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- 저자 : 송주홍(Ju Hung Song) (검색결과 11 건)
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안선호(Seon Ho Ahn),이재홍(Jae Hong Lee),이명수(Myeung Su Lee),송주홍(Ju Hung Song),이성근(Seong Keun Lee) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
Microscopic polyangiitis is a systemic small vessel vasculitis, which, although primarily associated with necrotizing and crescentic glomerulonephritis and pulmonary capillaritis, often has cutaneous and muscul-oskelectal features. Microscopic polyangiitis is strong]y associated with antineutrophil cytoplamic autoantibody that are a useful diagnostic serologic marker for the most common form of necrotizing vasculitis, and that have two patterns(C-ANCA and P-ANCA). We have experienced a case of microscopic polyangiitis with purpurae on both lower extrimities, C-ANCA positive and cresent formation on renal biopsy, which had no history of asthma and no pathologic evidence of granuloma. In our case, deterioration of renal function was recovered after steroid pulse therapy.
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저나트륨증을 동반한 Wernicke`s encephalopathy
안선호(Seon Ho Ahn),이재홍(Jae Hong Lee),이명수(Myeung Su Lee),송주홍(Ju Hung Song),이성근(Seong Keun Lee),박병현(Byoung Hyun Park),구기선(Ki Seon Gu) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1
Thiamine deficiency is known to lead to certain neurologic sequales including Wernicke-Korsakoff syndrome. Wernicke's encephalapathy is charac-terized by ataxia, ophthalmoplegia, nystagmus, and mental change. Although classically associated with chronic alcoholism, a number of other predisposing conditions exist such as hyperemesis gravidarum, thyrotoxicosis, starvation, anorexia nervosa, prolonged total parenteral nutrition, gastric plication and renal dialysis. We have experienced a case of Wernicke's encephalopathy associated with prolonged starvation which was misdiagnosed by hyponatremic ence-phalopathy at first, and which seemed to be developed by thiamine-free dextrose infusion in 39-year-old male patient. We report the case with review of the literature and emphasize the need for thiamine supplementation with slow correction of hyponatremia before the infusion of dextrose solution in the prolonged starved hyponatremic patient.
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사람 근위세뇨관 세포에서 고밀도지단백의 Endothelin-1 분비 효과에 대한 칼슘통로차단제의 영향
안선호,송주홍 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.5
Background:Human high density lipoprotein (HDL) is known to stimulate endothelin-1(ET-1) production through the phospholipase C(PLC)/Ca2?/ protein kinase C(PKC) pathway. Calcium channel blockers may be involved in the decrease of HDL- induced ET-1 production. This study was designed to evaluate whether HDL-induced ET-1 production was affected by Ca2? channel blockers in cultured human proximal tubular cells(PTC). Methods:The human PTC were obtained from human nephrectomized tissues, and cultured in six different media, which were bovine serum free(SF) DMEM/F12 medium alone, and five other SF DMEM/F12 media with 200?g/ml of HDL, with 200?g/ml of HDL and each 10?M of diltiazem, nifedipine, and verapamil solved in 100% ethanol 0.1 volume%, and with 200?g/ml of HDL and 0.1 volume% of 100% ethanol as a control. After 24 hours of exposure, ET-1 in the supernatant was measured by radioimmunoassay, and ET-1 level in each well were marked as pg ET-1/mg cell protein/ 24 hr in consideration of cell count. Result: In SF medium, ET-1 production was 1.803±0.295pg/mg cell protein/24 hr. In SF medium with 200μ±g/ml of HDL, ET-1 production significantly increased from 1.803±0.295 to 10.860±0.476 pg/mg cell protein/24 hr(P$lt;0.05). In SF medium with 200μg/ml of HDL and 100% ethanol 0.1 volume%, ET-1 production significantly decreased from 10.860±0.476 to 6.700±1.273pg/mg cell protein/ 24 hr(P$lt;0.05). In SF media with 200μg/ml of HDL and each 10μM of diltiazem, nifedipine, and verapamil solved in 100% ethanol 0.1 volume%, ET- 1 production was decreased from 6.700±1.273 to 4.043±1.550 by diltiazem(P$lt;0.05), to 3.260±0.752pg/ mg cell protein/24 hr by verapamil(P$lt;0.05), and to 4.414?1.567pg/mg cell protein/24 hr by nifedipine (P=0.067). Conclusion:These results suggest that the HDL-induced ET-1 production in cultured human PTC was significantly decreased by diltiazem and verapamil, and it seemed to be decreased by nifedipine.
