자궁경부도말에서 Atypical Squamous Cells of Undetermined Significance(ASCUS)의 조직학적 및 세포학적인 추적 관찰

신미경,Shin, Mi-Kyung 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

In 1988, The Bethesda System for reporting cervical and vaginal cytologic diagnoses was introduced and this was revised in 1991. The new diagnostic category "atypical squamous cells of undetermined significance(ASCUS)" introduced by The Bethesda System is an area of controversy about the diagnostic category, clinical significance and appropriate treatment. A retrospective 2 years and 9 months study(April, 1994-December, 1996) was performed to evaluate the significance of reporting ASCUS on cervical smears. Sixtyseven(1.17%) of 5,730 smears were diagnosed as ASCUS and 21 cases were followed by cervical biopsies and/or endocervical curettages in 4 cases(19%), and repeat cervical smears in 17 cases(81%). Tissue diagnoses were benign in 2 cases and squamous cell carcinoma in situ in 2 cases. Cytologic diagnosis of follow up smear were negative in 14 cases(82.4%) and persistent ASCUS in 3 cases(17.6%).

C5210-H(HP)와 NKT322-EH 소재의 협피치 커텍터에서 단조 가공에 의한 소재 폭 변화에 관한 연구

신미경,이춘규,Shin, Mi-Kyung,Lee, Chun-Kyu 한국금형공학회 2020 한국금형공학회지 Vol.14 No.3

As devices such as smartphones, tablet PC, and wearable devices have been miniaturized, the connectors that go into the devices are also designed to be very small. The connector combines the plug and the receptacle to transfer electricity. As devices are miniaturized, the contact shape is formed by partially thinning the thickness of the raw material of the terminal in order to lower the coupling height of the plug and receptacle. The product used in this study is a receptacle terminal used for 0.4mm pitch board to board connector among fine pitch connectors. When the material thickness is reduced by forging the receptacle terminal, the width change of the pin is checked. To reduce the thickness of the material by forging, pre-notching is applied in the first step, forging in the second step, and notching in the third step. After forming the width dimension of the pin to 0.28 mm in the pre-notching process, in the forging process, the material thickness 0.08 mm and 0.02 mm (25%) were forged and the thickness was changed to 0.06 mm and the width change amount of the pin was measured. The facility produced 10,000 pieces at 400 SPM using a Yamada Dobby (MXM-40L) press, and thirty pins were measured and the average value was shown. After forging by using C5210-H (HP) and NKT322-EH, which are frequently used in connectors, analyze the amount of change in each material. The effect of punching oil on forging is investigated by appling FM-200M, which is highly viscous, and FL-212, fast drying oil. This study aims to minimize mold modification by predicting the amount of material change after forging.

부비동과 비의 미분화 암종 - 1예 보고 -

신미경,채양석,Shin, Mi-Kyung,Chae, Yang-Seok 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1

Sinonasal undifferentiated carcinoma(SNUC) is a distinct, relatively rare neoplasm arising in the nasal cavity and paranasal sinuses composed of undifferentiated epithelial cells and clinically characterized by a fulminant course. We report a case of SNUC in a 56-year old man who have had bilateral neck masses since one month ago before coming to our hospital. The paranasal computed tomography showed soft mass density in the left maxillary sinus and the nasal cavity with bone destruction in the anterior medial and the inferior maxillary sinus wall. This mass was extruded into the left orbital wall. Biopsy of the nasal mass and fine needle aspiration(FNA) of the neck mass were done. FNA revealed medium-sized neoplastic cells forming clusters or individually dispersed. Nuclei were round to oval, slightly to moderately pleomorphic, and hyperchromatic. Chromatin was finely granular, but occasionally was coarsely granular. Nucleoli varied from large to inconspicuous and the cytoplasm was scanty.

