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배하림,박철호,이종휘 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
One of the bottle-necks of a salinity gradient power system is the limitation of membrane performance to extract high energy efficiency. This study demonstrates the membrane structure design to improve power density of pressure retarded osmosis (PRO) systems. To achieve an upgraded membrane for PRO, electrospinning technology was used to prepare the high porous support layer. A facile method was developed to fabricate interconnected electrospun nanomats. The opening pore size of nanomat was controlled by the electrical surface charge to promote the stability of active layers. The power density was 10 W/m<sup>2</sup> which is quite so high for commercialization when the fully aromatic polyamide was introduced as the active layer.
배하림,이종휘 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.40 No.-
The optimal design of an electrospun scaffold for tissue engineering is contingent on its functionality tomimic the native extracellular matrix (ECM) as much as possible. Using core-sheath particles forencapsulation, the scaffolds of particle-fiber hierarchical structures could play the dual roles of structuralmatrix and controlled delivery system of active ingredients. Herein, electrohydrodynamic jetting ofcountercharged nozzles was investigated to combine fibers and core-sheath particles based on theneutralization phenomenon between electrospun poly(L-lactide-co-D,L-lactide) fibers and electrosprayedpoly(lactide-co-glycolide) particles. It was revealed that the key features of particle-fibercomposites could be conveniently designed by controlling the composition of the binary mixture of ethylacetate and benzaldehyde (BA) for electrospraying. With an increase in the BA concentration, the arealdensity of the particles on the fibers (degree of combination) increased threefold, and the total loadingamount of lysozyme (model active ingredient) also increased threefold, while particle size and fiberdiameter did not change significantly. The composites prepared from a high BA content case providedsustained release profiles, which are independent from the degradation kinetics of fibers, such thatlysozyme could be released for more than a month. The use of a binary solvent mixture for this processseems to be an effective strategy for developing future functional scaffolds for tissue engineering.
Morphology control of eprosartan crystals via polymer-directed crystallization
배하림,이종휘 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.4
Improving the stability, processability and bioavailability of drug crystals is important during the development of most drugs. In traditional crystal engineering, different crystallization conditions are used to tailor the properties of crystals, often improving one property at the cost of another, or simply optimizing both properties. The influence of soluble polymers on the particle morphology of crystals during the crystallization of eprosartan was investigated to explore the possibility of improving the properties of the drug crystals. The presence of polyethylenimine (PEI) during the crystallization of eprosartan induced the self-assembly of small primary crystals into larger aggregates without changing the crystal polymorph. In particular, spherical aggregates of an ordered structure were obtained when eprosartan was crystallized by changing the pH from 12 to 4.2 in the presence of PEI. This technique of polymer-directed crystallization is promising for the property engineering of drug crystals, which has been limited by a few crystallization variables to date.
이민경,배하림,이소나,정내오,이해승,최소영,황선애,이종휘 한국고분자학회 2011 Macromolecular Research Vol.19 No.2
Drug stability and sustained release issues are important areas in drug-delivery research. The sustained release of proteins can be achieved by their encapsulation with a hydrophobic polymer, but this requires the proteins to be protected from the harsh processing environments of organic solvents and mechanical force. Preencapsulation with poly(vinyl alcohol) (PVA) using a freeze/thaw method has been shown to allow successful protection and sustained release. This study examined the effects of freezing/thawing on PVA encapsulation in the preparation of PVA-PLGA composite particles. Freezing/thawing slightly improved the crystalline peaks and the heat of fusion of PVA, but more distinct differences were observed when the properties of the surface layers were probed by AFM. The hardness of particles’ surfaces increased with increasing number of freezing/thawing cycles, whereas the adhesion force with an AFM cantilever tip decreased. The mean particle size and entrapment efficiency decreased. These results suggest that surface hardening is the major mechanism responsible for the sustained release characteristics.
박철호,배하림,최욱,이강원,오대균,이종휘,이정현 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.59 No.-
For extracting the salinity gradient energy, membrane is a key material with a high power density. For this purpose, thin film composite (TFC) membranes were synthesized by interfacial polymerization using various acyl chloride and amine monomers. TFC membranes were characterized by FT-IR, SEM, XPS, and AFM. Among the range of TFC, the best candidate was prepared by combining 3,5-diaminebenzonic acid (0.5 wt% with distilled water) and 1,3,5-benzenetricarbonyl trichloride (0.2 wt% with n-hexane). The TFC membrane (thickness = 0.02 mm) generated a power density of 7.2 W/m2 at salinity gradient between 0.005 and 0.5 M KCl solutions.