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주기중(Kee Joong Ju),서대홍(Dae Hong Suh),김춘섭(Chun Sup Kim),이창환(Chang Hwan Lee),심영웅(Young Woong Shim),송갑영(Kap Young Song) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.6
N/A Diagnostic imaging procedures of the pancreas have been revolutionized in recent years by the introduction of sonography and computed tomography. We compared the previous litera- tures of actue pancreatitis which did not use ultrasonography and computed tomography with the cases which use the imaging technigque as a diagnostic tool and for the early detection of complications. A clinical observation was made on the 175 cases of the acute pancreatitis con- firmed and treated at the Pusan Adventist Hospital as in patients during the 6 years period from March, 1988 to December, 1993. The possible etiologic factors of the disease seen in de- scending order were unknown origin(44.6% ), alcohol(26.9% ), biliary tract disease(9.7% ), overeating(6.9%) and peptic ulcer(6.3/o). The patients complained of upper abdominal pain, nausea, vorniting, fever with chills in order. The most commonly observed physical sign was tenderness in the upper abdomen. In the radiologic studies, we observed pancreatic enlarge- ment(83.6%), phlegmon formation(18.2%) and pseudocyst(9.1%) by the ultrasonic examina- tion and enlargement of pancreas(100%), obliteration of fat plane(76.5%), extrapancreatic phlegmonous mass(29.4% ), ascites(20.7% ) and pseudocyst(14.7% ) using the computed to- mography. The cornplications were phlegmon formation, ascites, pseudocyst, shock, atelectasis, septicemia and acute renal failure. The mortality rate during the hospitalization was in 1.7% and the main causes of death were due to septicemia and renal failure. In conclusion, we observed the frequency of complications of acute pancreatitis were higher than the previous studies because of using the advanced diagnostic imaging tools. (Korean J Gastroenterol 1994; 26: 995--1001)
위 질환 환자들에서 분리된 Helicobacter pylori 의 공포화 독소 ( Vacuolating Toxin ) 생성
김충기(Chung Kee Kim),정승수(Sung Soo Jeong),이겸철(Gyum Cheol Lee),서대홍(Dae Hong Suh),송갑영(Gap Young Song),최경현(Kyung Hun Choi),장명웅(Myung Woong Chang) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
N/A Objectives: This study was carried out to survey the prevalence of Helicobacter pylori infection and the incidence of vacuolating toxin producing H pylori. A further aim of this study was to evaluate the quantitative assay for cell vacuolation on the basis of the rapid uptake of neutral red dye by vaculoes of the cells. Methods: We studied the gastric biopsy specimens of patients with 154 cases of gastritis, 74 cases of gastric ulcer, and 167 cases of gastric cancer and in 44 cases of healthy persons, One of the biopsy specimen was placed into a CLOtest plate for rapid urease test and the other one of the biopsy spcimen was inoculated on Brain Heart Infusion blood agar for culture. The culture supernatant of isolated H. pylari was serially diluted with BHI broth. After 24 hour incubation of cultured RK-13 cells treated with the culture supernatgnt of H. pylori, cytoplasmic vacuolation of the cells were observed microscopically. Results: The positivity of urease test and the rate of isolation of K pylori from urease positive gastric biopsy materials were 34.1% and 93.3% in healthy person, 55.8% and 70.9% in gastritis, 60.8% and 71.1% in gastric ulcer, and 56.3% and 96.8% in gastric cancer. The isolation rate of H. pylari from patients between 20 and 39 years old was 16.8%, far patients between 40 and 59 years old it was 51.9%, and for patients above 60 years old it was 31.2%. The isolation rate of the vacuolating toxin producing H pylori from gastric biopsy specimens was 66.7% in a healthy person, 76.6% in gastritis, 79.4% in gastric ulcer, and 80% in gastric cancer. Conclusions: The isolation rate of H. pylori from the patients with gastric diseases is higher than the rate of H. pylori from healthy persons, but the isolation rate of the vacuolating toxin producing H. pylori is not different between the patients with gastric diseases and healthy persons. The titers of vacuolating toxin produced by some H, pylori isolated from the patients with gastric diseases are higher than those from healthy persons.
최환주,심영웅,서대홍,김춘섭,송갑영,임홍섭,김충기,이겸철 대한내과학회 1997 대한내과학회지 Vol.53 No.2
Hepatoma is one of the most common malignant disease among cancers that occur in Korea. Recently, according ta developing imaging diagnostic technology and non surgical treatment the hepatoma is easily detected in early diagnosis and appropriate treatment. From this point of view, the histologic pattern of hepatoma is markedly important. This is the first reported case of sclerosing hepatocellular carcinoma, which is characterized by intense fibrosis, in which the tubular neoplastic structures are embedded. The incidence of sclerosing hepatocellular carcinoma is very rare. Therefore the rare histologic pattern of hepatoma might be introduced by many studies and reports. We recently experienced a case of sclerosing hepatocellular carcinoma.
최준혁,최혜정,구미진,서대홍,신덕섭,조길호 영남대학교의과대학 1998 Yeungnam University Journal of Medicine Vol.15 No.2
1987년부터 1998년까지 영남대학교 의과대학 부속병원에서 연골모세포종으로 진단받은 8례를 대상으로 임상병리학적 특징의 분석과 면역조직화학적 검색을 시행하여 다음과 같은 결과를 얻었다. 환자의 연령은 17세에서 38세 사이였고 평균연령은 22.7세였다. 종양의 크기는 1.5cm에서 8.0cm사이이며 평균 크기는 4.0cm였다. 종양은 대퇴골(3례), 슬개골(2례), 경골(1례), 비골(1례) 및 척골(1례)에서 각각 발생하였다. 육안적으로 종괴는 회백색의 고형성 부위, 암갈색의 출혈, 괴사 및 낭성 변화가 다양한 비율로 섞여 있었고, 조직학적으로 연골성 분화는 8례중 7례(87.5%)에서 나타났으며, 유사분열은 5례(62.5%), 혈철소 침착은 5례(62.5%) 그리고 괴사는 3례(37.5%)에서 각각 발견되었다. 석회화는 3례(37.5%)에서 관찰되었고, 4례(50%)에서는 이차성 동맥류성 골낭을 보였으며 1례(12.5%)에서는 혈관침범이 관찰되었다. S-100 단백은 7례(87.5%)에서 종양세포의 세포질에 양성 반응을 나타내었고, 모든 예에서 cytokeratin에 대하여 음성 반응을 보였다. Elght cases of chondroblastoma were studied by analyzing the clinical and pathologic findings. The age of eight cases ranged from 17 to 38 years old(median age, 22.7 years old). The tumors developed in the femur(3 cases), patella(2 cases), tibia(1 case), fibula(1 case), and ulna(1 case). The mean diameter of tumors was 4.0cm(range, 1.5 to 8.0cm). Grossly, tumors showed grayish brown solid area with foci of secondary aneurysmal bone cyst. Histologically, the tumor cells were round or polygonal in shape with nuclear groove. And there were chondroid differentiation(7 cases), mitosis(3 cases), calcific deposits(3 cases), secondary aneurysmal bone cyst(4 cases), hemosiderin deposits(4 cases), necrosis(3 cases), vascular invasion(1 cases), and foamy histiocytes and cholesterol cleft(1 cases). All cases showed no metastasis to lymph node and distant organ. Seven cases(87.5%) were immunoreactive for S-100 protein. None was immunoreactive for cytokeratin.