Heme 산화효소 발현 유도체로서 Isoflavone-Free 검은콩 펩타이드의 항고혈압 활성

신미경(Mi-Kyung Shin),권용현(Yong-Hyun Kwon),안창원(Chang-Won Ahn),신동석(Dong-Seok Shin),박수현(Soo-Hyun Park),최보화(Bo-Hwa Choi),홍순선(Soon-Sun Hong),강주희(Ju-Hee Kang),박창신(Chang-Shin Park) 대한약학회 2012 약학회지 Vol.56 No.3

We previously reported that the novel isoflavone-free peptide mixture (black soybean peptide, BSP) had several beneficial effects like antiobesity and hypotriglyceridemic effect. However, there are no reports for BSP on anti-hypertensive activity. BSP induced heme oxygenase-1 (HO-1) in HUVECs, thus investigated the HO-1-induced activity in HUVECs and the anti-hypertensive effects in SHR animal model. BSP significantly induced HO-1 expression both at transcriptional and protein levels in a time- and dose-dependent manner as measured by RT-PCR and Western blot analysis, respectively. These inductions were abolished by pretreatment of N-acetyl-cystein (NAC, 1~10 mM), but not by employing Tempol, a superoxide dismutase (SOD) mimetic (1~5 mM). As expected, enzymatic activity (~2 fold) determined by bilirubin formation assay and cGMP concentration (~6 fold) were significantly increased in BSP-treated cells. Based on the numerous evidences on the beneficial effects of HO-1 and our results, we investigated in vivo effects of BSP on the antihypertensive activity. The administration of BSP (1% in drinking water) significantly decreased mean blood pressure (BP) (from 218.6±6.99 to 190.0±3.42 mm Hg, p<0.01). This result indicates that BSP is strong inducer of HO-1 expression, which may be triggered by oxidative stress, and has anti-hypertensive activity.

하수조(何首鳥)의 품질인증 방안

신미경 ( Mi Kyung Shin ),노성수 ( Seong Soo Roh ),길기정 ( Ki Jeong Kil ),서부일 ( Bu Il Seo ),서영배 ( Young Bae Seo ) 대전대학교 한의학연구소 2004 혜화의학회지 Vol.13 No.2

토마스 핀천의 『메이슨 & 딕슨』에 나타난 지도그리기의 탈식민적 함의

신미경 ( Mi Kyung Shin ) 한국영미문화학회 2002 영미문화 Vol.2 No.1

Syntactic Priming Effects on Active and Passive Sentence Production in Persons with Aphasia: Evidence from an Eye-tracking Study

신미경(Mi Kyung Shin),성지은(Jee Eun Sung) 한국언어청각임상학회 2020 Communication Sciences and Disorders Vol.25 No.1

