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Lipopolysaccharide로 활성화된 RAW264.7세포에서 염증반응사이토카인 발현에 대한 Epigallocatechin gallate의 억제효능연구
서은지(Eun Ji Seo),고준(Jun Go),김지은(Ji Eun Kim),고은경(Eun Kyoung Koh),송성화(Sung Hwa Song),성지은(Ji Eun Sung),박찬규(Chan Kyu Park),이현아(Hyun Ah Lee),김동섭(Dong Seob Kim),손홍주(Hong Joo Son),이충열(Cung Yeoul Lee),이희섭(Hee 한국생명과학회 2015 생명과학회지 Vol.25 No.9
Epigallocatechin gallate (EGCG)는 녹차(Camellia sinensis, green tea)에 포함되어 있는 대표적인 카테킨(Catechin)으로, 당뇨(diabetes), 신경퇴행성 질환(neurodegenerative disorders), 암(cancer), 심혈관계 질환(cardiovascular disease), 비만(obesity) 등의 다양한 임상질환에 우수한 치료효과를 나타내는 것으로 알려왔다. 본 연구에서는 EGCG가 LPS (Lipopolysaccaride)로 자극된 RAW264.7 세포의 염증억제과정에서 Nitric oxide (NO)관련인자와 사이토카인 발현에 미치는 영향을 분석하기 위해, NO농도, inducible NO synthase (iNOS) 발현량, TNF-α, IL-1β, IL-6, IL-10 사이토카인의 발현량을 분석하였다. 먼저, EGCG (100-400 μM)를 처리한 Raw264.7 세포에서 특이적인 독성이 나타나지 않음을 확인하였으며, 이후 Raw264.7 세포에 4가지 다른 농도(0.1, 0.5, 1.0, 5.0 ㎍/ml)의 LPS를 처리한 후 MTT분석, NO농도분석, IL-6농도분석을 실시하여, 염증을 유발할 수 있는 최적 LPS 농도를 1 ㎍/ml로 설정하였다. NO농도를 분석한 결과, LPS를 처리한 그룹이 No그룹에 비하여 급속히 증가하여 63 μ㏖/l까지 증가하였으나 400 μM EGCG를 처리한 그룹에서만 68.2% 정도 감소하였으며, 동시에 iNOS 발현 양상은 200, 400 μM EGCG/LPS 처리 그룹에서 각각 12.3%, 17.4% 감소하였다. 또한, 감소비율에는 차이가 있었으나, anti-inflammatory 사이토카인(IL-1β, TNF-α)과 pro-inflammatory 사이토카인(IL-10)의 발현은 EGCG/LPS 처리에 따라 유의적으로 감소하였다. 그러나, IL-6단백질과 mRNA 농도는 Vehicle/LPS 처리 그룹과 EGCG/LPS 처리 그룹에서 유의적인 차이를 나타내지 않았다. 따라서, 본 연구의 결과는 EGCG가 LPS의 자극에 의해 활성화된 Raw264.7 세포를 효과적으로 억제하는 효능을 나타냄을 제시하고 있으며, 이러한 과정에 사이토카인들이 서로 다르게 특이적 반응을 중계함을 제시하고 있다. Epigallocatechin gallate (EGCG), the main catechin in green tea, has been shown to have some beneficial effects against various human diseases, including diabetes, neurodegenerative disorders, cancer, cardiovascular disease and obesity. To investigate the mechanism of the suppressive effects of EGCG on inflammatory response in macrophages, alterations on the levels of nitric oxide (NO) regulatory factors and inflammatory cytokines were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells. No significant toxicity was detected in RAW264.7 cells treated with 100?400 μM EGCG. Moreover, the optimal concentration of LPS was determined to be 1 ㎍/ml based on the results of cell viability assay, NO assay and IL-6 enzyme-linked immunsorbent assay (ELISA). Furthermore, NO levels decreased significantly by 68.2% in the 400 μM EGCG/LPS treated group, while the level of inducible nitric oxide synthase (iNOS) expression decreased by 12-17% in the 200 and 400 μM EGCG/LPS treated group. A significant decrease in transcription of pro-inflammatory cytokines (TNF-α and IL-1β) and anti-inflammatory cytokine (IL-10) was also detected in the EGCG/LPS treated group. However, IL-6 transcript and protein was maintained at a constant level when in the LPS treated group relative to the EGCG/LPS treated group. Overall, these results suggest that the differential regulation of inflammatory cytokines is an important factor influencing the suppressive effects of EGCG against LPS-activated inflammatory response in RAW264.7 cells.
