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Cheol Min Jo(조철민),So Min lee(이소민),Bum Jung Kim(김범정),Kyung Jin Lee(이경진),Ho Young Choi(최호영) 한국약용작물학회 2021 한국약용작물학회 학술대회논문집 Vol.2021 No.1
Background : The purpose of this study was to investigate the vasorelaxant activity and action mechanism of the ethanol extract of Prunus mume (Siebold) Siebold & Zucc. branch (PMB). Methods and Results : PMB (2 –30 μg/㎖) activity on endothelium-intact and endothelium-denuded aortic rings pre-contracted by PE (1 μM) was determined. PMB caused concentration-dependent vasorelaxation on endothelium-intact but did not cause vasorelaxation on endothelium-denuded aortic rings. Pre-incubation with NG-nitro-L-arginine methyl ester (L-NAME), indomethacin, L-NAME + indomethacin, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), methylene blue (MB), atropine, tetraethylammonium chloride (TEA), glibenclamide, 4-aminopyridine (4-AP), and barium chloride(BaCl<sub>2</sub>) significantly reduced the EC50 values. All inhibitors used in the mechanism study significantly inhibited vascular relaxation. Conclusion : PMB caused endothelium-dependent vasorelaxation in rat aortic rings. The vasorelaxant activity of PMB were related to (1) NO-cGMP pathway, (2) PGI2 pathway, (3) muscarinic receptor pathway, and (4) potassium channels such as KV channel, K<sub>ATP</sub> channel, and K<sub>IR</sub> channel. Our study explains that PMB may be another approach to hypertension treatment to reduce the burden of cardiovascular disease.