배경 및 목적: 본 연구는 구문 점화 과제에서 정상 성인과 실어증 환자의 능동 및 피동 문장 산출 과정을 시선추적기를 활용하여 분석해 봄으로써 실어증 환자의 능동문과 피동문 산출 능력에 대해 알아보고자 하였다. 방법: 본 연구의 대상자는 실어증 환자 9명과 정상 성인 10명이었다. 동일한 구문구조의 점화 문장을 먼저 제시하여 목표 문장의 산출을 촉진하는 구문 점화 과제를 사용하였다. 정반응률과 문장 산출 반응시간이 분석되었으며, 시선추적 분석은 문장 산출 구간(Before onset, NP1, NP2, V-End)별로 관심 영역(행위자, 대상)에 대한 시선고정 횟수가 분석되었다. 결과: 실어증 환자는 능동문과 피동문 산출에서 정상 성인에 비해 정반응률이 유의하게 낮았고, 문장을 산출하는데 유의하게 더 오랜 시간이 걸리는 것으로 나타났다. 시선추적 분석 결과, 능동 및 피동형 점화 문장 조건에서 실어증 환자의 정반응은 정상 성인의 정반응과 비슷한 시선고정 패턴을 보이는 것으로 나타났으나, 실어증 환자의 오반응은 정상 성인과 실어증 환자의 정반응에서 나타나는 시선고정 패턴과 다르게 나타났다. 논의 및 결론: 실시간 처리과정을 살펴본 결과, 실어증 환자들은 능동문과 피동문 산출에 있어서 정반응을 할 때 정상 성인의 정반응과 유사하게 ‘대상’을 ‘행위자’보다 유의하게 더 오랫동안 응시하는 시선고정 패턴을 보이지만, 오반응을 할 때에는 이와 같은 시선고정 패턴이 나타나지 않아 실어증 환자들에게서 나타나는 문장처리의 어려움을 확인할 수 있었다. Objectives: The purpose of this study was to investigate active and passive sentence production ability in aphasia by analyzing the process of sentence production under conditions of syntactic priming using eye-tracking. Methods: Nine patients with aphasia and ten age and education matched normal adults participated in this study. Participants repeated prime sentences first, and then described picture events using the same verb. Accuracy and speech onset latencies from speech regions (NP1-NP2-V-End) were analyzed and fixation count of areas of interest (Agent, Theme) from speech regions (Before onset, NP1, NP2, V-End) were analyzed for eye movement measurement. Results: Aphasic patients performed significantly less accurately than normal adults in both active and passive sentences; and they also took significantly longer to produce both type of sentences accurately. Similar fixation pattern was found between normal adults and aphasic patients when they made correct responses. However, when aphasic patients made wrong responses, the fixation pattern was different from correct responses’ in normal adults and aphasic patients. Conclusion: The results of eye movement measurements suggests that eye movements of aphasic patients were similar to those of normal adults in correct response; fixating ‘Theme’ more than ‘Agent’. On the other hand, in the case of incorrect responses, eye movements of aphasic patients were different from those of normal adults; indicating that aphasic patients have difficulties in processing active and passive sentence.

개인화(Personalization)가 초등영어 학습자의 의사소통 능력 및 정의적 영역에 미치는 영향

신미경(Shin, Mi-Kyung),권영환(Kwon, Yung-Hwan) 한국영어교과교육학회 2013 영어교과교육 Vol.12 No.3

The purpose of this study is to examine the effect of personalized lessons on elementary school students’ communicative competence and on their attitudes towards English learning. For this purpose, the results were analyzed quantitatively and qualitatively. The quantitative analysis was measured using a speaking test, communication skills test and the students’ questionnaires which measured their interest, confidence, anxiety and motivation in English learning. The qualitative analysis was measured by the student feedback and the teacher’s observation journal. Two 5th grade classes (49 students in total) were asked to participate in the study, and were divided into a control group and an experimental group. Students from the control group engaged in learning English according to the textbook based on the 2009 Revised National Curriculum, whereas students from the experimental group participated in personalized English lessons twice a week. The experiment was carried out for a total of twelve weeks. The results of this study found that, with respect to the learner’s communicative competence, the quantitative data and the qualitative data show a statistically significant difference in the learner’s speaking and writing skills. Furthermore, the personalized lessons were effective in raising the learner’s interest, confidence and the expectation for the subject of this study. With this basis, this study suggests that teachers plan and make lessons that reflect the learners’ personal realities in their daily lives. This will then improve their communicative skills and change their attitudes towards learning English into positive ones, so it is beneficial for teachers to make their lessons personalized and relevant for their students.

함초를 첨가한 두부의 이화학적 특성 및 항산화성

신미경 ( Mi Kyung Shin ),김명희 ( Myung Hee Kim ),홍금주 ( Geum Ju Hong ) 한국식품조리과학회(구 한국조리과학회) 2013 한국식품조리과학회지 Vol.29 No.2