성지은 ( Ji Eun Sung ),양영애 ( Yeong Ae Yang ) 한국고령친화건강정책학회 2015 대한고령친화산업학회지 Vol.7 No.1
서론: 작업치료 관점에서 살펴본 노인의상디자인의 접근을 알아보고 노인 작업치료의 기초자료로 제공하고자 한다. 본론: 작업치료 관점에서 노인의상디자인을 접근하고자 작업치료와 옷입기, 노인과 옷입기, 노인의 이미지 메이킹, 노화에 대한 의상디자인으로 나누었다. 작업치료 수행영역 중 일상생활 활동의 옷입기는 여러 단계로 나뉘며 노인분들에게 도움이 필요하여 보조도구와 교육을 제공할 수 있다. 노화에 대한의상디자인에서 노인의 편의성을 위해 입기 쉬운 디자인, 기능적 패턴, 조절의 용이성 등이 고려되어야 한다. 결론: 노인 의상에서도 상황과 목적에 맞게 의상을 착용하면 노인의 일상생활활동에 도움이 되며 작업치료 관점에서도 노인 의상에 대한 많은 관심이 필요하다. Introduction : The purpose of this study is to know the approach of senior fashion design discussed in the occupational therapy perspectives and provide the material of occupational therapy for seniors. Detours : This study discussed aging, ADL & wearing, image making of elderly, costume design for aging. Dressing of ADL in occupational therapy performance area have many steps and occupational therapists provide assistive device for dressing and education for seniors. Design for wearing easily & using a functional design pattern & adjustable design are considered for convenience for aging. Conclusion : It need a lot of attention to the senior fashion design in the occupational therapy perspectives.
Production Frequency, Semantic Typicality, and Familiarity of Noun Exemplars for Elderly Adults
성지은(Jee Eun Sung),모경옥(Kyeong Ok Mo),이지선(Ji Sun Lee),심현섭(Hyun Sub Sim) 한국언어청각임상학회 2014 Communication Sciences and Disorders Vol.19 No.2
배경 및 목적: 본 연구는 향후 신경언어장애군을 대상으로 이름대기 중재 프로그램 개발을 위한 기초자료를 확보하는 목적으로, 명사 범주별 본보기 산출빈도, 의미전형성 및 친숙도에 대해 조사하였다. 방법: 실험 1에서는 전문가 및 보호자 75명을 대상으로 이름대기 중재에 필요한 명사 범주 총 17개를 중요한 순서대로 우선순위를 정하도록 하였다. 실험 2에서는 노년층 45명을 대상으로 17개의 명사 범주에 대한 생성이름대기를 실시하였다. 실험 3에서는 실험 2에 참여하지 않은 노년층 78명을 대상으로 실험 1에서 우선순위 3순위 안에 포함되는 6개 범주에서 정리된 각 항목별로 의미전형성 및 친숙도에 대한 7점 척도 평정을 실시하였다. 결과: 실험 1에 따르면, 우선순위가 가장 높은 범주는 음식(요리)인 것으로 나타났으며, 실험 2에서는 가장 많은 본보기 산출빈도를 보인 범주는 신체부위였다. 실험 3에서는 산출 본보기에 대한 의미전형성 및 친숙도 평정척도를 표준화점수(Z-score)로 환산하여 기초자료를 제시하였으며, 의미전형성 및 친숙도는 강한 정적 상관관계를 보였다. 논의 및 결론: 본 연구는 향후 신경언어장애군의 이름대기 중재 프로그램 개발을 위해 명사 범주별 속성에 관한 노년층 기초자료를 제공함으로써 임상적 활용가치가 높을 것으로 기대한다. Objectives: This study seeks to provide normative data on the production frequency and semantic typicality and familiarity of noun exemplars by semantic category for elderly individuals. Methods: A total of 198 individuals participated in the study. In Experiment 1, participants were categorized into two groups: professionals involved in dementia care and primary care-givers of patients with dementia. They ranked 17 semantic categories based on the priority of the stimuli required for naming treatment. Forty-five normal elderly individuals (NEIs) participated in Experiment 2, in which they were administered a generative naming task. Seventy-eight NEIs participated in Experiment 3, where they rated the semantic typicality and familiarity of each noun exemplar obtained from Experiment 2. Results: Experiment 1 revealed that ‘food (dish)’ was ranked as a top priority followed by ‘clothes’, ‘fruits’, and ‘body parts’. In Experiment 2, ‘body parts’ generated the highest mean of production frequency among 17 semantic categories. Results from Experiment 3 suggested that the semantic typicality was positively and strongly correlated with the familiarity ratings. Conclusion: These results are clinically important and meaningful given that they provide preliminary guidelines to select stimuli for the naming treatment of individuals with neurogenic language disorders.
