투영 기반 마이크로 광조형 시스템을 이용한 형상 모방형 구조체 제작

설영준(Young-Joon Seol),박정훈(Jeong Hun Park),강현욱(Hyun-Wook Kang),김성원(Sung Won Kim),주영훈(Young-Hoon Joo),조동우(Dong-Woo Cho) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.4

마이크로 광조형과 몰드 기술을 이용한 Hydroxyapatite 인공지지체 제작

설영준(Young-Joon Seol),김종영(Jong Young Kim),이승재(Seung-Jae Lee),박의균(Eui Kyun Park),김신윤(Shin-Yoon Kim),조동우(Dong-Woo Cho) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

Recently, many groups have researched the reconstruction of bone tissue and the development of bone scaffolds using solid free-form fabrication technology. However, due to difficulty in the manufacturing process, three-dimensional hydroxyapatite(HA) scaffolds have a limited ability to have a very accurate architecture. In this study, a HA scaffold with an accurate pore size and line width of about 300 ㎛ was fabricated using a Micro-stereolithography(MSTL) system and molding technology, and evaluated a cytotoxicity test using Agar-overlay to investigate the toxicity of a fabricated scaffold.

투영기반 마이크로 광조형 기술을 이용한 3 차원 인산칼슘 인공지지체 제작 및 골 분화 영향

설영준(Young-Joon Seol),박주영(Juyoung Park),조동우(Dong-Woo Cho) 대한기계학회 2011 大韓機械學會論文集B Vol.35 No.11

인산칼슘 재료는 하이드록시 아파타이트(Hydroxyapatite)와 트리칼슘 포스페이트(Tricalcium-phosphate)를 포함하고 있으며, 인체 골 조직의 무기성분으로 세포 독성이 없고 생체 적합한 성질을 가지고 골 전도성이 있다. 또한 두 재료가 혼합되어 있는 이상 인산칼슘(Biphasic calcium phosphate) 재료는 골 유도성이 있다고 알려져 있다. 이러한 골 조직 재생에 많은 장점을 가지고 있는 인산칼슘 재료는 파우더 타입으로, 3 차원 자유형상의 인공지지체를 제작하는 데 어려움이 있어 고분자 재료에 첨가하여 사용되었다. 본 연구에서는 자유형상 제작 기술을 이용하여 원하는 내/외부 형상을 가지는 3 차원 인산칼슘 인공지지체를 제작하고, 골 조직 재생용 인공지지체로의 사용이 적합한지를 확인하기 위해 MC3T3-E1 를 이용한 세포 증식, 골 조직 분화 실험을 수행하였다. Calcium phosphates are very interesting materials for use as scaffolds for bone tissue engineering. These materials include hydroxyapatite (HA) and tricalcium phosphate (TCP), which are inorganic components of human bone tissue and are both biocompatible and osteoconductive. Although these materials have excellent properties for use as bone scaffolds, many researchers have used these materials as additives to synthetic polymer scaffolds for bone tissue regeneration, because they are difficult to manufacture three-dimensional (3D) scaffolds. In this study, we fabricated 3D calcium phosphate scaffolds with the desired inner and outer architectures using solid freeform fabrication technology. To fabricate the scaffold, the sintering behavior was evaluated for various sintering temperatures and slurry concentrations. After the fabrication of the calcium phosphate scaffolds, in-vitro cell proliferation and osteogenic differentiation tests were carried out.

소아의 유연성 편평족 환아에서 족저압 검사 방법의 유용성과 방사선 검사와의 관련성

설영준(Young-Jun Seol),정성택(Sung-Taek Jung),양현기(Hyun-Kee Yang),이근배(Keun-Bae Lee),오창선(Chang-Seon Oh),정영주(Young-Ju Jung),조행난(Hang-Nan Cho) 대한정형외과학회 2014 대한정형외과학회지 Vol.49 No.5

