) among 858 approval statistics. Conclusion: Identifying a current Korea school health is essential through participating actively to OECD whose statistic indicators are internationally comparable with Students Physical Development Survey, MEST's approval statistics, using Korea Student Health Examination. It was also suggested that quantitative and qualitative expansions for Korea student health statistics by the activation of approval statistics including processed statistics, and by researchers' easy expanded access to a raw data.

의료급여 과다 이용 수급권자 중 장애인의 의료이용

신선미,김의숙,박창기,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Park, Chang-Ki,Lee, Hee-Woo 대한예방의학회 2010 예방의학회지 Vol.43 No.1

Objectives: In Korea, the top 10% of Medical Aid recipients represent nearly 60% of total payment, with the costs for those disabled for over 365 days representing approximately 30% of total payment. The purpose of this study was to compare Medical Aid use of the disabled with non-disabled recipients, and to identify contributing factors to the total payment in the top 2% of recipients identified as Medical Aid overusers. Methods: Subjects (n=2,211) selected were ${\geq}18$-years-of-age and received >1000 days of co-payment-free type I Medical Aid. Case managers (n=200) conducted interviews in December 2006, and collected data from Health Insurance Review & Assessment Service. Amounts over the 9 months from January September 2006 were analyzed descriptively and using Chi-square, ANCOVA, and robust multiple linear regression. Results: Disabled individuals (mean age 61.3 years) composed 36.6% of subjects; 44.8% of the disabled were male. On a monthly basis per capita, the disabled group averaged 10.5 outpatient days, total payment of 523,000 Korean Won(￦), inpatient payment of ￦359,000, and outpatient payment of ￦183,000. All values exceeded the monthly average for non-disabled individuals. Contributing factors were identified as male gender (￦82,000), elementary school or lower educational level (￦64,000), residence in a small city (￦82,000), lack of family support (￦61,000), kidney disability (￦673,000), intellectual disability (￦151,000), and multiple disabilities (￦119,000). Conclusions: The identification of contributing factors to Medical Aid use by those defined as disabled supports the adoption of comprehensive alternative policies such as strengthening of education and consultation services, provision of alternative facilities, and promotion of self-care.

발기부전 처방에 사용되는 쇄양(鎖陽)이 음경해면체 이완에 미치는 영향

신선미,박선영,Shin, Seon-mi,Park, Sun-young 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objective: This study aimed to examine the relaxation effects and underlying mechanisms of Cynomorii herba (CH) extract in isolated rabbit corpus cavernous tissues.Methods: We experimented with CH extract (0.01-3.0 mg/mL). Nω-nitro-L-arginine (L-NNA) was experimented before the CH extract to contracted strips induced by phenylephrine (PE, 1 μM)and compared with nonexperimented. In addition, we experimented with calcium chloride (Ca²⁺, 1 mM) after pretreatment of the CH extract in Ca²⁺-free Krebs-Ringer solution to contracted strips induced by PE. The cell viability and nitric oxide (NO) concentration of human umbilical vein endothelial cells (HUVECs) were measured by an methylthiazol-2-yl-2, 5-diphenyl tetrazoliumbromide (MTT) assay and Griess reagent system. The ratio of smooth muscles to collagen fibers, in addition to eNOS- and PDE-5-positive reactions, was examined by histochemical and immunohistochemical staining.Results: The CH extract significantly induced the relaxation of the cavernous strips, and the pretreatment with L-NNA inhibited CH extract-induced relaxation. The L-NNA pretreatment reduced the increased contraction induced by the addition of Ca²⁺in Ca²⁺-free solution. Furthermore, the NO concentration of the HUVECs increased. When the CH extract was applied to the corpus cavernosum of the penis (CCP) of Sprague Dawley rats, the ratio of smooth muscles to collagen fibers by PE and the formation of eNOS around the helicine artery increased. However, the CH extract treatment decreased PDE-5 positive reactions.Conclusions: These results show that the relaxation effects induced by the CH extract are associated with the suppression of the influx of extracellular Ca²⁺ via the production of NO and eNOS and inhibition of PDE-5.

의료급여 장기이용 수급권자의 잉여약물 실태와 관련요인

신선미,김의숙,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Lee, Hee-Woo 대한예방의학회 2009 예방의학회지 Vol.42 No.6

Objectives : The amount of medical utilization by Medical Aid recipients was 3.7 times that of patients with Korean Medical Insurance. This study aims to describe the surplus medicine and the medication-related utilization, and to determine factors contributing to surplus medicine. Methods : Among those who used copayment-free Class I Medical Aid in 2005, 146,880 subjects who were $\geq19$ year-old and received >365 days medical treatment per year were studied with their case managers by conducting face-to-face interviews. The analytic methods were description, chi-square, t-tests, ANCOVA and multiple logistic regressions. Results : Most subjects were female (68.6%), the elderly (62.5%), and the separated (61.6%), had an elementary graduation or less (74.8%), and had disabilities (33.2%). The percentage of subjects with surplus medicine was 18.5%. However, the percentage of females, the elderly, those with non-disabilities, the separated, the uneducated, those with a very poor perceived health status and those with an economical burden for medical treatment was 19.3%, 18.9%, 19.0%, 19.3%, 19.0%, 20.2% and 24.3%, respectively. For subjects with surplus medicine, averages for the number of used pharmacies, the pharmacy-visit days and the medication costs were 4.6 drugstores, 34.9 days and approximately 1,124 thousand Won(￦). These values were higher than those without surplus medicine (4.4 drugstores, 33.8 days, and ￦1,110 thousand, respectively). The odds ratios of the contributing factors to surplus medicine were female 1.11 (95% CI=1.07-1.14), the elderly 1.06 (95% CI=1.02-1.10), those with non-disabilities 1.08 (95% CI=1.05-1.12), the separated 1.14 (95% CI=1.10-1.18), the unmarried 1.12 (95% CI=1.07-1.18), the uneducated 1.03 (95% CI=1.01-1.08), those with a very poor perceived health status 1.04 (95% CI=1.01-1.08) and experiencing an economical burden for medical treatment 2.33 (95% CI=2.26-2.40). Conclusions : 18.5% of subjects had surplus medicine with a higher mean of medication cost. Therefore, health education and health promotion programs to prevent surplus medicine and to improve the appropriate usage of medication are necessary.