플랫아이롱 시술 후 시술자의 만족도와 소비자 재 구매의도 및 구전의도에 미치는 영향
성지은 ( Ji-eun Sung ),성명수 ( Myung-soo Sung ),김동표 ( Dong-pyo Kim ),박은준 ( Eun-jun Pack ) 한국미용예술경영학회 2013 미용예술경영연구 Vol.7 No.2
The aim of this study is to find out the level of satisfaction of professional hairdressers and consumers after flat iron hair service, and to analyze consumers’ intention of repurchase and recommendation of said service. The method is to divide the two groups-professional hairdressers and consumers, and analyzing frequency, and doing trustworthy and reason analysis to know the satisfaction level after service. Also, a multiple regression analysis was taken to find out the relationship between professionals’ satisfaction or consumers’ satisfaction when doing the service and consumers’ willingness to re-purchase afterwards. Firstly, common traits of professionals’ group subjects were with 3 to 5 years of experience and those with 10 or more years of experience. In the consumers’ group, subjects were mostly woman, in their 30s and 40s. Second, the level of professionals’ satisfaction on their flat iron service was reasoned out by the value of the service, frequency, training, the work environment, selling products, effect on the service, and condition of the hair. And consumers’ satisfaction on their flat iron service was based on the reasonability of the service, outcome, quality of the service, frequency, and purchase of the products. Third, in professional group, ‘Training’ was the factor of high satisfaction on flat iron service. Fourth, in consumers’ group, the intention of repurchase was dependent upon purchasing products, friendliness of the hair salon was dependent upon the result of the service, and intention of recommendation was depending on fairness on the price of the service and products. Finally, intention of continuous visits was affected by fairness of the price, and purchase of the product was the main factor of intention on re-visits regardless of services provided by other hair salons.
성지은 ( Ji Eun Sung ),박상준 ( Sang Jun Park ),남창우 ( Chang Woo Nam ),황재철 ( Jae Chol Hwang ),김영민 ( Young Min Kim ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.3
A hepatic hemangioma is the most frequent benign liver tumor. Once rupture occurs, the bleeding can barely be controlled by using conservative management or endovascular treatment. We report a case of traumatic hepatic hemangioma rupture. A 60-year-old man was referred to our hospital under cardiopulmonary cerebral resuscitation (CPCR). CPCR was continued for 16 minutes after his admission to the emergency room (ER). Computed tomography (CT) showed fluid accumulation in the peritoneal cavity with active contrast extravasation in the left lateral segment of the liver. Percutaneous transarterial embolization and massive transfusion were carried out. Embolization did not stop the bleeding, we decided on an exploration and then resected the lateral segment of the liver to control the bleeding. The specimen showed a ruptured hemangioma in the liver segment