목적: 유연성 편평족 소아에서 족저압 검사의 유용성과 방사선 검사와의 관련성을 알아보았다. 대상 및 방법: 환아 17명, 정상 10명을 대상으로 하여 방사선 검사를 통해 전후면 거골-제1 중족각, 측면상 거골-제1 중족각, 거골-수평각, 종골-수평각, 거종각을 측정하였다. 족저압 검사는 접촉 시간과 면적 비율, 압력 중심의 편향 정도 및 방사선과의 연관성을 알아보았다. 결과: 방사선 검사의 모든 측면 각들이 족저압 검사에서 전족부의 외측, 중족부의 내측과 외측, 후족부의 내측 족저압 비율이 차이가 났고, 전족부와 중족부의 접촉 면적 비율이 차이가 났으며 접촉 시간에서는 차이가 없었다. 그리고 전족부의 내측과 외측 족저압은 거종각과 관련성이 있었고 중족부의 내측과 외측 족저압은 모든 측면 각들과 관련성이 있었다. 중족부의 접촉 시간 및 전족부와 중족부의 접촉 면적은 모든 측면상의 방사선 결과값과 관련성이 있었다. 또한 압력 중심의 편향 정도는 전, 후면의 거골-제1 중족각과 측면의 거골-제1 중족각 및 거골-수평각과 관련성이 있었다. 결론: 족저압 검사와 방사선 검사는 많은 연관성이 있고 보행 중의 족부 변형 및 역학적 변화를 정량적 및 정성적으로 분석할 수 있는 유용한 검사방법이다. Purpose: The purpose of this study was to analyze the diagnostic availability and to examine the co-relation between pedobaragraphy and radiography of pediatric flexible flatfoot. Materials and Methods: Seventeen patients and ten normal children were studied. In radiographic evaluation, the talo-1st metatarsal angle was measured on anteroposterior radiographs; and the talo-1st metatarsal angle, the talo-horizontal angle, the calcaneal pitch, and the talocalcaneal angle were measured on lateral radiographs. In pedobarography, foot pressures were subdivided into eight areas for measurement of contact time, ratio of measured area and to investigate the relation between the degree of the medial deviation of the Center of pressure line and the radiographic measurements. Results: Flat foot group and normal group showed statistically significant difference in every angle measured in lateral radiographs. The foot pressure ratios of the lateral sides in forefoot and the medial and lateral sides of midfoot and the medial side of hindfoot between the flexible flatfoot group and normal group showed statistically significant difference in pedobarography and ratio of contact area in forefoot and hindfoot showed significant change in statistics but no changes in contact time. The relation between pedobarography and radiography was investigated: foot pressure of the medial and lateral side of forefoot and the talocalcaneal angle showed significant relation in statistics and foot pressure of the medial and lateral side of mid foot and every angle measured in lateral radiographs showed significant relation in statistics. Contact time of midfoot and every radiographic value measured in lateral radiograph showed significant relation in statistics and contact area of forefoot and midfoot showed significant relation with every radiographic value measured in lateral radiographs. In addition, medial deviation of center of pressure line showed significant relation in statistics with talus-first metatarsal angle measured on anteroposterior radiographs and talo-horizontal angle and talus-first metatarsal angle measured on lateral radiographs. Conclusion: The results of this study showed correlation between radiologic methods and pedobarography in diagnosis of pediatric flexible flatfoot and pedobarography is an useful tool in quantitative and qualitative analysis of the degree of foot deformity and medial deviation of center of pressure line.

골 조직 재생을 위한 세라믹 인공지지체의 기계적 특성 향상

설영준(Young-Joon Seol),박주영(Juyoung Park),조동우(Dong-Woo Cho) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

Calcium phosphate bioceramics including hydroxyapatite (HA) and tricalcium phosphate (TCP) are always discussed in relation with bone tissue regeneration because these two materials are the main inorganic components of bone tissue. Furthermore, biphasic calcium phosphate, mixture of HA and TCP, is well known as an osteoinductive material. Although bioceramics has a lot of advantages such as biocompatibility, osteoconductivity, biodegradability, etc. for bone tissue regeneration, mechanical properties of scaffolds fabricated from bioceramics are poor stable. In this study, we fabricated the 3 dimensional bioceramic scaffolds which has controlled inner and outer architecture using projection based microstereolithography. And cellular behaviors on the bioceramic scaffold were observed. After that, to improve the mechanical properties of scaffolds, we injected polycaprolactone (PCL) in the pores between bioceramic particles and evaluated the mechanical properties of scaffolds.

