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Streptozotocin 유발성 당뇨백서에서 해당효소에 대한 Phlorizin의 효과
배학연,정회상,박유환,전용준,이승일,문철웅,양성훈,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
In glycolysis, the reactions catalyzed by hexokinase, Phosphofructokinase, and pyruvate kinase are lally irreversible; hence they would be expected to have regulatory as well as catalytic roles. They ilso adaptive in a number of physiological states, and although the molecular mechanisms controlling adaptations are largely unknown, dietary and hormonal stimuli serve as environmental factors lating enzyme levels in vivo. The present study was undertaken to examine the effects of phlorizin, a blocker of renal tubular ose reabsorption, on the activities of glucokinase, hexokinase, and pyruvate kinase in the liver and nrocytes of streptozotocin (STZ) diabetic rats. The levels of plasma glucose and insulin and the activities of glycolytic enzymes were measured onchird day after phlonzin treatment in normal and STZ diabetic rats and the results were as follows. 1. Plasma glucose levels were reduced by 14.35%(P<0.05) in normal rats and by 39.38% (p<0.01) in STZ diabetic rats. 2. Plasma insulin levels were reduced by 45.6% (P<0.05) in normal rats and by 58.2% (P<0.01) in STZ diabetic rats. 3. On the third day after phlorizin treatment, hepatic glucokinase and pyruvate kinase activities in normal rats were reduced by approximately 56% (P<0.01) and 43% (P<0.01) respectively, and erythrocyte hexokinase and pyruvate kinase activities were reduced by approximately 18% (P<0.05) and 22% (P<0.01) respectively, In STZ diabetic rat shepatic glucokinase and pyruvate kina activities were reduced by approximately 52% (P<0.01) and 22% (P<0.01) respectively, a erythrocyte hexokmase and pyruvate kinase activities were reduced by approximately 4% and 3 respectively. Thus the overall decreases of the levels of plasma glucose and insulin and the activity of glycoly enzymes were observed on the third day after phlorizin treatment in normal and STZ diabetic ra These alterations in the enzyme activity with phlorizin treatment were shown to be a result of reducinsulin levels, and the smaller decrease in enzyme actvity in STZ diabetic rats than in normal rats thought to be probably due to the reduced response to changes in insulin levels at near basal levels enzyme activity.
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김현리,배학연,장성종,김희중,정재용,김양수,김태균,박유환,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.2
Objective: Leptin, the product of obesity (ob) gene, is a 16-kDa peptide hormone secreted by adipocytes and is thought to be a homeostatic signal that contributes to body weight regulation through modulating feeding behavior and/or energy expenditure. Mutations of the ob gene that led to leptin deficiency or production of a truncated inactive protein are associated with hyperphagia, hypometabolism, obesity, and noninsulindependent diabetes mellitus(NIDDM) in obese ob/ob mice. Leptin' s role in humans with obesity and NDDM is not known. Plasma leptin concentrations are shown to be elevated in obese humans. We questioned whether subjects with NIDDM have an altered regulation of serum leptin levels. Therefore, the object of this study is to evaluate the relationships between the serum leptin level and BMI, NIDDM. Method: This study were made of 70 subjects(control: 35, NIDDM:35) at Chosun University Hospital in Kwangju from March, 1998 to September, 1998. We measured the height and weight for BMI. Also, we measured leptin and C-peptide through radioimmunoassay. Result: The serum leptin concentration were not different in patients with type II diabetic and nondiabetic subjects (6.3 0.86/7.22 0.96, p=0.476) and the BMI was similar in diabetic and nondiabetic subjects(24 0.57/24 0.45, p=0.93). The leptin concentration were higher in women than in men regardless of diabetic status (diabetes: male 3.07 0.40 / female 8.20 1.18, p<0.05 control: male 4.88 1.28 / female 8.60 1.25, p<0.05). Conclusion: We concluded that the leptin concentrations were not different in diabetic and nondiabetic subjects and that the association of leptin with sexual dimorphism was similar in diabetic and nondiabetic subjects.
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Polyamide-66/Glass fiber 블렌드 조성물의 물리적 특성및 안경테 소재로써의 적용성에 관한 연구
손진영,이지은,최경만,배유환,김기홍 한국안광학회 2013 한국안광학회지 Vol.18 No.4
Purpose: In this study, we evaluated the physical and thermal properties of the compositions made by blending glass fiber (GF) of different contents into glass fiber polyamide-66, and investigated if the compositions applying to the glasses frame to replace the TR-90, which is polyamide-12 resin used as an injection-type spectacle frame material. Methods: To investigate the characteristics change of polyamide-66 (PA-66) compositions with the change of the content of glass fibers, we produced a composition of the content by using a twin-screw extruder. The mechanical strength of the composition production was measured and coating properties as well as cutting processability were evaluated. We evaluated the applicability of the glasses frame by comparison the results of new compositions with characterizations of traditional TR. Results: For the results of the characterization of Polyamide-66/GF composition, we found that the higher increase of content of the glass fiber, the less mold shrinkage rate, and the mechanical strength was increased. Tensile strength increased from 498 kg/cm2 for 0 wt%of the content of the glass fibers to 849 kg/cm2 for 30 wt% of the content of the glass fibers. As a result of a coating evaluation, the strength of coating was 4B in the GF 5wt% and 5B, which was extremely good coating characteristics, in the over than GF 5 wt%. Conclusions: In case that 30 wt% of the glass fiber was blended, the mechanical strength was greatly improved, the hardness was increased, injection temperature increased due to increase of the viscosity, and the flow mark of the product may occur. The paint coating of PA-66 blended with glass fiber was all excellent. With general evaluating physical properties and workability properties it was determined that around 10 wt% of the content of the glass fibers was possible to apply a spectacle frame. 목적: 본 연구에서는 사출형 안경테 소재로 사용되고 있는 폴리아미드-12 수지인 TR-90을 대체하기 위하여폴리아미드-66에 유리섬유(glass fiber)를 함량별로 블렌드하여 각 조성물의 물리적, 열적 특성을 평가하여안경테로써의 적용 가능성을 검토하였다. 방법: 유리섬유의 함량 변화에 따른 폴리아미드-66 조성물의 특성변화를 고찰하기 위해 이축압출기를 이용하여 함량별 조성물을 제조하였다. 제조된 조성물의 기계적강도,열적 특성, 코팅성 및 절삭가공성을 평가하였다. 이를 통하여 기존 TR 안경테 제품과의 성능 비교 및 안경테로써 적용 가능성을 평가하였다. 결과: 폴리아미드-66/유리섬유 조성물의 특성 평가 결과, 유리섬유의 함량이 증가할수록 성형수축율이 감소하며, 기계적 강도가 증가하는 것으로 나타났다. 유리섬유의 함량이0 wt%인 경우 인장강도는 498 kg/cm2에서 30 wt%가 함유된 경우 849 kg/cm2 까지 증가하였다. 코팅성 평가결과 유리섬유 5 wt%에서는 코팅강도가 4 B였고, 그 이상에서는 5 B로 매우 우수한 코팅 특성을 나타내었다. 결론: 30 wt%의 유리섬유가 블렌드된 경우 기계적 강도가 크게 향상되나 이와 더불어 경도가 상승되며, 점도가 증가하여 사출온도가 높아지며, 제품에 플로우 마크가 생기는 것으로 나타났다. 유리섬유가 블렌드된폴리아미드-66의 도료 코팅성은 모두 우수하였다. 전반적으로 물성 및 가공성 등을 평가해볼 때, 유리섬유의 함량이 약 10 wt% 내외의 경우 안경테로써의 적용이 가능하다고 판단된다.
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