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송영신,오태정,김경민,문재훈,최성희,장학철,박경수,임수 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.1
Background: The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the treatment of blood cholesterol recommends statin therapy for individuals at high risk of atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate serial trends in the percentages of Korean adults considered eligible for statin therapy according to the new ACC/AHA cholesterol guideline. Methods: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998, n=7,698), II (2001, n=5,654), III (2005, n=5,269), IV (2007 to 2009, n=15,727), and V (2010 to 2012, n=16,304), which used a stratified, multistage, probability sampling design, were used as representative of the entire Korean population. Results: The percentage of adults eligible for statin therapy according to the ACC/AHA cholesterol guideline increased with time: 17.0%, 19.0%, 20.8%, 20.2%, and 22.0% in KNHANES I, II, III, IV, and V, respectively (P=0.022). The prevalence of ASCVD was 1.4% in KNHANES I and increased to 3.3% in KNHANES V. The percentage of diabetic patients aged 40 to 75 years with a low density lipoprotein cholesterol levels of 70 to 189 mg/dL increased from 4.8% in KNHANES I to 6.1% in KNHANES V. People with an estimated 10-year ASCVD risk ≥7.5% and aged 40 to 75 years accounted for the largest percentage among the four statin benefit groups: 9.1% in KNHANES I and 11.0% in KNHANES V. Conclusion: Application of the 2013 ACC/AHA guideline has found that the percentage of Korean adults in the statin benefit groups has increased over the past 15 years.
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
송영신,임정아,박영주 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.3
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians.
Cu(3-amino-1-propanol)X_2 (X=C1, Br)의 분광학 및 자기적 성질
송영신,박윤창 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1
The Spectral and magnetic properties of [Cu(3-amino-1-propanol)X]_2 where X=Cl and Br have been studied and are compared with those of dimeric copper (Ⅱ) acetate monohydrate. The exchange interaction parameter J of [Cu(3-amino-1-propanol)Cl]_2 is estimated to be 391cm^-1, the zero field splitting parameters are D=0.438cm^-1 and E=0cm^-1. On the other hand the magnetic parameters of [Cu(3-amino-1-propanol)Br]_2 can not be obtained because its EPR spectrum shows only one absorption line that is broad and superimposed with the line due to monomer. The calculated Cu-Cu distance is 2.81Å. The super exchange interaction through alkoxo bridge is considered to be dominant rather than the direct exchange interaction through copper-copper. The visible, infrared and far-infrared spectra of these compounds are also discussed.