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Norepinephrine, Propranolol, Diltiazem 및 Isoproterenol이 흰쥐 심장에서 Apoptosis 발현에 미치는 영향
조원길,백두진,정호삼,김원규,윤지희,이창훈,백태경,이일수 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
Background----Myocardial sympathetic activity is increased in heart failure. In recent years myocardial sympathetic hyperactivity has been shown to induce myocardial cell apoptosis and this effect is responsible for myocardial hypertrophy and chronic progression of heart failure, at least, in part. There is many mechanism suggested that cause myocardial cell apoptosis. We tested the hypothesis that norepinephrine(NE) stimulates apoptosis in adult rat ventricular myocytes in vivo. Methods and Results----NE alone (0.1 g/min/kg), NE+ propranolol (20 g/Kg), NE+ diltiazem (0.25 mg/kg) and isoproterenol (0.3 g/min/kg) were infused for 24 hours to adult rats. The infusion was proceeded through left saphenous vein. It was observed that obvious increase of apoptosis in NE infused group, and this increase is completely blocked in NE + propranolol group and NE + diltiazem group. Isoproterenol group's result is resemble to that of NE group. Conclusions----NE, acting via the β-adrenergic pathway, stimulates apoptosis in adult rat cardiac myocytes in vivo, and this effect requires calcium entry via voltage-dependent calcium channels. This effect was completely blocked by the β-adrenergic antagonist propranolol or voltage-dependent calcium channel blocders diltiazem. Thus We suggest that adult rat ventricular myocyte apoptosis induced by NE is caused by direct stimulation of β-adrenergic receptor, and this effect is mediated by voltage-dependant calcium channel and exert excessive intracellular calcium influx that cause myocyte apoptosis. NE-stimulated apoptosis of cardiac myocytes may contirbute to the progression of myocardial failure.
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송순천,백태길,김진표 龍仁大學校 武道硏究所 1998 武道硏究所誌 Vol.9 No.1
The purpose of this study was to examine the relationship betwiin work value of boxing coach their job satisfaction. For this purpose, review of the related literatures that work value and job satistaction. This study setting up the population was boxing coaches, and questionnaire survey were conducted to boxing coach who was participated national tournament June 24-29 at SUNG-NAM gymnasium. The subject sampling used cluster sampling method. And data selection considered age, teaching grade of boxing coach. Data selected cluster sampling was 150 and final used data was 107. As an instrument for the collection of data, first, the scale of work value used as a modification Sim, young-gil(1987)'s view by the medel of value of Kluckhohn(1961). And Job satisfaction's scale used the developed JDI(Job Descriptive Index) by Smith (1969) and it translated in Korean and standardized by Cho, young-tak(1996). The Statistics employed in the study were frequencies statistics and one-way ANOVA, ANOVA. As a result of the analysis of collected data, the following conclusions were obtained: 1. A director of boxing, have hegative human relation in relative of coach, others the human relationship of married coach is more actie than single coach. 2. The older boxing coach is satisfied with fob task, satisfaction of task is totally higher than the coach, other and the married coach is higher than single. 3. The positive, active value of job is high the satisfaction about job itself, relative satisfaction of collegue.
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소형 SI 기관용 연료로서 가솔린과 LPG의 특성 비교에 관한 연구
조기현,백태실,정형길 한국마린엔지니어링학회 2001 한국마린엔지니어링학회지 Vol.25 No.4
This is a fundamental study to improve the performance of the LPG engine. The result were summarized as followed. 1. The measured torque and power on the fuel of LPG were indicated about 8% lower than those on gasoline with the same compression ratio. 2. In the case of LPG, BSFD at compression ratio of 9.7 was about 5% lower than that of 8.3 at 3,000ppm 3. HC and CO concentrations of the LPG were lower about 53%, 35% than those of gasoline
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폐식용유를 사용한 디젤기관에서의 LPG 공급에 의한 성능개선에 관한 연구
조기현,황의현,백태실,정형길 한국마린엔지니어링학회 2000 한국마린엔지니어링학회지 Vol.24 No.5
In this study, using frying oil, performance of engine and emission concentration were compared with the case of using diesel oil. And results are as follows. 1. Engine torque and brake horse power indicate nearly same value as the case of using diesel fuel. 2. Temperature of exhaust gas was increased with as high engine speed and load. 3. To reduce concentration of hydrocarbon, it is effective to operate using used frying oil in low engine speed and load, and adding LPG in high engine speed and load. 4. Concerning with concentration of carbon mono oxide and smoke emission, it was assured, that as engine load increased, lower concentration emitted in case of utilizing mixed fuel than that of utilizing pure diesel fuel.
