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백정화,진상만,배지철,지재환,유태양,김수경,허규연,이문규,김재현 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.1
Background: An association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in crosssectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study. Methods: We conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4.3 years (18,925 person-years). The risk of developing MetS was analyzed according to the baseline serum calcium levels. Results: A total of 3,448 incident cases (27.1%) of MetS developed during the follow-up period. The hazard ratio (HR) for incident MetS did not increase with increasing tertile of serum calcium level in an age- and sex-matched model (P for trend=0.915). The HRs (95% confidence interval [CI]) for incident MetS comparing the second and the third tertiles to the first tertile of baseline serum calcium level were 0.91 (95% CI, 0.84 to 0.99) and 0.85 (95% CI, 0.78 to 0.92) in a fully adjusted model, respectively (P for trend=0.001). A decreased risk of incident MetS in higher tertiles of serum calcium level was observed in subjects with central obesity and/or a metabolically unhealthy state at baseline. Conclusion: There was no positive correlation between baseline serum calcium levels and incident risk of MetS in this longitudinal study. There was an association between higher serum calcium levels and decreased incident MetS in individuals with central obesity or two components of MetS at baseline.
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백정화 한국어의미학회 2016 한국어 의미학 Vol.54 No.-
The aim of the study is to examine similarities and differences of the ‘passive-by itself’ construction that expressed ‘being damaged’ by spontaneous situation among several types of Korean passive construction and anticausative construction that mentioned in language typology, to get to know ‘passive-by itself’ construction has anticausative feature. Korean ‘passive-by itself’ construction has a lot in common morphologically․syntactically․semantically with anticausative construction of Indo-European, it unites in points that there is particularly no agent in sentence and it shows that event which happened spontaneously. Unlike anticausative construction ; however, cannot imply agent syntactically and semantically, there is able to ambiguous constructions that imply agent in Korean ‘passive-by itself’ construction. This study shows the reason why Korean ‘passive-by itself’ construction is expressed by passive verb and anticausative construction of Indo-European is expressed by reflexive. In addition, this study distinguished with ‘passive-by itself’ construction by applying ambiguous construction. There are a lot of ambiguous construction in Korean. When we make sentences that depend on context, we have to consider whether the agent should be places or not in order to subject constraint in connection with animacy hierarchy. Furthermore, referring to semantic map and semantic model of Hapelmath(1987), this study suggests meaning of Korean passive verb and Indo-European reflexive. While Indo-European reflexive has each meaning by sequential derivation, Korean passive verb shows phenomenon that meaning changed according to cause material each in a ’passive’ category.
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A Case Study on Leukopenia Patients Using Ortho-Cellular Nutrition Therapy (OCNT)
백정화 셀메드 세포교정의약학회 2023 셀메드 (CellMed) Vol.13 No.11
Objective: A case report on the Leukopenia Patients Using Ortho-Cellular Nutrition Therapy (OCNT)Methods: A Korean female in her 50s suffering from the rare side effect of leukopenia after taking athlete's foot medicine (Terbinafine HCl)Results: The results revealed that the white blood cell count, which had dropped before the OCNT, had improved to a normal level. Conclusion: The application of the OCNT can help change health-related figures in patients with relevant problems.