골조직 재생을 위한 세라믹 인공지지체의 기계적 특성 향상

설영준(Y.-J. Seol),강현욱(H.-W. Kang),조동우(D.-W. Cho) 한국정밀공학회 2010 한국정밀공학회 학술발표대회 논문집 Vol.2010 No.11월

Development and Analysis of Three-Dimensional (3D) Printed Biomimetic Ceramic

이정섭,설영준,성민,문원규,김성원,오정훈,조동우 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.12

Many finite element (FE) models have been designed based on geometric information from computed tomography (CT) data, and validated via comparison with experimental results for human cadaver ossicular bones. Here, we describe a novel method for developing and analyzing the biomimetic ceramic ossicles (BCO) in combination with 3D printing technology, and we establish an FE model of the BCO for analyzing vibration performance. Novel biomimetic ceramic ossicles (BCO) made of hydroxyapatite (HA) were fabricated using 3D printing technology, and their vibration properties were measured. We created a 3D model of the BCO using computer-aided design, which corresponds to the ossicular structure and geometry, and created an FE model of the human ossicles via a comparison of experimental and simulated vibrations to investigate the characteristics of the ossicular chain. The FE model was established based on the displacements of the malleus, incus, and stapes, which was analyzed using an externally applied vibrational force.

슬관절 주위에 발생한 골종양 환자에서 종양 대치물을 이용한 재건술 후 기능적 평가 및 보행 분석의 유용성

이진호,설영준,정성택,Lee, Jin-Ho,Seol, Young-Jun,Jung, Sung-Taek 대한근골격종양학회 2012 대한골관절종양학회지 Vol.18 No.2

Purpose: This study attempts to know functional results and gait analysis usefulness in patients with bone tumor around knee joint tumors who underwent prosthesis knee joint reconstruction. Materials and Methods: Retrospective study was conducted with 7 patients out of 30 patients who underwent prosthesis knee joint reconstruction after wide marginal excision for bone tumor around knee in orthopedics of this hospital from 2001 to 2010. Functional assessment and gait analysis were perforemed. Results: For the SF-36 score, while 'role physical' and 'role emotional' items showed 100% (100 points) high scores individually, general health, physical function, vitality, and social function showed low scores. The mean score of MSTS was 88.1% (23.8 points [17-27]), indicating a relatively high score. For the gait analysis, mean gait velocity was 97.2 m/s, mean cadence was 105.6 step/min, mean stride length was 111.3 m, mean step length was 61.5 cm, swing phase was 39.8%cycle, stance phase was 60.1%cycle, mean single limb support was 37.1%cycle, mean double limb support was 13.0%cycle, and mean push off was 60.7%cycle. Conclusion: It is expected that prosthesis reconstruction after wide marginal excision for bone tumor around knee has relatively good functional results. Gait analysis was considered one of method which showed gait phase and assessed functional ability objectively by quantitative assessment post operative patient condition. It might help treatment and post operative rehabilitation planning with the functional assessment. 목적: 슬관절 주위에 발생한 골종양 환자에서 종양 대치물을 이용한 재건술의 결과와 보행 분석의 유용성을 알아보고자 하였다. 대상 및 방법: 2001년부터 2010년까지 슬관절 주위에 발생한 골종양에 대하여 광범위 절제술 후 종양 대치물을 이용한 재건술을 시행 받은 30명 중 7명을 대상으로 하였으며 기능적 결과 및 보행 분석 검사를 평가하였다. 결과: SF-36 점수는 신체적, 정신적 역할제한 항목에서 각각 100% (100점)으로 높은 점수를 보였으며 일반 건강상태, 신체적 기능 정도, 활력, 사회적 기능에서 낮은 점수를 나타냈다. 또한 MSTS 평가의 종합 평균 점수는 88.1% (23.8점[17-27])였다. 보행 분석 검사상 평균 보행속도 97.2 m/s, 평균 분속수 105.6 step/min, 평균 활보장 111.3 m, 평균 보장 61.5 cm, 유각기 39.8%cycle, 입각기 60.1%cycle, 평균 단하지 지지기 37.1%cycle, 평균 양하지 지지기 13.0%cycle, 평균 발 들림시기 60.7%cycle였다. 결론: 슬관절 주위 종양에 대한 광범위 절제술 후 종양 대치물을 이용한 재건술은 좋은 기능적결과를 기대할 수 있으며, 보행 분석 검사는 술후 환자의 상태를 정량적으로 평가함으로써 보행 모습 및 기능을 객관화 할 수 있는 한 방법으로 사료되며 기능적 평가 방법과 함께 치료 및 술 후 재활 계획을 세우는데 도움이 되리라 생각된다.