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Adenosine 수용체 촉진제 및 KATP 통로 개구제가 Adriamycin 심근독성에 미치는 영향
이상(Sahng Lee),조원길(Wan-Gil Cho),백두진(Doo-Jin Paik),이방헌(Bang-Hun Lee),백태경(Tai-Kyoung Baik),김원규(Won-Kyu Kim),정호삼(Ho-Sam Chung) 대한체질인류학회 2001 해부·생물인류학 (Anat Biol Anthropol) Vol.14 No.1
간추림 본 연구는 adriamycin 투여 후 나타나는 심장독성과 항산화제를 병용투여 하거나 심장에서 항산화 기 능을 활성화 시키는 것으로 알려진 adenosine A₁ 수용체 혹은 KATP 통호를 개구시키는 약제를 병용투여한 후 나 타나는 심장독성을 비교 관찰하기 위해 본 실험을 시도하였다. 실험 동물은 체중 30-40 g 의 건강한 SPF(specific pathogen free)ICR 계 숫 생쥐를 사용하였으며, 대조문, Adriamycin (15 mg/kg) 투여군, SOD (superoxide dismutase, 2,000 U/kg) 전처치군, DMTU (dimethyl thiourea, 500 mg/kg) 전처치군 ,NAC(N-acetykysteine, 400 mg/kg) 전처치군, RPIA (R(-)N6-(2-Phenylisopropropyl)- adenosine, 150 μg/kg) 전처치군, 8-CPDPX (8-Cyclopentyl-l, 3-dipropyl-xanthine, 1 mg/kg) 천처치군, Pinacidil (1 mg/kg) 전처치군과 Glibenclamide (0.5 mg/kg) 전처치군으로 나누었으며 모든 실험군은 다시 l 일 경과군과 4 일 경과군으로 세분하여 관찰하였다. 심장세포에서의 apoptosis 를 확인하기 위한 방법으로 TUNEL assay 의 원리를 이용하였고, 혈중 creatine kinase 의 활성은 CK -10 kit (sigma diagnostics, USA) 를 사용하여 측정하였으며, Bcl-2 의 발현은 연역조직화학적인 방법으로 관찰하였다. 그리고 항암효과 변동 여부를 관찰하기 위해 96 well plate 에 2.5×103/well 의 293T 세포를 분주하고 24 시간 경과한 다음, adriamycin 단독 혹은 adriamycin과 SOD, DMTU, NAC, RPIA, 8-CPDPX, pinacidil과 glibenclamide 를 병용투여하고 18 시간 경과 후 well 에서 293T 세포의 증식 정도를 MTT 시약으로 측정하여 다음과 같은 결과를 얻었다. 1. RPIA 를 병용투여한 군에서는 adriamycin 만 투여한 군에 비해서 apoptosis 양성 세포가 다소 감소하는 양상을 보였고, g-CPDPX 룰 병용투여한 군에서는 apoptosis 양성 세포가 거의 같거내 다소 증가하는 양상을 보 였다. 2. Pinacidil 을 병용투여한 군에서 약물 투여 l 일 경과 군과 4 일 경과군 모두에서 apoptosis 양성세포가 많이 감소하는 양상을 보였으며, glibe nclamide를 병용투여한 군에서는 손상이 매우 증가하는 것을 관찰할 수 있 었다. 3.Bc1-2 면역염색반웅은 심장조직에서 손상이 심해지는 것에 비례해서 증가하는 것으로 관찰되였다. 4. MTI assay 결과 병용투여한 모든 약제들은 adriamycin 의 항암 작용에 유의한 영향을 끼치지 않았다. 이상의 결과를 종항해 보면 adriamycin 에 의한 심장독성이 자유산소기의 발생과 밀접한 연관이 있으며, SOD와 DMTU 의 방어효과는 약물 투여 l 일 경과군에서 SOD 가, 약물 투여 4 일 경과문에서 DMTU 가 더 효과적인 것으로 나타났다. 특히, KATP 통로의 개구제인 pinacidil 이 효과적으로 adriamycin 에 의한 심장독성을 감소시키는 것으로 결온 지을 수 있었다.
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