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장경애,문기찬,성경제,최지호,고재경,서치우 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.3
Job's syndrome is an inflammatory skin disease characterized by (1) severe eczema, (2) recurrent staphylococcal infections of the skin and sinopulmonary tract, (3) cold subcutaneous abscesses, and (4) high serum IgE levels. We describe a 55-year-old woman with long-standing atopic dermatitis-like eczema, recurrent abscesses, and a high level of serum IgE. We suspected this case as Job's syndrome.
안세진,장성은,문기찬,성경제,최지호,고재경,서호석,서치우,김소형,한만희,정의창,박일중 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.2
Background: In many epidemiologic reports of distribution of skin diseases, the outpatients of university hospitals have been the target groups of the analysis. But there has been no epidemiologic study of dermatoses in the field of rural area. Objective: The purposes of this study were to investigate the distribution of skin diseases in rural areas and to evaluate the rural population's concept of skin disease and the attitude to their skin problems. Method: We analysed the results of interview and responses of questionnaires from 481 residents who visited the local public health centers and the free clinics in the rural areas of Kyonggi-Do and Ulsan city. Results: The results of the study are summarized as follows: l. Of 481 residents, there were 328 females and 153 males. The mean age was 56.6 years old.The residents over 50 years old formed 73.2 percent of total population. 2. The common dermatoses were tinea pedis, onychomycosis, xerosis, seborrheic keratosis, chloasma, pruritus, hand eczema, contact dermatitis, lentigo, seborrheic dermatitis in order of frequency. 3. The cutaneous fungal infection was the most common dermatoses in each study population. 4. To treat skin diseases, 51.2% of the residents visited the drug store initially. 5. The major reason of not taking dermatological care in the rural population was customary habit. 6. The 39.5% of 238 respondents have used self-treatments, and 15.5% of 90 respondents have experienced side effects of self-treatments. 7. On the question about the negative concepts of dermatoses, 61.7% of 462 respondents agreed to the statement that dermatoses look unclean. 8. Half of the 463 respondents thought that dermatologic medicine was harmful. The 50.6% of the 328 respondents had no specific reason, and 34.1% experienced gastrointestinal trouble. 9. The most favorite type of dermatologic medicine was topical agent, which was preferred especially by the group of respondents using nonmedical service including drug store. Conclusion: The distribution of the skin diseases in rural areas was similar to other reported results except the high frequency of cutaneous fungal infection. This research could be a basis on the following epidemiologic studies of the skin diseases in rural areas. It is also suggested that the educational program to improve understanding of skin diseases should be performed in the rural areas.
자외선 B에 의한 HaCaT 세포의 Apoptosis에서 Nitric Oxide (NO)의 역할
김미정,백은미,성경제,최지호,서호석,서치우 대한피부과학회 1999 대한피부과학회지 Vol.37 No.11
Background:According to target cells, apoptosis-inducing agents, and NO concentration, NO concentration, NO shows both pro- and antiapoptotic effects. Objects:Our study was perfermed to verify the role of NO in UVB-induced apoptosis in HaCaT cells. Methods:After UVB irradiation, FACS using propidium iodide, LDH cytotoxicity assay, and nitrite assay based on Griess reaction were done in HaCaT cells. These procedures were repeated after UVB irradiation and NG-monomethyl-arginine (L-NMMA), a NO synthase (NOS) inhibitor, addition. Results:1) UVB irradiation (5-80mJ/cm2) induced apoptosis in HaCaT cells dose-dependently. 2) UVB irradiation (80mJ/cm2) stimulated NO production 30-50% more over baseline level, and this was inhibited by 500 μM L-NMMA. 3) 500 μM L-NMMA did not inhibit UVB-induced apoptosis. Conclusion:UVB irradiation evokes apoptosis in HaCaT keratinocytes through NO-independent mechanism.
장경애,문기찬,성경제,최지호,고재경,서치우 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.2
Congenital self-healing reticulohistiocytosis (CSHRH) is a rare Langerhans cell disorder showing spontaneous resolution within 3-4 months. By electron microscopy, the identification of many Birbeck granules and laminated dense bodies in the infiltrated cells is mandatory for the diagnosis of CSHRH. We describe a case of congenital self-healing reticulohistiocyt~osis in a 4-month-old male infant.