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만성 신부전 환자에서 혈액 투석 전후 좌심실 기능에 관한 연구
채수인,송주홍,박옥규 圓光大學校 醫科學硏究所 1990 圓光醫科學 Vol.6 No.1-2
Renal failure is often associated with electrolyte imbalance, anemia, hypertension, volume overload, metabolic acidosis, increase in parathyroid hormone level, all of which may contribute to the development of left ventricular dysfunction. To evaluate the left ventricular function in chronic renal failure patients undergoing maintenance hemodialysis and to assess the effect of hemodialysis on cardiac function, 13 normal subjects, 11 essential hypertensive and 15 chronic renal failure patients were examined with two dimensional and targeted M-mode echocardiograms, Doppler echocardiogram and indirect carotid pulse tracing. In hemodialysis patients, these were recorded pre and post-hemodialysis. The results were as follows : With hemodialysis, body weight decreased from 57.9±9.2 to 55.2±9.0 ㎏ (p<0.05) without a change in heart rate. LV end-diastolic dimension, an index of preload, was larger in chronic renal failure patients than in control and hypertensive group (5.96±0.78 vs. 5.00±0.47 ㎝ ; p=0.11, 5.30±0.83 ㎝ ; p=0.25), decreased by 3.5 % with dialysis. Left ventricular end-systolic dimension was also larger in chronic renal failure patients than in control and hypertensive group (4.25 ±0.74 vs. 3.52±0.34 ㎝ ; p<0.05, 3.36±0.68 ㎝ ; p<0.05, decreased by 6.0 % with dialysis. There was no difference in the thickness of ventricular septum among control, hypertensive and chronic renal failure groups. End-systolic and end-diastolic LV posterior wall were thicker in chronic renal failure patients than in control and hypertensive group (1.22±0.18 vs. 1.06±0.10 ㎝ ; p=0.12, 1.18±0.21 ㎝ ; p=0.62 in end systolic wall thickness and 0.81±0.15 vs. 0.58±0.07 ㎝ ; p=0.05, 0.66±0.16 ㎝ ; p<0.05 in end diastolic wall thickness), increased by 4 %, 2% with dialysis respectively. There was ventricular hypertrophy as demonstrated by an LVMI of 239.3±80.4 g/㎡, which was significantly higher than control (123.5±33.9 g/㎡) and hypertensive group (122.2±36.1 g/㎡). End-systolic wall stress, a measure of LV afterload, was greater in chronic renal failure and hypertensive group than in control (136.9±51.0, 112.7±26.5 vs. 91.7±9.6 g/㎝ ; p<0.05, respectively) and decreased by 18.8 % with dialysis. Percent fractional shortening (%△D) and LV rate-corrected velocity of fiber shortening (mVcfc) were lower in chronic renal failure patients than in control and hypertensive group (24.4±5.1 vs. 29.4±4.8 % ; p=0.16, 32.6±4.5% ; <0.05 in %△D and 0.84±0.22 vs. 0.94±0.17 circ/sec ; p=0.17, 1.06±0.19 circ/sec ; p<0.05). There was small increase (8%) in %△D with dialysis. In contrast, mVcfc increased significantly from 0.84±0.22 to 1.04±0.19 cire/sec(p<0.05) with the procedure. δes was inversely related to end-systolic wall stress in linear fashion. A_2D was the longest in the hypertensive group, linger in chronic renal failure patients than in control group (100.7±31.1 vs. 88.8±22.7 msec ; p=0.27). There was no change in A_2D with hemodialysis. PE was faster in chronic renal failure parients than control and hypertensive group (0.85±0.19 vs. 0.70 ±0.19 m/sec ; p<0.05, 0.63±0.11 m/sec ; p<0.05), PA was faster in hypertensive group and chronic renal failure patients than in control group (0.68±0.12, 0.79±0.27 vs. 0.44±0.16 m/sec ; p<0.05, respectively). With hemodialysis, there was significant decrease in PE (0.85±0.19 vs. 0.71±0.15 m/sec ; p<0.05), but no change in PA (0.79±0.27 vs. 0.76±0.20 ; p=0.97). E/A ratio was higher in control group than in chronic renal failure patients and