Comparison of Outcomes of Total Hip Arthroplasty between Patients with Ankylosing Spondylitis and Avascular Necrosis of the Femoral Head

이선호,이건우,설영준,박경순,윤택림 대한정형외과학회 2017 Clinics in Orthopedic Surgery Vol.9 No.3

Background: The objective of this study was to compare clinical and radiological outcomes of total hip arthroplasty (THA) between ankylosing spondylitis (AS) of the hip joint and avascular necrosis (AVN) of the femoral head. Methods: Thirty patients (30 hips) underwent cementless THA for AS between 2003 and 2012. They were compared to 30 patients (30 hips) who underwent the same procedure for AVN of the femoral head. Each group was matched for age and gender, and both groups had similar preoperative demographic characteristics. All cases were followed for minimum 4 postoperative years. Clinical evaluation was based on operation time, intraoperative blood loss, quantity of postoperative drainage, Harris Hip Score (HHS), and range of motion (ROM). Radiological results were evaluated by acetabular cup anteversion and inclination, femoral stem orientation, pre- and postoperative leg length discrepancy, and postoperative complications. Results: The operation time was significantly longer in the AS group (120.2 ± 26.2 min) than in the AVN group (79.5 ± 11.1 min). The volume of postoperative drainage was significantly greater in the AS group (764.5 ± 355.4 mL vs. 510.5 ± 195.6 mL). Preoperative HHS was lower in the AS group (55.6 ± 13.8 vs. 59.2 ± 2.8). Similarly, postoperative HHS was significantly lower in the AS group (92.8 ± 2.7 vs. 97.4 ± 2.6). The arc of ROM was improved from 146.5° ± 13.2° preoperatively to 254.7° ± 17.2° postoperatively in the AS group and from 182.6° ± 15.5° to 260.4° ± 13.7° in the AVN group. Implant position and postoperative leg length discrepancy were not different between the groups. However, three cases of heterotopic ossification was observed in the AS group, whereas only 1 case was found in the AVN group. One deep infection and one aseptic stem loosening were found in the AS group, whereas none was observed in the AVN group. Conclusions: Cementless THA showed satisfactory clinical and radiological results in both groups, despite the longer operation time, larger blood loss volume, and lower HHS score of the AS group. Our findings suggest that cementless THA is an effective and reliable treatment for both AS and AVN.

Acute Occlusion of a Femoro-Popliteal Bypass Graft after Primary Cementless Total Hip Arthroplasty

박경순,윤택림,설영준 대한정형외과학회 2013 대한정형외과학회지 Vol.48 No.2

Vascular complications after total hip arthroplasty (THA) are rare and mainly occur after revision surgery, and of these complications, large artery thrombosis is relatively uncommon. Nevertheless, this complication has potentially devastating effects on the affected lower extremity. The authors report a case of acute thrombosis in an iliac artery stent and femoro-popliteal bypass graft after primary cementless THA, and include relevant literature review.