WeXGene: 웹 기반 XML 데이터 생성기

신선미,정회진,이상호,Shin Sun Mi,Jeong Hoe Jin,Lee Sang Ho 한국정보처리학회 2005 정보처리학회논문지D Vol.12 No.2

XML 데이터베이스 시스템 성능 평가를 수행하기 위해서는 다양한 형태의 XML 데이터 생성을 필요로 한다. 기존 XML 데이터 생성기들은 특정 성능 평가에 적용 가능한 데이터만을 생성하고, 그 기능 또한 매우 제한적이다. 본 논문에서는 기존 XML 데이터 생성기들의 제한된 기능을 보완하고 동시에 새로운 기능들을 추가한 새로운 XML 데이터 생성기인 "WeXGene"을 제안한다. WeXGene은 열 단위 또는 행 단위의 데이터를 포함하는 사용자 데이터 화일 및 "SDTD(Symbolic DTD)" 또는 입력 파라미터를 명시한 구조 정의 화일을 이용하여 XML 데이터를 생성한다. 또한 사용자 데이터 화일 없이도 임의의 데이터론 포함하는 XML 데이터 생성이 가능하다. 본 논문은 WeXGene의 구체적인 설계 내용, 구조, 데이터 생성과정 등을 기술한다. 또한 타 XML 데이터 생성기와 기능을 비교 분석하였다. We need XML generate various kinds of XML data to evaluate XML database systems. Existing XML data generators are developed to generate XML data that are suitable for particular evaluation methods, and their functionalities are limited in terms of generating XML data This paper introduces a new XML data generator, WeXGene, that not only improves the drawbacks of existing data generators but also adds new data generation functionalities. For generating XML data WeXGene uses the user data files and the structure definition files, which specify SDTD(Symbolic DTD) or input parameters. The user data file is a text data file that has column data or row data. It is also possible that WeXGene generates XML data without accessing the user data file. This paper presents the design details, overall system architecture, and data generation process of WeXGene. An analytic comparison with other XML data generators is also presented.

다중빔음향측심자료를 이용한 침몰선박 주변 해양지질학적 변화 연구

신선미(Sun Mi Shin),정자헌(Ja Hun Jung),백승균(Seung Gyun Baek),서영교(Young Kyo Seo),장태철(Tae Cheol Jang),범주원(Ju Won Beom),김세훈(Se Hun Kim) 한국해양환경·에너지학회 2022 한국해양환경·에너지학회 학술대회논문집 Vol.2022 No.11

암환자가족이 지각하는 수술대기중 불안과 불확실성 및 의료인의 지지

신선미(Shin Sun-Mi),이은남(Lee Eun-Nam),강지연(Kang Ji-Yeon) 대한종양간호학회 2006 Asian Oncology Nursing Vol.6 No.1

Purpose: This study was to assess relationships among the uncertainty, medical staff's support, and anxiety perceived by family members with cancer patients while the family members were waiting for their patients undergoing surgery. Method: The data were collected from the family members of cancer patients who were undergoing surgery in D University Hospital at B city from February 1 to April 12, 2005. The used instruments were the State Anxiety Scale of Spielberger's(1975) STAI, Mishel's Uncertainty in Illness Scale (MUIS)(1981), and Relationship Questionnaires (Lee, 1978). The collected data was analyzed by using t-test, ANOVA, Pearson's coefficients, and stepwise multiple regression. Results: As the result, the most influential variable explaining anxiety of family members was uncertainty (ß=0.37), followed by perceived illness state (ß=-0.27). These two variables simultaneously explained 29.3% of the variance in anxiety. Conclusion: We suggest to develop a nursing intervention program to reduce the uncertainty through the medical staff's support and to test its effects.

『동의수세보원(東醫壽世保元),성명론(性命論)』의 용어(用語) 정의(定義) 및 영역(英譯) 연구(硏究)

신선미 ( Sun Mi Shin ),강구 ( Goo Kang ),백진웅 ( Jin Ung Baek ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.4

Based on the previous translation studies and 『WHO-IST』, we selected terminology, which are required the definition and explanation among jargon expressed in 『Dongeuisusebowon· Discourse on Nature and Act』, and the procedure of the definition, explanation, and translation in Korean and English has been followed. The outcomes of this study are presented as below: First, based on the existing translation studies, Korean and English translation of 『Dongeuisusebowon· Discourse on Nature and Act』is provided. Second, few of Terminology in 『Dongeuisusebowon(東醫壽世保元)』have been written in WHO-IST, even most of them have been standardized in terms of 『Huang Di Nei Jing(黃帝內經)』. Therefore, terminology related to Four-constitution medicine in WHO-IST would be required to be corrected, and unattatched terminology should be added in the future. Third, in order to standardize and globalize Four-constitution medicine, further definition, explanation, and translation studies of the rest of Dongeuisusebowon should be continued.

육미지황탕합이지환가감방(六味地黃湯合二至丸加減方)이 멜라닌 생성과 관련 유전자 발현에 미치는 영향

신선미 ( Sun Mi Shin ),유동열 ( Dong Youl Yoo ) 대한한방부인과학회 2009 大韓韓方婦人科學會誌 Vol.22 No.4