hypertensive group (1.61±0.45 vs. 0.93±0.22 ; p<0.05, 1.15±0.32 ; p<0.05), decreased from 1.15±0.32 to 1.00±0.27 ; p=0.17) with hemodialysis. There was no difference in decceleration time among groups. Parathyroid hormone level was higher in chronic renal failure patients than in control and hypertensive group (1.36±1.30 vs. 0.21±0.07 ; p<0.05, 0.21±0.17 ; p<0.05). As the results of above, left ventricular mass index(LVMI), end-diastolic dimension(preload) and end-systolic wall stress(afterload) were increased in chronic renal failure(CRF) patients. mVcfc, index of myocardial performance was decreased in CRF patients, but the decrease in mVcfc in CRF patients was not so much as expected from the relation between δes and mVcfc in control group. This suggest that left ventricular contractile state in CRF undergoing maintenance hemodialysis is preserved relatively well. With hemodialysis, mVcfc increased significantly. LV contractility, as determined by the load-independent relation between δes and mVcfc, did not change. So this increase in mVcfc in thought to be due to the decrease in afterload rather than enhanced contractile state with hemodialysis. Viewed from the A_2D and E/A ratio, left ventricular diastolic function was impaired in CRF patients, did not improved with dialysis.
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이재홍,안선호,이명수,송주홍 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.4
Systemic sclerosis is a generalized connective tissue disorder. It is characterized by fibrosis, degenerative changes and vascular lesions affecting the skin, joints, skeletal muscles and multiple internal organs. Clinical renal disease in systemic sclerosis ranges from scleroderma renal crisis to more subtle abnormalities. Scleroderma renal crisis is characterized by malignant hypertension and rapidly progressive renal failure. It can be successfully treated with angiotensin converting enzyme inhibitors, but remains the most feared complication of systemic sclerosis. We have experienced a 57 year old female patient who visited emergency room with a sudden onset of mental deterioration, azotemia and oliguria. She was under symptomatic treatment for Raynaud's phenomenon for 2 years. Renal biopsy of the patient showed onion-skin configuration in the interlobular arteries which is characteristic of scleroderma renal crisis. She proceded to maintenance hemodialysis despite a angiotensin converting enzyme inhibitor treatment. We report a case of SRC with a brief review of literature.
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이재홍,김학렬,안선호,나용호,서검석,이명수,최석재,송주홍 대한내과학회 1998 대한내과학회지 Vol.55 No.3
Methylbromide has been widely used of recent years in fire extinguishers for ships and aircraft and in refrigeration plants. because it exists as a gas at ordinary temperatures, most exposures occur by inhalation and absorption through the skin. The principal manifestations in acute poisoning depend on amount ingested or the concentration inhaled or absorbed. If the amount is large or concentration high, nausea, vomiting, vertigo, weakness, drowsiness, hypotention, coma, convulsion and pulmonary edema may occur after a latent period of up to 12 hour. After exposure to lower concentrations, symtoms are less severe and may be delayed twelve to twenty-four hours. We experienced 3 cases of acute methylbromide intoxication after inhalation. Of them, 2 patients with coma and convulsion were managed by mechanical ventilatior, anticonvulsant, hemodialysis and BAL, but they expired on 4th, 5th hospital day. We report them with review of literature.
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