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Soft Agar Assay를 이용한 배양골조직과 골세포의 Transforming Growth Factor-β유리에 관한 연구
백정화,김관식,정동균 대한구강생물학회 1991 International Journal of Oral Biology Vol.15 No.2
To study the effect of PTH, osteotropic hormone, on the TGF-β activity in conditioned medium prepared from bone explants, fetal rat ulnae and radii were removed at 19-day of gestation and organ cultured for 24 hours. Then media were changed with fresh BGJb media for control group or PTH-supplemented media (50 or 200 ng/㎖) for experimental group respectively and conditioned media were prepared by 2-day culture of explants. To study the cellular orgin of matrix-associatied TGF-β and the effect of PTH on the TGF-β activity in conditioned media prepared from bone cells, five bone cell populations were prepared from fetal rat calvaria by sequential enzyme digestion. After primary culture, each bone cell population was collected and resuspended as Ⅰ-Ⅱ, Ⅲ and Ⅳ-Ⅴ groups. After 24 hours, media were changed with fresh minimum essential medium(MEM) or 600 ng/㎖ PTH-supplemented media and conditioned media were prepared by 2-day culture. For activation of latent TGF-β activity in bone cell-conditioned media, media were acidified and then neutralized. TGF-β activities of conditioned media were measured by anchorage-independent growth of NRK fibroblasts using modified Todaro soft agar assay method(1987) and the number of colonies ≥ 50 ㎛ was counted. The observed results were as follows. 1. TGF-β, without 2 ng/㎖ EGF, did not induce colony formation in soft agar suspensions. 2. With 2 ng/㎖ EGF, TGF-β induced NRK cells to form large colonies in soft agar suspensions and colony numbers increased proportionally to TGF-β concentrations from 50 pg/㎖ to 1600 pg/㎖. 3. When ulnae and radii were incubated with 50 ng/㎖ PTH, TGF-β activity in conditioned media was not significantly different from control conditioned media. In contrast, TGF-β activity in conditioned media prepared from culture with supplementation of 200 ng/㎖ PTH, was significantly increased(p < 0.01). 4. TGF-β activity was detectable in all bone cell populations and the amount was not significantly different between cell populations. 5. When bone cell populations were incubated with 600 ng/㎖ PTH. TGF-β activity in conditioned media from each population was not significantly different from control conditioned media. These results suggest that all cell populations isolated from calvaria synthesize TGF-β and PTH has no apparent effects on the TGF-β production of bone cell populations. In addition, increased TGF-β activity in bone explant conditioned media by 200 ng/㎖ PTH appears to be due to the enhanced release of TGF-β from bone matrix secondary to bone resorptive process.
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백정화 ( Jeong Hwa Baek ),정은정 ( Eun Jeong Jeong ),전선영 ( Seon Young Jeon ),차용준 ( Yong Jun Cha ) 한국수산과학회 2012 한국수산과학회지 Vol.45 No.2
Crab-like flavorants (CFs) were made from snow crab cooker effluent (SCCE) using response surface methodology (RSM) and reaction flavoring technology (RFT). Type A CF was made from SCCE via RSM, RFT, adding starch syrup, centrifugation, and microfiltration. Type B was made from type A by adding the food additives dimethyl sulfide, ethyl valerate and fish sauce. The stability of the CFs was evaluated in terms of the color values, sensory evaluation, and flavor profiles after storage for 90 days at three different temperatures: 10, 20, and 30℃. The compounds, ethanol and 3-methyl-1-butanol, were considered key components of off-flavor and a decrease in dimethyl-2-vinylpyrazine affected the occurrence of off-flavor. It may be a microbial metabolite arising from contamination and lab-scale micro-filtration. At the lowest temperature (10℃), the decrease in volatile compounds, such as pyrazines, was not as dramatic as at 20℃ and 30℃ and alcohol formation was prevented or delayed. Therefore, it is necessary to store CFs at < 10℃ with suitable sterilization to preserve volatile flavor compounds and prevent off-flavor from occurring.
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백정화(Jeong-Hwa Baek) 대한치과의사협회 2013 대한치과의사협회지 Vol.51 No.3
Antibiotic is one of the mainly prescribed drugs in dental office. The substantial part of all antibiotics used in dental office is given to patients without signs or symptoms of infection to prevent infections, and antibiotics became the most widely abused prescribed drugs on the basis of inappropriate indications, dosages and durations. Considering that antibiotics are one of the drugs that affect not only a single patient but also entire populations of individuals through their collective effects on microbial ecology, the importance of proper use of antimicrobial therapy can hardly be overemphasized. Therefore, the main considerations for antibiotic therapy in dental office were summarized here.
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