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손현진,김창훈 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES To examine the effect of individual and area-level characteristics on the probability of public-private mix (PPM) support (PPM coverage) for tuberculosis (TB). METHODS This study is a retrospective cohort design using TB reporting and treatment management data in Korea. We analyzed PPM coverage through multilevel logistic regression and empirical Bayesian estimation according to individual and area-level characteristics and their interaction. RESULTS Patients aged 0-29 years, women, of Korean nationality, treated at a general hospital, a one-time reporting, urban areas, and the lowest deprivation index (DI) showed higher PPM coverage. Due to the cross-level interaction, PPM coverage in the urban areas (slope=-0.048, p<0.001) had a higher level but a steeper negative deprivation gradient than in rural areas (slope= -0.015, p<0.001). For a general hospital, the PPM coverage in urban is high but more significantly decreased than in rural areas with the higher DI (urban: slope=-0.047, p<0.001; rural: slope=-0.031, p<0.001). For clinics and hospitals, the effect of DI did not appear in urban areas, but in rural areas, the higher the DI, the higher the PPM coverage with a slope of 0.046 (p<0.001) and 0.063 (p<0.001), respectively. CONCLUSIONS The PPM program created a significant disparity in PPM coverage between urban-rural areas and type of healthcare provider according to DI. Considering the high risk of TB incidence in areas with higher DI, institutional improvement and program redesign are needed to improve accessibility and equity.
난소의 상피성 종양에서 c-erb B2 단백발현에 관한 연구
손현진,홍성직,이영직,이동근,정명자,최호열 의과학연구소 1998 全北醫大論文集 Vol.22 No.2
In the present study, immunohistochemical detection of c-erb B2 oncoprotein was performed to determine whether the histological type, histologic grades of malignancy(benign, borderline, or malignancy), and clinial stage can be related to degree of c-erb B2 oncoprotein expression. Paraffin section of 36 cases of serous tumor and 22 cases of mucinous tumor were examined for the overexpression of c-erb B2 oncoprotein by peroxidase immunohistochemistry. The obtained results were as follows : 1. All benign and borderline epithelial ovarian tumors showed negative staining for c-erb B2 oncoprotein. 2. C-erb B2 was expressed in 9 of 26 cases (34.6%) of malignant serous tumors, and 4 of 12 cases(33.3%) of malignant mucinous tumors. 3. C-erb B2 was expressed in 1 of 7 cases(14%) of histologic grade Ⅰ, 6 of 12 cases(505) of grade Ⅱ, and 2 of 7 cases(29%) of grade Ⅲ in malignant rumors. 4. The rate of expression of c-erb B2 was positively related with clinical stages [Ⅰ(12.5%), Ⅲ(40%, Ⅳ(44.4%)] but it is not statistically significant. According to the above results, the expression of c-erb B2 does not apear to be correlated with histologic type, histologic degrees of malignancy, histologic grade, and clinical stage of epithelial ovarian tumors. Further studies are needed for determining the role of c-erb B2 oncoprotein in the progression of epithelial ovarian tumors.
손현진,김미경,김현자,김호,최보율,Son, Hyun-Jin,Kim, Mi-Kyung,Kim, Hyun-Ja,Kim, Ho,Choi, Bo-Youl 대한예방의학회 2008 예방의학회지 Vol.41 No.6
Objectives: This study was performed to assess the association between physical activity and the clustering of metabolic abnormalities among Korean children. The effect of substituting moderate to vigorous physical activity for the time spent in inactivity was examined as well. Methods: The study subjects were comprised of 692 (354 boys, 338 girls) 4th grade elementary school students. We used a modified form of the physical activity questionnaire that was developed in the Five-City Project. The subjects with clustering of metabolic abnormalities were defined as having two or more of the following five characteristics: waist circumference ${\geq}90\;%$, systolic or diastolic blood pressure ${\geq}90\;%$, fasting glucose ${\geq}110\;mg/dl$, triglycerides ${\geq}110\;mg/dl$ and HDL cholesterol ${\geq}40\;mg/dl$. We calculated the odds ratios to assess the effect of substituting moderate to vigorous physical activity for time spent in inactivity. Results: The risk of clustered metabolic abnormalities was inversely correlated with the increased time spent on moderate to vigorous physical activity, but the correlation was not significant. The odds ratio for clustering of metabolic abnormalities that represented the effect of substituting moderate to vigorous physical activity for 30minutes of sedentary activity was 0.87(95% Cl=0.76-1.01). Conclusions: These findings suggest that substituting moderate to vigorous physical activity for sedentary activity could decrease the risk of clustered metabolic abnormalities.
