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Flurbiprofen과 Cyclodextrin과의 포접화물에 관한 연구
용재익,백완숙,김길수 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.1
The inclusion of α-cyclodextrin and β-cyclodextrin with flurbiprofen in aqueous phase was investigated by UV absorption and circular dichroism spectroscopies. The inclusion complex in solid powder form were made by the freeze-drying and coprecipitation methods in molar ratio 1 : 1. The inclusion complex formation was confirmed by infrared absorption spectroscopy. The freeze-drying method was successful in obtaining the inclusion compounds compared with the coprecipitation method. The dissolution of solid flurbiprofen inclusion complex was examined in comparison with those of flurbiprofen alone. The inclusion complex obtained by freeze-drying method increased the dissolution rate.