함초를 첨가가 두부 제품의 이화학적 특성과 항산화성에 미치는 영향을 알아보기 위해 함초를 4%~20%까지 첨가하여 이화학적 특성과 항산화성의 변화를 측정한 결과를 요약하면 다음과 같다. 수분함량과 조단백질은 모든 시료간에 차이를 보이지 않았으며, 조회분과 조지방이 함초 20%를 첨가한 두부가 가장 높게 나타났다. Fe과 K, Mg 및 Zn 함량은 함초 20%를 첨가한 두부가 가장 높게 나타났으며, Ca 함량은 함초 16%, 20%를 첨가한 두부가 높게 나타났다. 함초의 첨가량이 증가 할수록 Ca, Fe, K, Mg, Zn 함량이 증가하는 경향을 보이고 있다. DPPH radical 소거활성은 식품의 항산화력을 측정하는 방법으로서, 함초즙을 10배로 희석한 후 측정한 DPPH 의 값은 79.20으로 나타났으며, 두부는 함초 20%를 첨가한것이 높게 나타났다. 함초의 첨가량이 증가할수록 높은 소거활성을 보였다. 이상의 결과를 볼 때 함초를 16%~20% 첨가하여 제조한 두부가 저장성 및 항산화성이 좋은 것으로 나타 났으며, 이는 두부제조에서 함초 첨가는 두부의 저장성 및 항산화성에 영향을 주어 제품의 품질 향상에 기여함을 알 수 있었다. In this study the physiochemical characteristics and antioxidant activity of soybean curd were prepared with saltwort (Salicornia herbacea L.). The moisture and protein of the saltwort soybean curd showed no difference among the samples. Ash and lipid were found to be the highest in the soybean curd to which 20% saltwort was added. The contents of mineral(Fe, K, Mg, Zn) were highest in the soybean curd to which 20% saltwort was added, and Ca content was high in the soybean curd to which 16% and 20% saltwort was added. DPPH (1,1-dipheny1-2-picryl-hydrazyl) radical scavenging activity is a method of measuring the antioxidant power of food; this was high in the soybean curd to which 20% saltwort was added. Adding more saltwort led to higher scavenging activity. From the above results, it could be seen that the soybean curd, which is made by adding saltwort, contributed to enhancing the functionality of antioxidant activation and product quality.

홀리스틱 교육 관점을 토대로 한 사회적 공격성 척도개발 및 타당화

신미경(Shin, Mi Kyung),이지연(Lee, Jee Yon) 한국홀리스틱융합교육학회 2008 홀리스틱융합교육연구 Vol.12 No.3

이 연구의 목적은 Galen과 Underwood(1997)의 사회적 공격성 개념에 기초하여, 초등학생 여아의 사회적 공격성을 측정하는 사회적 공격성 척도를 개발하기 위한 목적으로 이루어졌다. 이를 위해 국내의 여아의 공격성에 관련된 연구와 사회적 공격성에 관련된 국외연구들을 참고하여 이론적 구인체계를 구성하고 문항을 작성하여 인천․경기도에 소재한 초등학교 4․5․6학년 여아들에게 예비검사와 본 검사를 실시한 결과를 분석하였다. 예비검사와 본 검사 자료 수집결과를 분석하여 최종적으로 3요인, 29문항으로 구성된 초등학교 여아의 사회적 공격성 척도를 개발하였다. 또한 척도의 준거- 관련 타당도를 검정하기 위해 사회 심리적 적응 및 정서조절과의 상관분석을 수행하였는데, 그 결과 사회적 공격성은 공격적 표현을 하는 정서조절과는 높은 상관관계를 나타내었지만, 사회심리적 적응과는 사회적 공격성의 하위요인인 부정적 신체표현만이 유의미한 상관관계를 나타냈다. 마지막으로 이 연구의 제한점과 앞으로의 연구방향을 홀리스틱 교육의 관점에서 논의하였다. The primary purpose of this study is to develop social aggression scale, based on social aggression definition by Galen and Underwood. Theoretical systim on social aggression definition organized, considering definitions by Galen and Underwood and new items for this study are created. 311 girls of elementary school students in Metropolitan area was surveyed. validity is verified by doing pilot survey and regular surveyed. social aggression scale, which are composed of three factors with 29 items show high correlation between items. Reliability from inter-item consistency reliability is also high. correlation analysis suggests that social aggression has strong interrelationship with emotion regulation. Finally, the study's limits and further discussion are suggested.