손현진 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2
Ameloblastic carcinoma is an ameloblastoma wi th histological malignant transformation with 01' without metastatic di sease_ We report an ameloblastic carcinoma ex ameloblastoma of right mandibular body in 7 -year-old girl with a heterogeneo us hi stologic components_ The tumor s howed so lid s heets composed of atypical kerati nized squamous cells. small ovoid cell s. and s pind le cells in addi tion to a bit of beni gn ameloblastoma component_ Immunohis tochemically, the squ amous cells were strongly cytokemtin posi ti ve/vimentin negati ve and the small ovoid and spindle ce lls were weakJy cytokeratin positi ve/v imentin pos it ive_
장간막에서 발생한 염증성 근섬유모세포종의 세침흡인 세포학적 소견 - 1예 보고 -
손현진,김주헌,문우성,최호열,강명재,Son, Hyun-Jin,Kim, Joo-Heon,Moon, Woo-Sung,Choi, Ho-Yeul,Kang, Myoung-Jae 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1
Since inflammatory myofibroblastic turner was initially recognized in the lung, this tumor has been described in other extrapulmonary sites. In spite of relatively uniform histologic findings in various organs, a rarity in extrapulmonary sites and highly vascular characteristics frequently lead to a misdiagnosis in preoperative radiology and fine needle aspiration cytology. We present a case of inflammatory myofibroblastic tumor occurring in the mesentery of a 4-month-old girl. Fine needle aspiration cytology smear disclosed characteristic spindle cells intermixed with prominent mature plasma cells and lymphocytes. According to the immunohistochemical staining, we recognized that the intervening spindle cells are myofibroblasts which have reactivity for the both actin and vimentin.
사형 주조 3D 프린팅용 소재의 기계적 특성 및 신뢰성
손현진,장성완,이환종,양정직,정영근,배창준,Son, Hyeon Jin,Jang, Seongwan,Lee, Hwan Jong,Yang, Jeong Jik,Jeong, Yeong Geun,Bae, Chang-Jun 한국재료학회 2020 한국재료학회지 Vol.30 No.1
Sand casting 3D printing uses a binder jetting method to produce a mold having complicated shape by spraying a binder on sand coated with activator. Appropriate heat treatment process in sand mold fabrication can increase the degree of polymerization to improve flexural strength. However, long heat treatment of over 24 hours decreases flexural strength and reliability due to chemical bond decomposition through thermal degradation. The main role of the activator is to control the reaction rate between the polymer chains. As a result, when the activator composition is increased from 0.15 wt% to 0.25 wt%, the flexural strength is increased by 218 N/㎠. However, excess activator (0.40 wt%) has been shown to decrease reliability without increasing flexural strength. The main role of the binder is to control the flexural strength of the specimen. As the binder composition is increased from 2.00 wt% to 4.00 wt%, the flexural strength increases to about 255 N/㎠, indicating the maximum flexural strength increase. Finally, the reliability of the flexural strength of the fabricated specimens is evaluated by a Weibull plot. Weibull modulus calculations are used to evaluate the flexural strength reliability of the specimens, and maximum reliability value of 11.7 is obtained at 0.20 wt% activator composition. Therefore, it is confirmed that this composition has maximum flexural strength reliability.
손현진,정재신,문우성,강명재 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.3
The diagnosis of mucinous adenocarcinoma of the prostate (MAP) requires that at least 25% of the tumor consists of pools of extracellular mucin. According to the above criteria, MAP is rare and about 70 cases have been reported in literature. Here we report a case of MAP arising in a 70-year-old man. In the present case, the proportion of the mucinous component was up to 95% of the total tumor volume, and Gleason’s score is 8 (4+4). The tumor cells were prostatic specific antigen (PSA)-immunoreactive in mucinous and nonmucinous components. Despite the mucin pools, the tumor cells themselves failed to stain with any of the mucin stains.